XLOC_009839 (twist1b)


Basic Information

Item Value
gene id XLOC_009839
gene name twist1b
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007127.7
NCBI id CM002900.2
chromosome length 55266484
location 19732543 ~ 19734149 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00019643
ATCTCTCTCCTCTCAAACACTTTACCAGACTATAAGAGCTCCCTAACTTTTTTCCTTTCAACCTAACACAAAGTTGCTTGGAATACCTAGTGATCTCCTCCAGAACACGAAACGTACGCGTGGAATTGTATTTCACCCTCATGCTGGAATAACGTCCTTATTCGCACGCGCTTTCAGCAGAGACTTAAGCGAGATGCCCGAAGAGCCCGCGCGAGACTCCTCCAGCTCCCCCGTGTCTCCCGCGGACAGTCTCAGCAACAGCGACGGAGAGCCCGACAGGCCACCAAAAAGGTGCGCAAGGAAAAGACGGTCGAGCAAGAAAAACGGGGAGGATTCCGATAGCTCGACCCTTGGGAAAAGGGGGAAAAAGTCTAGCAACAGCAGCAACAGCCCTCAGTCTTTCGAGGAGCTGCAGACGCAGCGCGTGATGGCGAACGTGCGCGAGCGACAGAGGACGCAGTCGCTCAACGAAGCGTTTGCGGCTTTACGCAAAATCATCCCCACTTTACCTTCCGATAAACTGAGCAAAATACAGACGCTGAAACTCGCCGCCAGGTACATCGATTTTCTCTGTCAGGTTCTACAGAGTGACGAGCTGGACTCCAAGATGGTCAAACCGTGAGCTGGGAAAACACGAGGACCAATGCTAATTCCATCATAATCTTGGGGAAAACGGCAAATGTTCCAACAGAGGTCATGGCTGTTACCGAGAGAAGGCCACGGGCAGCGAATTGTCATATGGATTTCCTCGCGAGTCTTATGACGACGAATGTTGGAAATATGTGcatatgcatgtttttttttttttttttttttttttttttggaagactCAGATGTGCATAACTTTCTGGAAGAAAGTGAATTTGCATTACAAGGACTGTCGATAAGAAAATGGGAATTGAAGCCTCTAGTTCGAATCCTGTGCAAATACAAAGCTTTAGT
>TCONS_00019644
ATCTCTCTCCTCTCAAACACTTTACCAGACTATAAGAGCTCCCTAACTTTTTTCCTTTCAACCTAACACAAAGTTGCTTGGAATACCTAGTGATCTCCTCCAGAACACGAAACGTACGCGTGGAATTGTATTTCACCCTCATGCTGGAATAACGTCCTTATTCGCACGCGCTTTCAGCAGAGACTTAAGCGAGATGCCCGAAGAGCCCGCGCGAGACTCCTCCAGCTCCCCCGTGTCTCCCGCGGACAGTCTCAGCAACAGCGACGGAGAGCCCGACAGGCCACCAAAAAGGTGCGCAAGGAAAAGACGGTCGAGCAAGAAAAACGGGGAGGATTCCGATAGCTCGACCCTTGGGAAAAGGGGGAAAAAGTCTAGCAACAGCAGCAACAGCCCTCAGTCTTTCGAGGAGCTGCAGACGCAGCGCGTGATGGCGAACGTGCGCGAGCGACAGAGGACGCAGTCGCTCAACGAAGCGTTTGCGGCTTTACGCAAAATCATCCCCACTTTACCTTCCGATAAACTGAGCAAAATACAGACGCTGAAACTCGCCGCCAGGTACATCGATTTTCTCTGTCAGGTTCTACAGAGTGACGAGCTGGACTCCAAGATGGCAAGTTGTAGTTATGTTGCTCACGAGCGTTTGAGCTACGCGTTCTCGGTTTGGAGGATGGAGGGCGCTTGGTCCATGTCTGCATCTCACTAGTGTGCAGGGAaactttttcttgttttgtttttaaatgGTCAAACCGTGAGCTGGGAAAACACGAGGACCAATGCTAATTCCATCATAATCTTGGGGAAAACGGCAAATGTTCCAACAGAGGTCATGGCTGTTACCGAGAGAAGGCCACGGGCAGCGAATTGTCATATGGATTTCCTCGCGAGTCTTATGACGACGAATGTTGGAAATATGTGcatatgcatgtttttttttttttttttttttttttttttggaagactCAGATGTGCATAACTTTCTGGAAGAAAGTGAATTTGCATTACAAGGACTGTCGATAAGAAAATGGGAATTGAAGCCTCTAGTTCGAATCCTGTGCAAATACAAAGCTTTAGTacaattctatttatttattgatgacaCACTTTTTGAAATGAAAGTAAATGTATCAAATGTGTtgaaatgcattattattttttattacttttgtaaataaatgtgtatttctgtaataaaaaaatgaagaattttaagaaa

