XLOC_008941 (tgfb1a)


Basic Information

Item Value
gene id XLOC_008941
gene name tgfb1a
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007126.7
NCBI id CM002899.2
chromosome length 48040578
location 2776506 ~ 2803313 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00017656
ATGAGGTTGGTTTGCTTGGTGCTGACCGCCCTGTGTTTGGTCACGGGAACGGGCAGCATGTCCACCTGTAAGACTCTGGATTTGGAGGTGGTGAGGAAGAAGCGGATTGAGGCTATTCGGGGTCAGATCCTCAGTAAACTGCGCATGGCTAAAGAGCCTGAATCCGGAGCGGACGACGACGGACAGAAGATCCCGGATTCCTTGCTTTCGTTATATAATAGCACTGTTGAACTGAGCGAAGAAATGAAGACGAAGATCGTCCCTGTGCAGGATGAGGATGAGGACTATTTTGGCAAGGAGGTGCATAAGTTCGTCTTCCAGCAAGCTCAGAATAACACAAAGCATCAGATGTTTTTCAACGTGTCCGAGATGAAGCGCAGTATTCCAGACTACCGGCTGCTGTCTCAAGCAGAATTGCGTCTTCGGATCAAGAATCCCACCATGGACCAGGAGCAGAGGCTGGAACTGTATCGCGGAGTGGGGGATCAGGCTCGATATCTGGGAACTCGCTTTGTCTCCAAGGACTTGTCCAACCGCTGGCTCTCATTTGACGTGAAACAGACAATGATAGAATGGCTGCAGGGTTCAGaagatgaAGAAACCTTGGAGCTGAGGTTATACTGCGACTGTAAAGCAAACCAGCAGAGCACGGATAAGTTCCTCTTCACTATATCAGggctaGACAAGCAGAGAGGTGACACCGCTGGTCTGGCAGATATGATGGTGAAGCCGTACATTTTGGCTTTATCTTTGCCTTCAAATGGCAACTCTCTTGCATCCGTTCGCAAGAAACGAGCTGTTGGCACCGATGAAACATGTGATGAAAAAACGGAGACCTGCTGTATGCGCAAGCTTTACATTGACTTTCGGAAAGATCTGGGTTGGAAGTGGATCCACAAGCCCAAGGGGTACTTTGCCAACTACTGCATGGGGTCCTGCACCTACATCTGGAATGCTGAGAACAAATACTCACAGATATTAGCCTTGTACAAACACCACAACCCTGGTGCCTCGGCTCAGCCATGCTGTGTACCCGCAATCCTTGACCCTCTGCCAATTCTTTATTACGTGGGAAGGCAACACAAGGTGGAGCAATTGTCCAACATGGTGGTGAGGAACTGCAAGTGCAGTTAAGAGTTCATCTGACTACAATACATCACCTTCAGAAAGTGGTTCATGGCTCGATTTCTCAGTCGGGATTGATAAGTAAGCCAACACACAAGAAAATGGACATACATAACATCTCAATGGGAGGACACATGGACAAAAAAAGGAAGAAATGATGAGAGATGGACTGAAGCAGAGGCAATAGGACGTAGAAAAGGATACAAATATCTTTGAAAATGCTTTGCACAATAACGCACAGACATTCTGTTACAGCATTTCACCAAACAAGCTCGATATTAAACCAAATATATGCTTCTGATAtctttataaatgtgtatatttacattattaattCCGTTAATTTATTACGCTCTTCAAGTTGATTGCACCACGAAAGCTGCCATGTAGCATCGCATGCCAATTGTAAAATGAAGACTTCTAATGGTGCTGTACTGATAAAGGAAGGCATGGCAAAGAAACTAACACCATGTGTCAATTGATTGTAAACATGGATTAAAAAGAATCGTATGCACTAAACAATGGAGATGAAGGCTCATGGCAAACAGTATGAGACTTATGTCTACAAAGGCAAGGGCACTAGAATATGTATTCATGAAATtctttgtttttaagtgcaggaCTGATTTTATCGATGTACACCGCTGTGTTCTAAAACCCGATGGTTTTTGTAgagtctaaggccccgtttacactaatgcgttttagttttaaaacgtaaAAGTTTTGCTaaggttacgccatccgtccacactacgccagagttttcgagcgccgaaaacggagcattttggaaacgctggagaggctgttctcattctgaaacgctgctgctccgtctcagtgtggatgagggaaaacggagacatctgaaaatggaggcgggtgTGCTGAGATTCGCctagctgattggggcttttgtgtcattgcataTCCTTCCcctattcgtcaagcccctatcacatgactataacacatggctttaacgctaccggaagacagcagaccagccttcactgtaaaaaataaatggacacatagaaaaaaaaataataataataaaaaataaacatagacacagaaatgggagcgttgtttgcactattgtatgttttaggcggcattgtgcagttgttcatttgttacatttagtaacaactcgacctcgtcgcctgtccacaaaaatacctctcttgctttctttgccatcgcattCATTGTTCatccggcgtttgttgactaacaataaccaaatgtcgagcgagacgcatgcttcctgtttatactagaacgcgcatgcccagagtgcacgaATAGTCATGTGATATAAGTTTTTggtggcatagtgtggacggagatatgttcagagacgctaggtgaaacgctagggTGGGCGTGGaacgtttttgatctaaaacgccgttttaaaactgaaacgcactagtgtaaacgacACCTAAGAAAACAAGTGATGTGCTCTCAAACTAAATGTTGCACACTATTCAAGTGTTACAAGAAGATGCATTTCAAAGCTGCCTATTTAGGGTCTGttcatttgaaaaatgtttttttaaaaactgactgATTTGATAAAACtgtgttttaaaaaagtaaaaaaaatgtgttcaggtcatattttataaaaaaaaaaactaataattgaACTGAATTCCATTTTAGGACAGTTAATGGGGTTCTATTATGcttctttttacaagatgtaaaataagtcccatgtccctggagtgtgtgtgtgtgaagtttcagcacaaaataccacacagataatgttttaacTCTCTTAAACTGACTCTTTTAGGGTTTGATTCTAatcgttttggtgactgtcgctttaaattcaaatgagattgtggtgtttttttttttaaagagggcggagctacagatgtctATGTGtcagcagattcaaaaacaacactaatgtcctatgctaatgaggaggagatggtcactagtgggcggagctttccccctctgatgacgtAATaagtgagaatgtcaatcaaagtgtttctgcagactgttcttATCAAGTCTGAtcataaacaatacaattaaacatttttaccattggaggctggttatattcacacactgctgacacaacCCTTcgtaaaagtgatttttgcataataggtgcttTTTAATATTGTTGTTCAATTGTTCAAAAGTTCAATTGACTGCATTTTGTTCACTGTAATGCACCTAATCAATTATTACAGTTTTTGATACTTGCAGAAAAATATTTCATACAGTTTGTGATCAAAAGAAATCATTATGGCGATATGAatagacaacacacacacaaaaacatggtCCTAAAAATGTAgggttttaatctttatttaaatgtacattttttcttTGAGTTTTGAGGtgaaatttgacttttttttttttttttacgtcagTCGTGTATGTGTAAGTGTGTTTATTGCTGTGTTTGTGCTAGTGAGAAAGTTTGAGTTAGTAAAGAAATGTTTCTTGcaaaatgtatgtttttctttcagttttaaGGTGAAATTTGACTGATGCTTGTATTTTTTAAGTCACTTatgtgtatgtaagtatgtatatTGCTGTAATTGTGTTGGTGAGAAAGTTTTAGTAAAGACATTATTGTTTCTGtattgatctgtgtgtgtgtgtgtgtgttccaaacAGCACATGGCCCACTTTTATGgcctttttataaaacattttttggcGACACTTGTTAATTTTGGTACATTTTTCATGTCCGACACCATTAAAGGGTAACAGAGTACATGAtgaattctgagtgtgcctcacacagtgggcttgacaaaccacctgtataaCTCTCTCTCTgagactttgggctctatttgAACTATTTttatctaggcgcaaagtctaaagctcatggcacaaaagcattaagggcatgtccgaatccacttttgctattttattttacgTTCTGCGCCACAGcgaatggtctaacagggttgtgcttagtctgttaataagttatgggtgtgttttgagcataacgtgcattaaaccaatcagagtctcctattccctttaatagtcagttgtgtcgcaccatggtgcgtttgctatttacatggtgactttgtaagtggaaaaactgaacactttactagcaagaaaacagttaaacagagcatctgcagcgcgattataaagaacgagcctcctccattcagcttctttacttttactctttactcctttactttggtggtgTATGGAAACGGTGAAAACTCTCCACTGAAGC

