XLOC_023334 (gli3)


Basic Information

Item Value
gene id XLOC_023334
gene name gli3
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007135.7
NCBI id CM002908.2
chromosome length 42172926
location 11528270 ~ 11821505 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00046157
GGCAGCAGGAGCTACAcacttcaaattttttttttttcccgagaACCTTAAATTACAGCCTTAACCACCATAAACATTTAGGAGTTTTACGGTTCGCTGTACTTTTGTGTATAGACTTAGAGATATGTAGATTATGTGTTACTGCGCTTTTCCTGCCAAACGCACACACTTTCCAGAAGGGAAAAcggagaaataaataaaaaacaaaaacaaaacaacaaaaaagttcgCAGACCAATTTTTGGAGTTTAAAGTAAAGAGGCTAGCATTCTCTGCATCAAGCATCTGCGTACGGGCGAGAAGGACGTCTGCGAAGAGAGGACAGAAAAGTTTCACAACAACGAGTATCCTGTCTTAATGATGCTCTGAGGAATGCCCAGTTGTCATGGAACCCCAATTCCAGACCAGTTCTTCAACAGAGAAGAGAATGGAGAACGTTGTAGGCACCAATAGTGCACCCACTCGTACAGACATCAGTGAGAAGGCTGTGGCCTCCAGCACTACATCCAATGaGGATGACAGTTCAGGTTCACCATATCACCTCGAGAGGCGAAACACCATTAGTGCGCAGACTGATGTTGTGAACACATCAGGAAAAGTCAGTGAAGAGCCATCCACCTCTACAGACGAACGTCCTCCACTGGTGAAGAAAGAACTTCAGAGCTCTCTGCACCGCTTGGCAGACCACACCCTGCCCTATCGTGGAACACTGTTTGCCATGGACCCTCGTTCTGGATATCTGGACCCTCACTATaCTGCACCACAGTTCTTTCCTGCTTTTCATCATCCAGTACCAATTGATGATAGACACACACAAGGCCGATACATTTACGAACCCTCGCCAGTACCATCACTACACATGCCTCCTGCACTGGCAGCAAGCCCGACATTTTCTGATATCTCCCTCATCCGGATCTCACCGCACCGGAACCCTTCAATGGGGACAGACTCACCCTTTAACCCTTCACATCCTTACATTAACCCCTACATGGACTACATACGCTCCTTGCACAGCAGTCCCTCTTTGTCCATGGTTTCTGCAGCCAGAGGCCTTAGTCCTGCAGATACACATCACACTGGTTTAACCACAGCAGAGTACTACCACCAAATGGCCCTGCTTGCTGGTCACCGCAGTCCCTACGCTGACCTCATTCCCTCAGTGGGGTCCACAACAGGGCCTGCAAGCAGTGCCCTGCATATGGAGTACCTGCAGGCTATGGAAAGTTCGAGATTTCCTAGTCCTAGGCTGATAAACCGGCCCAGCAGGAAAAGACCCATCCCCAACTCCCCTTCCTTGTCTGACCCCAGTTTTGACTTACAGGCCATGATTCGCACCTCTCCCAACTCTTTAGTCACTATCCTTAATAATTCTCGCTCTAGCTCATCTAACAGTGGATCTTATGGGCACCTATCTGCTGGAACTATCAGTCCTGCTTTGAGTTTTGCATATCCTCCAACACCTGTAGCACTGCAGATGCATCAGCAGCTAATCAGTCGACAACCAGGCATCGTAGGATCTGCATTTGGACACAGTCCACCACTCATGCACTCAGCACCTGCTTTTTCAACCCAGAGACCTGTTCCTGCCATCCAAACCTCCAGCCTGGCACCAACAGAACGTTCAATAGTCTCCAATGACTCacagagtAAACCCACAAGTGAGTCGGCTGTGAGCAGCACAGGGGACCCCATGAACCATAAAAGGTCCAAACTCAAACCTGAAGAAGAACCACCCAGCCCCAGAGCCGTTAGCATGCAgGAGCAAATGAATGGAATGACTCTGGTGAAGGAAGAGGGCGATAAAGAGGAGGGCAAGCAGGAGCCAGAGGTTGTGTATGAGACTAATTGTCACTGGGATGGTTGCTGCAGAGAGTTTGACACCCAAGAGCAGCTTGTGCATCACATAAATAATGACCATATTCATGGAGAAAAAAAGGAATTTGTGTGTCGCTGGGAGGAATGTTCAAGAGAACAGAAACCCTTTAAGGCCCAGTATATGCTGGTGGTGCACATGCGCAGACACACAGGAGAGAAGCCTCATAAATGCACGTTTGAAGGCTGTTCAAAGGCATATTCCAGATTAGAGAACCTGAAAACACATTTGCGTTCACACACAGGAGAGAAGCCATATGTGTGTGAACATGAAGGCTGCAACAAAGCCTTTTCGAATGCATCAGACCGAGCCAAACACCAGAATCGGACACACTCTAATGAGAAACCCTATGTGTGTAAAATTCCTGGCTGCACTAAGCGGTACACTGACCCAAGCTCCTTAAGGAAACATGTTAAAACTGTACATGGTCCTGAAGCCCATGTCACCAAAAAACAACGTGGGGAGACATACCCACGACCCCCACCTCAGCCACGAGAACCTGGAGCAACCACTGACCAAAAGGAGTATACCCATGCTACCTCAAAACAGGATGAATGTCTGCAAGTCAAGTCAATCAAAACAGAAAAGCCCATGACGTCTCAGTCAAGCCCTGGCAGTCAGTCTTCATGCAGCAGTGACCAGTCCATCAACGGCCCCCATGTCAGCCAGGGAGTCCAGCTTACTGTGAACAGTATTGGGCTTGCGGGGGAGGTGGCAATGCTTGAGGACATGGAAAATGAAGAGGAGGATGAGGagaacagagaaagagagaaggagGATGCCCCCATTATGGACTCTACAGTATCCACAGCAACATCCTCTGCGGCAACAATAGTTTTGCAGACTCATCGAAGTGTTGGACGGCCCCTACGCTGGATGGAGCATGTTAAGATGGAGAGGTTAAGGCAGGTGAATGGAGCTGTGCCTAGGCTAGGATTCCTGCCTCCAACACCGCCCCCTAAAGGCCAGGCCATGCCTGCCCTCACAGGAAAGGGTCAATGCCTTGGGAGGAGTACTTCTGTGAGGGTGCCTCCATGCCCTGAGCCGTCCAACACAGAGCTGACAATTCTGAGTTTGCTGCATGAACGACGGGACAGTAGTGGCAGCAACACTAGCTCAGCTTACCTGAGCAGCAGCCGTCGCTCATCTGGCATCTCCCCCTGCTTTTCCAGTCGCTGTTCTAGCCAGGCTTCACTGTCAGAGTACAGCCCCCATCGACATATCCATAATCTCAGTGCAACTGATTCTTATGACCCTATTTCCACTGATGCCTCTCGACGCTCCAGTGAAGCCAGCCAGTATGATGGAGGAAGTTCAAGTGCAGTGGTGTTTGGTGGAAGTGGAGTTTTCAAGGGCAGTGGTATGGGATCAAGAGGGGATCTGAACCTCACTCCAGCTCAACACTATAGCCTAAAGGCCAAGTATGCAGCAGCAACAGGTGGACCGCCTCCCACACCCTTGCCCAGTATGGGGCATATAAACCTAAAGAGTCACTTTGCTTTAAAGGAAGACAGAAAGGACACTGGCCAGCTTACACTACCACCACTGGTCAGGTCACGTCGCTGTAGTGATGGTGCACACAACTCGCATGACAGTCAAGCCGTGTATCAACGAAAGGGAACATACTTTGGTGGTGGTCCAGGGAAAAATGATCGAAGAGCTAGTGATCCTACACATCACAAACAAAATCTTAGTTCTTATGGCTTGCCACAAGTAcgacatttcagtagtttaaaCAATATGACTTCATCACCCAATCCTGCTAGTTATGGTTACTTAAACAGAGAAGATCACAGTCTGAACCTACAGAATTCCACCTGTCACGTAGATAGCTTTCAGAGTGGTCTGCACTCCCCTTGTCCTCCTAGCATCATGGAGCAATCAGCACTTGAGAACATTTCCATAAACCAGGATGGTCTTTTGTTACGTGTCAATGAAAACATCCAGTCTGACTTCATGCAGTATCTCCATTCCCAAGATCAGGAATCAATAATTAACCAAGACAACCATAGGCCTATTTTCAATCCCGCAAATGACCAGAACTTCCTCAGTCCACAGCAGCACCAAGAGGGAGTAGAGCAAGAAGACACTAGTATTGATCTGATGCCTATCCAGTCGAATGAAGTGAGCTCTGGTAGTGCCGATGTTACCATTCCAAGGCAGCCGTTTCAGAGGTGTGGCAGATGGTCAGACCAGAGTGGCTCAGTAAGCAACGCCTTTGGTCGATTTGGAAACATGGTTGTACAACAGCAGCCTATAGATTTTATTGATCAGCACTCAGCTCTTCAACACATGGGAGGTATAAGCTATGGGTGCAGAAATTCAGAGCAGCATCTACAAGTAGCAAAACCAGCCCAAGAGAAGTCCAGGATGAAAACAGGCATTAAGACTGAGTCTTCCTCAACCTTCCAACTGGAATCCAAACACAGCAACTTTGGTCGACCAGACTTCTCTCATATCTTTTCGGCCCCCATTCATCAAAAATGTTCCCAGCATACAGTTGTATCCCAATCTTATCCCCAACAAAATCAAATTACAAATCAAGATAGCAGCAACCTCTTTTTGCAAAGACCAGGTAACTGCAGCTTACTCTTGGCTTACCGGCCTCAGCCAGCTGTCAACACTTCCTACTCCACTAGGCAGGATATTAACAGCCATAATGTACAATCATGCCATCCACAAAGCTTGAACAATAGACTAGGCACAAATTGTTCCCCTTCAAATCAGGTTTCCGTTGTGAAGCTTGATCAAGTTAATCACCTTCAAATCAACTCTTGCTCATCAATTCAGCAACAAACACCTGTGTTTATTGATAAGTGTTTTGACCTAGAAAAGTCCAAGCTCTCTCACGCCATAGTACAGTCATGTCTAATGGAATCATTGATGGCAGAGAAAGAAAGAACTTCCAAAGTTCTTCTGTCATCTGGGGTTGGTCAGGTGACTAGCACAGTAGAAAGAAGCCCAGCTGAAAAAGTTGGTTTAGGAATTTGTTCCATTGGTGATGATAGTTATGATCAGGGCAGTGTAGTGTCTTCCTCTCAACTCAGTAATTCTCATGATTCCTTTGCATTTCACAGTGTGAATCCAGGCACTAACAACATGGCTATTAGTGACATGAGCTCCCTCCTCACCACCCTCGCAGAAGAGAGTAAATTTCTGGCAATCATCCAATAGTTTGTGAActcccccaccaaaaaaaaaaaaaaaattacacttaacacaaatttaaaatacttttgcATGCAAAGTTGTGGTATGAGAAAAAAGCCTTATGAACACTGTTTAACAGGCAGTGTTGATAAAAGAGTTGCTATAAACTCTATTTTGATGGGGGGGGGGGTTACATCTTCTTAGAGGATGATCATGAAGGCACCTAGAGGATGAAAGAGGCACCAATCTTTTTGCCTCATAGTTTTCAGTGTTGATTTTGCTCTTATTAAGTTCTGTTGCACTGTTGATACAAGTGCATGGCATTTTTCTTAAATGCTAAATTGTGCATAGTATTCACTAAAATGAGTAGGTTAACTCAtattgtgtacctttattttagAGTGCTTTGCAAACTACAAAGAAGATGTAAATATGCACAGACATGACTGTCAACAAGTTAAGAGAGGGTTGAATATTTTTACAggaaaaaatgtcatgtttaccAATGTTGTGGTGATTTAAGTTTTAACAAATCTTGTTTTGGCCAAATTTTCACACCATCGCTAGAAAGAGAAACATTTTGTAACGTGATCAACAAATCATCTAGAACTGATCTGTATCTTAACTATATTGCTACAACTTTGTAAATATTCTTTCTTTGTTTAccataataatttacattttacacattttctATATAACTGTTAATGACTGGGGTCAATGTTAAACAGTACTTTATGTGACAAAtgtcaagaaaaaaaacatctgtggTCATTTTAGTAAAGTTCAATATATGGCTTATTGCACAGAGGATTTGGAATTTGGGATCAAAAGGTGTTGTTTAGAGTACAAATTCATGTTTAAATTTATCTGAATATGTcagtaattttatttgttattttgtaaaaGTCAGTAGTGTGCTGTTTTTGTCACAGCAGTGCAGTAAATATATAGTAAGATGTCATGTATACCTTGACTTTTTAGATCAACTTGTCTTCTGTCTACACATTTATGATTACATAAGCAAATTTCACATTTATATAAACAATGGCACATCAAGAGCAAAAAGAGTTTAAAGCAGTATTAAAACAATCTGCAATGTCtatgtacagtttttttaaagatgtacTTCAGCAATTAAGTAATGTTTTTGTACAGTTATTTCTGCAGTCGTATTACAGTGTCttttattttaatcacaaaaGTGGTGTGACCCATTCCAATAGGACACGATCAGAAGGTTTACGCCTAAGGTATGTGCCTTATTTATGCCTGTCCATACAAAAGAATCACTGCCGTATTCCTTTTTTACACAAATTATAGAAAAACAAAAAGGGAGGATTCCTATGACTTCATGTTTTGGTTGGGCATTGAGAAATGTGACGTAAACATTgttgtttctgttgttgtttGATTTCTTCAAGCttgtaaatacatattaatttGGTACACTGTAGTCGGAATAGTTTGcatctgaagtcagaattagaaaaaaaaaatatcttcctAAATATCTAAAGCAGGAATATCTGTGTTTTGTCCtacatttaaacaaagaaattaaaatagAGTCATGGTGCCTAGCACTTTTAAACTGGGAACAACTCTTAATGCTTTTTATATAAGATTACAACAATTGTTTGTatggttttaataaaaaaataa

