XLOC_035586 (zap70)


Basic Information

Item Value
gene id XLOC_035586
gene name zap70
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007119.7
NCBI id CM002892.2
chromosome length 54304671
location 20393250 ~ 20414364 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00069773
GCCAGATCAGAGAGCTTCATCACTTCGGCAGACTAAATACATATAACTTCTTTACCAGTTCATCCGTGCCGTGTCTCctctcttttctttctctctctctctttctctttcattcTATCCCTCTTTTTCTGGATTTCAGCTACAGGCCACGCTCGTGATCTAGTTCGAGTCTTGGACCCCTCGGGACCTCCATCATGACCGAACCTGCCGCCGATCTCCCATTCTTCTATGGCAGCATCAGTCGCTCGGAGGCCGAGGAGCACCTCAAGCTGGCTGGTATGGGAGACGGCCTGTTCCTCCTGCGACAGTGCCTGCGCAGTCTGGGTGGCTATGTGCTGTCTATGATCTGGAACCTGGACTTCTACCATTACTCCATTGAGAAACAGCTCAACGGAACGTATTGTATCGCAGGAGGGAAGCCTCACTGTGGACCAGCGGAGCTCTGTGAATACTACAGCAAAGACCCCGACGGCCTTGTGTGCACCTTGAGGAAGCCCTGTCTGAGATCGCCTGAAACAGAAATCCGGAAAGGCGTCTTCGATAACCTGAGGGACAACATGCTCAGGGAATATGTGCGGCATACCTGGAAACTGGAGGGGGATGCCATGGAGCAAGCCATCATCAGCCAGGCTCCACAGCTAGAGAAACTGATCGCCACCACAGCGCATGAGAAAATGCCCTGGTTCCACGGCAAGATCCCTCGGCAGGAGGGGGAAAGACGACTGTACTCTGGATCTCAGCCGGACGGAAAGTTCCTagTTCGAGAGAGAGATGAAATGGGCACCTTTGCACTGTCTGTGACGTATGGAAAAACTGTGTACCATTATCAGATCTTGCGTGACAAATCAGGGAAAATCGCAATGCCAGAAGGAACTAAATTTGACACTGTGTGGCAGCTGGTTGAATACTTAAAAATGAAGCCTGATGGTCTTGTGACTGTATTGAGAGAACCGTGTGTTAACCAAAACAACGCAGCTCCAGCTCCTGCAAACGCTCCGAGGAGGTCAAGAGGTAATGGATACACACCACCCCCTATGGTGCCTAAGCCAATGGGAGCTGAGGGTTCACGCCCATCTCTACCAATGGACCACGACGGATTCACTAGTCCTTATGACGATCCAAACGAACTGAAGAAAAAGACCCTGTTCATCAAAAGAGACAAATTGATGATCGACGAGGTGGAGCTTGGGTCTGGAAACTTCGGCTGCGTCAAGAAAGGTGTTTTCAAAATGGAAAGCAAACAGATCGATGTGGCAATTAAAGTGCTGAAGAATGAGAACGAGAAATCGGTGAGGGATGAAATGATGCGAGAGGCTGAGATTATGCATCAGCTGAGTGATCCCTTCATTGTGCGCATGATTGGACTCTGTGAGGCCGAAGCGCTCATGCTGGTGATGGAAATGGCCCCTGCCGGCCCGCTCAACAAGTTCCTCTCTGGAAAGAAAGACCAGATCACTACGGAAAACATTGTGATGTTAATGCATCAGGTGTCAATGGGGATGAAGTATTTAGAAGGAAGGAACTTTGTGCACAGAGATCTGGCTGCTCGTAATGTGCTCCTGGTCAACCAGCAATATGCCAAAATCAGCGACTTCGGCCTCTCCAAAGCACTGGGTGCAGATGATAACTATTACAAGGCCAGAACAGGAGGAAAATGGCCTCTGAAGTGGTACGCGCCAGAGTGCATTCATTTTCACAAGTTTTCCAGCAAAAGTGACGTTTGGAGTTTTGGCATCACGATGTGGGAGGCCTTTTCCTTTGGAGGAAAGCCGTATAAGAAAATGAAAGGTCCAGAGGTGATAACATATATTGAAGGTGGTAGTCGTTTGGATTGTCCTGCCGCATGTCCTGAGGCCATGTATGAGCTGATGAAAGAATGCTGGACCTACAAGCATGAAGAACGGCTAAATTTTGCAAAAGTGGAGGAGAAGATGAGAACTTTTTATTACTCCATAGCAAAGAAGATCCCGGATTACCTGAAAACAGAGAATGGAACTCCTCCAAAGTGATATGAGGGCCAAATGGAAACATTTGTAGACAGGATAGAATGACAACAGTTTTCAGATATTTGACGTTTAAACATTATGTTTGGTAAACtataatatatttgttattttcatGTTGTCTATCAAACTAGCTGACTGATCAATGCAAGATGCCGTTTTATATTACTGGCCTGCTACTATCAGTGCTATTAATGCTATTTGTGCTCGGTGCCTATTTAAATATGCCATATTATAGGTGGTAATCAAAAGTTTCTCTCTCGCAATAGTGTTTTAGTACATAACATCAGATTGAGGCTCttactcatccatccatttacatttttgaagagAAAAGAGATATTTACTCAAACTTCAGGGTCTGGTTCTCTGTTAAATGTTCTGTGATTGTACTTTTGCTCTGATTTTGGTATATTGTTTTGTTCAATTTGTGTATTCAAACTATTAATTGTTTTTGTGACAATTTAGACTTTTTGAAACTGGGAAAAACTGCAAATCCAATTACAAACTGATGTTgattttttgataaataaacatgttGGAGCTG
>TCONS_00069774
CTCTGCCTGAAAGCATCTCCATTTCCACAGCTCGTGATCTAGTTCGAGTCTTGGACCCCTCGGGACCTCCATCATGACCGAACCTGCCGCCGATCTCCCATTCTTCTATGGCAGCATCAGTCGCTCGGAGGCCGAGGAGCACCTCAAGCTGGCTGGTATGGGAGACGGCCTGTTCCTCCTGCGACAGTGCCTGCGCAGTCTGGGTGGCTATGTGCTGTCTATGATCTGGAACCTGGACTTCTACCATTACTCCATTGAGAAACAGCTCAACGGAACGTATTGTATCGCAGGAGGGAAGCCTCACTGTGGACCAGCGGAGCTCTGTGAATACTACAGCAAAGACCCCGACGGCCTTGTGTGCACCTTGAGGAAGCCCTGTCTGAGATCGCCTGAAACAGAAATCCGGAAAGGCGTCTTCGATAACCTGAGGGACAACATGCTCAGGGAATATGTGCGGCATACCTGGAAACTGGAGGGGGATGCCATGGAGCAAGCCATCATCAGCCAGGCTCCACAGCTAGAGAAACTGATCGCCACCACAGCGCATGAGAAAATGCCCTGGTTCCACGGCAAGATCCCTCGGCAGGAGGGGGAAAGACGACTGTACTCTGGATCTCAGCCGGACGGAAAGTTCCTagTTCGAGAGAGAGATGAAATGGGCACCTTTGCACTGTCTGTGACGTATGGAAAAACTGTGTACCATTATCAGATCTTGCGTGACAAATCA

