XLOC_030176 (ruvbl2)


Basic Information

Item Value
gene id XLOC_030176
gene name ruvbl2
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007116.7
NCBI id CM002889.2
chromosome length 72500376
location 30759232 ~ 30770807 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00059005
ATTTCCAATGCGCACCCATTCAGATACAACCGCCTTTCGCGAGAGAACATGGCAGCGCAGGTGGCAACCACAAAGGTTCCGGAGGTGCGGGACATCACTCGCATTGAGAGAATCGGCGCACACTCTCACATTCGTGGCCTTGGGTTGGATGATGCTCTGGAGCCACGACAGGTGTCTCAGGGGATGGTGGGCCAGCTGGCATCTCGAAGGGCAGCCGGGCTGATTCTTGAAATGATCAAAGATGGTCAGATTGCTGGTCGCGCAGTCCTTATCGCTGGCCAACCTGGGACGGGCAAGACAGCTATTGCTATGGGTATTGCCCAGTCACTTGGTCCTGACACACCTTTCACTGCTCTGGCTGGGAGTGAGATTTTCTCTCTGGAGATGAGCAAGACTGAGGCTTTGAGCCAAGCATTCCGCAAGGCCATAGGAGTCAGAATAAAAGAGGAGACGGAGATCATTGAAGGAGAGGTGGTAGAGATTCAGATTGACAGACCTGCTACAGGAACAGGTGCAAAAGTTGGTAAACTCACTCTGAAGACGACAGAGATGGAAACCATATATGATCTGGGGACTAAGATGATCGAGAGCCTCAGTAAAGAGAGAGTACAAGCCGGAGATGTGATTACTATTGATAAAGCCACAGGGAAGATTAGCAAGCTTGGACGGTCATTTACTCGAGCAAGAGACTATGATGCCATGGGAGCACAGACGCAGTTTGTGCAGTGTCCAGAGGGGGAACTTCAAAAAAGGAAGGAGGTTGTTCACACCGTCTCTCTTCATGAAATTGACGTCATCAACAGCCGCACACAGGGATTCTTGGCCTTATTTTCAGGCGACACAGGAGAGATTAAGTCAGAGGTTCGGGAGCAGATCAATGCTAAAGTGTCTGAATGGAGAGAGGAAGGCAAAGCTGAAATTATTCCTGGGGTTCTTTTCATAGACGAGGTCCACATGCTGGACATAGAATGCTTTTCATTCCTGAACCGAGCCCTAGAGAGTGATCTTTCTCCTGTACTCATCATGGCTACCAACAGAGGCATCACTCgAATTAGAGGCACCAATTACCAGAGTCCTCATGGTATTCCCATAGACATGCTGGACCGTCTGCTTATCATCGCTACTACTCCTTACACAGAGAAAGAGACCAGACAGATCCTAAAGATTCGCTGTGAGGAGGAGGATGTTGAGCTCAGTGAAGAGGCACATACAGTTTTAACACGTATCGGACAGGAGACTTCACTCCGCTACGCCATCCAGCTCATCAGTACTGCAGGCCTGGTGTGCCGTAAACGCAGGGGCACAGAAGTCCAAGTGGAGGACATTAAAAGGGTTTATTCTCTCTTCCTGGATGAGGCCAGGTCCTCACAGTACATGAAAGAGTATCAGGACTCCTTCCTCTTCAATGAAACACAAACCTCTCAGATGGACACCTCGTAACGAGTGGAGCTGTGAATAAGCATGTCCAGTCATTGCTCCTGTGAAGACCTTTCTCTTATGACCTCTCCTAGTGCTGAGCCACCTCTCAAGTGTTCAGGCAATTCAGTGTTCATGCACTCAAATCCTCATCTtcaagtcctttttttttttttttttttttttttgctattgctAGATTTTATATGTTTtgcaatgaataaaaataatttcttcTTGTTTGGTTGTATAACATGGCAACTTAAAGGATGAAATAAAAGATATTTGACCATGAA

Function

symbol description
ruvbl2 Enables ATP hydrolysis activity. Acts upstream of or within several processes, including cilium assembly; epithelial cilium movement involved in extracellular fluid movement; and regulation of heart growth. Predicted to be located in dynein axonemal particle and nucleus. Predicted to be part of R2TP complex and nuclear lumen. Is expressed in central nervous system; neural tube; posterior lateral line; and pronephric duct. Orthologous to human RUVBL2 (RuvB like AAA ATPase 2).