Function

symbol description
tgfb1a Predicted to enable cytokine activity; type II transforming growth factor beta receptor binding activity; and type III transforming growth factor beta receptor binding activity. Acts upstream of or within hematopoietic stem cell differentiation; otolith development; and posterior lateral line development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including cardiovascular system; digestive system; epidermis; fin; and sensory system. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; Camurati-Engelmann disease; aphthous stomatitis; artery disease (multiple); and lung disease (multiple). Orthologous to human TGFB1 (transforming growth factor beta 1).

GO:

id name namespace
GO:0007179 transforming growth factor beta receptor signaling pathway biological_process
GO:0042127 regulation of cell population proliferation biological_process
GO:0060395 SMAD protein signal transduction biological_process
GO:0051781 positive regulation of cell division biological_process
GO:0048840 otolith development biological_process
GO:0030509 BMP signaling pathway biological_process
GO:0060218 hematopoietic stem cell differentiation biological_process
GO:0035677 posterior lateral line neuromast hair cell development biological_process
GO:0048919 posterior lateral line neuromast development biological_process
GO:0048920 posterior lateral line neuromast primordium migration biological_process
GO:0048922 posterior lateral line neuromast deposition biological_process
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation biological_process
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0034714 type III transforming growth factor beta receptor binding molecular_function
GO:0005114 type II transforming growth factor beta receptor binding molecular_function
GO:0005125 cytokine activity molecular_function
GO:0005160 transforming growth factor beta receptor binding molecular_function
GO:0008083 growth factor activity molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-030618-1 Predicted to enable cytokine activity; type II transforming growth factor beta receptor binding activity; and type III transforming growth factor beta receptor binding activity. Acts upstream of or within hematopoietic stem cell differentiation; otolith development; and posterior lateral line development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including cardiovascular system; digestive system; epidermis; fin; and sensory system. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; Camurati-Engelmann disease; aphthous stomatitis; artery disease (multiple); and lung disease (multiple). Orthologous to human TGFB1 (transforming growth factor beta 1).

Ensembl:

ensembl_id ENSDARG00000041502

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00017656 True 4414 mRNA 0.41 7 2776506 2803313

Neighbor

gene id symbol gene type direction distance location
XLOC_008939 ppp5c coding downstream 22450 2727670 ~ 2754056 (-)
XLOC_008940 CABZ01086049.1 coding downstream 40008 2736383 ~ 2736498 (-)
XLOC_008938 si:ch211-235m3.5 coding downstream 49844 2700646 ~ 2726662 (-)
XLOC_008937 cldna coding downstream 118998 2655566 ~ 2657508 (-)
XLOC_008936 cldnf coding downstream 123866 2650787 ~ 2652640 (-)
XLOC_008942 NA coding upstream 10203 2813516 ~ 2816142 (-)
XLOC_008943 CABZ01086041.1 coding upstream 17455 2820768 ~ 2841677 (-)
XLOC_008944 ankrd49 coding upstream 47652 2850965 ~ 2857961 (-)
XLOC_008945 guca1c coding upstream 81398 2884711 ~ 2903475 (-)
XLOC_008946 CABZ01086029.1 coding upstream 114944 2918257 ~ 2931021 (-)
XLOC_008933 NA non-coding downstream 150578 2618279 ~ 2625928 (-)
XLOC_008932 NA non-coding downstream 165336 2598804 ~ 2611170 (-)
XLOC_008928 NA non-coding downstream 448222 2323666 ~ 2328284 (-)
XLOC_008927 AL954387.2 non-coding downstream 510423 2265969 ~ 2266083 (-)
XLOC_008951 NA non-coding upstream 312024 3115337 ~ 3116262 (-)
XLOC_008952 NA non-coding upstream 357125 3160438 ~ 3162459 (-)
XLOC_008957 NA non-coding upstream 951253 3754566 ~ 3760957 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000091_00120666_00139417 TGFB1A coding CI01000091 null 120666 ~ 139785 (+)