XLOC_033789 (aph1b)


Basic Information

Item Value
gene id XLOC_033789
gene name aph1b
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007118.7
NCBI id CM002891.2
chromosome length 74282399
location 29176924 ~ 29186939 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00066097
aatataattgaaaCATATAATTGAATGCTGACGAATTAACCCAATATGAGTAAACATTTTCGTAATAAATTTCAGTTTTAGAAATACATTGcagactttaaaataataatttgaacaatacattttaagGCGGATATATAGGACTCGGGAATTCATGCACTTAAATGTGTGTCAAGTTTCACAGGACAATAGTAGGGTTCAATAACGCTGTTAATAAACGGACTTCAGTGGGTGAGGGCATTTTTCTGGCTGGTGTCTTTGCTGCTGTCGTCTCTCGTGTGGTTCATCACGGTCCAGATCAGCAACAAGAACAGTGCCACTCAGCAGAGAGGGCTGCTCATTTTCGGAGTTGTGCTCTCTGTCCTGCTTCAGGAGGCTTTCAGATATGGTTACTACAGACTGCTGAAAAAAGCAAATGAAGGCCTGTTGGCTCTCAGTCAGGAGGACACCATGCCCATCTCCATGCGGCAGCTAGCTTATGTGTCCGGTCTGGGCTTTGGCTTCATGAGCGGTGCGTTCTCTGTGGTCAACATCCTCTCTGACTCCTTGGGTCCAGGAACCGTTGGCATTCATGGCGAATCCCAGCATTACTTCATATCGTCAGCCTTCATGACTTTGGCCATTATCCTGCTCCACATGTTCTGGGGGGTGGTTTTCTTCGAGGCCTGTGAGCGTCAGAGATGGTGGGCTCTCGGAGCCGTGGTCGCCAGTCATCTAGTAGTGTCATG
>TCONS_00066098
GAAACACATGAAGTCACATGACTAGGAACCGGAAGTAACCTTAGACGCTGTGCTGAACAGTTTCAATCGCTGCGCTGAATGCACTCAACACATTTGGAAAAAACGGGCACAACAAACGCCTCCATAACGATTCATCTATGGTGCTTACAGAAACTGACTGACAGCCGTAGGACTCTCTCGTGGATGGAGTGTGTTAATAGCCTCCGAGAGCACTTATCCGTCTGAAGCGGCGGTCTTTTGAGTGCATTAGCAGGTTAGCCGAGCTACATCATGACAGTGGCGGTGTTTTTCGGCTGTACGTTTATCGCGTTCGGCCCGGCCATcgctttgtttatgtttacaatCGCTCGGGACCCGCTGCGTGTCATCTTTCTCATAGCAGGGGCATTTTTCTGGCTGGTGTCTTTGCTGCTGTCGTCTCTCGTGTGGTTCATCACGGTCCAGATCAGCAACAAGAACAGTGCCACTCAGCAGAGAGGGCTGCTCATTTTCGGAGTTGTGCTCTCTGTCCTGCTTCAGGAGGCTTTCAGATATGGTTACTACAGACTGCTGAAAAAAGCAAATGAAGGCCTGTTGGCTCTCAGTCAGGAGGACACCATGCCCATCTCCATGCGGCAGCTAGCTTATGTGTCCGGTCTGGGCTTTGGCTTCATGAGCGGTGCGTTCTCTGTGGTCAACATCCTCTCTGACTCCTTGGGTCCAGGAACCGTTGGCATTCATGGCGAATCCCAGCATTACTTCATATCGTCAGCCTTCATGACTTTGGCCATTATCCTGCTCCACATGTTCTGGGGGGTGGTTTTCTTCGAGGCCTGTGAGCGTCAGAGATGGTGGGCTCTCGGAGCCGTGGTCGCCAGTCATCTAGTAGTGTCATGTCTGACGTTTGTGAACCCACACTATCAAGGCAGTTTGATCCCGACCTACATCATACTGTCAGTCATGGCCGTCTGGGCATATTTATGTGCCGGAGGATCTTTGAGGAACCTGAAACTCTGCCTCACCTGTAAAGACAAAGACTTCCTGCTGGCCAATCACAGGCCCAGATAACCCACTAACAGGAGTTCTTTTTCCCTCCCAAAGACCGACTCTCGAAGCCAGTGTGCCGAAAACACGGCCAGCAGCCCTGCACTGAGAGGTTTATGCTCTGGGCTTTCTGAACGGTTGCGGAGTAACAGGAATTTTATGTCTGCAGATCTTGCACTTTCTGTAATGACCTCCTCTTCTGTTttttctgttgtgtgtgtgtgtgtgtgtgagagagatactGAGATTGTCAGAGAGAGTGAGTGTTTTGTTCTCAGAGCCTGTAGCAGGTTTTTAAATAAGGTCTTGTGTAGATTTGACCTTTAAATAGTTCACGTTTCCCCCCATGTCAGGCTTTTTCCTCCTGTGTATTTTACGTTTAACTGACCAATTAGACTCGAATGATTTGCCAATGTCCTGTCTTCAGTCTTAGCTCTTCAAATTTTCTGCTGATTAAAACCTGGAGTGACTagctttgtgttttctttttaattcgcGTGTCTGGTGTTGTCTTTTTAAGCTCAAGCTTATTTTTCCCAGGTGTTGTCATTTAAGGGGTGTTGGAATGTATTTGGATGATTAAGGCAATGGCCACTTCTCCATATAAACCACTACATTGAAGCTCCTCTGCTGGAAAGGTCTGACTGATTTGAACACACAGGGCTCAGCGGGATCAGTTTAGATGTCACTTTTATTGGACTCCTATGGGTTTAGTTTCTTTTGACTGTGAGGTGTATGAAGTTTTCATTCATAATAAAGTAGCTTGAGCTCCAGTCTGCTGTATTTTCTTCATTGTGGGCTGTCATGTACTTCCTGAAATCAAAGAACCTTTTGTTTATGAGCATTTATTGACAGTAGAGGTTGATGTTTTAATCCCTGTCATGTTGTGAATGAGAAGCAAAGAAACTATTCCTAATGTGAAACATTCTAATTGAAACGCTGATCTCACAA
>TCONS_00066099
TTGGCAAAGGACCCGCAGCTGGGACTTTAACTCGGGTCACTGTGAGCACCACTAGGCTATTGACACCAAGAAAAAGAAAGCACAAGCCCTAGCACATTTCCACTGTGTTTAAATAAGCAAAGGATTCCGTCAATGATTGACATTGGCAGTCAGTAGGAGGGTTGTTGTTAACCGTCTGTCATTGTATCTCTCACAGAAAAGCAAATGAAGGCCTGTTGGCTCTCAGTCAGGAGGACACCATGCCCATCTCCATGCGGCAGCTAGCTTATGTGTCCGGTCTGGGCTTTGGCTTCATGAGCGGTGCGTTCTCTGTGGTCAACATCCTCTCTGACTCCTTGGGTCCAGGAACCGTTGGCATTCATGGCGAATCCCAGCATTACTTCATATCGTCAGCCTTCATGACTTTGGCCATTATCCTGCTCCACATGTTCTGGGGGGTGGTTTTCTTCGAGGCCTGTGAGCGTCAGAGATGGTGGGCTCTCGGAGCCGTGGTCGCCAGT

