XLOC_012757 (map2k1)


Basic Information

Item Value
gene id XLOC_012757
gene name map2k1
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007129.7
NCBI id CM002902.2
chromosome length 51023478
location 19419120 ~ 19451165 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00025463
AATCTCAGCACCCATCCTCTGCTGTCGCACACCCATAGAAATACTCTAAATAAGCTATTTTTCGAAACAACCACTATCGTACCCGCAAGAAGACCATGCGAGACTGTCGTTAGCTGCattctgtgtttatttatttatttattgtaaagcaAACAGCCATTGGTAGGGTGTGATAGGCTATTCATAGCTTATGCATCACTGCTCTGTCGGCGGGTGAGTTGGTGTAGTCTGCGGATCAGATTGCTTCTGTTTGAGTCTTTTTTTTCGTCTGCTGCCGAGAAGCCAGCTATTAGGATTCATCATGCAGAAAAGGAGGAAGCCAGAGCCGATCCAACTGAACCCAATTCCAGATGGGAACGCTATCAACGGCACCGGGGCCACAGAAACAAATCTGGAAGCTCTGCAGAAGAAGCTGGAGGAACTGGAGCTGGACGAGCAGCAGAAAAAACGCCTGGAAGCTTTCCTCACCCAAAAGCAGAAGGTCGGAGAGTTAAAAGACGATGACTTCGAGAAGATCAGCGAGTTGGGAGCAGGCAATGGAGGAGTTGTGTTTAAAGTCTTACACAGGCCGTCAGGCTTCATCATGGCCAGGAAGTTGATCCACCTTGAGATTAAGCCAGCAATAAGGAATCAGATCATCAGAGAGCTGCAGGTGCTGCATGAATGTAACTCTCCCTACATCGTGGGCTTCTATGGGGCTTTCTACAGCGACGGAGAGATCAGCATCTGTATGGAGAACATGGATGGCGGCTCTTTGGACCAGTGCCTTAAGAAAGCAGGCAAGATCCCAGAACAAATACTGGGCAAAGTTAGCATTGCGGTGATTAAAGGTCTGTCATACCTGCGGGAGAAACACAAGATCATGCACAGAGATGTAAAGCCATCTAACATCTTGGTCAACTCGCGTGGGGAGATCAAGTTGTGTGACTTTGGTGTGAGTGGACAACTCATTGACTCCATGGCCAATTCCTTCGTGGGAACCAGGTCCTACATGTCTCCCGAACGCCTTCAAGGCACTCACTACTCTGTCCAGTCTGACATATGGAGCATGGGTCTCTCTCTGGTGGAGATGGCCATCGGACGCTTCCCGATCCCACCACCTGATGCCAAAGAGCTGGAACAAATCTTCGGTCAGCCCCTGGAGGGAGACCCATCAGCCAGTGACACTTCTCCAAAACCCAGGCCCCCTGGTCGACCTGGCAGCTCATACGGTCCAGACAGCAGACCTCCCATGGCTATATTTGAGCTACTTGATTATATTGTCAATGAACCACCTCCAAAGCTACCAAGTATCTTTGGTGCAGAATTTCAAGACTTTGTAAACAAATGTTTAATCAAAAATCCAGCAGAAAGAGCAGACCTCAAGCAGCTGATGGTTCATTCGTTTATCAAGAACTCAGAGGCTGAGGAGGTTGACTTCGCTGGATGGTTGTGCAGCACCATTGGACTGAACCAGCCAGCAACTCCGACTCACAGTGTGGGAATGTGAAAACAGCCATATTTTTCTAAGCCAACTGTTGGTGTTTCTTCACCCTCAAAATCTTCAGTTCCACCCAGAGGTCAACAGCAAACTACTGCCTCCTGAATCCACCCAGTCTTATTTTAGGTGTTGTCTAAGTATTAACAAACACACTGCTGTAATTAACAAAACATCACATCACAGTGCACTCAAAACCTGTTCTACAACATATCGGTTGGTTTATGCTAGGATGGCATCTGTGAGAGATGACAAATACCTATTTTTTCCTTACACCAAAATCTCAATTGCAAAAGCTATCAAATGGCAGACGTTACACCGCGCAAATGCAAAAGACCTCCCTTCTAAATGTCCACTTGTGATTGATATACTTTTTAAACTTAAAGATTTATGATTGAAGTCTTTGACCCCAGAGATGCTTACGTGGTTTTATTGTAATGTTGTGTTCTGCTTTCAGTATGGTGAATTTGCAGCCTTTAATTCAAAGAGAGTGAAAAATCAGTCATTTAACTTATACAAATGTGTATACTATGATAGGATTTATTTAACAGATGGCAACCAATGGAACGTGGCAATGCTTATATTGTATGCAGTGAATTAAAATGGacagatttta

