CI01000016_07784248_07784757 (TWIST1, TWIST1.L, TWIST1A, TWIST1B, TWST2, TWIST1.S)


Basic Information

Item Value
gene id CI01000016_07784248_07784757
gene name TWIST1, TWIST1.L, TWIST1A, TWIST1B, TWST2, TWIST1.S
gene type misc
species grasscarp (Ctenopharyngodon idella)
category of species economic fish

Chromosome Information

Item Value
chromosome id CI01000016
NCBI id null
chromosome length 12175457
location 7783987 ~ 7784996 (+)
genome version v1_2015/06_NatureGenetics_grasscarp_Genome

Sequence

>CI01000016_07784248_07784757.mRNA
GTTTAAAAGCAAAGTTCCCCCCACCCTCCTTCTCACGTCTTAAGCCTTCTTGGCCAATCATCTCTCTTCTCACAAACACTTTACCAGACTATAAGAACTCCCCAACTTTTTCGTTTCAACCTAACTCAAAGTTGCTTGGAATCCTGGATACCTAGTTATTTCCTCCAGAATAAGAAACGTACGCTTGGAATTGTATTTCACCCTCATGAGGGAATAACGTCTTTAGGCTATTCGCACGCGCTTTCAGCAGACTTGAGCGAGATGCCCGAAGAGCCCGCGCGAGACTCCTCCAGCTCCCCCGTGTCTCCAGCGGACAGCCTCAGCAACAGCGACGGAGAGCCCGACAGGCCACCGAAGAGAAGCGGGAGAAAAAGACGGTCGAGCAAGAAAAACGGGGAGGATTCCGACAGCTCGACCCTTGGGAAAAGGGGGAAAAAGTCTAGCAACAGCAGCAACAGCCCCCAGTCTTTTGAGGAGCTGCAGACACAGCGCGTGATGGCGAACGTGCGCGAGCGACAGAGGACGCAGTCGCTCAACGAAGCGTTTGCGGCTTTGCGCAAAATCATCCCAACTTTACCATCCGATAAACTGAGCAAAATACAGACGCTGAAACTCGCCGCCAGGTACATCGATTTTCTCTGTCAGGTTCTACAGAGTGACGAGCTGGACTCCAAGATGGCAAGTTGTAGTTATGTTGCTCACGAGCGCTTGAGCTACGCGTTCTCGGTTTGGAGGATGGAGGGCGCTTGGTCCATGTCTGCATCTCACTAGTGTGCAGGGAGATTTTTTTGTTTTTATTTTCAGATGGTACGCTTTCACAATATCCATCGCCTTTAATGATGTAGTATTGTAAACAATTCTCAAAAACCTTTACTACATTCTACACGTTTAGGCACGAGTTGTAAAGCCAACAGCTGTTGCATGTAATTCAGATCGGCTGGATTTGTTTACTAGCAGTATGGCTTTATTTTGACGATCTTTCTCTCTATTTAGAGATAGTAATAGCGCAA

Function

symbol description
twist1a Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within pharyngeal system development and sprouting angiogenesis. Is expressed in several structures, including mesenchyme; mesoderm; nervous system; neural crest; and pharyngeal arch. Human ortholog(s) of this gene implicated in Saethre-Chotzen syndrome; Sweeney-Cox syndrome; acrocephalosyndactylia; and craniosynostosis. Orthologous to human TWIST1 (twist family bHLH transcription factor 1).
twist1b Enables cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including pharyngeal system development; regulation of bone mineralization; and sprouting angiogenesis. Predicted to be located in nucleus. Is expressed in several structures, including brain; cardiovascular system; cranial vault; mesoderm; and pharyngeal arch. Human ortholog(s) of this gene implicated in Saethre-Chotzen syndrome; Sweeney-Cox syndrome; acrocephalosyndactylia; and craniosynostosis. Orthologous to human TWIST1 (twist family bHLH transcription factor 1).
twist1 Enables DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding activity; and bHLH transcription factor binding activity. Involved in several processes, including animal organ development; regulation of cellular response to stress; and regulation of gene expression. Located in nucleus. Implicated in Saethre-Chotzen syndrome; Sweeney-Cox syndrome; acrocephalosyndactylia; and craniosynostosis. Biomarker of pulmonary fibrosis.

GO:

id name namespace
GO:0030500 regulation of bone mineralization biological_process

KEGG:

id description
K09069 TWIST; twist

RNA

RNA id representative length rna type GC content exon number start site end site
CI01000016_07784248_07784757.mRNA False 1010 mRNA 0.48 1 7783987 7784996

Neighbor

gene id symbol gene type direction distance location
CI01000016_07759095_07759370 NA coding upstream 22713 7759095 ~ 7761274 (+)
CI01000016_07743396_07746536 MACC1 coding upstream 36604 7743088 ~ 7747383 (+)
CI01000016_07711605_07715888 SP8, SP8B coding upstream 67726 7711605 ~ 7716261 (+)
CI01000016_07484583_07551063 NA coding upstream 232924 7484583 ~ 7551063 (+)
CI01000016_07463735_07471367 NA coding upstream 312159 7463735 ~ 7471828 (+)
CI01000016_07851297_07854401 NA coding downstream 65760 7850756 ~ 7854610 (+)
CI01000016_07937188_07955977 ANKRD44, ANKRD28B, ANKRD28 coding downstream 152192 7937188 ~ 7956457 (+)
CI01000016_07956184_07965721 C16H2ORF66 coding downstream 171075 7956071 ~ 7965940 (+)
CI01000016_07969424_07983149 HACL1 coding downstream 183332 7968328 ~ 7983566 (+)
CI01000016_07998560_08008403 COLQ coding downstream 213564 7998560 ~ 8008446 (+)
G97764 NA non-coding upstream 5595 7778071 ~ 7778392 (+)
G97760 NA non-coding upstream 12022 7771638 ~ 7771965 (+)
G97724 NA non-coding upstream 131634 7652042 ~ 7652353 (+)
G96518 NA non-coding upstream 229447 7554210 ~ 7554540 (+)
G96453 NA non-coding upstream 452976 7329766 ~ 7331011 (+)
G97745 NA non-coding downstream 40392 7825388 ~ 7827695 (+)
G97746 NA non-coding downstream 60920 7845916 ~ 7847529 (+)
G97747 NA non-coding downstream 62661 7847657 ~ 7859181 (+)
G97788 NA non-coding downstream 121228 7906224 ~ 7906558 (+)
G96389 NA other upstream 622697 7160641 ~ 7161290 (+)
CI01000016_05405791_05407797 AICDA other upstream 2376124 5405791 ~ 5407963 (+)
G95792 NA other upstream 2558046 5219880 ~ 5225941 (+)
CI01000016_04829592_04837305 NA other upstream 2947332 4829592 ~ 4837457 (+)
G95648 NA other upstream 3510082 4272636 ~ 4273905 (+)
G97824 NA other downstream 229367 8014363 ~ 8015775 (+)
G98288 NA other downstream 1211102 8996098 ~ 9002717 (+)
CI01000016_09796196_09842235 NA other downstream 2010635 9795950 ~ 9842576 (+)
G99041 NA other downstream 2139422 9924418 ~ 9925654 (+)
G99410 NA other downstream 2449404 10234400 ~ 10236851 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
zebrafish (Danio rerio) XLOC_009839 twist1b coding NC_007127.7 CM002900.2 19732543 ~ 19734149 (+)