XLOC_021920 (src)


Basic Information

Item Value
gene id XLOC_021920
gene name src
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007134.7
NCBI id CM002907.2
chromosome length 46223584
location 39346774 ~ 39450700 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00043406
CGttttatggggggggggggggggggggggggttggggtaTTACTAATGGGGTTTCTCTTTCTCGCTCTCTCCTTCTGTAGGCTTGTCCCTGCTAGTCAAGTGTAATGTAGTAAAAACAGTGTCACGTCAAAGCGCCCTGCCCTCCCGACGCTGTCTTACCAGTTTTCTATCATCTCCAGGGTTTGACTCCCTTCTGCcgtgtgctgctgctgctggttcTCAGGGACACATTGAGAAACTGCTGCTATACCGCTCGCTTTTAATCGTGACGctggatttatttatattaattgttaCCGGCGTCCGGTTGTTATCAGAAGATGACTCGTGCAGCTGTGCGCTTTCTCAGGCAAACCCCCGTCATGAACGCGCACTGACCGCGCTCGCGCTCTCCGTTTCATTCCGTGTATCAGAAGCGGTCAACATTATTGACCATGGAAAGCTGAGCCTCGTTCATTCATAGACAGAAAACAGTCAACCAAAGGTCAGCCAGAAAAACAAAGGGATTTTATTCACGCCACATTTCGTGTGGTTTTCGACGAGGCCTCGGCCATGGGTGGAGTCAAGAGTAAACCCAAAGAGCTGGGCCAGCGCTCGCGGAGTCTGGACGACGGCACCGGAGGACACCACCACCACACCCCCAACCCCACCTCCTTCACCCCTAACCGCAGTCCACCGGTGGAGGGGTCCCGGCGCGGCACACAGCCCAACATCATAAACGCGGAGCAGGCGCTCTTTGGGGGAGTGAACTCCACCACCAACAGCATCACATCTCCTAATCGAATCGGCATATTAGGCGGCGTGACCACATTTGTGGCTCTGTATGACTACGAGTCACGAACCGCCTCCGATTTGTCATTCAGGAAAGGAGAACGACTCCAGATTGTCAATAACACGAGAAAGTTGAACCCCAGGGAGGGTGACTGGTGGCTAGCGCGATCACTGACGACAGGAGAGAGCGGATACATTCCCAGCAATTACGTGGCACCGTCTGACTCCATCCAGGCTGAAGAATGGTACTTCGGAAAAATCACACGCAGAGACTCTGAGCGACTGCTCTTGAATCTGGAGAACAGACGAGGAACTTTCCTGGTCAGAGAGAGCGAGACCACCAAAGGTGCCTACTGTCTCTCCGTCCTGGATTACGACAACGTGAAGGGCCTGAATGTAAAACATTATAAGATCCGCAAACTGGACAGCGGTGGATTTTACATCACGTCCCGCACACAGTTCAGCACATTACAGCAGCTGGTCAACCACTACCGCCAGCACGCAGACGGCCTGTGCCACTCCCTGACTGACGTGTGTCCAGTGCTGAAGCCTCCGACTCAGGGTCTGGCACGTGATGCCTGGGAGATTCCTCGAGACTCGCTGAGACTGGATGTCAAGCTGGGCCAGGGCTGCTTCGGGGAGGTCTGGATGGGCACCTGGAACGGGACGACACGTGTGGCCATCAAGACTCTGAAGCCTGGCACCATGTCTCCCGAAGCGTTCCTGCAGGAGGCGCAAGTGATGAAGAAGCTCCGGCATGAGAAGCTGGTGCAGCTTTACGCCGTCGTCTCAGAGGAGCCCATTTACATAGTCACTGAGTACATGGGTCAAGGAAGCCTGCTGGATTTCCTGAAAGGTGACATGGGGAAAATGCTGCGTTTGCCTCAGCTCGTGGACATGGCCTCTCAGATCGCCTCAGGAATGGCATACGTGGAGAGAATGAACTATGTGCACAGGGACCTCAGGGCTGCCAACATCCTGGTGGGCGATAACCTGGTGTGTAAAGTGGCTGATTTCGGCCTCGCTCGACTCATTGAGGACAACGAATACACCGCGAGACAAGGAGCAAAGTTTCCTATTAAGTGGACTGCACCGGAGGCAGCTCTGTACGGACGCTTCACCATCAAATCTGACGTGTGGTCGTTTGGGATTTTACTGACGGAGCTCACCACCAAAGGCAGGGTGCCTTATCCAGGTATGGTGAACCGCGAGGTGCTTGACCAGGTGGAGCGTGGCTACAGGATGCCCTGCCCGGCCGAATGCCCTGACTCCCTGCACGAGCTCATGCTGACCTGCTGGCGCAAAGAGCCCGAAGAGCGGCCCACATTCGAGTACCTGCAGGGTTTCCTGGAGGACTACTTCACCTCCACCGAACCACAATACCAACCCGGAGAAAACCTCTAG
>TCONS_00043407
TTACCAGTTTTCTATCATCTCCAGGGTTTGACTCCCTTCTGCcgtgtgctgctgctgctggttcTCAGGGACACATTGAGAAACTGCTGCTATACCGCTCGCTTTTAATCGTGACGctggatttatttatattaattgttaCCGGCGTCCGGTTGTTATCAGAAGATGACTCGTGCAGCTGTGCGCTTTCTCAGGCAAACCCCCGTCATGAACGCGCACTGACCGCGCTCGCGCTCTCCGTTTCATTCCGTGTATCAGAAGCGGTCAACATTATTGACCATGGAAAGCTGAGCCTCGTTCATTCATAGACAGAAAACAGTCAACCAAAGGTCAGCCAGAAAAACAAAGGGATTTTATTCACGCCACATTTCGTGTGGTTTTCGACGAGGCCTCGGCCATGGGTGGAGTCAAGAGTAAACCCAAAGAGCTGGGCCAGCGCTCGCGGAGTCTGGACGACGGCACCGGAGGACACCACCACCACACCCCCAACCCCACCTCCTTCACCCCTAACCGCAGTCCACCGGTGGAGGGGTCCCGGCGCGGCACACAGCCCAACATCATAAACGCGGAGCAGGCGCTCTTTGGGGGAGTGAACTCCACCACCAACAGCATCACATCTCCTAATCGAATCGGCATATTAGGCGGCGTGACCACATTTGTGGCTCTGTATGACTACGAGTCACGAACCGCCTCCGATTTGTCATTCAGGAAAGGAGAACGACTCCAGATTGTCAATAACACGGAGGGTGACTGGTGGCTAGCGCGATCACTGACGACAGGAGAGAGCGGATACATTCCCAGCAATTACGTGGCACCGTCTGACTCCATCCAGGCTGAAGAATGGTACTTCGGAAAAATCACACGCAGAGACTCTGAGCGACTGCTCTTGAATCTGGAGAACAGACGAGGAACTTTCCTGGTCAGAGAGAGCGAGACCACCAAAGGTGCCTACTGTCTCTCCGTCCTGGATTACGACAACGTGAAGGGCCTGAATGTAAAACATTATAAGATCCGCAAACTGGACAGCGGTGGATTTTACATCACGTCCCGCACACAGTTCAGCACATTACAGCAGCTGGTCAACCACTACCGCCAGCACGCAGACGGCCTGTGCCACTCCCTGACTGACGTGTGTCCAGTGCTGAAGCCTCCGACTCAGGGTCTGGCACGTGATGCCTGGGAGATTCCTCGAGACTCGCTGAGACTGGATGTCAAGCTGGGCCAGGGCTGCTTCGGGGAGGTCTGGATGGGCACCTGGAACGGGACGACACGTGTGGCCATCAAGACTCTGAAGCCTGGCACCATGTCTCCCGAAGCGTTCCTGCAGGAGGCGCAAGTGATGAAGAAGCTCCGGCATGAGAAGCTGGTGCAGCTTTACGCCGTCGTCTCAGAGGAGCCCATTTACATAGTCACTGAGTACATGGGTCAAGGAAGCCTGCTGGATTTCCTGAAAGGTGACATGGGGAAAATGCTGCGTTTGCCTCAGCTCGTGGACATGGCCTCTCAGATCGCCTCAGGAATGGCATACGTGGAGAGAATGAACTATGTGCACAGGGACCTCAGGGCTGCCAACATCCTGGTGGGCGATAACCTGGTGTGTAAAGTGGCTGATTTCGGCCTCGCTCGACTCATTGAGGACAACGAATACACCGCGAGACAAGGAGCAAAGTTTCCTATTAAGTGGACTGCACCGGAGGCAGCTCTGTACGGACGCTTCACCATCAAATCTGACGTGTGGTCGTTTGGGATTTTACTGACGGAGCTCACCACCAAAGGCAGGGTGCCTTATCCAGGTATGGTGAACCGCGAGGTGCTTGACCAGGTGGAGCGTGGCTACAGGATGCCCTGCCCGGCCGAATGCCCTGACTCCCTGCACGAGCTCATGCTGACCTGCTGGCGCAAAGAGCCCGAAGAGCGGCCCACATTCGAGTACCTGCAGGGTTTCCTGGAGGACTACTTCACCTCCACCGAACCACAATACCAACCCGGAGAAAACCTCTAGGCCAAAGAGGAAATACACGTGCTTTAACCCAAACAACACCAATCAATATGGGGGGGAAAAAAAACGAGAGGGTATCCAGCAGTATTAGACTACATGCTCTGTCATTTTCATGCATGTCTATTTTGTTTCTGCATCTTTTCTCCATCAGATGCATTGATCTTCAGCTGCGTTTCTTGACCTCGTTGTACAAACTAAACCCTTTTAGCGGATGCTCCAGATCTGTcattcatcctcctcctcctcttcccaCAATCCTTCTTCTGTCCTCTCCCTTCCCCCTCCTTCAAAGCATCGGTTCATCATTCACGAACTCTACGACCCCGTTCAAGAGCTCTGATGGATGAGATGTGATGTTGGATAATGAACGGACAGGTCCCGTTTTATGTCTTCCAATAGATATCCAGGGTCTGCATCTGAACGCTATTATGccttttactgtcattatgagtgtttatttacctttttatcaACCTGGATTAACTGGAACAAAAAGATGAGTGGTCACGAAGAAATTCGTTCATACTGAAAATTCTTCCTTTTGATTGTGAACAATGGGAAGACGTTCGTTTGACACGGTTATCCTACTCTTCTAGTAATCGAAACAACtactgatataaatatatataaataagcatCGTTTGACTGTATAGTCCTACTTTGTGTGCCAATACAAAggagaaaagaacaaaaaaaaaacaacaaataaatttttgtactgttttattatgtataaaa
>TCONS_00043408
CAGAAGCGGTCAACATTATTGACCATGGAAAGCTGAGCCTCGTTCATTCATAGACAGAAAACAGTCAACCAAAGGTCAGCCAGAAAAACAAAGGGATTTTATTCACGCCACATTTCGTGTGGTTTTCGACGAGGCCTCGGCCATGGGTGGAGTCAAGAGTAAACCCAAAGAGCTGGGCCAGCGCTCGCGGAGTCTGGACGACGGCACCGGAGGACACCACCACCACACCCCCAACCCCACCTCCTTCACCCCTAACCGCAGTCCACCGGTGGAGGGGTCCCGGCGCGGCACACAGCCCAACATCATAAACGCGGAGCAGGCGCTCTTTGGGGGAGTGAACTCCACCACCAACAGCATCACATCTCCTAATCGAATCGGCATATTAGGCGGCGTGACCACATTTGTGGCTCTGTATGACTACGAGTCACGAACCGCCTCCGATTTGTCATTCAGGAAAGGAGAACGACTCCAGATTGTCAATAACACGGAGGGTGACTGGTGGCTAGCGCGATCACTGACGACAGGAGAGAGCGGATACATTCCCAGCAATTACGTGGCACCGTCTGACTCCATCCAGGCTGAAGAGTAaatcctcctcctccttttttttctctcctttttttgCTTTGCTCTTCTCCTCCCTGAGGCTCCATTGGTTTGCTTTTGATTTCCCTTTGTTGTGATGTCAGAACTCTCTAATCCAATTGGATCTCTCCCTGACATGATTCTGATTCCT
>TCONS_00043409
TGCAGGCCTCGGCCATGGGTGGAGTCAAGAGTAAACCCAAAGAGCTGGGCCAGCGCTCGCGGAGTCTGGACGACGGCACCGGAGGACACCACCACCACACCCCCAACCCCACCTCCTTCACCCCTAACCGCAGTCCACCGGTGGAGGGGTCCCGGCGCGGCACACAGCCCAACATCATAAACGCGGAGCAGGCGCTCTTTGGGGGAGTGAACTCCACCACCAACAGCATCACATCTCCTAATCGAATCGGCATATTAGGCGGCGTGACCACATTTGTGGCTCTGTATGACTACGAGTCACGAACCGCCTCCGATTTGTCATTCAGGAAAGGAGAACGACTCCAGATTGTCAATAACACGGAGGGTGACTGGTGGCTAGCGCGATCACTGACGACAGGAGAGAGCGGATACATTCCCAGCAATTACGTGGCACCGTCTGACTCCATCCAGGCTGAAGAATGGTACTTCGGAAAAATCACACGCAGAGACTCTGAGCGACTGCTCTTGAATCTGGAGAACAGACGAGGAACTTTCCTGGTCAGAGAGAGCGAGACCACCAAAGGTGCCTACTGTCTCTCCGTCCTGGATTACGACAACGTGAAGGGCCTGAATGTAAAACATTATAAGATCCGCAAACTGGACAGCGGTGGATTTTACATCACGTCCCGCACACAGTTCAGCACATTACAGCAGCTGGTCAACCACTACCGCCAGCACGCAGACGGCCTGTGCCACTCCCTGACTGACGTGTGTCCAGTGCTGAAGCCTCCGACTCAGGGTCTGGCACGTGATGCCTGGGAGATTCCTCGAGACTCGCTGAGACTGGATGTCAAGCTGGGCCAGGGCTGCTTCGGGGAGGTCTGGATGGGCACCTGGAACGGGACGACACGTGTGGCCATCAAGACTCTGAAGCCTGGCACCATGTCTCCCGAAGCGTTCCTGCAGGAGGCGCAAGTGATGAAGAAGCTCCGGCATGAGAAGCTGGTGCAGCTTTACGCCGTCGTCTCAGAGGAGCCCATTTACATAGTCACTGAGTACATGGGTCAAGGAAGCCTGCTGGATTTCCTGAAAGGTGACATGGGGAAAATGCTGCGTTTGCCTCAGCTCGTGGACATGGCCTCTCAGATCGCCTCAGGAATGGCATACGTGGAGAGAATGAACTATGTGCACAGGGACCTCAGGGCTGCCAACATCCTGGTGGGCGATAACCTGGTGTGTAAAGTGGCTGATTTCGGCCTCGCTCGACTCATTGAGGACAACGAATACACCGCGAGACAAGGAGCAAAGTTTCCTATTAAGTGGACTGCACCGGAGGCAGCTCTGTACGGACGCTTCACCATCAAATCTGACGTGTGGTCGTTTGGGATTTTACTGACGGAGCTCACCACCAAAGGCAGGGTGCCTTATCCAGGTATGGTGAACCGCGAGGTGCTTGACCAGGTGGAGCGTGGCTACAGGATGCCCTGCCCGGCCGAATGCCCTGACTCCCTGCACGAGCTCATGCTGACCTGCTGGCGCAAAGAGCCCGAAGAGCGGCCCACATTCGAGTACCTGCAGGGTTTCCTGGAGGACTACTTCACCTCCACCGAACCACAATACCAACCCGGAGAAAACCTCTAG

