Gene
RNA
| Item | Value |
|---|---|
| gene id | XLOC_035891 |
| gene name | gck |
| gene type | coding |
| species | zebrafish (Danio rerio) |
| category of species | model fish |
| Item | Value |
|---|---|
| chromosome id | NC_007119.7 |
| NCBI id | CM002892.2 |
| chromosome length | 54304671 |
| location | 40476811 ~ 40490593 (+) |
| genome version | GRCz11_2017_zebrafish_Genome |
| symbol | description |
|---|---|
| gck | Predicted to enable fructokinase activity; glucokinase activity; and mannokinase activity. Acts upstream of or within glucose homeostasis; pancreas regeneration; and type B pancreatic cell development. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including digestive system; female organism; heart; male organism; and muscle. Human ortholog(s) of this gene implicated in artery disease (multiple); familial hyperinsulinemic hypoglycemia 3; and glucose metabolism disease (multiple). Orthologous to human GCK (glucokinase). |
| id | name | namespace |
|---|---|---|
| GO:0032024 | positive regulation of insulin secretion | biological_process |
| GO:0051156 | glucose 6-phosphate metabolic process | biological_process |
| GO:0006096 | glycolytic process | biological_process |
| GO:0031018 | endocrine pancreas development | biological_process |
| GO:0042593 | glucose homeostasis | biological_process |
| GO:1990798 | pancreas regeneration | biological_process |
| GO:0050796 | regulation of insulin secretion | biological_process |
| GO:0005975 | carbohydrate metabolic process | biological_process |
| GO:0016310 | phosphorylation | biological_process |
| GO:0001678 | cellular glucose homeostasis | biological_process |
| GO:0003323 | type B pancreatic cell development | biological_process |
| GO:0005829 | cytosol | cellular_component |
| GO:0005739 | mitochondrion | cellular_component |
| GO:0016740 | transferase activity | molecular_function |
| GO:0005524 | ATP binding | molecular_function |
| GO:0005536 | glucose binding | molecular_function |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | molecular_function |
| GO:0000166 | nucleotide binding | molecular_function |
| GO:0008865 | fructokinase activity | molecular_function |
| GO:0004340 | glucokinase activity | molecular_function |
| GO:0004396 | hexokinase activity | molecular_function |
| GO:0016301 | kinase activity | molecular_function |
| GO:0019158 | mannokinase activity | molecular_function |
| id | description |
|---|---|
| ko00010 | Glycolysis / Gluconeogenesis |
| ko00030 | Pentose phosphate pathway |
| ko00052 | Galactose metabolism |
| ko00500 | Starch and sucrose metabolism |
| ko00520 | Amino sugar and nucleotide sugar metabolism |
| ko00630 | Glyoxylate and dicarboxylate metabolism |
| ko00680 | Methane metabolism |
| ko00561 | Glycerolipid metabolism |
| ko00260 | Glycine, serine and threonine metabolism |
| ko00521 | Streptomycin biosynthesis |
| ko00524 | Neomycin, kanamycin and gentamicin biosynthesis |
| ko04010 | MAPK signaling pathway |
| ko04911 | Insulin secretion |
| ko04910 | Insulin signaling pathway |
| ko04922 | Glucagon signaling pathway |
| ko04917 | Prolactin signaling pathway |
| ko05230 | Central carbon metabolism in cancer |
| ko04930 | Type II diabetes mellitus |
| ko04950 | Maturity onset diabetes of the young |
| ko01001 | Protein kinases |
| id | description |
|---|---|
| ZDB-GENE-060825-204 | Predicted to enable fructokinase activity; glucokinase activity; and mannokinase activity. Acts upstream of or within glucose homeostasis; pancreas regeneration; and type B pancreatic cell development. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including digestive system; female organism; heart; male organism; and muscle. Human ortholog(s) of this gene implicated in artery disease (multiple); familial hyperinsulinemic hypoglycemia 3; and glucose metabolism disease (multiple). Orthologous to human GCK (glucokinase). |
| ensembl_id | ENSDARG00000068006 |
| RNA id | representative | length | rna type | GC content | exon number | start site | end site |
|---|---|---|---|---|---|---|---|
| TCONS_00070356 | False | 2495 | mRNA | 0.44 | 10 | 40476811 | 40490593 |
| TCONS_00070357 | True | 1427 | mRNA | 0.44 | 7 | 40477264 | 40485323 |
| gene id | symbol | gene type | direction | distance | location |
|---|---|---|---|---|---|
| XLOC_035890 | orai1a | coding | upstream | 188588 | 40275830 ~ 40288223 (+) |
| XLOC_035889 | rnf34a | coding | upstream | 238302 | 40210398 ~ 40238509 (+) |
| XLOC_035888 | lrrc75ba | coding | upstream | 313564 | 40080728 ~ 40163247 (+) |
| XLOC_035887 | ggt5a | coding | upstream | 445800 | 39998467 ~ 40031011 (+) |
| XLOC_035886 | NA | coding | upstream | 632841 | 39830606 ~ 39843970 (+) |
| XLOC_035892 | CABZ01044746.1 | coding | downstream | 12172 | 40502765 ~ 40526398 (+) |
| XLOC_035893 | NA | coding | downstream | 44403 | 40534996 ~ 40538212 (+) |
| XLOC_035894 | izumo1 | coding | downstream | 82544 | 40573137 ~ 40590816 (+) |
| XLOC_035895 | dusp2 | coding | downstream | 138333 | 40628926 ~ 40633991 (+) |
| XLOC_035896 | adra2b | coding | downstream | 154245 | 40644838 ~ 40646418 (+) |
| XLOC_035885 | CT027598.1 | non-coding | upstream | 670381 | 39806314 ~ 39806430 (+) |
| XLOC_035875 | CR533430.1 | non-coding | upstream | 1141268 | 39332416 ~ 39335543 (+) |
| XLOC_035874 | NA | non-coding | upstream | 1239719 | 39235987 ~ 39237092 (+) |
| XLOC_035873 | NA | non-coding | upstream | 1417863 | 39056888 ~ 39058948 (+) |
| XLOC_035897 | AL935142.1 | non-coding | downstream | 442129 | 40932722 ~ 40932838 (+) |
| XLOC_035898 | NA | non-coding | downstream | 475935 | 40966528 ~ 40966788 (+) |
| XLOC_035902 | CR382384.1 | non-coding | downstream | 844477 | 41335070 ~ 41335184 (+) |
