XLOC_028448 (ntf3)


Basic Information

Item Value
gene id XLOC_028448
gene name ntf3
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007115.7
NCBI id CM002888.2
chromosome length 78093715
location 4397503 ~ 4431975 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00055218
GTGAGACTCTCAGCACGCACCGCGCGCTTTTCTATCTGGAAACTTACGACAAAAGGATTCGTTATAAACTCCATTACCTTCATGTCGGCTCTGCTGAATATTTCCTCACCGATGCTATGGTTACCTTTATTACGATCTTACAGGTGAATCTAGTGATGTCCATCTTGCTGTACGTGATGTTCCTCGCGTACCTTTATGGTATCTCCGCCTCTACAATGGACAAGCAGCGGCCCATGCAGGATCCCATCAGTGCGCTCATCATAAAGCTCCTGCAGGCTGATATCAGCCGCCAGAAACAGGGCGACGTCATTCCCTCCTCCACCTTAAATGTGTCCACAGTCGCAGACTACAAGGAAAAAGACAACAATACCCCCATGGTGGACAGTTCGGAGGAGCTGCTACGCCAGTACAAGCGCTACAACTCTCCACGTGTCCTCTTAAGCGACCGACCTCCAATGCAACCACCGGCTTTCTACCTCATGGATAAATTCATCAGCGGTCAGGACTCCAACAAGACGCGGCAGAAACGCTTTGCCGAGCACAAGAGCTACAGAGGAGAGTTTTCAGTGTGCGACAGCGAGAGCAATTGGGTTACAAACAGGACCTCAGCGGTGGATTCTCGTGGAAATCATGTCACCGTTTTGAATTCCTTCACTGTAAAACAGAAATACACGCAGTACTTTTATGAGACCAAGTGTAAAACTCCTCACTCCCACCGCAAGAGCCGATGTTTAGGTATTGATGAGAAGCACTGGAATTCGCAGTGCAAAACCACGCAGACTTACGTACGAGCGCTTACTCAGCACAAATCGCTGGTTTCTTGGAATTGGATACGGATAGACACGGCATGCGTCTGCGCGCTCTCAAAGAAACATAGAAGGACGTGAAAAATGGTGGAAAAAACACTTTCAATTCTCCATTGTCTTGCTAGTGTTTCCTGGGGGCTgtacatatataaattattatttaagttaTATAGAATGCATATAGTTTATACATGTCTATGTATAATGTATAAAGatacttgttatttatttaaaagttataaaatctttggaaaaaaaatgaaa

Function

symbol description
ntf3 Predicted to enable growth factor activity and nerve growth factor receptor binding activity. Acts upstream of or within negative regulation of programmed cell death and peripheral nervous system development. Predicted to be located in extracellular region and membrane. Predicted to be integral component of membrane. Predicted to be active in several cellular components, including axon; dendrite; and synaptic vesicle. Is expressed in several structures, including brain; cardiovascular system; otic placode; pancreas primordium; and retina. Human ortholog(s) of this gene implicated in Alzheimer's disease and asthma. Orthologous to human NTF3 (neurotrophin 3).

GO:

id name namespace
GO:0033138 positive regulation of peptidyl-serine phosphorylation biological_process
GO:0048812 neuron projection morphogenesis biological_process
GO:0043069 negative regulation of programmed cell death biological_process
GO:0007613 memory biological_process
GO:0021675 nerve development biological_process
GO:0038180 nerve growth factor signaling pathway biological_process
GO:0050804 modulation of chemical synaptic transmission biological_process
GO:0045664 regulation of neuron differentiation biological_process
GO:0007422 peripheral nervous system development biological_process
GO:0043524 negative regulation of neuron apoptotic process biological_process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway biological_process
GO:0030424 axon cellular_component
GO:0030425 dendrite cellular_component
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0031410 cytoplasmic vesicle cellular_component
GO:0008021 synaptic vesicle cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0005102 signaling receptor binding molecular_function
GO:0005163 nerve growth factor receptor binding molecular_function
GO:0005165 neurotrophin receptor binding molecular_function
GO:0008083 growth factor activity molecular_function

KEGG:

id description
ko04010 MAPK signaling pathway
ko04014 Ras signaling pathway
ko04151 PI3K-Akt signaling pathway
ko04722 Neurotrophin signaling pathway
ko04052 Cytokines and growth factors

ZFIN:

id description
ZDB-GENE-031118-66 Predicted to enable growth factor activity and nerve growth factor receptor binding activity. Acts upstream of or within negative regulation of programmed cell death and peripheral nervous system development. Predicted to be located in extracellular region and membrane. Predicted to be integral component of membrane. Predicted to be active in several cellular components, including axon; dendrite; and synaptic vesicle. Is expressed in several structures, including brain; cardiovascular system; otic placode; pancreas primordium; and retina. Human ortholog(s) of this gene implicated in Alzheimer's disease and asthma. Orthologous to human NTF3 (neurotrophin 3).

Ensembl:

ensembl_id ENSDARG00000059043

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00055218 True 1070 mRNA 0.45 2 4397503 4431975

Neighbor

gene id symbol gene type direction distance location
XLOC_028447 CU468826.3 coding downstream 10491 4376498 ~ 4387012 (-)
XLOC_028446 CU468826.1 coding downstream 22799 4321168 ~ 4374704 (-)
XLOC_028445 cd9b coding downstream 135830 4234994 ~ 4261673 (-)
XLOC_028443 NA coding downstream 168348 4178834 ~ 4229155 (-)
XLOC_028444 NA coding downstream 187039 4207590 ~ 4210464 (-)
XLOC_028449 tbc1d30 coding upstream 52676 4484651 ~ 4507761 (-)
XLOC_028450 FP102892.1 coding upstream 82463 4514438 ~ 4516508 (-)
XLOC_028451 zgc:194209 coding upstream 94273 4526248 ~ 4535189 (-)
XLOC_028452 rassf3 coding upstream 108248 4540223 ~ 4592287 (-)
XLOC_028453 CABZ01020840.1 coding upstream 169840 4601815 ~ 4612116 (-)
XLOC_028442 NA non-coding downstream 233627 4162825 ~ 4163876 (-)
XLOC_028441 NA non-coding downstream 239968 4147628 ~ 4157535 (-)
XLOC_028461 NA non-coding upstream 508492 4940467 ~ 4962892 (-)
XLOC_028462 NA non-coding upstream 530982 4962957 ~ 4967711 (-)
XLOC_028471 NA non-coding upstream 989771 5421746 ~ 5459469 (-)
XLOC_028472 NA non-coding upstream 996343 5428318 ~ 5441954 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000066_01640177_01643928 NA coding CI01000066 null 1640177 ~ 1645798 (+)