XLOC_022908 (drd3)


Basic Information

Item Value
gene id XLOC_022908
gene name drd3
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007135.7
NCBI id CM002908.2
chromosome length 42172926
location 20968308 ~ 21006319 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00045540
TGAAAGCAGGGACGCTTCGTGCGTAAAGGAGCTTTTGGAGATGGCGCGGAGCTTGTAACCATCCTTGCGAATCTGGCTGTGCGCGAAACCATTGTGGGCATCATTCAATGCTCAAAAGCGTCGCGAGTAAGCATATTTGGAGCTGTGTATTAGTAAGTTTTGCGTACGCGGTAAGGATGGAGTCCCTTCCACAGCGGCAACGGCGAAGGGCGACTGGACCGATAAGTTTAACCTCAAGGAAAGTGCGTTCAGATGGGGTTCTGTTTCGGTTCTTCGCTGGAGAAGCTTAACAGATCTTCCACACTTATGGCAATGTTTAGCAGTGGTGAATGGCTCTGGAATGACTCTGAGCATTCATTCACCCCTGGGGGAAACTACAGCCCAGCGTCAGGCGTTGAAGAAGCGAAGAGGAATTATTATGCCATGCTCTATTCCCTGCTCATCCTGGCTATCGTGTTTGGGAATGTTCTGGTTTGCATTGCTGTGCTTCGAGAGAGAGCTCTTCAGACCACCACCAACTACCTGGTGGTCAGTCTGGCAGTGGCTGATCTGTTGGTCGCCTCACTGGTCATGCCTTGGGCAGTTTATTTGGAAGTGGTCGGCGGAGCTTGGCTTTTCAGTCGCCTGTACTGCAATGTCTTTGTGACCCTGGATGTGATGATGTGCACCGCAAGCATACTTAACCTGTGTGCCATCAGTATCGACAGGTATACAGCTGTGGTGATGCCCGTGTTATACAACACCACCCACAGCTCCCGCAAAAGGGTTTCAGTCATGATTGCCACGGTTTGGGTCCTCGCCTTTGCCGTCTCCTGCCCTCTACTGTTTGGATTCAACACTACAGATGACCCTGCGGTGTGCTCAATTTCAAACCCTGATTTTGTTATCTACTCCTCCGTGGTGTCGTTTTACTTGCCGTTTGCGGTGACCCTTCTGGTCTATGTGCGCATTTACATCTTTCTCAGAAGGAGAAGGAAGAAAATCACCTTCCGCCAAGGCAGTGGCAAAGTTCAGCCAGCATCCGCTCCACCATCAGTGGAGATGTGTTTACAAGACGACGCACACAAAGAGAAAAGAGACCTTTCCCCCATCAGGATCAATGTGATAACTGAAAGCAAGGAGCAGGTGATCCGTCCGCGGCTCCTAGCCAACTGTCTGAGGCGCAAACGGCCTCAAACCGCACCTGCCGAGAACTCGTTGCTGCCTCCGGTGATCACGCTGAATTACTGCAGCATCAGCCAAGCGTCTTTTGCTCGCACTGAACAAGATGCAAACCGcgaggaagaggagggtggggATGAGGAGCAGGTGGCGGTGAGGAGCTGTGAGGTGAAGAAGTTGGCAAAcggacgcacacacacaagcctGCGGCCACCCCGGGCCGCACACGCCATGGTTTGCCCCAGTCAGGCACGCTGCAGAAGTATGCACTCCAAGGAGAAGAAAGCCACGCAGATGTTGGCCATCGTTCTGGgTGTTTTTCTTATTTGCTGGCTGCCTTTCTTTGTGACCCACATCCTCAACACTCATTGCAGAGCTTGTCACATTCCTCCTGAGGTCTACAGCGCCTTCACTTGGCTCGGCTACGTCAACAGCGCTCTCAATCCCGTCATCTACACCACGTTCAACATCGAGTTTCGCAGAGCCTTCATTAAAATCCTGAGCTGCTAAACCATGGGCTATATTCCCATAAAACGTTTAATGCGGCTTTCAGACACTGTGGATGCCATTTTGGGATGCAATATGCCATACACAGAGGATATTAAAAGACTGTCTGAATGTGTTCAGGGGGATTTCACAGTCACTATAAAGCACACTACGCTTGCAATCGGTGGATAAGAATTGATTGCAATCTTCTTCAAGTTCACAGGAGAACCAGTTTGTGCTTCACATCCAACGTCAAAGCCTAGAAGATCTTTTTGTGTTCTCCATCTCAGCACCTTGTCGCATGTGGGCAAATCCAGAGTTcattgtgtgtatgcatgtgtctcACCATGGATTAAGCTGAGATGAGTTTTACCTGAAACACTTCAGTTGAAACACAGCGGGGAAAACTGCAGTTTATGAGGCTACAAAGGCTAGTGATTTGTCAAAGGGACCATAAAACAGGTGGACCAAAAGAGTGTGAAGGTAAAAGATTGAAGACTGTGTTGTGCTTTTATTGGATTCGTGATACAACTGCATATCAGAAGAaaaaacagaggaaaaaaaaagaagatggtTGTGATTGTTATGGATGAAACGTGATTTTATTCCATGAATTAAAGCTACATTGAATCCTCAAA
>TCONS_00045541
AAAATCTGTCCACCCTCTCCAGATCTTCCACACTTATGGCAATGTTTAGCAGTGGTGAATGGCTCTGGAATGACTCTGAGCATTCATTCACCCCTGGGGGAAACTACAGCCCAGCGTCAGGCGTTGAAGAAGCGAAGAGGAATTATTATGCCATGCTCTATTCCCTGCTCATCCTGGCTATCGTGTTTGGGAATGTTCTGGTTTGCATTGCTGTGCTTCGAGAGAGAGCTCTTCAGACCACCACCAACTACCTGGTGGTCAGTCTGGCAGTGGCTGATCTGTTGGTCGCCTCACTGGTCATGCCTTGGGCAGTTTATTTGGAAGTGGTCGGCGGAGCTTGGCTTTTCAGTCGCCTGTACTGCAATGTCTTTGTGACCCTGGATGTGATGATGTGCACCGCAAGCATACTTAACCTGTGTGCCATCAGTATCGACAGGTATACAGCTGTGGTGATGCCCGTGTTATACAACACCACCCACAGCTCCCGCAAAAGGGTTTCAGTCATGATTGCCACGGTTTGGGTCCTCGCCTTTGCCGTCTCCTGCCCTCTACTGTTTGGATTCAACACTACAGATGACCCTGCGGTGTGCTCAATTTCAAACCCTGATTTTGTTATCTACTCCTCCGTGGTGTCGTTTTACTTGCCGTTTGCGGTGACCCTTCTGGTCTATGTGCGCATTTACATCTTTCTCAGAAGGAGAAGGAAGAAAATCACCTTCCGCCAAGGCAGTGGCAAAGTTCAGCCAGCATCCGCTCCACCATCAGTGGAGATGTGTTTACAAGACGACGCACACAAAGAGAAAAGAGACCTTTCCCCCATCAGGATCAATGTGATAACTGAAAGCAAGGAGCAGGTGATCCGTCCGCGGCTCCTAGCCAACTGTCTGAGGCGCAAACGGCCTCAAACCGCACCTGCCGAGAACTCGTTGCTGCCTCCGGTGATCACGCTGAATTACTGCAGCATCAGCCAAGCGTCTTTTGCTCGCACTGAACAAGATGCAAACCGcgaggaagaggagggtggggATGAGGAGCAGGTGGCGGTGAGGAGCTGTGAGGTGAAGAAGTTGGCAAAcggacgcacacacacaagcctGCGGCCACCCCGGGCCGCACACGCCATGGTTTGCCCCAGTCAGGCACGCTGCAGAAGTATGCACTCCAAGGAGAAGAAAGCCACGCAGATGTTGGCCATCGTTCTGGgTGTTTTTCTTATTTGCTGGCTGCCTTTCTTTGTGACCCACATCCTCAACACTCATTGCAGAGCTTGTCACATTCCTCCTGAGGTCTACAGCGCCTTCACTTGGCTCGGCTACGTCAACAGCGCTCTCAATCCCGTCATCTACACCACGTTCAACATCGAGTTTCGCAGAGCCTTCATTAAAATCCTGAGCTGCTAA

