XLOC_015499 (mc4r)


Basic Information

Item Value
gene id XLOC_015499
gene name mc4r
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007113.7
NCBI id CM002886.2
chromosome length 59640629
location 27932781 ~ 27933864 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00030999
ATGAACACCTCACATCATCATGGACTGCATCATTCATTTCGGAACCACAGCCAAGGAGCTCTGCCGGTGGGAAAGCCCTCTCATGGTGACAGAGGATCAGCTTCTGGATGCTACGAGCAGCTGCTGATCTCCACGGAGATCTTCCTCACGCTCGGCCTGGTCAGCCTCCTGGAGAACATCCTTGTGATTGCAGCCATCGTCAAAAACAAGAACCTACATTCCCCTATGTACTTCTTCATCTGCAGCTTGGCTGTAGCAGACTTGTTAGTGAGTGTCTCCAATGCTTCGGAAACAGTTGTGATGGCGCTCATCACTGGAGGCAACCTGACCAACCGTGAGAGCATCATTAAGAACATGGACAACGTGTTTGACTCTATGATCTGCAGCTCTCTGTTGGCCTCCATTTGGAGTTTGTTGGCCATCGCGGTGGACCGCTACATCACAATCTTCTACGCTTTGCGCTACCACAACATCATGACCCAGCGGCGGGCGGGCACCATCATCACCTGCATCTGGACCTTCTGCACAGTCTCCGGCGTACTCTTTATCGTGTATTCAGAAAGCACCACTGTTCTCATCTGCCTCATCAGCATGTTCTTCACCATGCTGGCGCTCATGGCCTCACTCTACGTCCACATGTTCCTTCTAGCCCGGCTGCACATGAAACGGATCGCCGCCTTACCTGGAAACGGCCCGATATGGCAGGCGGCGAATATGAAGGGCGCCATTACCATTACTATACTACTGGGGGTGTTTGTGGTGTGCTGGGCGCCCTTTTTCTTGCACCTCATCCTCATGATCTCCTGCCCGCGGAATCCTTATTGTGTCTGCTTCATGTCACACTTCAACATGTATCTGATCCTCATTATGTGCAACTCGGTCATAGACCCGCTCATATATGCCTTCAGAAGCCAAGAAATGAGGAAGACCTTCAAGgagatctgctgctgctggtATGGACTTGCATCTCTGTGTGTATAAGTGCCGATTTTATTCTGACAGCACTTAGCAACTGGAAGATGCTGAGAATTTTGTGTATGGTAATTCTACTGTGCAGATGTGATACTGTGGTCATGCTGACCAA

Function

symbol description
mc4r Enables melanocortin receptor activity. Involved in energy homeostasis and energy reserve metabolic process. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; negative regulation of feeding behavior; and regulation of growth. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in brain and myotome. Human ortholog(s) of this gene implicated in morbid obesity and obesity. Orthologous to human MC4R (melanocortin 4 receptor).

GO:

id name namespace
GO:0007186 G protein-coupled receptor signaling pathway biological_process
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway biological_process
GO:0019222 regulation of metabolic process biological_process
GO:0006112 energy reserve metabolic process biological_process
GO:2000252 negative regulation of feeding behavior biological_process
GO:0040008 regulation of growth biological_process
GO:0097009 energy homeostasis biological_process
GO:0007165 signal transduction biological_process
GO:0005886 plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0005737 cytoplasm cellular_component
GO:0004930 G protein-coupled receptor activity molecular_function
GO:0004977 melanocortin receptor activity molecular_function
GO:0004980 melanocyte-stimulating hormone receptor activity molecular_function

KEGG:

id description
ko04080 Neuroactive ligand-receptor interaction
ko04030 G protein-coupled receptors

ZFIN:

id description
ZDB-GENE-021223-2 Enables melanocortin receptor activity. Involved in energy homeostasis and energy reserve metabolic process. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; negative regulation of feeding behavior; and regulation of growth. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in brain and myotome. Human ortholog(s) of this gene implicated in morbid obesity and obesity. Orthologous to human MC4R (melanocortin 4 receptor).

Ensembl:

ensembl_id ENSDARG00000015515

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00030999 True 1084 mRNA 0.50 1 27932781 27933864

Neighbor

gene id symbol gene type direction distance location
XLOC_015498 rnf152 coding upstream 61727 27867830 ~ 27871054 (+)
XLOC_015497 buc coding upstream 73223 27855102 ~ 27859558 (+)
XLOC_015496 FO834800.2 coding upstream 90615 27830436 ~ 27842166 (+)
XLOC_015495 tmem68 coding upstream 267242 27651984 ~ 27665539 (+)
XLOC_015494 zswim5 coding upstream 388839 27491066 ~ 27543942 (+)
XLOC_015500 CR925777.1 coding downstream 41690 27975554 ~ 28038625 (+)
XLOC_015501 NA coding downstream 260274 28194138 ~ 28194608 (+)
XLOC_015502 NA coding downstream 311596 28245460 ~ 28350447 (+)
XLOC_015503 NA coding downstream 460079 28393943 ~ 28423487 (+)
XLOC_015504 mmp15b coding downstream 519474 28453338 ~ 28521429 (+)
XLOC_015489 BX649522.1 non-coding upstream 608600 27321014 ~ 27324181 (+)
XLOC_015488 BX649522.3 non-coding upstream 690070 27218149 ~ 27242711 (+)
XLOC_015486 BX511023.1 non-coding upstream 922436 27000542 ~ 27010345 (+)
XLOC_015485 NA non-coding upstream 1190575 26721068 ~ 26742206 (+)
XLOC_015483 BX248497.1 non-coding upstream 1259934 26667680 ~ 26672847 (+)
XLOC_015511 NA non-coding downstream 1778346 29712210 ~ 29727457 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000004_09684489_09685469 MC4R coding CI01000004 null 9684489 ~ 9686012 (+)