XLOC_000012 (cul4a)


Basic Information

Item Value
gene id XLOC_000012
gene name cul4a
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007112.7
NCBI id CM002885.2
chromosome length 59578282
location 157793 ~ 167398 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00000026
GCGGAATATGGAGTGTGTATGATAAATATGAGGGAtatctgcaggtgtgtgtgtgcaggtgtcgGTCCACAGTGGCGGCGGGAGTCTCTTCACGAGCTTTAATCGCCCCATGGCTGTGATTGTGTGTTGTCAGAGCTAACGGCTAACAGCTCGACTCTCGCGCTAGCGTTGTTGTtatcgtcattattattaatattatagttttaCACCGTCAAATGCACTGAGGCCAGAGCAGCTCATGATGGCAGAAGATGTTCAGCACCAGCAGAAGTCCAGCTTTAATGGACTCAGCAAATCCGCCAAAGCAGGAGCGTCGAAGAAGCTGGTCATCAAGAACTTTAAAG
>TCONS_00000027
ATGGCAGAAGATGTTCAGCACCAGCAGAAGTCCAGCTTTAATGGACTCAGCAAATCCGCCAAAGCAGGAGCGTCGAAGAAGCTGGTCATCAAGAACTTTAAAGACAGACCCAAGCTGACAGACTCCTACACTGAAGACACGTGGCTGAAGCTCAGAGATGCTGTGAGCGCCATTCAGAACAGCACATCCATCCAATACAACCTGGAGGAGCTTTaccagGCTGTGGAGAATCTGTGTTCGTATAAAGTGTCGCCGATGTTGTACAAGCAGCTGCGACAGGTGTGTGAAGAGCACGTGCAGGCGCAGATTCACCAGTTCAGGGAAGAGTCTCTGGACAGCCTGTCGTTCCTGAAGAGGATGAACCGCTGCTGGCAGGACCACTGCAGACAGACGATCATGATCCGCAGTATTTTCCTCTTCCTGGACCGAACGTACGTCCTCCAGAACTCGCTGCTGCCGTCCATCTGGGACACAGGGCTGGAGCTGTTCCGCACACACATAGTGAGTGACGCGGCGGTTCAGAGCCGGACGGTGCAGGGGATCCTGGAGCAGGTGGAGCGCGAGCGCAGCGGGGAGACGGTGGACCGCAGTCTGCTCAGGAGCCTACTGGGCATGCTCTCTgacctgcaggtgTATAAGGACTCGTTCGAGCAGAGGTTTTTATCAGAGACGACCCGTCTGTACGCCGCTGAGGGACAGAGACTGATGCAGGAGAGAGACGTTCCAGAGTATCTCCATCATGTGGCGCGGCGTCTGGAGGAAGAGAACGACCGCGTCATCAGCTATCTGGACCAGAGCacacaGAAGCCTCTGATCGCCACGGTGGAGAAGCAGCTGCTGGGAGAACACATGACCACCATCCTGCAGAAAGgcCTGCGGACGCTGCTGGATGAGAACCGTGTGTGTGAGCTGACGCTGCTCTATGAGCTCTTCAGTAAGGTTAAAGGCGGCCTGACGGCACTGCTGCAGTCCTGGAGAGAATACatcaagAGTGTGGGAGCGGAGACGGTGTGTTCTCCGGAGCGGGACAGGGAGATGGTGCAGGAGCTGCTGGACTTTAAGGATCAGATGGACTCGGTGACGCAGAGCTGCTTCCAGAGGAACGAGAGCTTCATCAACGCCATGAAGGAGGCCTTCGAGAACTTCATCAACCAGAGACCCAACAAACCCGCAGAGCTCatcgCCAAATATGTGGACTCTAAGCTGCGAGCGGGAAATAAAGAAGCcacagaggaggagctggagagAATCCTGGACAAGATCATGATCATCTTCCGCTTCAtccacgGTAAGGATGTGTTCGAGGCGTTCTACAAGAAGGATCTGGCCAAGCGTCTGCTGGTGGGCAAGAGCGCTTCAGTGGATGCAGAGAAGTCCATGCTCTCCAAACTCAAACACGagTGTGGAGCAGCGTTCACCAGTAAACTTGAGGGAATGTTCAAAGATATGGAGCTCTCCAAAGACATCATGATCCAGTtcaaacagtatatGCAGAATCAAACTGAGCCCAGCAACATTGAGCTGACCGTCAACATCCTGACTATGGGCTACTGGCCCTCGTACACACCGATGGACGTCCATCTGCCTGCTGAGatggtGAAGCTGCAGGAGGTGTTTAAGCTCTTCTATCTGGGTAAACACAGCGGACGGAAACTACAGTGGCAGCCGACACTTGGACACGCAGTGCTGAAGACAGAGTTTAAAgagggtAAGAAGGAGCTGCAGGTTTCTCTGTTCCAGACTCTGGTTCTGCTGATGTTCAATGAGTCTGACGAGTGTTCAGTGGAGGAGATCAGAGTGGCTACAGGCATcgaggagGGCGAGCTGAAGCGTACGCTGCAGTCTCTGGCGTGTGGTAAAGCTCGAGTGCTCAATAAGACCCCCCGAGGGAAAGAGGTGGAGGAC

