XLOC_023484 (mbtps2)


Basic Information

Item Value
gene id XLOC_023484
gene name mbtps2
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007135.7
NCBI id CM002908.2
chromosome length 42172926
location 25447911 ~ 25461267 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00046463
ACACGCGGAAGCGACGGCTTCCACTGGTGTTTTGTACACAGTGGATGTGCAGAGCCGTGCTGGACAATTGAAATTGCCCTGGAATTGGTGTGTGTTTTAGACGCATGCAGCCCGGTGTGCCATGATCCCCATAGCGGTGGTGGTGTGTGTGATGGGCGGCTGGTGTACCGTGTATCTGGCGGATACGCTGCTGCGGTCATCCAGTTCGGTAAAGAACCGCTATGAATCATGGTTATCCTCGAATGGATTCACACTATCTCCCTTCCATATCAAGTGGCACACGGGCATCTTCAACCGTCTGTTTGCCAGATGTGCTCATTTCAACCCTCACTTTCTCTACATCTGGTTCAGTGCTGGTATGGTGTTCGGGGTTTTGGCGATGTTTGGCTCAGTTGTTCTCCTGAGCAAAACATTACTGCAGACTCTGCATCAGATGATGGCAGACACACCGGACGGGTCCCACGAACAGGTTTTGCAAGTGGTGGTGCCTGGTGTAAATCTTCCTGTCAGTCAACTGGCCTATTTTTTCATCGCTATCTTGGTCAGTGGAGTCATACATGAGTTTGGCCATGGGGTGGCAGCACTGAGGGAGCAGGTGAGGCTGAATGGTTTTGGCATGTTCATGTTTGTGATTTATCCCGGAGCGTTTGTGGATCTCTTCACCACACATCTGAACCTCATCTCTCCAGTCCAGCAGCTCAGAATATTCTGCGCTGGAGTCTGGCACAACTTCATGCTGTGTGTTGTGGCTCTCAGCTTCCTGTTCTTGCTGCCCATCTTTCTGTTTCCCTTCTATTACACCGGAGCAGGAGCGCTGGTCACTGAAGTGGTGGAGggttCTCCCTCGAGTGGACCTCGTGGGCTATTTTTAGGTGATCTGATCACACAGCTGGAAGACTGTACAGTTCGGGGTGTACAGGACTGGCACAGCTGCGTTCAGCATCTATCCCATAATCCTCAGACAGGCTACTGCGTCCACACTGCCAAACTCCATCTCAGCTACACGCAAGGAAGAGCATTCAAGCGTCTGGATGGCACTATGGAGTGCTGTGGGAACAACAGCTTGACAGACCTCTGCTTCTCTTACAGTAACAACGTGGAGAGCAAATTAtttgcCTGCCTGCCGGTGAGAAAGACCATTGAAGCGAGTCGTACATGTCACACCAACACAGACTGTCAAACAGACTTCACCCCAAGCTTGTGTTTAATCCCTTCTCTGGAGAACCAGACCCGATTGATCCGGGTCAAACATCCTCCACAAACAGACATGCTCTTTGTCGGATACTCTTCACACCTACAGTATTCAGtgagtCTAACCAATTTTGTTCCTCGGCTGGGCTTTCTTCATCCAGACTTGCCTGTCATGCTGGAAACCTTCTGCAAATACCTGGTCTCACTGTCCGGGGCTCTTGCAGTGGTAAATGCAGTTCCATGTTTCGCTCTGGACGGTCAATGGATGCTCACAGCCTTCCTCGAAGCCACGCTGAGCTCCGTTATCCAGGAGAGGAACAACCGAGAGCTGATCGGCTTCTTTTTTCTACTGGGAGGCAGTGCTCTTCTAGCAGCAAATGTGGCTCTGGGCCTGTGGATGGTCACGGCACGGTAACACACACCCATCTCCTCCAATCAGACGGTTTGGGGGAAATGTTGATTCAATATCCTTCTTGAACTGATGGAGGAAACCACTGGGTTGTTTTACCTTTGCTGGTTATTGTCAGGCTGTAGAACCAAAGGGTTTAGATCGTTGCTTTATCCGAGAACACTGGTGATCTTGGTTTGATTGGCTTGAATAGAAACAAGCGGTAAAGAAGATCTTGAAGCTGTGTGCTTTTGCAATGTGACCTCAGGACAGCACCAATAGTGCCGTATCTGATCAATATGTGATCACATTGTGTCTGATTCATCATGCAAACCCACAAATGAAGCTTTAATAACAAATACATGATGGATTTTGAAGGCATTAAATGCCTGTTTGGCCTTTTTGTCTTCCTTATACATATGATATCCGTAGGTTTAAAGGtgtagttcacctcaaaatgaaaTTTATTcgctatttactcatcctcaagtggttataaacctttatgagtaactttcttctgttgaacactatagaagatattttaagaaagctgaaaacctgtaaccattgacatccgtagtaggaaaaacatatactatggaagtcaatggatagaggtttccagctttcttcaacatGTCTTAATTTCTGTTCAAAGGGAGAAGAAGCTCAGATACGATTGGAACAAGCAAagtaaaaaataacagaaattaaaaaaaaaaaaaaactgagtaaatattgacagaattttcatttttgggtgaagtatcctCTTTTAGTTTTAAATTGAAAAGTTCGTCAATACTCATGTCACTTCAACCCAAACCTTAACATctgtactttaaaaataaaaacaattactttATTTACCTCAGTAGGGAAGTTTaggaattaaaaacaaacatgttgtcatttgaaaaaaaatttagtcTTGAAGTAaccttaaaaaatgtacatttagtcCACATGACCAGCCAAACCGACtgaaatttatttaatgtaaaaaaaaaaaaacaagaattaaaatgtacatataGCGAATGGACACATATAGCATGAAAACggcacaaataaacaaactactgCAGTGATTTGAGCTTTGGGGAGTAGCTTTAGTGGGTTAGCCAGAGATTTAATGGCTGATTGTTAATTTTACCAGAGGTATATGCGCTGAAACAACTGTTAACTGTGAAGATGTTCTCGTATACAACATACCAAAAGAAACATTCGCTAAAATACGCTTGGGAAGCATTCATATTGTTTATGATCTGTATACTGTGAAATATTTTACCCAACAACAATTAGCCAGACTGTGGGTTAGAGCTGCACTAAACTAGGAATTATTACTTGttatcacacacacattctcttgCTCTTTTAATTTGTTGTCTTTATCATCCTACCTGGCCTGttgtaaatatgtttataaaagtcaTTTACATAA