Function

symbol description
zap70 Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Acts upstream of or within lymphangiogenesis and positive regulation of cell migration involved in sprouting angiogenesis. Predicted to be located in cytoplasm. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Is expressed in gut. Human ortholog(s) of this gene implicated in immunodeficiency 48 and severe combined immunodeficiency. Orthologous to human ZAP70 (zeta chain of T cell receptor associated protein kinase 70).

GO:

id name namespace
GO:0045087 innate immune response biological_process
GO:0042127 regulation of cell population proliferation biological_process
GO:0030154 cell differentiation biological_process
GO:0035556 intracellular signal transduction biological_process
GO:0038083 peptidyl-tyrosine autophosphorylation biological_process
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis biological_process
GO:0006468 protein phosphorylation biological_process
GO:0016310 phosphorylation biological_process
GO:0001946 lymphangiogenesis biological_process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway biological_process
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005102 signaling receptor binding molecular_function
GO:0016740 transferase activity molecular_function
GO:0005524 ATP binding molecular_function
GO:0000166 nucleotide binding molecular_function
GO:0004672 protein kinase activity molecular_function
GO:0016301 kinase activity molecular_function
GO:0004713 protein tyrosine kinase activity molecular_function
GO:0004715 non-membrane spanning protein tyrosine kinase activity molecular_function

KEGG:

id description
ko04014 Ras signaling pathway
ko04064 NF-kappa B signaling pathway
ko04650 Natural killer cell mediated cytotoxicity
ko04660 T cell receptor signaling pathway
ko04658 Th1 and Th2 cell differentiation
ko04659 Th17 cell differentiation
ko05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
ko05135 Yersinia infection
ko05340 Primary immunodeficiency
ko01001 Protein kinases

ZFIN:

id description
ZDB-GENE-050522-257 Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Acts upstream of or within lymphangiogenesis and positive regulation of cell migration involved in sprouting angiogenesis. Predicted to be located in cytoplasm. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Is expressed in gut. Human ortholog(s) of this gene implicated in immunodeficiency 48 and severe combined immunodeficiency. Orthologous to human ZAP70 (zeta chain of T cell receptor associated protein kinase 70).

Ensembl:

ensembl_id ENSDARG00000015752

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00069773 False 2550 mRNA 0.45 13 20393250 20414364
TCONS_00069774 True 727 mRNA 0.54 3 20398445 20402321

Neighbor

gene id symbol gene type direction distance location
XLOC_035585 BX664738.1 coding upstream 152381 20229705 ~ 20240869 (+)
XLOC_035584 NA coding upstream 197045 20194192 ~ 20196205 (+)
XLOC_035583 acsbg2 coding upstream 201099 20140321 ~ 20192151 (+)
XLOC_035582 fcho1 coding upstream 320474 20037368 ~ 20072776 (+)
XLOC_035581 znf692 coding upstream 392185 19977712 ~ 20001065 (+)
XLOC_035587 mob3a coding downstream 1460 20415824 ~ 20429843 (+)
XLOC_035588 mknk2b coding downstream 24520 20438884 ~ 20450375 (+)
XLOC_035589 rexo1 coding downstream 40770 20455134 ~ 20471546 (+)
XLOC_035590 zgc:101100 coding downstream 73958 20488322 ~ 20491779 (+)
XLOC_035591 csnk1g2b coding downstream 81525 20495889 ~ 20559955 (+)
XLOC_035580 BX901930.2 non-coding upstream 427373 19965223 ~ 19965877 (+)
XLOC_035579 BX901930.3 non-coding upstream 434132 19958485 ~ 19959118 (+)
XLOC_035578 BX901930.1 non-coding upstream 440870 19951733 ~ 19952380 (+)
XLOC_035592 BX323082.1 non-coding downstream 150257 20564621 ~ 20580582 (+)
XLOC_035593 NA non-coding downstream 171627 20585991 ~ 20590845 (+)
XLOC_035595 NA non-coding downstream 410519 20824883 ~ 20856485 (+)
XLOC_035599 CU861651.1 non-coding downstream 523616 20937980 ~ 20940847 (+)
XLOC_035604 BX664618.1 non-coding downstream 615778 21030142 ~ 21043897 (+)

Expression


Co-expression Network