XLOC_028365 (eps8a)


Basic Information

Item Value
gene id XLOC_028365
gene name eps8a
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007115.7
NCBI id CM002888.2
chromosome length 78093715
location 151506 ~ 178510 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00055096
GACGGGTGCGCGCGCTCGTGTCTGTGAGGCGGAGCGCGGTCAAACTCACACAGACGGAGGATCATTTGCTCATTTAACGGAGAAACTCCGTGACAGTCGCCGTCAGCGGAcgagctgtgtgtgtttgtgcttctgTCATGCGGTAAAAGCGGAGACCGCACAAACAGgagCGGATCTGTGTGTGTGGGGCAGAGTCCAGACATGAACGGATACACACCGCCAGCCTCACAGATGAAcggACACGGCTCGCTGTCTCCAGATGTTCCCGGCAAAAAGTCGAGTGGTAAAGCTCTGTACGAGCAAAGGAAAAACTACACCAAAAACAGCATCAACAGCCTGACGGACACGTCTCAGTATCATGTGGAGcatCTGACCACGTTTGTGATGGACCGTAAGGAGGCGATGCTGACCATCGAGGACGGCATCAGGAAACTGCGGCTGCTGGACGCTAAAGGGAAGATCTGGACTCAGGACATGCTGCTGCAGGTGGACAACAGAGCAGTCAGCCTCATAGACCACGACAGCAAGaatgAGCTGGAGAACTTTCCTCTGGGCTCCATCCAGCACTGTCAGCCCGTCACCAACGCCTGCAGCTACGACTCCATCTTGGCTCTAGTGTGTAAGGAGTCCGGGCAGGGGAAACCAGACCTGCACCTGTTCCAGTGCGAGGACATCaagGCCAGTCTAATCCACATGGACATCGAGAGCGCCATCAGCGACCACAAGGGCGGGAAAATCAAGAAGAGGCCGGAGGTGCTGAAgaTGATCCTGAAGAGTGACGGAAGCATCCCTCCGCCTCCAGGAGGCCCCGCCCCTCAGGCGCcagcagctgtcaatcaagtggacACCAAGAGCCGAGTGGCCAGCTGGTCAGCCTGGACCAATGAGCAGCAGGACAacGACCCACAGAGACActacacagagctggacacgcctccTGAGATGAGCGCAGCACAGGTGGACAGAGATGTGCAAATCCTCAATCACATTCTGGACGACATCGAACACTTCGTCACCAAACTGCAGAAAGCTGCCGAGGCCTTTAACGAGCTCTCCAAACGCAAGAAGAGTAAGAAGAGCAAGAAGAAGGGCCCTGGAGAGGGAGTTCTGACACTGAGAGCCAAACCGCCGACTCAGGACGAGTTCATCGACTGCTTCCAGAAGTTCAAACACGCCTTCAACCTGCTGGGGAAGTTGAAGAACCACATTCAGAATCCCAGCGCTGTAGATCTGGTTCACTTCCTGTTCAATCCACTCAAGCTGGTGATCCAGACGTCTGGAGGAGTTGATCTGGCTAAAAGTGTAGTCGTTCCTCTCCTCACCAGAGAAGCCATCGAGTTCCTGCACACAGCGGGATCTGCGGAGGAGAGACACCTATGGGTGACACTAGGAGATGCATGGACCAAGTGCAAGCTGGAGTGGCCGAAGGATTATCCGTTTCCTTCGCACACGTTGAGTTTTCGGGATGGCTGGGAGCCGCCGGTGCTGGTGTCGCGGGAGCAGGACGTCACTCAGCTAGCGGAGAGACTGAACGCTGCGCAGAGCGAGACTCCGAGGCCGCCAATCACTCAGCAGACAGTGCAGGATTTCAGCAGTGCAGACGGGAATCTGGACGCTCACAGCAGGACGGCGCAGAGAAACTTTGCCAAATCCAAGTATGACTTTGTGGCCAGAAACAACACGGAGCTGTCTGTGCTGAAGGACGAGGTGGTGGAGGTGCTGGACGACAGGAAGCAGTGGTGGAAGGTGCGCAACGGAGCGGGAGCGTCAGGATACGTGCCAAACAACATCCTGGAGATCAGCAGAGCGGTGGACATGACGGGCCGCGGAGAGCCCATATACAGCCACACTAtacagAAGCAGCGGACAGATTATGTGCCCAGGCCGACAGTGACTGAAGCTCCGCCCACGCCGACCCCCCCTCCCCCGCCAGCCCCACTGCTACCCACTGCCAGCCCAGCCAATCAGAGTGCAGCAGCCATCATCCCAGCTAATCAGAGCACAGGGGCCACCAGCCCGGCCAATCAAAGAGCAGTGGCCACAAGCCCGGCCAATCAGAGCACAGCAGCTGCTGATCAGGCCAACCAAAGTGAGAGCAACAGCGGAGAGCAGCACGACGACACTGTGAGCGAGAGCGACAGCGTGAACATGAGAGAGCAGCAGAGGGAGAGAGCAGCGCCGGCCAaccGGCGTAAGTCTAACATGGAGGAGGTCCAGGATGAGCTGATGTACAGGCTGACTCTGGGTCGCAGCGCGCAGAAGCGGATCCAGACCCCGAGCCGGAGCAGTCAGCCGGCGCTCAGCATCAGCTACGACTCCACACCGCAGCAGGTCAAGGACTGGCTGATGCTCAAAGGCTTCAGCGCCGCGACCGTGAGCAGTCTCGGGGTGCTGACCGGCGCTCAGCTCTTCTCTCTGAATAAAGACGAGCTGAAGACGGTGTGTCCAGATGACGGCGCTCGCGTCTTCAGCCAGATCAGCGTGCAGAAGGCCGCTCTGGAGAGGAGCTCCGGCTCTGAGCTGATGGAGGTCATGCGGCGGCGGCAGGAGAAGCTAGCGGCGACAGCTACGAGCGACTCAGGAGTGGAGTCCTTCGACGAGGCCAGCAGCCACTGACCCCTCTCTGACCTTTTACAGGACGCTGCCGAGCGCGCTCAGTTCGCCGCCATAATGCGCCGTCGTCAGGAACTCTTGGACCCGTCTGATAACGGCACCGGCTCAGACGCGGAGGAGCTCGCCTGAGGAGGACGCTCATGTTCTCGTAGTCTAGTGCCATCGAGTTCTGCCTTCATAGTCCAACGTCTGATTACCGTCCGATCAAACCTGCTGTACATACACCGACACCGCACCGCTCATCTGTCAGCTGCTTTGAGTGGAGGATTATGGGTAAGACTGCTCGATCTGCGGGTTTCACACTAGTAAATGATCACACTTCTGATTGTCTTGTACTCAGCCGTACTGCCAAAACACAAGCTTCATAGGAGGACCGACAGCGCTCAGTCTGGAGCTCCTCTGAGGATGAGGAAGAGTCCTGCTAATGTGATGATGAAGGCCAAATCATGCTCTGGGTGGAGGTTTCagtgggaacacacacacacacacacacacacacacacacacaccttcagtctgtatatataatgtgtgtgctGAATAAATGCAATCATCTG
>TCONS_00055097
CATGAACGGATACACACCGCCAGCCTCACAGATGAAcggACACGGCTCGCTGTCTCCAGATGTTCCCGGCAAAAAGTCGAGTGGTAAAGCTCTGTACGAGCAAAGGAAAAACTACACCAAAAACAGCATCAACAGCCTGACGGACACGTCTCAGTATCATGTGGAGcatCTGACCACGTTTGTGATGGACCGTAAGGAGGCGATGCTGACCATCGAGGACGGCATCAGGAAACTGCGGCTGCTGGACGCTAAAGGGAAGATCTGGACTCAGGACATGCTGCTGCAGGTGGACAACAGAGCAGTCAGCCTCATAGACCACGACAGCAAGaatgAGCTGGAGAACTTTCCTCTGGGCTCCATCCAGCACTGTCAGCCCGTCACCAACGCCTGCAGCTACGACTCCATCTTGGCTCTAGTGTGTAAGGAGTCCGGGCAGGGGAAACCAGACCTGCACCTGTTCCAGTGCGAGGACATCaagGCCAGTCTAATCCACATGGACATCGAGAGCGCCATCAGCGACCACAAGGGCGGGAAAATCAAGAAGAGGCCGGAGGTGCTGAAgaTGATCCTGAAGAGTGACGGAAGCATCCCTCCGCCTCCAGGAGGCCCCGCCCCTCAGGCGCcagcagctgtcaatcaagtggacACCAAGAGCCGAGTGGCCAGCTGGTCAGCCTGGACCAATGAGCAGCAGGACAacGACCCACAGAGACActacacagagctggacacgcctccTGAGATGAGCGCAGCACAGGTGGACAGAGATGTGCAAATCCTCAATCACATTCTGGACGACATCGAACACTTCGTCACCAAACTGCAGAAAGCTGCCGAGGCCTTTAACGAGCTCTCCAAACGCAAGAAGAGTAAGAAGAGCAAGAAGAAGGGCCCTGGAGAGGGAGTTCTGACACTGAGAGCCAAACCGCCGACTCAGGACGAGTTCATCGACTGCTTCCAGAAGTTCAAACACGCCTTCAACCTGCTGGGGAAGTTGAAGAACCACATTCAGAATCCCAGCGCTGTAGATCTGGTTCACTTCCTGTTCAATCCACTCAAGCTGGTGATCCAGACGTCTGGAGGAGTTGATCTGGCTAAAAGTGTAGTCGTTCCTCTCCTCACCAGAGAAGCCATCGAGTTCCTGCACACAGCGGGATCTGCGGAGGAGAGACACCTATGGGTGACACTAGGAGATGCATGGACCAAGTGCAAGCTGGAGTGGCCGAAGGATTATCCGTTTCCTTCGCACACGTTGAGTTTTCGGGATGGCTGGGAGCCGCCGGTGCTGGTGTCGCGGGAGCAGGACGTCACTCAGCTAGCGGAGAGACTGAACGCTGCGCAGAGCGAGACTCCGAGGCCGCCAATCACTCAGCAGACAGTGCAGGATTTCAGCAGTGCAGACGGGAATCTGGACGCTCACAGCAGGACGGCGCAGAGAAACTTTGCCAAATCCAAGTATGACTTTGTGGCCAGAAACAACACGGAGCTGTCTGTGCTGAAGGACGAGGTGGTGGAGGTGCTGGACGACAGGAAGCAGTGGTGGAAGGTGCGCAACGGAGCGGGAGCGTCAGGATACGTGCCAAACAACATCCTGGAGATCAGCAGAGCGGTGGACATGACGGGCCGCGGAGAGCCCATATACAGCCACACTAtacagAAGCAGCGGACAGATTATGTGCCCAGGCCGACAGTGACTGAAGCTCCGCCCACGCCGACCCCCCCTCCCCCGCCAGCCCCACTGCTACCCACTGCCAGCCCAGCCAATCAGAGTGCAGCAGCCATCATCCCAGCTAATCAGAGCACAGGGGCCACCAGCCCGGCCAATCAAAGAGCAGTGGCCACAAGCCCGGCCAATCAGAGCACAGCAGCTGCTGATCAGGCCAACCAAAGTGAGAGCAACAGCGGAGAGCAGCACGACGACACTGTGAGCGAGAGCGACAGCGTGAACATGAGAGAGCAGCAGAGGGAGAGAGCAGCGCCGGCCAaccGGCGTAAGTCTAACATGGAGGAGGTCCAGGATGAGCTGATGTACAGGCTGACTCTGGGTCGCAGCGCGCAGAAGCGGATCCAGACCCCGAGCCGGAGCAGTCAGCCGGCGCTCAGCATCAGCTACGACTCCACACCGCAGCAGGTCAAGGACTGGCTGATGCTCAAAGGCTTCAGCGCCGCGACCGTGAGCAGTCTCGGGGTGCTGACCGGCGCTCAGCTCTTCTCTCTGAATAAAGACGAGCTGAAGACGGTGTGTCCAGATGACGGCGCTCGCGTCTTCAGCCAGATCAGCGTGCAGAAGGCCGCTCTGGAGAGGAGCTCCGGCTCTGAGCTGATGGAGGTCATGCGGCGGCGGCAGGAGAAGCTAGCGGCGACAGCTACGAGCGACTCAGGAGTGGAGTCCTTCGACGAGGCCAGCAGCCACTGACCC