Function

symbol description
twist1b Enables cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including pharyngeal system development; regulation of bone mineralization; and sprouting angiogenesis. Predicted to be located in nucleus. Is expressed in several structures, including brain; cardiovascular system; cranial vault; mesoderm; and pharyngeal arch. Human ortholog(s) of this gene implicated in Saethre-Chotzen syndrome; Sweeney-Cox syndrome; acrocephalosyndactylia; and craniosynostosis. Orthologous to human TWIST1 (twist family bHLH transcription factor 1).

GO:

id name namespace
GO:0006357 regulation of transcription by RNA polymerase II biological_process
GO:0002040 sprouting angiogenesis biological_process
GO:0030500 regulation of bone mineralization biological_process
GO:0009953 dorsal/ventral pattern formation biological_process
GO:0032502 developmental process biological_process
GO:0060037 pharyngeal system development biological_process
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding molecular_function
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific molecular_function
GO:0000987 cis-regulatory region sequence-specific DNA binding molecular_function
GO:0046983 protein dimerization activity molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-050417-357 Enables cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including pharyngeal system development; regulation of bone mineralization; and sprouting angiogenesis. Predicted to be located in nucleus. Is expressed in several structures, including brain; cardiovascular system; cranial vault; mesoderm; and pharyngeal arch. Human ortholog(s) of this gene implicated in Saethre-Chotzen syndrome; Sweeney-Cox syndrome; acrocephalosyndactylia; and craniosynostosis. Orthologous to human TWIST1 (twist family bHLH transcription factor 1).

Ensembl:

ensembl_id ENSDARG00000076010

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00019643 False 944 mRNA 0.48 2 19732543 19734008
TCONS_00019644 True 1215 mRNA 0.44 2 19732543 19734149

Neighbor

gene id symbol gene type direction distance location
XLOC_009837 BX005389.4 coding upstream 17333 19686713 ~ 19715210 (+)
XLOC_009838 BX005389.1 coding upstream 28005 19704424 ~ 19704538 (+)
XLOC_009836 tmem196b coding upstream 51261 19677484 ~ 19681282 (+)
XLOC_009835 macc1 coding upstream 55168 19637384 ~ 19677375 (+)
XLOC_009834 sp8b coding upstream 193767 19536614 ~ 19538776 (+)
XLOC_009840 CU855688.1 coding downstream 70872 19805021 ~ 19809117 (+)
XLOC_009841 ankrd28b coding downstream 321729 20055878 ~ 20154859 (+)
XLOC_009842 c16h2orf66 coding downstream 427656 20161805 ~ 20164454 (+)
XLOC_009843 hacl1 coding downstream 433662 20167811 ~ 20194385 (+)
XLOC_009844 colq coding downstream 463915 20198064 ~ 20238985 (+)
XLOC_009833 NA non-coding upstream 218552 19508738 ~ 19513991 (+)
XLOC_009831 NA non-coding upstream 320122 19375634 ~ 19412421 (+)
XLOC_009832 NA non-coding upstream 351251 19380866 ~ 19381292 (+)
XLOC_009847 NA non-coding downstream 795976 20530125 ~ 20531772 (+)
XLOC_009848 NA non-coding downstream 950791 20684940 ~ 20695517 (+)
XLOC_009854 mir196d non-coding downstream 1179264 20913413 ~ 20913484 (+)
XLOC_009859 NA non-coding downstream 1406899 21141048 ~ 21142516 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location