Function

symbol description
drd3 Predicted to enable G protein-coupled receptor activity and dopamine neurotransmitter receptor activity, coupled via Gi/Go. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; negative regulation of cytosolic calcium ion concentration; and regulation of ion transport. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in myotome; nervous system; and somite. Human ortholog(s) of this gene implicated in Parkinson's disease; essential tremor; essential tremor 1; and schizophrenia. Orthologous to human DRD3 (dopamine receptor D3).

GO:

id name namespace
GO:0051967 negative regulation of synaptic transmission, glutamatergic biological_process
GO:0007186 G protein-coupled receptor signaling pathway biological_process
GO:0043266 regulation of potassium ion transport biological_process
GO:0007194 negative regulation of adenylate cyclase activity biological_process
GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway biological_process
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway biological_process
GO:0051481 negative regulation of cytosolic calcium ion concentration biological_process
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway biological_process
GO:0060158 phospholipase C-activating dopamine receptor signaling pathway biological_process
GO:1901386 negative regulation of voltage-gated calcium channel activity biological_process
GO:0014059 regulation of dopamine secretion biological_process
GO:0007165 signal transduction biological_process
GO:0001963 synaptic transmission, dopaminergic biological_process
GO:0005887 integral component of plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0004930 G protein-coupled receptor activity molecular_function
GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go molecular_function

KEGG:

id description
ko04080 Neuroactive ligand-receptor interaction
ko04728 Dopaminergic synapse
ko04030 G protein-coupled receptors

ZFIN:

id description
ZDB-GENE-021119-1 Predicted to enable G protein-coupled receptor activity and dopamine neurotransmitter receptor activity, coupled via Gi/Go. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; negative regulation of cytosolic calcium ion concentration; and regulation of ion transport. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in myotome; nervous system; and somite. Human ortholog(s) of this gene implicated in Parkinson's disease; essential tremor; essential tremor 1; and schizophrenia. Orthologous to human DRD3 (dopamine receptor D3).

Ensembl:

ensembl_id ENSDARG00000032131

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00045540 False 2285 mRNA 0.49 8 20968308 21006319
TCONS_00045541 True 1400 mRNA 0.52 7 20969358 21005705

Neighbor

gene id symbol gene type direction distance location
XLOC_022907 si:ch211-161h7.8 coding upstream 3929 20960216 ~ 20964379 (+)
XLOC_022906 fam162a coding upstream 33642 20927135 ~ 20934666 (+)
XLOC_022905 cst14a.2 coding upstream 46594 20920563 ~ 20921714 (+)
XLOC_022904 NA coding upstream 49896 20916745 ~ 20918412 (+)
XLOC_022903 CR931724.1 coding upstream 180024 20788168 ~ 20788284 (+)
XLOC_022909 ccdc191 coding downstream 85837 21092156 ~ 21120182 (+)
XLOC_022910 naa50 coding downstream 168204 21174523 ~ 21183891 (+)
XLOC_022911 usf3 coding downstream 180708 21187027 ~ 21203876 (+)
XLOC_022912 CU915780.1 coding downstream 266293 21272612 ~ 21272728 (+)
XLOC_022913 NA coding downstream 301248 21307567 ~ 21308014 (+)
XLOC_022896 NA non-coding upstream 891012 20060772 ~ 20077296 (+)
XLOC_022895 NA non-coding upstream 913350 20054470 ~ 20054958 (+)
XLOC_022892 NA non-coding upstream 1253084 19704715 ~ 19715224 (+)
XLOC_022915 AL929009.1 non-coding downstream 495540 21501859 ~ 21502569 (+)
XLOC_022919 AL929009.2 non-coding downstream 623406 21629725 ~ 21629840 (+)
XLOC_022924 NA non-coding downstream 876626 21882945 ~ 21883972 (+)

Expression


Co-expression Network