XLOC_014913 (rrm2b)


Basic Information

Item Value
gene id XLOC_014913
gene name rrm2b
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007130.7
NCBI id CM002903.2
chromosome length 48449771
location 32916372 ~ 32928486 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00029422
TTCTCAGTCAATATGTAATTTTCAATGACAGTCGACGAGCAGACACCGCAGCTTCACTGCTGCTGACCAAACACCATTATAAACATGAACTCCTGCACAAGCAACACTCCGACGGTTATTACGGGATATCAGAACGGTCACAAGGATGTCGACCCAAACAGTGTTGAAGATGAGCCTCTGCTCAGAGAGAATCCCAAACGATTTGTCATTTTCCCTATTCAGTATCCAGACATCTGGAAAATGTACAAACAAGCACAGGCTTCTTTCTGGACAGTTGAGGAGGTGGATTTATCAAAGGATTTAACTCACTGGGACGGCCTGAAGTCTGAAGAGAAACACTTCATATCACATGTATTGGCTTTCTTTGCGGCAAGTGATGGGATAGTCAATGAGAACCTGGTCCAGAGGTTCAGTCAGGAGGTGCAGCTCCCCGAGGCTCGTTCCTTCTACGGCTTTCAAATATTAATTGAGAACGTGCACTCAGAGATGTACAGCATGCTCATTAACACCTACATTAGGGATCTGAAAGAGAGAGACTATTTGTTTAATGCAGTTCAGACCATGCCCTGTGTGAGGCGGAAAGCAGACTGGGCCTTACAGTGGATTTCAGACACAAACTCAACTTTCGGTGAGCGGTTGGTAGCGTTTGCAGCAGTGGAAGGCATTTTTTTCTCAGGATCATTTGCTGCCATCTATTGGTTAAAGAAAAGAGGCCTGATGCCTGGACTCACCTACTCCAATGAGCTCATCAGCAGAGACGAGGGCCTACACTGCAATTTTGCCTGTTTAATATACAGTTACTTAGTGAAAAAACCTTCTGTTGACCGAGTGAATGACATTATCGCTAAAGCTGTGAGCATTGAACAGGAGTTTCTCACAGAAGCTTTACCAGTCAATTTGATCGGGATGAACTGCTCTCTCATGAAGCAGTACATTGAGTTTGTTGCTGACCGCTTGCTGACCGACTTAGGATTGCCCAAAGCTTACTGTTCAGAAAACCCCTTCGACTTCATGGAGTCCATTTCATTGGAGGGGAAAACAAATTTCTTTGAGAAGCGAGTGGCCGAATACCAGCGACTTGGAGTGATGTCAAATGTTAAGGATTGTGAATTCACACTGGATGCAGATTTCTGAAGAACTAGatgatgttgtttatttatttggatgCTGTTACATTATGTTCTGAAAGTGAGAAATATAGTAAGCTTTTAAGGTTTGGTTTTATGAGTTTTGTTATGAGTTTTTCATCTGGTGTAAAGCTTCAACTTTTAAAGGTGTTTTAGATTAAAACGCAGCCAGTATTGATTGTGAGCATGATGATAACCCATGATTACATTAACTGGGGCTACAAAAGGCTTTAGATTGAAAATGTTCTGTGTGAAATTCTATTATTTTGTAGgatttgattataaaaaaaagtgatttttatttccTGGAACAGCAGGATACAAACTGATTTTGATAATTCCAGGTACCGATTATGTGCTTTAATGTTCATTTTGTGTGGTCTGTAGTACAGCCATACTGAAAGCGACAATGTAAAAATGATACCatcttaaaaatgaaattaatacaTGAACATTAAATCTTGAAATACCTTGT
>TCONS_00029423
AATTTTCAATGACAGTCGACGAGCAGACACCGCAGCTTCACTGCTGCTGACCAAACACCATTATAAACATGAACTCCTGCACAAGCAACACTCCGACGGTTATTACGGGATATCAGAACGGTCACAAGGATGTCGACCCAAACAGTGTTGAAGATGAGCCTCTGCTCAGAGAGAATCCCAAACGATTTGTCATTTTCCCTATTCAGTATCCAGACATCTGGAAAATGTACAAACAAGCACAGGCTTCTTTCTGGACAGTTGAGGAGGTGGATTTATCAAAGGATTTAACTCACTGGGACGGCCTGAAGTCTGAAGAGAAACACTTCATATCACATGTATTGGCTTTCTTTGCGGCAAGTGATGGGATAGTCAATGAGAACCTGGTCCAGAGGTTCAGTCAGGAGGTGCAGCTCCCCGAGGCTCGTTCCTTCTACGGCTTTCAAATATTAATTGAGAACGTGCACTCAGAGATGTACAGCATGCTCATTAACACCTACATTAGGGATCTGAAAGAGAGAGACTATTTGTTTAATGCAGTTCAGACCATGCCCTGTGTGAGGCGGAAAGCAGACTGGGCCTTACAGTGGATTTCAGACACAAACTCAACTTTCGGTGAGCGGTTGGTAGCGTTTGCAGCAGTGGAAGGCATTTTTTTCTCAGGATCATTTGCTGCCATCTATTGGTTAAAGAAAAGAGGCCTGATGCCTGGACTCACCTACTCCAATGAGCTCATCAGCAGAGACGAGGGCCTACACTGCAATTTTGCCTGTTTAATATACAGTTACTTAGTGAAAAAACCTTCTGTTGACCGAGTGAATGACATTATCGCTAAAGCTGTGAGCATTGAACAGGAGTTTCTCACAGAAGCTTTACCAGTCAATTTGATCGGGATGAACTGCTCTCTCATGAAGCAGTACATTGAGTTTGTTGCTGACCGCTTGCTGACCGACTTAGGATTGCCCAAAGCTTACTGTTCAGAAAACCCCTTCGACTTCATGGAGTCCATTTCATTGGAGGGGAAAACAAATTTCTTTGAGAAGCGAGTGGCCGAATACCAGCGACTTGGAGTGATGTCAAATGTTAAGGATTGTGAATTCACACTGGATGCAGATTTCTGAAGAACTAGatgatgttgtttatttatttggatgCTGTTACATTATGTTCTGAAAGTGAGAAATATAGTAAGCTTTTAAGGTTTGGTTTTATGAGTTTTGTTATGAGTTTTTCATCTGGTGTAAAGCTTCAACTTTTAAAGGTGTTTTAGATTAAAACGCAGCCAGTATTGA

