XLOC_013337 (tph2)


Basic Information

Item Value
gene id XLOC_013337
gene name tph2
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007129.7
NCBI id CM002902.2
chromosome length 51023478
location 16989764 ~ 17001056 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00026367
GCAATTCCGAAGATGCAACCTGCCATGATGATGTTCTCCAGCAAATACTGGGCTCGGAGAGGACTATCTTTGGATTCAGCTATGTATGACCAACAGCACCTTGCATCCTCCATGCTCCGCAGGACATCCTTTAATCGGATAGATGAAAGACCTGACAAAGAAGAACAGAAATCCACTCATGACCTTGGGAAGCTGGCAGTGATTTTCTCTCTGAAGAATGAAGTTGGCTTTCTGGTGAAAGCGCTGAGGCTCTTTCAGGAGAAGCATGTGAATTTGGCGCACATTGAGTCTCGGAGATCAAAGAGACTCACCAATGAGATTGAGATATATGCAGAATGCAACTGCACAAAGAAAGAGTTCAACGAACTGGTGCAACACCTCAAAGACCACGTTAATATTGTCTCGTATAACACACCTCAACATGTGTGGTCTGCAGAGACCGACTGtttggactgtgtgtgtgttttgggtggATTGCCAGATGGGGAAGGAATACCATGGTTTCCCCAAAAAATCTCAGAGCTGGATCAGTGCTCCCATAGAGTGCTAATGTATGGCTCTGAACTGGATGCTGATCATCCAGGCTTTAAAGACAAGGTCTATCGGCAGAGGAGAAAGTACTTTGTGGAGGTTGCAATGAACTACAAATTTGGGCAGCCCATCCCACGGATTGAGTACACTGCAGAGGAAGTAAAGACATGGGGAGTCGTTTACAGAGAACTTACAAAACTCTATCCAACTCATGCCTGCCGCGAATACTTAAAAAACCTTCCTCTGCTGACAAAGCATTGTGGGTACAGAGAGGACAACATCCCACAGCTGGAGGACGTGTCTCTATTCTTAAGAGAGAGGTCAGGGTTTACCGTAAGGCCTGTGGCTGGATATCTCTCACCACGAGACTTCCTGGCTGGACTGGCTTATCGAGTGTTTAATTGCACTCAGTATATTCGTCACAGCACAGACCCTCTCTATACACCAGAGCCGGACACCTGCCATGAACTGCTTGGTCACGTGCCGCTCCTGGCCGATCCCAAATTTGCTCAGTTTTCTCAGGAGATTGGCCTTGCATCTCTAGGCGCTTCAGACGAAGATGTGCAAAAGCTGGCAACTTGTTATTTCTTCACAATAGAGTTTGGGCTGTGCAAACAAGATGGTCAGTTGAGAGTCTATGGAGCAGGTCTACTGTCTTCTATTGGAGAGTTAAGGCATGCGCTTTCTGATAAAGCAACAGTGAAGGTGTTTGACCCCAAAACCACGTGCTACCAGGAGTGCCTCATTACCACATTTCAAGATGTGTATTTTGTCTCTGAGAGCTTTGAGGAGGCAAAAGAGAAAATGAGGGAATTTGCTAAATCAATAAAGAGGCCTTTTTCTGTCTACTACAACCCTTACACGCAGAGCATCGACTTACTCAAGGACACCAGGAGCATTGAAAATGTGGTTCAAGATCTACGCAGCGACTTAACCACCGTCTGTGACGCCCTGGGAAAAATGAACAAATACCTCGGTATCTAAACAAACACAGTCCCTCAACAATGCTGTATGATTCAGTTCAGGTGAATCATATAGTTCAGTTCATCATTCCTTCTATAACAGTTGTTGTGATTATCTGGGCTAAACATACTGGCCTTTCCTTGTTATTAGGATGTACGTCACATAAACACAGGTGTGAAATGTCGCAACCAATTAAAAACGGCTATTATTATAATGTATTCAGACACTAAAGGAACAACAAAGGAAAAGAATCAAGTGTAGTCTTTGCCTCTTTGTGCCTAATGTTGTGCTTAATCATACcagatttgtgttttattttaactacATACTGCAGTATCTACCAAATGAAGGCAGTTGATATTATGTACACATAATAATTCAATGTAAAAGTCCATACGCATTGTTCCGATGCCAATGCTATAGTGTATTTGTATAGTATGTTTGTGGTGCTTGCTTGATTTGTTGCTCACAAAGCCAACaatcaataaaacattatattttaggAGTTTCTTTTAG
