XLOC_018902 (chek1)


Basic Information

Item Value
gene id XLOC_018902
gene name chek1
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007132.7
NCBI id CM002905.2
chromosome length 45934066
location 22558187 ~ 22565170 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00037565
aacgcAAAAAGTTGTCCATCGTGTTAGCGGtttaagcttttattttgaaaattcttTCCTCTTAGCGTTTCCGATGATGTCACGTCTCTAGAAGGCGCCAAAGTTTGGACAGACGCTCTTGTATTATTATGTCTGCATAGACACTTATCAAGGGGGTGTGTGATTATAACAACAAATTACATTAACAAACCGCTTCACATGGGACAACGTTACCTCTGATATACGCGAAGATTGCATAATGGCTGTGCCTTTTGTTAAAGACTGGGATGTGGTACAAACTCTTGGAGAGGGAGCATATGGAGAGGTGCGACTGCTGGTCAACAAGAAAACAGAAGAGGCTGTGGCGGTGAAAGTTGTGGACATGGCAAAAGCCAAGGATTGCATCGAGAATGTGAAGAAGGAGGTCTGCATATGCAAGATGCTTTCACACCCCAACATTGTACGTTTCTTTGGGCACAGTGTTGGGATTACACATCGTGACATAAAGCCTGAGAATATTCTTCTTGATGATAAAGATAATCTGAAGATCTCTGACTTTGGCCTGGCTACCATGTTCAGGCACCGTGGCCGTGAGCGAGCATTGAACCGTCTGTGTGGTACTCTGCCCTATGTTGCCCCAGAGTTGATGTCACGCTCATCTTTTAACGCTCAGCCTGCGGACACTTGGGCTTGTGGCATTGTGCTCACTGCAATGTTAGCTGGAGAGTTACCCTGGGATCAGCCGAGTGAAAACTGTCAGGAGTATTTGGACTGGCTGGAAAGAAAGACCTACCTTACGCCCTGGAAGAAAATTGATGCGGTACCCCTTAGTCTGTTGTCTAAGATATTACTGCACAATCCAGAAGACAGGTTCACCATTCCTGAAATTAAGAAACACCGCTGGTTTAGCAGAAGTTTCAAATCAGCAGTACAACGTCAGGGCATCACACCAGCAGCCAAGATTCAACGGGCTGACTCTGAGCTGAGACGAAAAAACAGTGATGACCGAGCGCAGATCTCAAGCTCTCAGCCTGAGCCACAGGGATTATGGGAGGAGAAGGAGGTTACAGTTCACACCGATGTCAGTGTCAGCTTTTCACAACCGACCTGTCCTGACCACATGCTGCTGGGCACACAACTGCTTGGCACACCGGGTGCAAGCCAGAGCCCCTGGCAGCGTTTGGTGAGGAGAATGACCAGGTTCTTTACTACAGAAAATACAGAGGCATCTTGCATTGCTCTCCGTGATTCTTGTATTGCTTTGGGTCACACATGGAAACAGAGCTGTAATAATCAGGCGACAGTGTCTACAATGGATCGTCGCAATAATAAGCTGATATTCATAGTGCACTTCCTGGAAATGGAGGAACGTATTTTAGTTGATTTCCGGCTGTCAAAGGGTGACGGTTTGGAATTCAAGCGAATATTCCTGAAACTCAAACAGAAGCTGTCTGACATTATTAGCAACCAAAAGGTTTTGCCATTGATTTGATGCATATACACATTTTACCATGCAAAGCCTGCCTtcacatgagcacacacacacacacacacactaaattgtTATATGTTTGTGGTATGTGTTGTGATCTGTTTGTCTGAAGTTGTATATGTCTGTTTTGTTGATCCACGAGTGAAGGAATGAAGAGAAATTGTCAGGTATAGTTTGTCTGTTCATGTTTCGTTACTGTGACAAAGAGGGTTTTAGTTTTCTACCTCCTAAATAGATTGTAGGGTTCAGAACATCacaaaaaatggaaaataaatcCACTTTT

Function

symbol description
chek1 Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage; mitotic G2 DNA damage checkpoint signaling; and protein phosphorylation. Predicted to be active in nucleus. Is expressed in forebrain; hindbrain; immature eye; and midbrain. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human CHEK1 (checkpoint kinase 1).

GO:

id name namespace
GO:0035556 intracellular signal transduction biological_process
GO:0006468 protein phosphorylation biological_process
GO:0007095 mitotic G2 DNA damage checkpoint biological_process
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage biological_process
GO:0016310 phosphorylation biological_process
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0016740 transferase activity molecular_function
GO:0005524 ATP binding molecular_function
GO:0000166 nucleotide binding molecular_function
GO:0004672 protein kinase activity molecular_function
GO:0004674 protein serine/threonine kinase activity molecular_function
GO:0016301 kinase activity molecular_function

KEGG:

id description
ko04110 Cell cycle
ko04111 Cell cycle - yeast
ko04113 Meiosis - yeast
ko04115 p53 signaling pathway
ko04218 Cellular senescence
ko05203 Viral carcinogenesis
ko05166 Human T-cell leukemia virus 1 infection
ko05170 Human immunodeficiency virus 1 infection
ko01001 Protein kinases
ko03400 DNA repair and recombination proteins

ZFIN:

id description
ZDB-GENE-040426-896 Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage; mitotic G2 DNA damage checkpoint signaling; and protein phosphorylation. Predicted to be active in nucleus. Is expressed in forebrain; hindbrain; immature eye; and midbrain. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human CHEK1 (checkpoint kinase 1).

Ensembl:

ensembl_id ENSDARG00000104765

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00037565 True 1754 mRNA 0.45 12 22558187 22565170

Neighbor

gene id symbol gene type direction distance location
XLOC_018901 capslb coding upstream 129859 22423286 ~ 22428328 (+)
XLOC_018900 lmbrd2b coding upstream 135248 22400951 ~ 22422939 (+)
XLOC_018899 CU466287.3 coding upstream 185975 22369869 ~ 22372212 (+)
XLOC_018898 nadk2 coding upstream 211464 22330005 ~ 22346723 (+)
XLOC_018897 myo7ab coding upstream 248721 22237964 ~ 22309466 (+)
XLOC_018903 si:dkeyp-69c1.7 coding downstream 65127 22630297 ~ 22634926 (+)
XLOC_018904 NA coding downstream 70234 22635404 ~ 22662564 (+)
XLOC_018905 bud13 coding downstream 131889 22697059 ~ 22705347 (+)
XLOC_018906 NA coding downstream 155044 22720214 ~ 22733107 (+)
XLOC_018907 arhgap42a coding downstream 173769 22738939 ~ 22796064 (+)
XLOC_018896 NA non-coding upstream 332289 22225366 ~ 22225898 (+)
XLOC_018893 NA non-coding upstream 455014 22098376 ~ 22103173 (+)
XLOC_018892 CR854959.2 non-coding upstream 522010 22036061 ~ 22036177 (+)
XLOC_018891 CR854959.1 non-coding upstream 637978 21920077 ~ 21920209 (+)
XLOC_018914 NA non-coding downstream 483367 23048537 ~ 23051547 (+)
XLOC_018917 NA non-coding downstream 594967 23160137 ~ 23164308 (+)
XLOC_018918 NA non-coding downstream 740356 23305526 ~ 23308245 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000006_06194768_06199541 CHEK1 coding CI01000006 null 6194494 ~ 6199541 (-)