GO:

id name namespace
GO:0006310 DNA recombination biological_process
GO:0003351 epithelial cilium movement involved in extracellular fluid movement biological_process
GO:0006338 chromatin remodeling biological_process
GO:0007507 heart development biological_process
GO:0006357 regulation of transcription by RNA polymerase II biological_process
GO:0070286 axonemal dynein complex assembly biological_process
GO:0044458 motile cilium assembly biological_process
GO:0006974 cellular response to DNA damage stimulus biological_process
GO:0060420 regulation of heart growth biological_process
GO:0048565 digestive tract development biological_process
GO:0016573 histone acetylation biological_process
GO:0045892 negative regulation of transcription, DNA-templated biological_process
GO:0000492 box C/D snoRNP assembly biological_process
GO:0006281 DNA repair biological_process
GO:0000812 Swr1 complex cellular_component
GO:0035267 NuA4 histone acetyltransferase complex cellular_component
GO:0071339 MLL1 complex cellular_component
GO:0031011 Ino80 complex cellular_component
GO:0005634 nucleus cellular_component
GO:0097255 R2TP complex cellular_component
GO:0005524 ATP binding molecular_function
GO:0016787 hydrolase activity molecular_function
GO:0003678 DNA helicase activity molecular_function
GO:0000166 nucleotide binding molecular_function
GO:0043139 5'-3' DNA helicase activity molecular_function
GO:0016887 ATPase activity molecular_function
GO:0004386 helicase activity molecular_function

KEGG:

id description
ko03036 Chromosome and associated proteins

ZFIN:

id description
ZDB-GENE-030109-1 Enables ATP hydrolysis activity. Acts upstream of or within several processes, including cilium assembly; epithelial cilium movement involved in extracellular fluid movement; and regulation of heart growth. Predicted to be located in dynein axonemal particle and nucleus. Predicted to be part of R2TP complex and nuclear lumen. Is expressed in central nervous system; neural tube; posterior lateral line; and pronephric duct. Orthologous to human RUVBL2 (RuvB like AAA ATPase 2).

Ensembl:

ensembl_id ENSDARG00000055639

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00059005 True 1712 mRNA 0.47 15 30759232 30770807

Neighbor

gene id symbol gene type direction distance location
XLOC_030175 ftr83 coding upstream 6065 30741730 ~ 30753167 (+)
XLOC_030174 BX276103.2 coding upstream 31584 30723129 ~ 30727648 (+)
XLOC_030173 atp5l coding upstream 57341 30699260 ~ 30701891 (+)
XLOC_030172 pdzd3b coding upstream 61324 30680804 ~ 30697908 (+)
XLOC_030171 abcg4a coding upstream 86750 30624183 ~ 30672482 (+)
XLOC_030177 NA coding downstream 9623 30780430 ~ 30974079 (+)
XLOC_030178 NA coding downstream 181416 30952223 ~ 30954521 (+)
XLOC_030179 ube2g1a coding downstream 215705 30986512 ~ 30995108 (+)
XLOC_030180 ankfy1 coding downstream 225515 30996322 ~ 31030840 (+)
XLOC_030181 zzef1 coding downstream 266104 31036911 ~ 31109968 (+)
XLOC_030164 BX897688.1 non-coding upstream 592660 30166456 ~ 30166572 (+)
XLOC_030162 dre-mir-125b-2 non-coding upstream 760385 29998762 ~ 29998847 (+)
XLOC_030161 dre-let-7a-4 non-coding upstream 768688 29990452 ~ 29990544 (+)
XLOC_030160 mir100-2 non-coding upstream 769011 29990147 ~ 29990221 (+)
XLOC_030185 CR759893.1 non-coding downstream 777505 31548312 ~ 31548787 (+)
XLOC_030191 NA non-coding downstream 1134040 31904847 ~ 31912078 (+)
XLOC_030192 NA non-coding downstream 1140196 31911003 ~ 31918136 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000339_06069549_06075897 RUVBL2.L, RUVBL2 coding CI01000339 null 6069549 ~ 6076100 (+)