XLOC_010574 (tnfrsf1a)


Basic Information

Item Value
gene id XLOC_010574
gene name tnfrsf1a
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007127.7
NCBI id CM002900.2
chromosome length 55266484
location 17060758 ~ 17072561 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00020719
cGCAGCTTGAATGCTGTGCCTTTCTTAAAGCTGAAATGCTTTCGAATTCTCCAATTCCATGTAAAAAGGAGGAGCAGAGCGTTACGTGACGCTTAACATTTCCAGTAAAACACTGCCCTTATTTGAGGAAATGGACGACAGCGATACAGCAGTCtcacgtttttaaaaaaatacgCATTTCTATATAATTGTATCAGCTCAGTCggtaatgataaaaaaacaactttcCAAGAGAACTCAATGAAAATGCTGGATCGCCATGAGTAgaggtaagttcaagctcttgatAAAATCTTCGCGGAGAAAAAGATTGCCAACACAAATGTCACTGTGGGGGCGTAATACTGTACTGGACGAAGTGGGAGAAAATGTTAAAGCGATTGGCACAATATGTGAAACGGTCTCGACTGGCACAATCAAAACTGTATTTAAGATTTTATGTGGGGTTTAGTTGCGAATGCTAGAACCATTACTATTTCGCAACAGGTTAGATATTCTCGCCTGGATAAAGGATACAAGGAAATTAAAGATCATGCTGTTTGCTGTTGCAGAACTGTTGGTGTTTCTTGAATAGATAATAGTGAGATTAGAATTGTCATTCTTATATTGTCATTCACATACTGTAGCCTAATAATGCCCTCTCTATTTTATGAATCGACCCACCGCCCTTTACGGACAGTTTGAAGGGAGCAGGACTGCGCCACCTAGCTGTCATGAGGATATGTCAACTGACTGCGTGTTTGTTTCTGGTTCTAACCAGCCAGTTATATACAATATCAGGACTTGGTGGAAACAAGACTATGAAGGGAAATTGTCTTGAAAATGAATACTGGAATAAGGAAGGATTCTGCTGTGATAAATGCCATCAAGGGTATAAGTTAAAACAGGAATGCAGTGCAGAAAACATGAGGTCAAAATGTGagaaatgtgatgaaggaacctACCTGGAACAAGCAAACTATAGCCCAAACTGCTTCAGATGCCAGCAATGCACAAAACCCCATTCCAGGGAGTCTTCACCCTGCACACCCTACTCCAACAGGGTGTGTGAATGTGATACTGATTATTACAAGAAGAAGCTAGGTGATTTAGGATGGGAATGCTCTCGCTGTAAAAAGTGTGGAGATGGGCAAATTGAAATTCAGAACTGCACTAAGGAAGAGAATAGACAGTGCAAATGCCAGGAAAATCATTACCCTGTTAATAAAAACTCCTGTAAGCTGTGCGATAAATGTCAGCCAGGATGTGATCACCTATGCAAAACCAGCATTCCCCCAGTCTTTTTTACATCTACTAAGTCAAATAGTCCTGAAGACACGGTACCTAAAATAGTAGTTCCTGTTTGTGCAAGTATCATGGTTCTATCGTTAGCCATTTTTATGGCATACGAAGGCATCAGACATTGGCGGAAGAGGGCACAAGCTTCGTCATCTCAGTCATCGTCACCTGCTACAGAAGAAGAGGCATTCATCATCACTGTAGTGCAGGACTCAAAAAATAAGAGCGTATCATTCACAAATCAGCCATGTGAATCCAAACCTCTAGGGAATCTCCCAGACTGCATCCCAAGAGAGATCAAAATTCACGAGTTCTTCTATTTTGTGCTGGACGAGGTCCCTATCGGACGATTTAAAGAGCTTGTACGTCGGCTTGGAGTTTCTGAGCAGAACATTGACCGGGCAGAACATGACCACCGGAACTGCAAGGACGCCCAGTATCAGATGCTGAAAGTTTGGAGTGATGGTGGCAGTGGAGGAGGGAACAATGTTGTGCCGTATGACCAAATCCAGATGCTCATGAGCACACTGAAAGACATGTGTCTGGTTAGCTGCGCAGATAACATTGAGAACAAGTTCCTTTCACAGAACACAAGCGTTTCGTAATGAGGACATCGGAGGAGAATGGAGAACAGGGCATTAACAGAGATCTTTAACTTCCACTCGTTCGCATTGGATTTCATTGAAAGTGGAAGTCTCAAGAGCTAGACACCAAATCAGACGTATTGCCAGACTGAAAATTTCACACTAAAATGTTTTATGAACTTGTGAACATTCTGTGTTCAATGACGTATGTACTTTTTTAtattacatgtatatattttGTCAAAGATTTTTAGAGCTATTTTTTGAATGGGTGGTTGGGTCAATGGGGTTTGGGTGATTTCTGCAAATCgcacatttaataaaacatgtcCTGGTCACATTTCacagtatacagtgctcagcatatataagtacacccctcacaaatctatcttttaaattcatatttttaataggaagctattgaatattatatttgtgcatatacattagattaggcagtactgaagccaagtctgaagcttatctaacaaagaAGCCTACACCATCCAAGAACCAgtgcacccaaatttatgttacagaaaattattaaacacaaattttaaaaagaggaaaaaatcaagaggagcaaaaacattttgatttagtaatgatttagttgaaattttgtagtttgtaattttttaacgatatttagcatgaatttaattgtattatctttcaatttctaaatatgtttggtgacaaaaatattattttaataaatatatctgtttaataaatttgtgcACCAGAATACATTgccaatattcactgagaaatggatgaaaATGGCATGTACTCTGTTATGCTGAGCACtctatttgttttctttaattttttgtattcttttacttttattttcttatattctGTTGTGTCCACTGATTTTGGCAGCAAAATCTCTTCATTTTTACTTTAAGAagcataaaatcttttttttattagactGTTTTCGGGGTGAAAATGACCCGGGCATGTTGTCATACATTAGTTTATGTAACAGTATatgcactgtatttaaatgtgtaaGAGCAGAGCTGTTAGTAATTGCATTTGTGTTGCACATTCTTTCTGTGTATCAATCCATGTTATAATATGGTGCTTGGAAACATATTACAACTAGcattaaattgaataataaaaaataacaataataaaatgtaaataaaggcatagaacaaacatgatttatatgtgtttttagaATTTTCATGCAAGTTTATTGGCCAAAACAATGTTAATTTCGTtgacaaaaatattttgtcataattttcatgacaaacaagtttctaccAACATAAACTAGATGAAAACTAAATAAAGATGAAGTGATGATGTtgagaaatataataaaaatatactaatattttccatgaataataaaaacaagatgaGAATGTGATTGAGGGACGTATTATATGTTGTAATAACAatcaataataatttcttacatttatatagtgctttccTAGACACTCAAAGGGCTTTACAAATTGGGGGGAATGTCCTCATCCACTACTAGTGTGCAGAATCCATCTGACAGAGTGATGAAATCAATTATAACATAGgcatggttaggaggccatgatggacagaggagTGTAGAAAACCCTACTCTTTTTtcacaaccacagagagtcgggaccacGGTTTatcatctcatccaaaagatgacGCTCAAAGGAAGCAacttagctttcccatgtggtctcccatccaggtcctgaccaggcacagccctgcttaacttcagtgggCAATCATGtgggagttgcagagagctacaGTAGCTGCTGGCTGAATAATATGTGACACATTATCATTTGCCAGTCAAATGTCATTACTCTACTTAtttaatcagtgctttacagctGAGCACCAACTACCGTAACACCAACTACAAAAGCAAAGCTTAGTAGACTGACATTGCAAAGTGGACTTTAACTAAGCCCTTTCAAAGACATAATGGCTTGAAACTGTTCAACAAATTGGTTTAAAAGACTAGTAGTTTACCACGTTAAAATCAAGGGTTTGATTAATAAttgcgatgcagtggcgcagtgggtagtgctgttgcctcacagcaagaaggttgctggtttgagcctcggctggggcagttggcatttctttgtggagtttgcatgttctccctgtgtttgcgtgggtttcctccaggtgcaccagtttcccccacagtccaaagatatgcagtacaggtgaattaggtaggctaagtttgccgtagtgtatgatatctgctgcataaaacatatgctggataagttggtggttcattcccctgtggcaacccaaattaataaagggtctaagccacaaagaaattgaatgaatgaatgaatgataaataattGCACAAATCTGCATTTTCAGATGGCTATACTGTTCTTACATGTGGATTGATTGCCGACACATAATTTTACATATTACTTATAAACAATGCATatctaatttgtatatatttatatatatatatatatatatata
>TCONS_00020720
