CI01000306_01756353_01763570 (PYCR1B, PYCR1.L, PYCR1, PYCR1A, PYCR2)


Basic Information

Item Value
gene id CI01000306_01756353_01763570
gene name PYCR1B, PYCR1.L, PYCR1, PYCR1A, PYCR2
gene type coding
species grasscarp (Ctenopharyngodon idella)
category of species economic fish

Chromosome Information

Item Value
chromosome id CI01000306
NCBI id null
chromosome length 11491657
location 1756175 ~ 1764246 (-)
genome version v1_2015/06_NatureGenetics_grasscarp_Genome

Sequence

>CI01000306_01756353_01763570.mRNA
AGCGCTTATTCTACAGGAACTGATGCAATAAGACCTCTCTGTTACAAACCCCGCCCTCACTTCATCCAAGAGCGCTGATTGGTCTGACGCGACAGCATCTCGTCTCTCATTGGTGCCTCCATGTGTCGGTCAGAGCGTGGTCTCTCTGCACATGGAGGGAATGAAGCCACGTTGACACCAATTAAAATTTTGTACCGATTTTTTAGAACACCGAACCGAATCTACATTTCAGTGAATCTCGGCGAAGGTGAGAAAATATTCCTTTTTCTGAGATGATGAAATGTTTTCGAGATTGTATCAGGCTGCAGGATAAGGAATGATTATTCATATGCACTGATCATACTCACAATAACATCATGTTTATACTTTATTCTATTGTGTATCACAACAATATTACTCTAGTAGTTGATGCACAATTAAGCAAAATGTTTATGTTGCAATGTATGCATAATATGACTGTATAATTGTTGTTTTACAGTGTTTTCTTGTAATTTATTATTGTCTTCCAGCTTCTTCAGGTTCTGAATGTGTTGTAGCTCAAGCTTTGATTTCCAGTGAATGCATGAACAGCATATGTTCTGAATGCAATGCATGTTTGTTTGGATGAAAGTGTCTGGCAGATGAGTAATCGAGTTGATGTGTGTGATTGTGTTTCTGCAGGTGAGGAATCATCAGGATGAGTGTGGGCTTCATTGGAGCGGGTCAGCTGGCACATGCCCTGGTCAAGGGCTTCACAGCGGCGGGTGTAATTGCTGCAAACAGAATCACAGCGAGTTCACCTGACACAGATCTGCCAACAGTCTCCGGTCTACGGAAAATGGGCGTCAGTATGACTACAAGCAACAAAGAAGCCACAAACAAGAGTGACGTTCTGTTTTTGGCGGTCAAGCCGCACATCATCCCGTTCGTTCTGGATGAAATCGGTCCGGATATCGAGGACCGTCACCTCATCGTCTCCTGTGCCGCTGGAGTCACGATCAGCTCCATCGAGAAGAAGCTGCTTCAGTACCGCACGTCTCCTAAAGTGATGCGCTGCATGACCAACACGCCGGTGGTGGTACGCGAGGGGGCGACGGTTTACGCCACAGGAACTCACGCTGATGTGGAGGACGGGAAGCTCCTGGAGCAGCTCATGGCGAGTGTCGGCTTCTGTACGGAGGTGGAGGAGGATCTGATTGACGCCGTGACGGGCCTCAGCGGCAGCGGACCTGCTTACGCGTTTACGGCTCTGGACGCTCTGGCTGATGGCGGGGTGAAGATGGGGTTGCCACGGAGACTGGCGGTGAGACTGGGAGCTCAAGCTTTACTGGGCGCAGCTAAAATGCTTCTGGACTCGGAGCAGCACCCGGGGCAACTGAAGGACAATGTCTGCTCACCAGGTGGCGCTACAATCCACGCGCTGCACTTCCTGGAGAGCGGAGGCTTCCGGAGTCTCCTCATCAACGCCGTGGAGGCGTCCTGCATCCGAACCCGAGAGCTGCAGTCTCTGGCCGATCAGGAGAAGATCTCGCCCGCTGCCATCAAGAAGACGACGCTGGATAAAGTGCTGCAGCAGCCGGGCGTCTCGTCCACGTCAGTGGGAACCAAGAGCAGAGTGAACCTGTTCAACAACCGGAGCGGCGCCAAGAAGAACTGAACATGACGGTCTGATCTCTCACGGGACAATACAAGATAATGGCAGTGGCGTCCGTCCATACAAACACACACAATCAGACTGAAGTGCATTATGATGTTACACTAGTACAGGAAACATGTCATTATGGAGTGTAATTTCTTGTCATATCTCTGAAAATTTAAAGGAAACTATATATAAA