Function

symbol description
gli3 Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within regulation of neurogenesis. Located in chromatin. Is expressed in several structures, including brain; ceratohyal cartilage; hindbrain neural tube; neural keel; and neural rod. Human ortholog(s) of this gene implicated in Greig cephalopolysyndactyly syndrome; Pallister-Hall syndrome; anodontia; polydactyly; and syndactyly. Orthologous to human GLI3 (GLI family zinc finger 3).

GO:

id name namespace
GO:0006355 regulation of transcription, DNA-templated biological_process
GO:0007224 smoothened signaling pathway biological_process
GO:0048568 embryonic organ development biological_process
GO:0009952 anterior/posterior pattern specification biological_process
GO:0009953 dorsal/ventral pattern formation biological_process
GO:0050767 regulation of neurogenesis biological_process
GO:0045944 positive regulation of transcription by RNA polymerase II biological_process
GO:0048699 generation of neurons biological_process
GO:0005634 nucleus cellular_component
GO:0046872 metal ion binding molecular_function
GO:0003676 nucleic acid binding molecular_function
GO:0003677 DNA binding molecular_function
GO:0003700 DNA-binding transcription factor activity molecular_function
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding molecular_function
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific molecular_function

KEGG:

id description
ko04340 Hedgehog signaling pathway
ko04024 cAMP signaling pathway
ko05200 Pathways in cancer
ko05217 Basal cell carcinoma
ko03000 Transcription factors

ZFIN:

id description
ZDB-GENE-041111-162 Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within regulation of neurogenesis. Located in chromatin. Is expressed in several structures, including brain; ceratohyal cartilage; hindbrain neural tube; neural keel; and neural rod. Human ortholog(s) of this gene implicated in Greig cephalopolysyndactyly syndrome; Pallister-Hall syndrome; anodontia; polydactyly; and syndactyly. Orthologous to human GLI3 (GLI family zinc finger 3).

Ensembl:

ensembl_id ENSDARG00000052131

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00046157 True 6688 mRNA 0.44 15 11528270 11821505

Neighbor

gene id symbol gene type direction distance location
XLOC_023333 prpf4bb coding downstream 22206 11469811 ~ 11506064 (-)
XLOC_023332 pxdc1b coding downstream 60721 11451077 ~ 11467549 (-)
XLOC_023330 acad11 coding downstream 82104 11350330 ~ 11446166 (-)
XLOC_023331 BX005057.1 coding downstream 116329 11411822 ~ 11411941 (-)
XLOC_023329 myrip coding downstream 202421 11112113 ~ 11325849 (-)
XLOC_023335 NA coding upstream 52832 11874337 ~ 11875212 (-)
XLOC_023336 tm9sf1 coding upstream 66380 11887885 ~ 11908115 (-)
XLOC_023337 CU929203.2 coding upstream 307000 12128505 ~ 12129456 (-)
XLOC_023338 CR855257.1 coding upstream 333602 12155107 ~ 12156644 (-)
XLOC_023339 NA coding upstream 775033 12596538 ~ 12601729 (-)
XLOC_023665 dre-mir-735 misc upstream 26356456 38177961 ~ 38178027 (-)
XLOC_023326 AL840641.2 non-coding downstream 479710 11048446 ~ 11048560 (-)
XLOC_023325 AL840641.1 non-coding downstream 516719 11011436 ~ 11011551 (-)
XLOC_023324 dre-mir-7147 non-coding downstream 580125 10948064 ~ 10948145 (-)
XLOC_023323 AL840641.3 non-coding downstream 622984 10905172 ~ 10905286 (-)
XLOC_023341 NA non-coding upstream 920431 12741936 ~ 12746499 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000327_04196209_04202497 GLI3 coding CI01000327 null 4195990 ~ 4203470 (-)