Function

symbol description
src Predicted to enable growth factor receptor binding activity and non-membrane spanning protein tyrosine kinase activity. Acts upstream of or within posterior lateral line neuromast primordium migration; regulation of vascular permeability; and response to yeast. Predicted to be located in several cellular components, including focal adhesion; mitochondrial inner membrane; and perinuclear region of cytoplasm. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Is expressed in several structures, including adaxial cell; central nervous system; musculature system; periderm; and retina. Human ortholog(s) of this gene implicated in colorectal cancer (multiple); ductal carcinoma in situ; prostate cancer; thrombocytopenia; and type 2 diabetes mellitus. Orthologous to human SRC (SRC proto-oncogene, non-receptor tyrosine kinase).

GO:

id name namespace
GO:0045087 innate immune response biological_process
GO:0036035 osteoclast development biological_process
GO:0045453 bone resorption biological_process
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway biological_process
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway biological_process
GO:0042127 regulation of cell population proliferation biological_process
GO:0030154 cell differentiation biological_process
GO:0038083 peptidyl-tyrosine autophosphorylation biological_process
GO:0006468 protein phosphorylation biological_process
GO:0043114 regulation of vascular permeability biological_process
GO:0007049 cell cycle biological_process
GO:0001878 response to yeast biological_process
GO:0048920 posterior lateral line neuromast primordium migration biological_process
GO:0016310 phosphorylation biological_process
GO:0007155 cell adhesion biological_process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway biological_process
GO:0050847 progesterone receptor signaling pathway biological_process
GO:0007173 epidermal growth factor receptor signaling pathway biological_process
GO:0005743 mitochondrial inner membrane cellular_component
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane cellular_component
GO:0048471 perinuclear region of cytoplasm cellular_component
GO:0005856 cytoskeleton cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005925 focal adhesion cellular_component
GO:0005634 nucleus cellular_component
GO:0030054 cell junction cellular_component
GO:0016020 membrane cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005739 mitochondrion cellular_component
GO:0005102 signaling receptor binding molecular_function
GO:0016740 transferase activity molecular_function
GO:0005524 ATP binding molecular_function
GO:0070851 growth factor receptor binding molecular_function
GO:0000166 nucleotide binding molecular_function
GO:0004672 protein kinase activity molecular_function
GO:0016301 kinase activity molecular_function
GO:0004713 protein tyrosine kinase activity molecular_function
GO:0004715 non-membrane spanning protein tyrosine kinase activity molecular_function

KEGG:

id description
ko04013 MAPK signaling pathway - fly
ko04012 ErbB signaling pathway
ko04015 Rap1 signaling pathway
ko04370 VEGF signaling pathway
ko04144 Endocytosis
ko04137 Mitophagy - animal
ko04510 Focal adhesion
ko04520 Adherens junction
ko04530 Tight junction
ko04540 Gap junction
ko04810 Regulation of actin cytoskeleton
ko04611 Platelet activation
ko04613 Neutrophil extracellular trap formation
ko04625 C-type lectin receptor signaling pathway
ko04062 Chemokine signaling pathway
ko04912 GnRH signaling pathway
ko04915 Estrogen signaling pathway
ko04917 Prolactin signaling pathway
ko04921 Oxytocin signaling pathway
ko04926 Relaxin signaling pathway
ko04919 Thyroid hormone signaling pathway
ko04727 GABAergic synapse
ko04750 Inflammatory mediator regulation of TRP channels
ko04360 Axon guidance
ko05205 Proteoglycans in cancer
ko05207 Chemical carcinogenesis - receptor activation
ko05208 Chemical carcinogenesis - reactive oxygen species
ko05203 Viral carcinogenesis
ko05219 Bladder cancer
ko05161 Hepatitis B
ko05168 Herpes simplex virus 1 infection
ko05163 Human cytomegalovirus infection
ko05167 Kaposi sarcoma-associated herpesvirus infection
ko05120 Epithelial cell signaling in Helicobacter pylori infection
ko05130 Pathogenic Escherichia coli infection
ko05131 Shigellosis
ko05135 Yersinia infection
ko05152 Tuberculosis
ko05100 Bacterial invasion of epithelial cells
ko05417 Lipid and atherosclerosis
ko05418 Fluid shear stress and atherosclerosis
ko01521 EGFR tyrosine kinase inhibitor resistance
ko01522 Endocrine resistance
ko01001 Protein kinases
ko04131 Membrane trafficking
ko03200 Viral proteins

