XLOC_035969 (her3)


Basic Information

Item Value
gene id XLOC_035969
gene name her3
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007119.7
NCBI id CM002892.2
chromosome length 54304671
location 46641314 ~ 46642556 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00070462
CACTCAACTCAAGGAAGTCTGATAGTCCTTATTCATCTGGATTTTTTAAACACACTGAGCATTTAAGGACAATGGCTGCAGCATCCAACAGTGCGGCGACGGCAAAACCCCAAAACGTTAAAAAGGTTTCAAAACCACTGATGGAGAAAAAAAGAAGGGCgcgtataaataaatgtttgaatcaATTAAAGAGCCTTCTGGAAAGCGCCTGTTCTAACAATATCCGCAAGCGAAAACTGGAAAAGGCTGACATTCTGGAGCTCACTGTGAAACATCTGAGGCATCTGCAAAATACGAAAAGAGGACTGTCCAAAGCTTGTGACTCTGCTGAATATCACGCTGGTTACAGAAGTTGTCTCAACACTGTAAGTCATTATCTACGAGCGTCGGACACAGACAGAGATTCCCGCTCCATCATGCTGACAAATCTTACGAGCGGTCTTAACCACAATAGAGTTCCTGATTTCAGTACCGTGGAGAGCGATCCCGCATTGATCTTTACACTACCAAGTACACTTCGACGACCACACAAAGTTCCCATTAGAACAGACGTCTCTTATTCCAGCTTTCAACAAACTGCAGAGAGAAAAGTTTGCTTAATGCCCAagaggactgagattggtgataGCGACAGAATGTCATTGGACGCAGCTCTTAGGAGCCAGGAATCCAAAAAGGCAGAAACCACACACTTCAGACCTAAAGATTTAAAGGTCATTGAGTGCTGCATTTTCAAACAGAATTATTGGCGACCTTGGTAGGCTAATGACTGCCCCTGATCTCATTGTTTTAACACTTAGACGTAAAAAAAAGACCTCTATTTTGCTTCTCATGCACtgtgtatttagatttttttttcaagaatgatgacgaatgtatattttattaataaacgtttacaacAT

Function

symbol description
her3 Enables DNA binding activity. Acts upstream of or within negative regulation of neurogenesis and negative regulation of transcription, DNA-templated. Predicted to be active in nucleus. Is expressed in several structures, including DEL; central nervous system; epiblast; midbrain neural keel; and neural plate. Orthologous to human HES3 (hes family bHLH transcription factor 3).

GO:

id name namespace
GO:0007219 Notch signaling pathway biological_process
GO:0006355 regulation of transcription, DNA-templated biological_process
GO:0006357 regulation of transcription by RNA polymerase II biological_process
GO:0009952 anterior/posterior pattern specification biological_process
GO:0045892 negative regulation of transcription, DNA-templated biological_process
GO:0050767 regulation of neurogenesis biological_process
GO:0050768 negative regulation of neurogenesis biological_process
GO:0045665 negative regulation of neuron differentiation biological_process
GO:0005634 nucleus cellular_component
GO:0003677 DNA binding molecular_function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding molecular_function
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific molecular_function
GO:0046983 protein dimerization activity molecular_function

KEGG:

id description
ko04010 MAPK signaling pathway
ko04012 ErbB signaling pathway
ko04020 Calcium signaling pathway
ko04151 PI3K-Akt signaling pathway
ko05206 MicroRNAs in cancer
ko05205 Proteoglycans in cancer
ko01521 EGFR tyrosine kinase inhibitor resistance
ko01001 Protein kinases

ZFIN:

id description
ZDB-GENE-980526-204 Enables DNA binding activity. Acts upstream of or within negative regulation of neurogenesis and negative regulation of transcription, DNA-templated. Predicted to be active in nucleus. Is expressed in several structures, including DEL; central nervous system; epiblast; midbrain neural keel; and neural plate. Orthologous to human HES3 (hes family bHLH transcription factor 3).

Ensembl:

ensembl_id ENSDARG00000076857

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00070462 True 905 mRNA 0.41 4 46641314 46642556

Neighbor

gene id symbol gene type direction distance location
XLOC_035968 tas1r2.2 coding upstream 21694 46610020 ~ 46619620 (+)
XLOC_035967 tas1r2.2 coding upstream 43563 46587593 ~ 46597751 (+)
XLOC_035966 pimr186 coding upstream 86153 46552778 ~ 46555161 (+)
XLOC_035965 pimr187 coding upstream 102036 46536893 ~ 46539278 (+)
XLOC_035964 si:ch211-196g2.4 coding upstream 207559 46418996 ~ 46433755 (+)
XLOC_035970 NA coding downstream 65664 46708220 ~ 46709848 (+)
XLOC_035971 FO704898.1 coding downstream 123873 46766429 ~ 46766545 (+)
XLOC_035972 espn coding downstream 296835 46939391 ~ 47088528 (+)
XLOC_035973 BX000472.2 coding downstream 417845 47060401 ~ 47060515 (+)
XLOC_035974 BX000472.1 coding downstream 429664 47072220 ~ 47072337 (+)
XLOC_035960 NA non-coding upstream 494612 46045163 ~ 46146702 (+)
XLOC_035957 CU137648.1 non-coding upstream 868695 45767653 ~ 45772619 (+)
XLOC_035955 NA non-coding upstream 898409 45731192 ~ 45742905 (+)
XLOC_035954 BX088696.2 non-coding upstream 1030531 45608540 ~ 45610783 (+)
XLOC_035953 NA non-coding upstream 1036659 45600915 ~ 45604655 (+)
XLOC_035976 CR792439.1 non-coding downstream 512106 47154662 ~ 47159033 (+)

Expression


Co-expression Network