XLOC_025366 (mcm5)


Basic Information

Item Value
gene id XLOC_025366
gene name mcm5
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007114.7
NCBI id CM002887.2
chromosome length 62628489
location 25999477 ~ 26011440 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00050045
ATAATTATAGCAATATCTTAATCGATCATCGACAGCACTTATCGAAACTATTTCTTATTATTAGTTTATAACAAGGTGTACATTCCTGAATATTTGCAAGAATGTCGGGATTTGATGATCCAGGAGTTTATTACAGTGACAGCTTTGGTGGAGGAGAAAGCGTCGGCGACGAGGGAGTCGTGAAACGGAGCCAGATCAAGAAGAAGTTCCGTGAGTTTCTGAGGCAGTTCAGAGTCGGAACCGATCGCACTGGATTTACCTACAAATACAGAGATGAGCTCAAGAGACACTATACTTTGGGAGAGTATTGGATCGAGGTGGAAATGGAGGATTTGGCCAGTTTTGATGAAGATCTATCAGACTGTCTGTACAAACTTCCTGCTGAGAACCTGCCTTTGTTGGAGGAGGCTGCGCAGGAAGTGGCTGATGAGGTCACACGTCCTCGGCCAGTAGGAGAAGAGACTGTTCAAGACATACAGGTCATGCTGAAGAGCGACGCTCATCCAGCCTCCATCCGCAGTCTGAAGTCAGAGCAGGTTTCGCGTCTGGTGAAGATTCCCGGGATCATCATCTCCTCTACTGCTGTGAGGGCCAAAGCCACCAGAGTGTGTCTTCAGTGCCGCGGATGCAGAGCGGTGATCAGCAACATCCCTCTGCCACCGGGGCTGCAGGGTTACGCTCTGCCTCGCAAGTGCAACACTGAGCAGGCAGGGCGTGTCAAGTGCCCTGTGGATCCATATTTCATCATTCCAgaccgctgtgtgtgtgtggatttccaGACTCAGCGTCTGCAGGAAGCTCCTGATGCCGTTCCTCATGGAGAGATGCCACGACACATGCAGCTCTACTGCGACAGATACTTGTGTGATCGTGTAGTACCAGGCAACAGAGTGACAGTCATGGGCATCTACTCCATCAAGAAGGTGGCGCAGACCAAAGCCAAAGGCCGTGATAAGGGAACTGGTGTTGGCATTCGCTCGGCATATCTGCGTGTTGTCGGCATTGATGTGGACACTGAAGGAGCAGGCCGTGGTGCCACTGGTTCAGTTTCTCCCCAAGAAGAAGAGGAGTTAAGATCTCTGGCTGCTTCTCCCTCTGTTTATGACTCTCTGGCTCGCTCTCTCGCCCCGTCCATCTATGGCAGTGATGACCTGAAAAAAGCTATCGCCTGCCTGCTGTTCGGCGGCTCCAGGAAGAGGTTGCCTGATGGTCTGACACGCAGAGGGGATATTAACCTGCTGATGCTGGGAGATCCAGGCACAGCCAAGTCTCAACTGCTGAAGTTTGTTGAGAGATGCTCTCCAATTGGGGTCTACACCTCTGGAAAGGGCAGCAGTGCAGCTGGTTTGACCGCCTCTGTTCTTCGGGACCCCACCACTCGTGGTTTTGTCATGGAGGGAGGCGCTATGGTGTTAGCTGATGGTGGAGTCGTCTGCATCGATGAGTTTGACAAGATGAGAGAGGATGATAGAGTCGCAATCCATGAGGCCATGGAGCAGCAGACCATCTCTATTGCAAAGGCTGGCATCACCACCACTCTGAACTCGCGCTGCTCTGTATTAGCTGCCGCCAACTCTGTGTTTGGTCGCTGGGATGACACAAAGGGAGAGGACAACATTGACTTCATGCCCACCATTCTGTCTCGATTCGACATGATCTTCATCATCAAAGATCATCACGACCAACAGCGAGACATGACTTTGGCTCGACACGTGATGAATGTTCACCTGAGCGCTCAAACGCAGACGGAGGGGGTCGAGGGAGAGATTCCTCTGGCCACGTTGAAGAAATACATCGCCTATTCTAGAGTAAAATGTGGACCTCGACTGTCTGCGGCGGCTGCAGAGAAGCTGAAGAACAGATACGTGTTGATGAGAAGCGGAGCGAAGGAGCATGAGAGAGAGACTGACAGACGAGTGTCCATCCCTATCACTGTTAGGCAGCTAGAGGCCGTGGTGCGCATTGCGGAGTCACTTGCTAAGATGAAGCTGCAGCCCATCGCTGGAGAAGAAGAGGTGGACGAGGCTCTGAGACTCTTCCAAGTGTCCACGCTGGATGCTGCTCTGTCCGGCAGCCTCTCCGGTGTTGAAGGGTTTACCACTCAGGAGGATCAGGAGATGATCTCCCGCATCGAAAAACAGCTGAAGAGACGCTTCGCCATCGGCTCGCAGGTGTCTGAGCACAGCATCATACAGGACTTCGCCAAACAGAAATATCCAGAGCACGCTATTCAAAAGGTCCTTTACCTGATGTTGAGGAGAGGTGAACTGCAGCACCGCATGCAGAGGAAGGTGCTTTACAGGGTCAAATAGATGAACGCTTTGGGTTTACTTCATAAGAGTCTGGTGGGTGTCCAAATACATAACAGAAATGAAATGCAACTCAGAATTATTGTACATAGTTGTCTGGACACTTTATTGCTGGAGATATGTGCTGTGTATCATTCTTGCTTGTTGTTATAGCTTTGTGTGGTTTAAAGTGTTACAAATACAACAGTATGCTCTACTGTCTACTTTCaatgaaaaaaagtttaattaaaaatccACTTTAATTGATTGTCAAACTAAAGAATGCAGCCTTTTTGTATGGGAATTTATTAAAGCAGTTAAGAAACAAA

