XLOC_003759 (pycr1b)


Basic Information

Item Value
gene id XLOC_003759
gene name pycr1b
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007122.7
NCBI id CM002895.2
chromosome length 45484837
location 45286911 ~ 45298524 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00007234
tatatatatatatatatatttgtaactcTGTCCTATGCTGCCTGTCTTGACCAGGACTCCCTGCTAGAAAAGATATTGCATCTCAATGGCACATTACTggttcaacaaacaaacaaacaaacaaacaaataaatatttcaacTTCCAAACATGCAAACATCCAGATTCATCCTCTATTGTAAAGCGGttgaattttaaataaacaatgctgtctccaatttaaaacagaaatacatttaacaattaaaatctATATGTTAACATATTTAttgtaacatttgtttgtttattaatgttcTACACAAAACGTGTCTCCTTATTTCACTGTCcttgtttatattattgtattcaaTGCTGTGAAGTCATTTCTTTTACAGTTTGCCTTGTACAGTAGCCTGTAAAGTGTGAAGCGTTAACATTAAGTGACGtgtccgcgcacacacacacacacacacacacacacacacacacacacacacacacacacacactgacctatATCTAGCATTTATTGCACAGGAACTGATGCAATAAGACCGCTCTGTTCCCAGCCCCGCCCTCCGCGCTTCAGAAGCGCCGATTGGTCACAATCACGACATCTGCTCTATGATTGGCCGGCTCGTGTGTCAGTCAGAGCGCAGAGCTGCTGCACATGGAAGCGCTGGAGCCACGTTGACATCACTGGTGTTTCTACAGCTTCTCCAACAACAATCTCAAGTTCAAGTTCAGTCTCGGCGCAGgtgtgtgtgtgtgtgtgtgtgtcgatcTTCATCAGGATGAGTGTGGGCTTCATTGGAGCGGGTCAGCTGGCTCATGCCATGGTCAAGGGCTTCACCGCAGCGGgtgtcaTTGCAGCAAACAGAATCACAGCGAGTTCACCAGACACTGAACTGCCCACTGTCTCAGGCCTGCGGaaaatggGGGTGAATTTGACCACAAGCAACAAAGAAGCGACGCACAGGAGCGACGTTCTGTTTCTGGCCGTGAAGCCGCACATCATCCCGTTTGTACTGGACGAGATCGGCCCCGATATTGAAGACCGACACCTCATCGTGTCCTGCGCTGCTGGAGTCACTATCAGCTCCATAGAGAAgaagctGCTGCAGTACCGTGAGTCTCCTAAAGTGATGCGATGCATGACGAACACCCCGGTGGTGGTGCGCGAGGGGGCGACGGTGTACGCCACAGGCACACACGCACATCTGGAGGACGGCAAACTGCTGGAGCAGCTGATGGCCAGCGTGGGCTTCTGCACCGAGGTGGAGGAGGACCTGATCGATGCCGTCACTGGACTCAGCGGCAGCGGACCCGCATATgcatTCACGGCTCTGGATGCTCTTGCTGATGGTGGGGTGAAGATGGGTTTGCCGAGGAGGCTGGCTGTGCGTCTGGGGGCTCAGGCTCTAATGggagCAGCGAAGATGTTGTTGGACAGTGAGCAGCACCCGGGTCAGCTGAAGGATAATGTGTGTTCTCCAGGTGGAGCTACAATACACGCGCTGCACTTCCTGGAGAGCGGAGGCTTCCGGAGCTTGCTGATCAACGCTGTGGAGGCGTCCTGCATACgcacaagGGAGCTTCAGTCTCTGGCAGATCAGGAGCAGATCTCCGCCGCAGCCATCAAGAAGACCACGCTGGATAAAGTCCTGCAGCAGCCCGGCGTCACGCACAACAGTGTCGGCACCAGGAGCAGAGTAAACCTGTTCAACAACCGCAGCAAGAAGAGCTGAGACACTAACATACGCACACACTCATTTGCACATTcacatatacataaacacactcaaacacgcacTTATTGAACATACACTGGCACACTCATATGCACTTTcacttacatatacacacacacacacttatataaacacatactctcatacacacacacacacacacacacacagatgcatacTCATACACACTTGTATAAACACACTTGTATGCATATACACATaacctacacacacatacattcaaacACTCACAAACtcgtgtatacacacacacacacacacacacacactctctcatatACACGTTTATATACTAACCCACACATgtgtgcacgcacacacgcaaatGGACTcactcatatatacacacacacacacacacacacacacacacacacacactgactgacaCATACATGCAAACATTATCTCCCACAGAGGAGAGCCGTCCACACCTATCCCCCCACacccctcaaaacacacacacacacacacacacacacacacacacacacacacacacacacacatatccagtGGAACTCCTCCTGACTGCAGATCTGCAGGATCTTCTCTGAAGTGTCACAGGAAGTGATGTCACAGAATGAAATGCTGATTTCCTTTTTCTCTGGACGTGTATGTGATGGACAGTGAagatgtgcgtgtgtgcgtgcgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtcagatctgCACTTCTGTCTGTTACTTTATAGGTTTGTTCTCTTCAATGCTGGATGACAAACAGCCAAAGTGTGTttatacattgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgcgtgtgagagagcaTTTGTGAATGAGTcagagagtttgtgtgtgagtCTGAGAGTGAGTGTTTGTGAGAGAATCTGtgtatctgagtgtgtgtgtgtgtgttggagaaaTGTGTATCAGTGGTGTTTCTGCTTGCTGTTGTGTTTCTGTGAATAAAGTGAGGGAATGAAGCAGTTCTTGTTTCATTATTAAACACTACAGAAGAAGACGAGCtgcgtctcacacacacacacacacacacacacacacacagattcaacACTACTCACTGCAGAGTTAATGTTTTGTTACTGAATTCTACAGCAGAATtcaatgagcacacacacacacacacacacagacacagacaagtGTTATTATATAAAGTGTGCGTAAGTGTTTGTGCATATGTTTTGTgactattgtgtgtgtgcgtgtgccgTCTGCTGGAGGCTCAGGTTATTTGTAGCTTTGATGTTGGAGATGTTTCTCTGTCAGTATGCAgacgagtgtgtgtgtctgtgaccgCTGAagactgtatgtgtgtatcaTTGTGAAAAccgaagtttgtttgtttgtttgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtttctctgtggacTCTGAAGAGTGTGTCATTGTGAACACTGAAGAGTGTCTGTGTCTGTTTTGCTGTGAACactgaaaagtgtgtgtgtattgctgtatactataaaaaaaaaaccgtgtgtgtgtgtgtgtgtctcgctGTAAAGTGTTTCTCGTTGTAGACACAtaagaacagtgtgtgtgtgagagacacaTTTAGAACCTGCTCTGACCTGCAGGTCAAAGTTCATCTGCAGGTTCAGAACGCTTCATCAAAGTTCTTTGAAGTTCTGGAACAAAGTAGCAACATTTAAACCCAGAGGAATGagctcatcacacacacacacacacacacacatacactactgtaGAGTCTACTGTGAAGAAACATCAAGCAAACCCTGATCCTCCAGGAGTGATGCTGTAATGAGGCGTTTGTGTCTGCATTATGAGGACAGCAGTGTGTTATTAACAGTGTTGCAGGAGCGTTTGCTCTTAACATTAGCAGAACGTTCTCCGTCAGCTGATAATGGCGTCTCTAATCCTGCCGCTGTTGTATTAGTTCTGTGCTCAACTCATTCCCTTCACCAACATCATCTGCTGTCGTCGTGTGAAAGCACTAATGAAGTCTGACCAGAGAAACTCCTCACAGAAAGACTTGTGTTTGATAAGAGCgccgcacgtgtgtgtgtgtgtgtgtgtgtgtgtacgcaggATTAGTTCCAGAGGAGCCGCTGCTCTTGTGTTTGTCTCTGTTTATTTGTGTCTCTGATTGGAAGTCGAGGAGGCGCTAAAGAGTTGTATAATCCTCCTTTTATTGCGGAGGTTCCTCTCGGCTCGGCCCAGCGCCTCACACACTGATAAGctcaagagtgtgtgtgttcctgCTATTCCTCTGAAACACTGCTGATCAtattcaccacacacacacacacaatcactgcGCTTCCCCATTCAGAATCATTGTGTTCCTCCAGCGCTGGAGGATTAGTGTAGTTCAGATGATGAGTTGAGTTCATTCACTGACAAACCAGAGCGAATAAACAACGTGTACACTTCAATATCAGGAGGACAATAatgaccaacacacacacactccccaaACACCATCATAAACAGTGGAGATATGACTGGAGTCAGGGTGTTGAAGACTCGGTCAGTGTTTGGTCTGTCATATTAGTGTTGCTGTATTATGTGTTGTTACTTACCTAAAGTCATTAATTaccaattaaatcattaaaaaaacggTGActtcccggctgggtcagttggtgtttctgtgtggagtttgcatgttctccctgtgttggtgtgggtttcctctgggtgctctggtttcccccacagtccaaacacatgcgctataggggaactgatcaactacactggccgtagtgtatgagtgtttaccAGTTGTAGCTgcaaaggcatccgctgtgtaaaacatgatggattagttagtggttcattccgctgtggcgacccctgattaataaatggactaagctgaaggaaaatgaatgagtgaaaattgtgactgtgtgtgtgtgtttgtgcagcacGCACATGcatatgtgtaagtgtgtgattgtatgcgtgtgtgtatatgtatgtgcatgaccatgtgtttgtgagagtgtgtttatatgtatttgtgtgtacttatgtgtgtctgtctttatatttgtgtgtgtgtgtgtgtgtttgtctgtgtctctgtatgtgtatatgtttgtgtctatatatgtgtgtttttgtgtgtgtgtttgtatgactgtatgtgtgtgtgtgtgtgtgtgtacatgtctgtgactattgtatgtgtgtgattatatatttgtgtctgtgtgtgtgtgtgtttgtttgtatgtatgagtgtatgtgtatgcatgtgtgtttatgtatgcatgtatttgtgtgtgtgtgtgtgtgtgtgtgtgcatgtgtgtgtctgtgtatgtatatgtgtgtaagagtgtgtaagtttgtttgtgtatatgtgtctgtctctctctctctctctctctctctctctctctctctctatatatatatatatatatatatatatatatatatatatatatatatgtgtgtgtgtgtgtgtgtggtgacctGAGGCCGGTGTTCTCCATCAGATCTGCAGTGGTGTTGTGGACTGAAGCTGAAGCTGGTTCTCTGTGGTTTTCAGAGGAACCGTCAGACCCAGATCTGCTCTTCCTCTTTCTCCAGTCGCCGGCAGCTGTAGAGCACCGATAAAACATAtctgcgcaaacacacacacacacacacacacacacacacacttctgcttcCCGTCACTCTCTGGGAGAATATCAGAACAGCTGGAATAAAGAGCTGAAATACATCTGCAACGTGTGTGAGCGCGTgcctgtgtgtatgtctgtgtgtgcatttatgtgtgtgtgtgtatgtgtgtctatcTGTATTTGTGAgtatgtgtgcgagtgtgtaaatgtgagtgagtgtgtgcctGTATGTGTATgttagtgtgtgtatgtctgtgtgtgagtgtgtgcatatgtgtatttgtgtatggtatgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtatatctctgtgtgaatgtgtatgtttgtgtgtgtttatttctgtaTGATTGTGTCtaagtgtgagtgagtgagtgagtgagtgagaatatatgtatgtatttatgtgtaagtttgtgcatgtgtgtacatgtgtgtatgtgtctgtacCTGAGTGTGTGCGCCTAATGAACACTTGAGACAGATCCTGGAGCAGATGTCTGTTGATGGTCTTTAATCAGTGCGAGTGTGGTcagataagtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgttcctccacATCTGCACCTCTCTCCTCTGTTCAGGAAGAGCTGAGGCAGCTGATCTCTGGAGGAGCTGAAGAGCACAG