Function

symbol description
map2k1 Predicted to enable MAP kinase kinase activity. Predicted to act upstream of or within protein phosphorylation. Is expressed in cardiac ventricle. Human ortholog(s) of this gene implicated in carcinoma (multiple); cardiofaciocutaneous syndrome 3; high grade glioma; and melorheostosis. Orthologous to human MAP2K1 (mitogen-activated protein kinase kinase 1).

GO:

id name namespace
GO:0006468 protein phosphorylation biological_process
GO:0000187 activation of MAPK activity biological_process
GO:0016310 phosphorylation biological_process
GO:0016740 transferase activity molecular_function
GO:0005524 ATP binding molecular_function
GO:0000166 nucleotide binding molecular_function
GO:0004672 protein kinase activity molecular_function
GO:0004674 protein serine/threonine kinase activity molecular_function
GO:0016301 kinase activity molecular_function
GO:0004708 MAP kinase kinase activity molecular_function

KEGG:

id description
ko04010 MAPK signaling pathway
ko04013 MAPK signaling pathway - fly
ko04012 ErbB signaling pathway
ko04014 Ras signaling pathway
ko04015 Rap1 signaling pathway
ko04370 VEGF signaling pathway
ko04371 Apelin signaling pathway
ko04668 TNF signaling pathway
ko04066 HIF-1 signaling pathway
ko04068 FoxO signaling pathway
ko04072 Phospholipase D signaling pathway
ko04071 Sphingolipid signaling pathway
ko04024 cAMP signaling pathway
ko04022 cGMP-PKG signaling pathway
ko04151 PI3K-Akt signaling pathway
ko04150 mTOR signaling pathway
ko04140 Autophagy - animal
ko04114 Oocyte meiosis
ko04210 Apoptosis
ko04218 Cellular senescence
ko04510 Focal adhesion
ko04540 Gap junction
ko04550 Signaling pathways regulating pluripotency of stem cells
ko04810 Regulation of actin cytoskeleton
ko04613 Neutrophil extracellular trap formation
ko04620 Toll-like receptor signaling pathway
ko04650 Natural killer cell mediated cytotoxicity
ko04660 T cell receptor signaling pathway
ko04662 B cell receptor signaling pathway
ko04664 Fc epsilon RI signaling pathway
ko04666 Fc gamma R-mediated phagocytosis
ko04062 Chemokine signaling pathway
ko04910 Insulin signaling pathway
ko04929 GnRH secretion
ko04912 GnRH signaling pathway
ko04915 Estrogen signaling pathway
ko04914 Progesterone-mediated oocyte maturation
ko04917 Prolactin signaling pathway
ko04921 Oxytocin signaling pathway
ko04926 Relaxin signaling pathway
ko04935 Growth hormone synthesis, secretion and action
ko04919 Thyroid hormone signaling pathway
ko04928 Parathyroid hormone synthesis, secretion and action
ko04916 Melanogenesis
ko04270 Vascular smooth muscle contraction
ko04725 Cholinergic synapse
ko04726 Serotonergic synapse
ko04720 Long-term potentiation
ko04730 Long-term depression
ko04722 Neurotrophin signaling pathway
ko04320 Dorso-ventral axis formation
ko04380 Osteoclast differentiation
ko04626 Plant-pathogen interaction
ko05200 Pathways in cancer
ko05206 MicroRNAs in cancer
ko05205 Proteoglycans in cancer
ko05207 Chemical carcinogenesis - receptor activation
ko05208 Chemical carcinogenesis - reactive oxygen species
ko05230 Central carbon metabolism in cancer
ko05231 Choline metabolism in cancer
ko05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
ko05210 Colorectal cancer
ko05212 Pancreatic cancer
ko05225 Hepatocellular carcinoma
ko05226 Gastric cancer
ko05214 Glioma
ko05216 Thyroid cancer
ko05221 Acute myeloid leukemia
ko05220 Chronic myeloid leukemia
ko05218 Melanoma
ko05211 Renal cell carcinoma
ko05219 Bladder cancer
ko05215 Prostate cancer
ko05213 Endometrial cancer
ko05224 Breast cancer
ko05223 Non-small cell lung cancer
ko05166 Human T-cell leukemia virus 1 infection
ko05170 Human immunodeficiency virus 1 infection
ko05161 Hepatitis B
ko05160 Hepatitis C
ko05164 Influenza A
ko05163 Human cytomegalovirus infection
ko05167 Kaposi sarcoma-associated herpesvirus infection
ko05165 Human papillomavirus infection
ko05132 Salmonella infection
ko05135 Yersinia infection
ko05010 Alzheimer disease
ko05022 Pathways of neurodegeneration - multiple diseases
ko05034 Alcoholism
ko04934 Cushing syndrome
ko01521 EGFR tyrosine kinase inhibitor resistance
ko01522 Endocrine resistance
ko01001 Protein kinases