Function

symbol description
mcm5 Predicted to enable single-stranded DNA binding activity. Predicted to contribute to 3'-5' DNA helicase activity and single-stranded DNA helicase activity. Acts upstream of or within chordate embryonic development; mitotic cell cycle; and negative regulation of apoptotic process. Predicted to be part of MCM complex. Predicted to be active in nucleus. Is expressed in several structures, including endoderm; head; nervous system; pronephric duct; and tail bud. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 8. Orthologous to human MCM5 (minichromosome maintenance complex component 5).

GO:

id name namespace
GO:0043009 chordate embryonic development biological_process
GO:0043066 negative regulation of apoptotic process biological_process
GO:0000727 double-strand break repair via break-induced replication biological_process
GO:0006260 DNA replication biological_process
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication biological_process
GO:0006270 DNA replication initiation biological_process
GO:0000278 mitotic cell cycle biological_process
GO:0042555 MCM complex cellular_component
GO:0005634 nucleus cellular_component
GO:0005524 ATP binding molecular_function
GO:0016787 hydrolase activity molecular_function
GO:0003677 DNA binding molecular_function
GO:0017116 single-stranded DNA helicase activity molecular_function
GO:0003678 DNA helicase activity molecular_function
GO:0003688 DNA replication origin binding molecular_function
GO:0003697 single-stranded DNA binding molecular_function
GO:0000166 nucleotide binding molecular_function
GO:0043138 3'-5' DNA helicase activity molecular_function
GO:0004386 helicase activity molecular_function

KEGG:

id description
ko03030 DNA replication
ko04110 Cell cycle
ko04111 Cell cycle - yeast
ko04113 Meiosis - yeast
ko03032 DNA replication proteins
ko03036 Chromosome and associated proteins

ZFIN:

id description
ZDB-GENE-021209-1 Predicted to enable single-stranded DNA binding activity. Predicted to contribute to 3'-5' DNA helicase activity and single-stranded DNA helicase activity. Acts upstream of or within chordate embryonic development; mitotic cell cycle; and negative regulation of apoptotic process. Predicted to be part of MCM complex. Predicted to be active in nucleus. Is expressed in several structures, including endoderm; head; nervous system; pronephric duct; and tail bud. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 8. Orthologous to human MCM5 (minichromosome maintenance complex component 5).

Ensembl:

ensembl_id ENSDARG00000019507

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00050045 True 2617 mRNA 0.50 16 25999477 26011440

Neighbor

gene id symbol gene type direction distance location
XLOC_025365 gcat coding upstream 1234 25990052 ~ 25998243 (+)
XLOC_025364 NA coding upstream 12533 25985339 ~ 25986944 (+)
XLOC_025363 tom1 coding upstream 60218 25907266 ~ 25939259 (+)
XLOC_025362 zgc:171844 coding upstream 105353 25857008 ~ 25894124 (+)
XLOC_025361 mfsd6l coding upstream 146898 25849560 ~ 25852579 (+)
XLOC_025367 foxred2 coding downstream 7986 26019426 ~ 26032712 (+)
XLOC_025368 ankrd54 coding downstream 24110 26035550 ~ 26044759 (+)
XLOC_025369 hmgxb4a coding downstream 33529 26044969 ~ 26060047 (+)
XLOC_025370 si:dkeyp-69e1.8 coding downstream 52651 26064091 ~ 26070801 (+)
XLOC_025371 NA coding downstream 65054 26076494 ~ 26080400 (+)
XLOC_025429 BX649540.1 misc downstream 4237299 30248739 ~ 30249036 (+)
XLOC_025360 FP101990.1 non-coding upstream 154149 25844151 ~ 25845328 (+)
XLOC_025358 BX120006.1 non-coding upstream 245928 25752221 ~ 25753549 (+)
XLOC_025357 BX120006.2 non-coding upstream 252559 25745636 ~ 25746918 (+)
XLOC_025356 NA non-coding upstream 279263 25700591 ~ 25720214 (+)
XLOC_025374 FP016144.1 non-coding downstream 182904 26194344 ~ 26194459 (+)
XLOC_025382 NA non-coding downstream 343854 26355294 ~ 26361798 (+)
XLOC_025383 NA non-coding downstream 399793 26411233 ~ 26416784 (+)
XLOC_025384 NA non-coding downstream 624380 26635820 ~ 26636398 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000034_04229970_04238150 MCM5.S, MCM5, MCM5.L coding CI01000034 null 4229970 ~ 4238467 (+)
bowfin (Amia calva) AMCG00014911 mcm5,LOC106607002 coding CM030128.1 CM030128.1 39630690 ~ 39636561 (+)