ZFIN:

id description
ZDB-GENE-030131-3809 Predicted to enable growth factor receptor binding activity and non-membrane spanning protein tyrosine kinase activity. Acts upstream of or within posterior lateral line neuromast primordium migration; regulation of vascular permeability; and response to yeast. Predicted to be located in several cellular components, including focal adhesion; mitochondrial inner membrane; and perinuclear region of cytoplasm. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Is expressed in several structures, including adaxial cell; central nervous system; musculature system; periderm; and retina. Human ortholog(s) of this gene implicated in colorectal cancer (multiple); ductal carcinoma in situ; prostate cancer; thrombocytopenia; and type 2 diabetes mellitus. Orthologous to human SRC (SRC proto-oncogene, non-receptor tyrosine kinase).

Ensembl:

ensembl_id ENSDARG00000008107

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00043406 False 2176 mRNA 0.55 13 39346774 39449965
TCONS_00043407 False 2737 mRNA 0.51 12 39346930 39450700
TCONS_00043408 False 736 lncRNA 0.52 4 39347185 39425796
TCONS_00043409 True 1619 mRNA 0.57 11 39413163 39449965

Neighbor

gene id symbol gene type direction distance location
XLOC_021919 kcng1 coding upstream 13461 39281229 ~ 39333313 (+)
XLOC_021918 CABZ01054023.1 coding upstream 162465 39183246 ~ 39184309 (+)
XLOC_021917 nfatc2a coding upstream 181908 39089574 ~ 39164866 (+)
XLOC_021916 sall4 coding upstream 283177 38940700 ~ 39063597 (+)
XLOC_021915 zfp64 coding upstream 527658 38806861 ~ 38819116 (+)
XLOC_021921 mical1 coding downstream 11289 39461989 ~ 39528988 (+)
XLOC_021922 camk1gb coding downstream 107808 39558508 ~ 39597901 (+)
XLOC_021923 g0s2 coding downstream 155408 39606108 ~ 39607679 (+)
XLOC_021924 otud3 coding downstream 160988 39611688 ~ 39626681 (+)
XLOC_021925 tmco4 coding downstream 245127 39695827 ~ 39727347 (+)
XLOC_021914 NA non-coding upstream 791479 38537568 ~ 38555295 (+)
XLOC_021913 FO904868.1 non-coding upstream 1010890 38335760 ~ 38335884 (+)
XLOC_021912 CABZ01070579.1 non-coding upstream 1049985 38266163 ~ 38296789 (+)
XLOC_021909 NA non-coding upstream 1252214 38091326 ~ 38094560 (+)
XLOC_021926 NA non-coding downstream 301788 39752488 ~ 39752964 (+)
XLOC_021932 CABZ01067001.1 non-coding downstream 855544 40306244 ~ 40306371 (+)
XLOC_021935 CR354556.1 non-coding downstream 1015802 40466502 ~ 40472088 (+)
XLOC_021936 CR354556.3 non-coding downstream 1026520 40477220 ~ 40480582 (+)
XLOC_021937 NA non-coding downstream 1073694 40524394 ~ 40526983 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000001_00580789_00602408 SRC coding CI01000001 null 579076 ~ 602628 (-)