>TCONS_00026368
GGAGAGTGTCAGGTACTGTGGTGTGAACTCCATAGCAGCAGCTTAAGGAGAAATAATCTGAGATAAAAAACTACCTTTGCCATATTAAATGCAAGGGAAGAAAACCTCTCAAGAGACAACAGCAACTATGTCTAATGAACTGCAAACTAATCCAAAGGGGCAGCAAACAGCCCCTAAATCACCTGTTGGGCTTCTTAGGAAAAGAGGTCAAGAAGCAATTCCGAAGATGCAACCTGCCATGATGATGTTCTCCAGCAAATACTGGGCTCGGAGAGGACTATCTTTGGATTCAGCTATGTATGACCAACAGCACCTTGCATCCTCCATGGACATCCTTTAATCGGATAGATGAAAGACCTGACAAAGAAGAACAGAAATCCACTCATGACCTTGGGAAGCTGGCAGTGATTTTCTCTCTGAAGAATGAAGTTGGCTTTCTGGTGAAAGCGCTGAGGCTCTTTCAGGAGAAGCATGTGAATTTGGCGCACATTGAGTCTCGGAGATCAAAGAGACTCACCAATGAGATTGAGATATATGCAGAATGCAACTGCACAAAGAAAGAGTTCAACGAACTGGTGCAACACCTCAAAGACCACGTTAATATTGTCTCGTATAACACACCTCAACATGTGTGGTCTGCAGAGACCGACTGtttggactgtgtgtgtgttttgggtggATTGCCAGATGGGGAAGGAATACCATGGTTTCCCCAAAAAATCTCAGAGCTGGATCAGTGCTCCCATAGAGTGCTAATGTATGGCTCTGAACTGGATGCTGATCATCCAGGCTTTAAAGACAAGGTCTATCGGCAGAGGAGAAAGTACTTTGTGGAGGTTGCAATGAACTACAAATTTGGGCAGCCCATCCCACGGATTGAGTACACTGCAGAGGAAGTAAAGACATGGGGAGTCGTTTACAGAGAACTTACAAAACTCTATCCAACTCATGCCTGCCGCGAATACTTAAAAAACCTTCCTCTGCTGACAAAGCATTGTGGGTACAGAGAGGACAACATCCCACAGCTGGAGGACGTGTCTCTATTCTTAAGAGAGAGGTCAGGGTTTACCGTAAGGCCTGTGGCTGGATATCTCTCACCACGAGACTTCCTGGCTGGACTGGCTTATCGAGTGTTTAATTGCACTCAGTATATTCGTCACAGCACAGACCCTCTCTATACACCAGAGCCGGACACCTGCCATGAACTGCTTGGTCACGTGCCGCTCCTGGCCGATCCCAAATTTGCTCAGTTTTCTCAGGAGATTGGCCTTGCATCTCTAGGCGCTTCAGACGAAGATGTGCAAAAGCTGGCAACTTGTTATTTCTTCACAATAGAGTTTGGGCTGTGCAAACAAGATGGTCAGTTGAGAGTCTATGGAGCAGGTCTACTGTCTTCTATTGGAGAGTTAAGGCATGCGCTTTCTGATAAAGCAACAGTGAAGGTGTTTGACCCCAAAACCACGTGCTACCAGGAGTGCCTCATTACCACATTTCAAGATGTGTATTTTGTCTCTGAGAGCTTTGAGGAGGCAAAAGAGAAAATGAGGGAATTTGCTAAATCAATAAAGAGGCCTTTTTCTGTCTACTACAACCCTTACACGCAGAGCATCGACTTACTCAAGGACACCAGGAGCATTGAAAATGTGGTTCAAGATCTACGCAGCGACTTAACCACCGTCTGTGACGCCCTGGGAAAAATGAACAAATACCTCGGTATCTAAACAAACACAGTCCCTCAACAATGCTGTATGATTCAGTTCAGGTGAATCATATAGTTCAGTTCATCATTCCTTCTATAACAGTTGTTGTGATTATCTGGGCTAAACATACTGGCCTTTCCTTGTTATTAGGATGTACGTCACATAAACACAGGTGTGAAATGTCGCAACCAATTAAAAACGGCTATTATTATAATGTATTCAGACACTAAAGGAACAACAAAGGAAAAGAATCAAGTGTAGTCTTTGCCTCTTTGTGCCTAATGTTGTGCTTAATCATACcagatttgtgttttattttaactacATACTGCAGTATCTACCAAATGAAGGCAGTTGATATTATGTACACATAATAATTCAATGTAAAAGTCCATACGCATTGTTCCGATGCCAATGCTATAGTGTATTTGTATAGTATGTTTGTGGTGCTTGCTTGATTTGTTGCTCACAAAGCCAACaatcaataaaacattatattttaggAGTTTCTTTTAG