Function

symbol description
rrm2b Predicted to enable ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Acts upstream of or within cellular response to DNA damage stimulus. Located in cytoplasm. Is expressed in several structures, including brain; eye; liver; otic vesicle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5; mitochondrial DNA depletion syndrome 8a; and mitochondrial DNA depletion syndrome 8b. Orthologous to human RRM2B (ribonucleotide reductase regulatory TP53 inducible subunit M2B).

GO:

id name namespace
GO:0009263 deoxyribonucleotide biosynthetic process biological_process
GO:0006974 cellular response to DNA damage stimulus biological_process
GO:0055114 oxidation-reduction process biological_process
GO:0005829 cytosol cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0005737 cytoplasm cellular_component
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor molecular_function
GO:0046872 metal ion binding molecular_function
GO:0016491 oxidoreductase activity molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-030616-614 Predicted to enable ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Acts upstream of or within cellular response to DNA damage stimulus. Located in cytoplasm. Is expressed in several structures, including brain; eye; liver; otic vesicle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5; mitochondrial DNA depletion syndrome 8a; and mitochondrial DNA depletion syndrome 8b. Orthologous to human RRM2B (ribonucleotide reductase regulatory TP53 inducible subunit M2B).

Ensembl:

ensembl_id ENSDARG00000033367

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00029422 False 1602 mRNA 0.41 10 32916372 32928486
TCONS_00029423 True 1289 mRNA 0.43 9 32918131 32928470

Neighbor

gene id symbol gene type direction distance location
XLOC_014912 mtdha coding downstream 2067 32895379 ~ 32914305 (-)
XLOC_014911 laptm4b coding downstream 27614 32864577 ~ 32888758 (-)
XLOC_014910 si:dkey-284p5.3 coding downstream 67336 32840143 ~ 32849036 (-)
XLOC_014909 nt5c1aa coding downstream 111837 32766423 ~ 32804535 (-)
XLOC_014907 hpca coding downstream 205450 32622177 ~ 32710922 (-)
XLOC_014914 azin1b coding upstream 1990 32930476 ~ 32944050 (-)
XLOC_014915 klhl38a coding upstream 155580 33084066 ~ 33087246 (-)
XLOC_014916 trib1 coding upstream 271780 33200266 ~ 33212023 (-)
XLOC_014917 fam92a1 coding upstream 330086 33258572 ~ 33275035 (-)
XLOC_014918 nkd3l coding upstream 439666 33368152 ~ 33370271 (-)
XLOC_014711 CR382300.3 misc downstream 13187617 19728690 ~ 19728755 (-)
XLOC_014908 CR318628.1 non-coding downstream 266591 32649667 ~ 32649781 (-)
XLOC_014901 CR382336.1 non-coding downstream 585742 32330513 ~ 32330630 (-)
XLOC_014888 BX465206.1 non-coding downstream 1832399 31079326 ~ 31083973 (-)
XLOC_014885 BX927219.1 non-coding downstream 1950711 30962723 ~ 30965661 (-)
XLOC_014883 NA non-coding downstream 2081275 30831190 ~ 30835097 (-)
XLOC_014919 BX957357.1 non-coding upstream 443878 33372364 ~ 33372694 (-)
XLOC_014920 NA non-coding upstream 854297 33782783 ~ 33786703 (-)
XLOC_014924 CU928445.1 non-coding upstream 1049392 33977878 ~ 33977994 (-)
XLOC_014927 NA non-coding upstream 1259706 34188192 ~ 34230285 (-)
XLOC_014928 NA non-coding upstream 1353400 34281886 ~ 34283008 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000054_06967494_06972758 RRM2B coding CI01000054 null 6967014 ~ 6972876 (+)
bowfin (Amia calva) AMCG00002685 rrm2b,LOC107556385,LOC108425040,LOC107394698,LOC106956493 coding CM030136.1 CM030136.1 26382511 ~ 26390982 (-)