TTTGAGGAAATGGACGACAGCGATACAGCAGTCtcacgtttttaaaaaaatacgCATTTCTATATAATTGTATCAGCTCAGTCggtaatgataaaaaaacaactttcCAAGAGAACTCAATGAAAATGCTGGATCGCCATGAGTAgagTTTGAAGGGAGCAGGACTGCGCCACCTAGCTGTCATGAGGATATGTCAACTGACTGCGTGTTTGTTTCTGGTTCTAACCAGCCAGTTATATACAATATCAGGACTTGGTGGAAACAAGACTATGAAGGGAAATTGTCTTGAAAATGAATACTGGAATAAGGAAGGATTCTGCTGTGATAAATGCCATCAAGGGTATAAGTTAAAACAGGAATGCAGTGCAGAAAACATGAGGTCAAAATGTGagaaatgtgatgaaggaacctACCTGGAACAAGCAAACTATAGCCCAAACTGCTTCAGATGCCAGCAATGCACAAAACCCCATTCCAGGGAGTCTTCACCCTGCACACCCTACTCCAACAGGGTGTGTGAATGTGATACTGATTATTACAAGAAGAAGCTAGGTGATTTAGGATGGGAATGCTCTCGCTGTAAAAAGTGTGGAGATGGGCAAATTGAAATTCAGAACTGCACTAAGGAAGAGAATAGACAGTGCAAATGCCAGGAAAATCATTACCCTGTTAATAAAAACTCCTGTAAGCTGTGCGATAAATGTCAGCCAGGATGTGATCACCTATGCAAAACCAGCATTCCCCCAGTCTTTTTTACATCTACTAAGTCAAATAGTCCTGAAGACACGGTACCTAAAATAGTAGTTCCTGTTTGTGCAAGTATCATGGTTCTATCGTTAGCCATTTTTATGGCATACGAAGGCATCAGACATTGGCGGAAGAGGGCACAAGCTTCGTCATCTCAGTCATCGTCACCTGCTACAGAAGAAGAGGCATTCATCATCACTGTAGTGCAGGACTCAAAAAATAAGAGCGTATCATTCACAAATCAGCCATGTGAATCCAAACCTCTAGGGAATCTCCCAGACTGCATCCCAAGAGAGATCAAAATTCACGAGTTCTTCTATTTTGTGCTGGACGAGGTCCCTATCGGACGATTTAAAGAGCTTGTACGTCGGCTTGGAGTTTCTGAGCAGAACATTGACCGGGCAGAACATGACCACCGGAACTGCAAGGACGCCCAGTATCAGATGCTGAAAGTTTGGAGTGATGGTGGCAGTGGAGGAGGGAACAATGTTGTGCCGTATGACCAAATCCAGATGCTCATGAGCACACTGAAAGACATGTGTCTGGTTAGCTGCGCAGATAACATTGAGAACAAGTTCCTTTCACAGAACACAAGCGTTTCGTAATGAGGACATCGGAGGAGAATGGAGAACAGGGCATTAACAGAGATCTTTAACTTCCACTCGTTCGCATTGGATTTCATTGAAAGTGGAAGTCTCAAGAGCTAGACACCAAATCAGACGTATTGCCAGACTGAAAATTTCACACTAAAATGTTTTATGAACTTGTGAACATTCTGTGTTCAATGACGTATGTACTTTTTTAtattacatgtatatattttGTCAAAGATTTTTAGAGCTATTTTTTGAATGGGTGGTTGGGTCAATGGGGTTTGGGTGATTTCTGCAAATCgcacatttaataaaacatgtcCTGGTCACATTTCacagtatacagtgctcagcatatataagtacacccctcacaaatctatcttttaaattcatatttttaataggaagctattgaatattatatttgtgcatatacattagattaggcagtactgaagccaagtctgaagcttatctaacaaagaAGCCTACACCATCCAAGAACCAgtgcacccaaatttatgttacagaaaattattaaacacaaattttaaaaagaggaaaaaatcaagaggagcaaaaacattttgatttagtaatgatttagttgaaattttgtagtttgtaattttttaacgatatttagcatgaatttaattgtattatctttcaatttctaaatatgtttggtgacaaaaatattattttaataaatatatctgtttaataaatttgtgcACCAGAATACATTgccaatattcactgagaaatggatgaaaATGGCATGTACTCTGTTATGCTGAGCACtctatttgttttctttaattttttgtattcttttacttttattttcttatattctGTTGTGTCCACTGATTTTGGCAGCAAAATCTCTTCATTTTTACTTTAAGAagcataaaatcttttttttattagactGTTTTCGGGGTGAAAATGACCCGGGCATGTTGTCATACATTAGTTTATGTAACAGTATatgcactgtatttaaatgtgtaaGAGCAGAGCTGTTAGTAATTGCATTTGTGTTGCACATTCTTTCTGTGTATCAATCCATGTTATAATATGGTGCTTGGAAACATATTACAACTAGcattaaattgaataataaaaaataacaataataaaatgtaaataaaggcata