>TCONS_00007235
TCAGAGCGCAGAGCTGCTGCACATGGAAGCGCTGGAGCCACGTTGACATCACTGGTGTTTCTACAGCTTCTCCAACAACAATCTCAAGTTCAAGTTCAGTCTCGGCGCAGGATGAGTGTGGGCTTCATTGGAGCGGGTCAGCTGGCTCATGCCATGGTCAAGGGCTTCACCGCAGCGGgtgtcaTTGCAGCAAACAGAATCACAGCGAGTTCACCAGACACTGAACTGCCCACTGTCTCAGGCCTGCGGaaaatggGGGTGAATTTGACCACAAGCAACAAAGAAGCGACGCACAGGAGCGACGTTCTGTTTCTGGCCGTGAAGCCGCACATCATCCCGTTTGTACTGGACGAGATCGGCCCCGATATTGAAGACCGACACCTCATCGTGTCCTGCGCTGCTGGAGTCACTATCAGCTCCATAGAGAAgaagctGCTGCAGTACCGTGAGTCTCCTAAAGTGATGCGATGCATGACGAACACCCCGGTGGTGGTGCGCGAGGGGGCGACGGTGTACGCCACAGGCACACACGCACATCTGGAGGACGGCAAACTGCTGGAGCAGCTGATGGCCAGCGTGGGCTTCTGCACCGAGGTGGAGGAGGACCTGATCGATGCCGTCACTGGACTCAGCGGCAGCGGACCCGCATATgcatTCACGGCTCTGGATGCTCTTGCTGATGGTGGGGTGAAGATGGGTTTGCCGAGGAGGCTGGCTGTGCGTCTGGGGGCTCAGGCTCTAATGggagCAGCGAAGATGTTGTTGGACAGTGAGCAGCACCCGGGTCAGCTGAAGGATAATGTGTGTTCTCCAGGTGGAGCTACAATACACGCGCTGCACTTCCTGGAGAGCGGAGGCTTCCGGAGCTTGCTGATCAACGCTGTGGAGGCGTCCTGCATACgcacaagGGAGCTTCAGTCTCTGGCAGATCAGGAGCAGATCTCCGCCGCAGCCATCAAGAAGACCACGCTGGATAAAGTCCTGCAGCAGCCCGGCGTCACGCACAACAGTGTCGGCACCAGGAGCAGAGTAAACCTGTTCAACAACCGCAGCAAGAAGAGCTGAGACACTAACATACGCACACACTCATTTGCACATTcacatatacataaacacactcaaacacgcacTTATTGAACATACACTGGCACACTCATATGCACTTTcacttacatatacacacacacacacttatataaacacatactctcatacacacacacacacacacacacacagatgcatacTCATACACACTTGTATAAACACACTTGTATGCATATACACATaacctacacacacatacattcaaacACTCACAAACtcgtgtatacacacacacacacacacacacacactctctcatatACACGTTTATATACTAACCCACACATgtgtgcacgcacacacgcaaatGGACTcactcatatatacacacacacacacacacacacacacacacacacacactgactgacaCATACATGCAAACATTATCTCCCACAGAGGAGAGCCGTCCACACCTATCCCCCCACacccctcaaaacacacacacacacacacacacacacacacacacacacacacacacacacacatatccagtGGAACTCCTCCTGACTGCAGATCTGCAGGATCTTCTCTGAAGTGTCACAGGAAGTGATGTCACAGAATGAAATGCTGATTTCCTTTTTCTCTGGACGTGTATGTGATGGACAGTGAagatgtgcgtgtgtgcgtgcgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtcagatctgCACTTCTGTCTGTTACTTTATAGGTTTGTTCTCTTCAATGCTGGATGACAAACAGCCAAAGTGTGTttatacattgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgcgtgtgagagagcaTTTGTGAATGAGTcagagagtttgtgtgtgagtCTGAGAGTGAGTGTTTGTGAGAGAATCTGtgtatctgagtgtgtgtgtgtgtgttggagaaaTGTGTATCAGTGGTGTTTCTGCTTGCTGTTGTGTTTCTGTGAATAAAGTGAGGGAATGAAG