Function

symbol description
mbtps2 Predicted to enable metalloendopeptidase activity. Acts upstream of or within cartilage development and lipid metabolic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in X-linked keratosis follicularis spinulosa decalvans; X-linked mutilating palmoplantar keratoderma with periorificial keratotic plaques; ichthyosis follicularis-alopecia-photophobia syndrome 1; and osteogenesis imperfecta type 19. Orthologous to human MBTPS2 (membrane bound transcription factor peptidase, site 2).

GO:

id name namespace
GO:0006629 lipid metabolic process biological_process
GO:0031293 membrane protein intracellular domain proteolysis biological_process
GO:0051216 cartilage development biological_process
GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress biological_process
GO:0006508 proteolysis biological_process
GO:0051091 positive regulation of DNA-binding transcription factor activity biological_process
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0005737 cytoplasm cellular_component
GO:0004222 metalloendopeptidase activity molecular_function
GO:0016787 hydrolase activity molecular_function
GO:0008233 peptidase activity molecular_function

KEGG:

id description
ko04141 Protein processing in endoplasmic reticulum
ko01002 Peptidases and inhibitors

ZFIN:

id description
ZDB-GENE-030131-6598 Predicted to enable metalloendopeptidase activity. Acts upstream of or within cartilage development and lipid metabolic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in X-linked keratosis follicularis spinulosa decalvans; X-linked mutilating palmoplantar keratoderma with periorificial keratotic plaques; ichthyosis follicularis-alopecia-photophobia syndrome 1; and osteogenesis imperfecta type 19. Orthologous to human MBTPS2 (membrane bound transcription factor peptidase, site 2).

Ensembl:

ensembl_id ENSDARG00000057577

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00046463 True 3026 mRNA 0.43 11 25447911 25461267

Neighbor

gene id symbol gene type direction distance location
XLOC_023483 phex coding downstream 5565 25404358 ~ 25442346 (-)
XLOC_023482 ptchd1 coding downstream 83136 25347503 ~ 25364775 (-)
XLOC_023481 adgrg2a coding downstream 146200 25285758 ~ 25301711 (-)
XLOC_023480 hhla2b.1 coding downstream 191241 25244946 ~ 25256670 (-)
XLOC_023479 hhla2b.2 coding downstream 203273 25236381 ~ 25244638 (-)
XLOC_023485 cnksr2a coding upstream 23997 25485264 ~ 25673442 (-)
XLOC_023486 chrnd coding upstream 221804 25683071 ~ 25691020 (-)
XLOC_023487 NA coding upstream 289369 25750636 ~ 25754146 (-)
XLOC_023488 klhl24b coding upstream 299719 25760986 ~ 25788841 (-)
XLOC_023489 CR352209.2 coding upstream 544362 26005629 ~ 26025582 (-)
XLOC_023665 dre-mir-735 misc upstream 12716694 38177961 ~ 38178027 (-)
XLOC_023471 NA non-coding downstream 618510 24800776 ~ 24829401 (-)
XLOC_023468 NA non-coding downstream 752154 24553793 ~ 24695757 (-)
XLOC_023466 NA non-coding downstream 944889 24416324 ~ 24503022 (-)
XLOC_023467 NA non-coding downstream 955394 24492203 ~ 24492517 (-)
XLOC_023461 NA non-coding downstream 1349032 24095316 ~ 24098879 (-)
XLOC_023490 NA non-coding upstream 569981 26031248 ~ 26032271 (-)
XLOC_023491 NA non-coding upstream 771433 26232700 ~ 26236578 (-)
XLOC_023496 NA non-coding upstream 893429 26354696 ~ 26369185 (-)
XLOC_023503 NA non-coding upstream 1180632 26641899 ~ 26648023 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000018_06757523_06763462 MBTPS2 coding CI01000018 null 6756756 ~ 6764763 (-)