Function

symbol description
tnfrsf1a Predicted to enable tumor necrosis factor binding activity and tumor necrosis factor-activated receptor activity. Acts upstream of or within several processes, including defense response to other organism; fin regeneration; and neutrophil chemotaxis. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in membrane raft and mitochondrion. Is expressed in several structures, including heart; nervous system; notochord; otic vesicle; and pronephric duct. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; acne; allergic bronchopulmonary aspergillosis; autoimmune disease (multiple); and autosomal dominant familial periodic fever. Orthologous to human TNFRSF1A (TNF receptor superfamily member 1A).

GO:

id name namespace
GO:0045087 innate immune response biological_process
GO:0042742 defense response to bacterium biological_process
GO:0006954 inflammatory response biological_process
GO:0009615 response to virus biological_process
GO:0009617 response to bacterium biological_process
GO:0002631 regulation of granuloma formation biological_process
GO:0031101 fin regeneration biological_process
GO:0030593 neutrophil chemotaxis biological_process
GO:0007165 signal transduction biological_process
GO:0045121 membrane raft cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0043235 receptor complex cellular_component
GO:0005739 mitochondrion cellular_component
GO:0043120 tumor necrosis factor binding molecular_function
GO:0005031 tumor necrosis factor-activated receptor activity molecular_function

KEGG:

id description
ko04010 MAPK signaling pathway
ko04064 NF-kappa B signaling pathway
ko04668 TNF signaling pathway
ko04071 Sphingolipid signaling pathway
ko04150 mTOR signaling pathway
ko04060 Cytokine-cytokine receptor interaction
ko04061 Viral protein interaction with cytokine and cytokine receptor
ko04210 Apoptosis
ko04215 Apoptosis - multiple species
ko04217 Necroptosis
ko04920 Adipocytokine signaling pathway
ko04380 Osteoclast differentiation
ko05166 Human T-cell leukemia virus 1 infection
ko05170 Human immunodeficiency virus 1 infection
ko05160 Hepatitis C
ko05171 Coronavirus disease - COVID-19
ko05164 Influenza A
ko05168 Herpes simplex virus 1 infection
ko05163 Human cytomegalovirus infection
ko05167 Kaposi sarcoma-associated herpesvirus infection
ko05165 Human papillomavirus infection
ko05130 Pathogenic Escherichia coli infection
ko05132 Salmonella infection
ko05131 Shigellosis
ko05152 Tuberculosis
ko05145 Toxoplasmosis
ko05142 Chagas disease
ko05010 Alzheimer disease
ko05014 Amyotrophic lateral sclerosis
ko05022 Pathways of neurodegeneration - multiple diseases
ko05417 Lipid and atherosclerosis
ko05418 Fluid shear stress and atherosclerosis
ko04932 Non-alcoholic fatty liver disease
ko04931 Insulin resistance
ko04050 Cytokine receptors
ko04090 CD molecules

ZFIN:

id description
ZDB-GENE-040426-2252 Predicted to enable tumor necrosis factor binding activity and tumor necrosis factor-activated receptor activity. Acts upstream of or within several processes, including defense response to other organism; fin regeneration; and neutrophil chemotaxis. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in membrane raft and mitochondrion. Is expressed in several structures, including heart; nervous system; notochord; otic vesicle; and pronephric duct. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; acne; allergic bronchopulmonary aspergillosis; autoimmune disease (multiple); and autosomal dominant familial periodic fever. Orthologous to human TNFRSF1A (TNF receptor superfamily member 1A).

Ensembl:

ensembl_id ENSDARG00000018569

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00020719 False 4373 mRNA 0.38 9 17060758 17072561
TCONS_00020720 True 2509 mRNA 0.37 10 17062091 17072440

Neighbor

gene id symbol gene type direction distance location
XLOC_010573 plekhg6 coding downstream 4128 17007089 ~ 17056630 (-)
XLOC_010572 uts2r3 coding downstream 299594 16757219 ~ 16761164 (-)
XLOC_010571 c4b coding downstream 359040 16665203 ~ 16701718 (-)
XLOC_010570 tnxba coding downstream 410994 16621242 ~ 16649764 (-)
XLOC_010569 cyp21a2 coding downstream 440861 16605517 ~ 16619897 (-)
XLOC_010575 si:dkey-260g12.1 coding upstream 29542 17102103 ~ 17116499 (-)
XLOC_010576 CU861451.1 coding upstream 47503 17120064 ~ 17120186 (-)
XLOC_010577 iffo1b coding upstream 49425 17121986 ~ 17162843 (-)
XLOC_010578 opn9 coding upstream 90632 17163193 ~ 17188294 (-)
XLOC_010579 gapdh coding upstream 117278 17189839 ~ 17200120 (-)
XLOC_010626 CR392024.2 misc upstream 3822551 20895112 ~ 20895175 (-)
XLOC_010568 NA non-coding downstream 456678 16593349 ~ 16604080 (-)
XLOC_010567 CR848667.3 non-coding downstream 487228 16573414 ~ 16573530 (-)
XLOC_010565 CR848667.2 non-coding downstream 530786 16526975 ~ 16529972 (-)
XLOC_010562 NA non-coding downstream 790323 16266556 ~ 16270435 (-)
XLOC_010554 CT573799.2 non-coding downstream 1246257 15813506 ~ 15814501 (-)
XLOC_010582 CR936322.1 non-coding upstream 172347 17244908 ~ 17245047 (-)
XLOC_010583 CR936322.2 non-coding upstream 174661 17247222 ~ 17247363 (-)
XLOC_010592 NA non-coding upstream 632269 17704830 ~ 17706764 (-)
XLOC_010594 NA non-coding upstream 750886 17823447 ~ 17824848 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000016_08800360_08805384 NA coding CI01000016 null 8798407 ~ 8805384 (-)