>TCONS_00007236
GCGCAGAGCTGCTGCACATGGAAGCGCTGGAGCCACGTTGACATCACTGGTGTTTCTACAGCTTCTCCAACAACAATCTCAAtgtgtgtgtgtgtgtgtgtgtcgatcTTCATCAGGATGAGTGTGGGCTTCATTGGAGCGGGTCAGCTGGCTCATGCCATGGTCAAGGGCTTCACCGCAGCGGgtgtcaTTGCAGCAAACAGAATCACAGCGAGTTCACCAGACACTGAACTGCCCACTGTCTCAGGCCTGCGGaaaatggGGGTGAATTTGACCACAAGCAACAAAGAAGCGACGCACAGGAGCGACGTTCTGTTTCTGGCCGTGAAGCCGCACATCATCCCGTTTGTACTGGACGAGATCGGCCCCGATATTGAAGACCGACACCTCATCGTGTCCTGCGCTGCTGGAGTCACTATCAGCTCCATAGAGAAgaagctGCTGCAGTACCGTGAGTCTCCTAAAGTGATGCGATGCATGACGAACACCCCGGTGGTGGTGCGCGAGGGGGCGACGGTGTACGCCACAGGCACACACGCACATCTGGAGGACGGCAAACTGCTGGAGCAGCTGATGGCCAGCGTGGGCTTCTGCACCGAGGTGGAGGAGGACCTGATCGATGCCGTCACTGGACTCAGCGGCAGCGGACCCGCATATgcatTCACGGCTCTGGATGCTCTTGCTGATGGTGGGGTGAAGATGGGTTTGCCGAGGAGGCTGGCTGTGCGTCTGGGGGCTCAGGCTCTAATGggagCAGCGAAGATGTTGTTGGACAGTGAGCAGCACCCGGGTCAGCTGAAGGATAATGTGTGTTCTCCAGGTGGAGCTACAATACACGCGCTGCACTTCCTGGAGAGCGGAGGCTTCCGGAGCTTGCTGATCAACGCTGTGGAGGCGTCCTGCATACgcacaagGGAGCTTCAGTCTCTGGCAGATCAGGAGCAGATCTCCGCCGCAGCCATCAAGAAGACCACGCTGGATAAAGTCCTGCAGCAGCCCGGCGTCACGCACAACAGTGTCGGCACCAGGAGCAGAGTAAACCTGTTCAACAACCGCAGCAAGAAGAGCTGAGACACTAACATACGCACACACTCATTTGCACATTcacatatacataaacacactcaaacacgcacTTATTGAACATACACTGGCACACTCATATGCACTTTcacttacatatacacacacacacacttatataaacacatactctcatacacacacacacacacacacacacagatgcatacTCATACACACTTGTATAAACACACTTGTATGCATATACACATaacctacacacacatacattcaaacACTCACAAACtcgtgtatacacacacacacacacacacacacactctctcatatACACGTTTATATACTAACCCACACATgtgtgcacgcacacacgcaaatGGACTcactcatatatacacacacacacacacacacacacacacacacacacactgactgacaCATACATGCAAACATTATCTCCCACAGAGGAGAGCCGTCCACACCTATCCCCCCACacccctcaaaacacacacacacacacacacacacacacacacacacacacacacacacacacatatccagtGGAACTCCTCCTGACTGCAGATCTGCAGGATCTTCTCTGAAGTGTCACAGGAAGTGATGTCACAGAATGAAATGCTGATTTCCTTTTTCTCTGGACGTGTATGTGATGGACAGTGAagatgtgcgtgtgtgcgtgcgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtcagatctgCACTTCTGTCTGTTACTTTATAGGTTTGTTCTCTTCAATGCTGGATGACAAACAGCCAAAGTGTGTttatacattgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgcgtgtgagagagcaTTTGTGAATGAGTcagagagtttgtgtgtgagtCTGAGAGTGAGTGTTTGTGAGAGAATCTGtgtatctgagtgtgtgtgtgtgtgttggagaaaTGTGTATCAGTGGTGTTTCTGCTTGCTGTTGTGTTTCTGTGAATAAAGTGAGGGAATGAAG