Function

symbol description
tph2 Predicted to enable tryptophan 5-monooxygenase activity. Acts upstream of or within regulation of hematopoietic stem cell differentiation. Predicted to be active in neuron projection. Is expressed in brain and neurons. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; autistic disorder; major depressive disorder; and panic disorder. Orthologous to human TPH2 (tryptophan hydroxylase 2).

GO:

id name namespace
GO:1902036 regulation of hematopoietic stem cell differentiation biological_process
GO:0042427 serotonin biosynthetic process biological_process
GO:0009072 aromatic amino acid family metabolic process biological_process
GO:0055114 oxidation-reduction process biological_process
GO:0043005 neuron projection cellular_component
GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen molecular_function
GO:0004497 monooxygenase activity molecular_function
GO:0005506 iron ion binding molecular_function
GO:0004510 tryptophan 5-monooxygenase activity molecular_function
GO:0046872 metal ion binding molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-040624-4 Predicted to enable tryptophan 5-monooxygenase activity. Acts upstream of or within regulation of hematopoietic stem cell differentiation. Predicted to be active in neuron projection. Is expressed in brain and neurons. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; autistic disorder; major depressive disorder; and panic disorder. Orthologous to human TPH2 (tryptophan hydroxylase 2).

Ensembl:

ensembl_id ENSDARG00000057239

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00026367 False 2010 mRNA 0.43 11 16989764 17000842
TCONS_00026368 True 2216 mRNA 0.43 11 16989764 17001056

Neighbor

gene id symbol gene type direction distance location
XLOC_013336 akip1 coding downstream 35786 16950724 ~ 16953978 (-)
XLOC_013335 znf143b coding downstream 52655 16924865 ~ 16937109 (-)
XLOC_013334 wee1 coding downstream 65543 16918426 ~ 16924221 (-)
XLOC_013333 swap70b coding downstream 72924 16876833 ~ 16916840 (-)
XLOC_013332 admb coding downstream 188731 16798854 ~ 16801033 (-)
XLOC_013338 tbc1d15 coding upstream 1108 17002164 ~ 17020231 (-)
XLOC_013339 has3 coding upstream 26818 17027874 ~ 17030870 (-)
XLOC_013340 tango6 coding upstream 31256 17032312 ~ 17075098 (-)
XLOC_013341 il17c coding upstream 74929 17075985 ~ 17147803 (-)
XLOC_013342 zfpm1 coding upstream 269371 17270427 ~ 17399376 (-)
XLOC_013384 BX323829.1 misc upstream 2541046 19542102 ~ 19542231 (-)
XLOC_013329 NA non-coding downstream 612423 16372210 ~ 16377341 (-)
XLOC_013327 NA non-coding downstream 681827 16224790 ~ 16307937 (-)
XLOC_013324 NA non-coding downstream 971677 15991454 ~ 16018087 (-)
XLOC_013323 NA non-coding downstream 1019191 15939261 ~ 15970573 (-)
XLOC_013321 CR854977.1 non-coding downstream 1113984 15875662 ~ 15875780 (-)
XLOC_013345 NA non-coding upstream 490265 17491321 ~ 17492706 (-)
XLOC_013349 NA non-coding upstream 776471 17777527 ~ 17786790 (-)
XLOC_013351 NA non-coding upstream 1110938 18111994 ~ 18113888 (-)
XLOC_013355 BX470163.3 non-coding upstream 1568185 18569241 ~ 18569322 (-)
XLOC_013356 BX470163.2 non-coding upstream 1576418 18577474 ~ 18577549 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000013_05885911_05904644 TPH2, TBC1D15 coding CI01000013 null 5885911 ~ 5905150 (+)
bowfin (Amia calva) AMCG00006703 tph2,LOC108263971,LOC108423504,LOC106561539 coding CM030134.1 CM030134.1 15006312 ~ 15037025 (+)