Function

symbol description
eps8a Predicted to enable actin binding activity. Predicted to be involved in Rho protein signal transduction; positive regulation of ruffle assembly; and regulation of Rho protein signal transduction. Predicted to act upstream of or within actin filament bundle assembly and barbed-end actin filament capping. Predicted to be located in cytoplasm. Predicted to be active in ruffle membrane. Is expressed in nervous system; pronephric duct; and yolk syncytial layer. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 102. Orthologous to human EPS8 (epidermal growth factor receptor pathway substrate 8).

GO:

id name namespace
GO:0035023 regulation of Rho protein signal transduction biological_process
GO:0007266 Rho protein signal transduction biological_process
GO:1900029 positive regulation of ruffle assembly biological_process
GO:0051016 barbed-end actin filament capping biological_process
GO:0051017 actin filament bundle assembly biological_process
GO:0032587 ruffle membrane cellular_component
GO:0005886 plasma membrane cellular_component
GO:0035591 signaling adaptor activity molecular_function
GO:0003779 actin binding molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-040426-871 Predicted to enable actin binding activity. Predicted to be involved in Rho protein signal transduction; positive regulation of ruffle assembly; and regulation of Rho protein signal transduction. Predicted to act upstream of or within actin filament bundle assembly and barbed-end actin filament capping. Predicted to be located in cytoplasm. Predicted to be active in ruffle membrane. Is expressed in nervous system; pronephric duct; and yolk syncytial layer. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 102. Orthologous to human EPS8 (epidermal growth factor receptor pathway substrate 8).

Ensembl:

ensembl_id ENSDARG00000102128

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00055096 False 3170 mRNA 0.57 21 151506 178510
TCONS_00055097 True 2419 mRNA 0.58 20 152057 170120

Neighbor

gene id symbol gene type direction distance location
XLOC_028364 tbk1 coding downstream 2172 134412 ~ 149334 (-)
XLOC_028363 gpr19 coding downstream 18014 128697 ~ 133492 (-)
XLOC_028361 dusp16 coding downstream 31817 107287 ~ 119689 (-)
XLOC_028362 NA coding downstream 32312 116322 ~ 119194 (-)
XLOC_028360 NA coding downstream 50129 99991 ~ 101377 (-)
XLOC_028366 ptpro coding upstream 6353 184863 ~ 193762 (-)
XLOC_028367 ptpro coding upstream 12037 190547 ~ 211714 (-)
XLOC_028368 RERG coding upstream 55302 233812 ~ 240737 (-)
XLOC_028369 si:ch73-252i11.1 coding upstream 90933 269443 ~ 277081 (-)
XLOC_028370 echdc3 coding upstream 107915 286425 ~ 287425 (-)
XLOC_028359 NA non-coding downstream 76898 73430 ~ 74608 (-)
XLOC_028358 NA non-coding downstream 78848 71463 ~ 72658 (-)
XLOC_028357 NA non-coding downstream 86803 56025 ~ 64703 (-)
XLOC_028373 NA non-coding upstream 215041 393551 ~ 396819 (-)
XLOC_028375 CU855889.2 non-coding upstream 523102 701612 ~ 734347 (-)
XLOC_028376 NA non-coding upstream 545320 723830 ~ 732484 (-)
XLOC_028383 NA non-coding upstream 721452 899962 ~ 904022 (-)
XLOC_028385 NA non-coding upstream 741242 919752 ~ 921761 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000322_00008829_00019784 EPS8 coding CI01000322 null 8829 ~ 19784 (+)