Function

symbol description
pycr1a Predicted to enable pyrroline-5-carboxylate reductase activity. Predicted to be involved in L-proline biosynthetic process. Predicted to act upstream of or within proline biosynthetic process. Used to study autosomal recessive cutis laxa type IIB. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIB and autosomal recessive cutis laxa type IIIB. Orthologous to human PYCR1 (pyrroline-5-carboxylate reductase 1).
pycr1b Predicted to enable pyrroline-5-carboxylate reductase activity. Acts upstream of or within brain development. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIB; autosomal recessive cutis laxa type IIIB; and hypomyelinating leukodystrophy 10. Orthologous to several human genes including PYCR1 (pyrroline-5-carboxylate reductase 1).
pycr2 Predicted to enable pyrroline-5-carboxylate reductase activity. Involved in cellular response to oxidative stress and proline biosynthetic process. Located in mitochondrion. Implicated in hypomyelinating leukodystrophy 10.
pycr1 Enables identical protein binding activity and pyrroline-5-carboxylate reductase activity. Involved in several processes, including negative regulation of hydrogen peroxide-induced cell death; proline biosynthetic process; and regulation of mitochondrial membrane potential. Located in mitochondrion. Implicated in autosomal recessive cutis laxa type IIB and autosomal recessive cutis laxa type IIIB.

GO:

id name namespace
GO:0008652 cellular amino acid biosynthetic process biological_process

KEGG:

id description
K00286 proC; pyrroline-5-carboxylate reductase

RNA

RNA id representative length rna type GC content exon number start site end site
CI01000306_01756353_01763570.mRNA True 1814 mRNA 0.49 7 1756175 1764246

Neighbor

gene id symbol gene type direction distance location
CI01000306_01723684_01726043 MAFGA, MAFGB, MAFG coding downstream 30132 1717933 ~ 1726043 (-)
CI01000306_01665458_01676209 NA coding downstream 79952 1664797 ~ 1676223 (-)
CI01000306_01633237_01635512 HRASLS coding downstream 119402 1633073 ~ 1636773 (-)
CI01000306_01580628_01611787 SOS1 coding downstream 144388 1580374 ~ 1611787 (-)
CI01000306_01572341_01576690 NA coding downstream 179485 1572341 ~ 1576690 (-)
CI01000306_01775235_01776152 NA coding upstream 10951 1775197 ~ 1776432 (-)
CI01000306_01792788_01804803 ASPSCR1 coding upstream 28542 1792788 ~ 1804803 (-)
CI01000306_01826418_01844251 MFN1B coding upstream 61851 1826097 ~ 1844251 (-)
CI01000306_01859514_01870761 NA coding upstream 94759 1859005 ~ 1870822 (-)
CI01000306_01905901_01906725 NA coding upstream 141452 1905698 ~ 1907020 (-)
G431747 NA non-coding downstream 1671 1753414 ~ 1754504 (-)
G431757 NA non-coding downstream 15555 1732745 ~ 1740620 (-)
G431746 NA non-coding downstream 23750 1727489 ~ 1732425 (-)
G431737 NA non-coding downstream 50104 1705349 ~ 1706071 (-)
G431732 NA non-coding downstream 130158 1625345 ~ 1626017 (-)
G431913 NA non-coding upstream 21339 1785585 ~ 1786256 (-)
G431916 NA non-coding upstream 42599 1806845 ~ 1807068 (-)
G431918 NA non-coding upstream 45597 1809843 ~ 1810059 (-)
G431751 NA non-coding upstream 92551 1856797 ~ 1898332 (-)
G431933 NA non-coding upstream 134619 1898865 ~ 1899107 (-)
G431814 NA other downstream 443741 1311702 ~ 1312434 (-)
G431706 NA other downstream 592837 1163027 ~ 1163338 (-)
CI01000306_00482506_00494090 PFKLB, PFKL other downstream 1272526 482482 ~ 494090 (-)
G432022 NA other upstream 1235990 3000236 ~ 3003891 (-)
CI01000306_04544349_04545034 NA other upstream 2778477 4542723 ~ 4545244 (-)
G433450 NA other upstream 3597397 5361643 ~ 5383763 (-)
G433670 NA other upstream 4276768 6041014 ~ 6041283 (-)
G433985 NA other upstream 4431861 6196107 ~ 6197210 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
zebrafish (Danio rerio) XLOC_003759 pycr1b coding NC_007122.7 CM002895.2 45286911 ~ 45298524 (+)