ZFIN:

id description
ZDB-GENE-040426-2759 Predicted to enable MAP kinase kinase activity. Predicted to act upstream of or within protein phosphorylation. Is expressed in cardiac ventricle. Human ortholog(s) of this gene implicated in carcinoma (multiple); cardiofaciocutaneous syndrome 3; high grade glioma; and melorheostosis. Orthologous to human MAP2K1 (mitogen-activated protein kinase kinase 1).

Ensembl:

ensembl_id ENSDARG00000007825

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00025463 True 2093 mRNA 0.45 11 19419120 19451165

Neighbor

gene id symbol gene type direction distance location
XLOC_012756 NA coding upstream 3080 19413097 ~ 19416040 (+)
XLOC_012755 rab11a coding upstream 279968 19131773 ~ 19139152 (+)
XLOC_012754 si:dkey-242h9.3 coding upstream 294808 19120984 ~ 19124312 (+)
XLOC_012753 si:dkey-242h9.5 coding upstream 315156 19101679 ~ 19103964 (+)
XLOC_012751 slc24a1 coding upstream 379160 19006063 ~ 19039960 (+)
XLOC_012758 zwilch coding downstream 5483 19456648 ~ 19472646 (+)
XLOC_012759 NA coding downstream 73676 19524841 ~ 19620953 (+)
XLOC_012760 smad6b coding downstream 197110 19648275 ~ 19699061 (+)
XLOC_012761 smad3b coding downstream 321709 19772874 ~ 19806209 (+)
XLOC_012762 iqch coding downstream 368843 19820008 ~ 19880934 (+)
XLOC_012752 BX548060.1 non-coding upstream 385907 19025989 ~ 19033213 (+)
XLOC_012749 NA non-coding upstream 449354 18968890 ~ 18969766 (+)
XLOC_012748 BX571681.4 non-coding upstream 507505 18910366 ~ 18911615 (+)
XLOC_012745 NA non-coding upstream 590635 18827219 ~ 18828485 (+)
XLOC_012769 BX890624.2 non-coding downstream 638216 20089381 ~ 20208129 (+)
XLOC_012771 NA non-coding downstream 865278 20316443 ~ 20325221 (+)
XLOC_012772 NA non-coding downstream 876954 20328119 ~ 20376935 (+)
XLOC_012781 BX548061.1 non-coding downstream 1570534 21021699 ~ 21023601 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location