Function

symbol description
pycr1b Predicted to enable pyrroline-5-carboxylate reductase activity. Acts upstream of or within brain development. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIB; autosomal recessive cutis laxa type IIIB; and hypomyelinating leukodystrophy 10. Orthologous to several human genes including PYCR1 (pyrroline-5-carboxylate reductase 1).

GO:

id name namespace
GO:0055114 oxidation-reduction process biological_process
GO:0055129 L-proline biosynthetic process biological_process
GO:0008652 cellular amino acid biosynthetic process biological_process
GO:0007420 brain development biological_process
GO:0006561 proline biosynthetic process biological_process
GO:0005575 cellular_component cellular_component
GO:0016491 oxidoreductase activity molecular_function
GO:0004735 pyrroline-5-carboxylate reductase activity molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-050522-26 Predicted to enable pyrroline-5-carboxylate reductase activity. Acts upstream of or within brain development. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIB; autosomal recessive cutis laxa type IIIB; and hypomyelinating leukodystrophy 10. Orthologous to several human genes including PYCR1 (pyrroline-5-carboxylate reductase 1).

Ensembl:

ensembl_id ENSDARG00000098639

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00007234 False 6134 mRNA 0.45 8 45286911 45298524
TCONS_00007235 False 2084 mRNA 0.51 8 45287541 45295139
TCONS_00007236 True 2090 mRNA 0.51 9 45287546 45295139

Neighbor

gene id symbol gene type direction distance location
XLOC_003758 aspscr1 coding upstream 11702 45255774 ~ 45275209 (+)
XLOC_003756 tmc6b coding upstream 42270 45233348 ~ 45244641 (+)
XLOC_003757 CABZ01078080.1 coding upstream 50177 45234480 ~ 45236734 (+)
XLOC_003755 tmc6b coding upstream 55712 45219558 ~ 45231199 (+)
XLOC_003754 NA coding upstream 67524 45212765 ~ 45219387 (+)
XLOC_003760 mafgb coding downstream 923 45299447 ~ 45328509 (+)
XLOC_003761 NA coding downstream 32877 45331401 ~ 45335873 (+)
XLOC_003762 si:ch73-100l22.3 coding downstream 41382 45339906 ~ 45351824 (+)
XLOC_003763 NA coding downstream 56331 45354855 ~ 45356339 (+)
XLOC_003764 srsf11 coding downstream 89602 45388126 ~ 45400146 (+)
XLOC_003369 CR854846.2 misc upstream 29163829 16122786 ~ 16123082 (+)
XLOC_003318 CR450764.6 misc upstream 32574915 12711700 ~ 12711996 (+)
XLOC_003317 CR450764.16 misc upstream 32592648 12693967 ~ 12694263 (+)
XLOC_003316 CR450764.11 misc upstream 32601312 12685304 ~ 12685599 (+)
XLOC_003315 CR450764.18 misc upstream 32606883 12679732 ~ 12680028 (+)
XLOC_003752 NA non-coding upstream 143071 45136015 ~ 45143840 (+)
XLOC_003748 NA non-coding upstream 375692 44907969 ~ 44911219 (+)
XLOC_003747 FO744859.1 non-coding upstream 435318 44851474 ~ 44851593 (+)
XLOC_003765 CU459093.1 non-coding downstream 90853 45389377 ~ 45390076 (+)
XLOC_003766 NA non-coding downstream 114299 45412823 ~ 45413797 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000306_01756353_01763570 PYCR1B, PYCR1.L, PYCR1, PYCR1A, PYCR2 coding CI01000306 null 1756175 ~ 1764246 (-)