Function

symbol description
cul4a Predicted to enable ubiquitin protein ligase binding activity and ubiquitin-protein transferase activity. Acts upstream of or within embryonic pectoral fin morphogenesis; heart development; and otic vesicle morphogenesis. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex. Is expressed in brain; heart; and pectoral fin. Orthologous to human CUL4A (cullin 4A).

GO:

id name namespace
GO:0007507 heart development biological_process
GO:0071600 otic vesicle morphogenesis biological_process
GO:0006974 cellular response to DNA damage stimulus biological_process
GO:0016567 protein ubiquitination biological_process
GO:0035118 embryonic pectoral fin morphogenesis biological_process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process biological_process
GO:0006511 ubiquitin-dependent protein catabolic process biological_process
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process biological_process
GO:0033339 pectoral fin development biological_process
GO:0019005 SCF ubiquitin ligase complex cellular_component
GO:0080008 Cul4-RING E3 ubiquitin ligase complex cellular_component
GO:0031461 cullin-RING ubiquitin ligase complex cellular_component
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex cellular_component
GO:0004842 ubiquitin-protein transferase activity molecular_function
GO:0031625 ubiquitin protein ligase binding molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-040426-1357 Predicted to enable ubiquitin protein ligase binding activity and ubiquitin-protein transferase activity. Acts upstream of or within embryonic pectoral fin morphogenesis; heart development; and otic vesicle morphogenesis. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex. Is expressed in brain; heart; and pectoral fin. Orthologous to human CUL4A (cullin 4A).

Ensembl:

ensembl_id ENSDARG00000096578

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00000026 False 344 mRNA 0.48 1 157793 158136
TCONS_00000027 True 1905 mRNA 0.54 18 158034 167398

Neighbor

gene id symbol gene type direction distance location
XLOC_000011 NA coding upstream 511 156792 ~ 157282 (+)
XLOC_000010 prozb coding upstream 5795 144284 ~ 151998 (+)
XLOC_000009 f10 coding upstream 15324 135903 ~ 142469 (+)
XLOC_000008 f7i coding upstream 23714 127250 ~ 134079 (+)
XLOC_000007 f7 coding upstream 32547 119960 ~ 125246 (+)
XLOC_000013 lamp1a coding downstream 9185 176583 ~ 182258 (+)
XLOC_000014 tmco3 coding downstream 51126 218524 ~ 225137 (+)
XLOC_000015 tfdp1b coding downstream 59843 227241 ~ 243798 (+)
XLOC_000016 grk1a coding downstream 77678 245076 ~ 258138 (+)
XLOC_000017 cenpe coding downstream 92641 260039 ~ 296057 (+)
XLOC_000018 NA non-coding downstream 188083 355481 ~ 358562 (+)
XLOC_000024 dre-mir-155 non-coding downstream 409046 576444 ~ 576521 (+)
XLOC_000026 NA non-coding downstream 627578 794976 ~ 911551 (+)
XLOC_000028 NA non-coding downstream 848414 1015812 ~ 1033638 (+)
XLOC_000029 CR450787.2 non-coding downstream 1051293 1218691 ~ 1218805 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000299_06257032_06266210 CUL4A coding CI01000299 null 6255857 ~ 6266210 (-)