Function

symbol description
aph1b Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in Notch receptor processing; Notch signaling pathway; and protein processing. Predicted to act upstream of or within positive regulation of catalytic activity. Predicted to be located in membrane. Predicted to be part of gamma-secretase complex. Predicted to be active in endoplasmic reticulum. Predicted to be integral component of membrane. Is expressed in forebrain; hindbrain; midbrain; presumptive neural retina; and trunk. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to several human genes including APH1B (aph-1 homolog B, gamma-secretase subunit).

GO:

id name namespace
GO:0007219 Notch signaling pathway biological_process
GO:0007220 Notch receptor processing biological_process
GO:0016485 protein processing biological_process
GO:0043085 positive regulation of catalytic activity biological_process
GO:0070765 gamma-secretase complex cellular_component
GO:0005783 endoplasmic reticulum cellular_component
GO:0005887 integral component of plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0004175 endopeptidase activity molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-031118-31 Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in Notch receptor processing; Notch signaling pathway; and protein processing. Predicted to act upstream of or within positive regulation of catalytic activity. Predicted to be located in membrane. Predicted to be part of gamma-secretase complex. Predicted to be active in endoplasmic reticulum. Predicted to be integral component of membrane. Is expressed in forebrain; hindbrain; midbrain; presumptive neural retina; and trunk. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to several human genes including APH1B (aph-1 homolog B, gamma-secretase subunit).

Ensembl:

ensembl_id ENSDARG00000005612

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00066097 False 728 processed_transcript 0.46 5 29176924 29182744
TCONS_00066098 False 1974 mRNA 0.46 6 29177191 29186939
TCONS_00066099 True 500 lncRNA 0.51 3 29182076 29182727

Neighbor

gene id symbol gene type direction distance location
XLOC_033788 slc38a8b coding upstream 717 29163762 ~ 29176207 (+)
XLOC_033787 tmppe coding upstream 15001 29153018 ~ 29161923 (+)
XLOC_033786 mtbl coding upstream 27696 29148714 ~ 29149228 (+)
XLOC_033785 gnao1b coding upstream 32377 29133321 ~ 29144547 (+)
XLOC_033784 tradd coding upstream 52346 29115890 ~ 29124578 (+)
XLOC_033790 NA coding downstream 91628 29278567 ~ 29280954 (+)
XLOC_033791 si:ch211-112g6.4 coding downstream 106513 29293452 ~ 29298477 (+)
XLOC_033792 rab8b coding downstream 114558 29301497 ~ 29310861 (+)
XLOC_033793 foxb1b coding downstream 274121 29461060 ~ 29463253 (+)
XLOC_033794 NA coding downstream 280199 29467138 ~ 29467407 (+)
XLOC_033780 NA non-coding upstream 112527 29062175 ~ 29064397 (+)
XLOC_033770 BX323591.1 non-coding upstream 715346 28461463 ~ 28461578 (+)
XLOC_033769 BX072554.2 non-coding upstream 918298 28253644 ~ 28258626 (+)
XLOC_033768 BX005056.1 non-coding upstream 1263869 27912938 ~ 27913055 (+)
XLOC_033765 BX005056.3 non-coding upstream 1350863 27825945 ~ 27826061 (+)
XLOC_033795 BX927082.2 non-coding downstream 315935 29502874 ~ 29506147 (+)
XLOC_033797 NA non-coding downstream 373629 29560568 ~ 29631080 (+)
XLOC_033798 CR388046.6 non-coding downstream 544315 29731254 ~ 29732610 (+)

Expression


Co-expression Network