XLOC_004195 (cybb)


Basic Information

Item Value
gene id XLOC_004195
gene name cybb
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007122.7
NCBI id CM002895.2
chromosome length 45484837
location 29795155 ~ 29833698 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00008028
ATGCCGAGTCCTCTTTCTGTCTTGTGGCTCACTTTCTCTCGATCTCATCTCCTGATCTTCTCTTTCAACTCTGCTCAACATCATGGGAAACTTTGCTGCAAATGAAGGACTATCCGTTTTTGTTATCCTGGTATGGCTCGGGATCAATGTGTTTCTCTTTGTATATTTTTACATGGCCTTTTTGATTGACAAATACTACTATACTAGAGTCATTCTTGGGCATGCTCTCTCGTGGGCCAGAGCTCCAGCTGCATGTCTCAACTTTAACTGCATGTTGATCCTGCTGCCGGTCTGCAGAAATCTGCTCTCGTTTCTCCGAGGATCTATACAGTGCTGCAGCCGCACTGCAGCTCGACAGCTTGACAGAAACATCACTTTCCACAAATTGGTGGCCTACATGATTGCCTTCCACACAGCCGTCCACATCATAGCCCACCTGTTTAACTTTGAGAGATTCATGGACTCTCAGCTGATGATCAACAGCAGTCACCTGCCGTATGTGCTCTCTCAGATTGGCAACAATGACAACAGATCCTACCTGAACCCCATCAGGAGCAATGACACGAACCCGACCATAGTGATGTTTACGACAGTAGCAGGATTGACGGGTGTCGTGATCACCCTCGCCCTCATCCTCATCATCACCTCCTCCATGGAGGTCATCCGAAGGTCCTACTTTGAGGTCTTCTGGTTCACGCATCACCTGTTTATCGTCTTTTTCATTGGATTGGTGCTTCATGGAATCGGGCGTATTGTTCGAGGCCAGACTGATGCAGATCTACACGTTCATGACCCAACTATATGTCACAGCAAGTTTGAGAAGTGGGGCCAAAATGGCACCGACTGCCCAGTACCCATCTTTGCAGGAAACCCACCAAAGACATGGAAGTGGGTGGTTGGCCCCATGTTCCTGTATGTCTGTGAGAGACTGGTGCGCTTCTACCGCTCGCAGCAAAAAGTGGTCATTACTAAGGTTGTAACGCACCCTTCCAAAACCCTTGAGCTGCAGATGAAGAAGAAAGGCTTTAAGATGGAGGTGGGCCAATATATTTTCATGATGTGCCCGTCGATCTCTCAGTTAGAATGGCATCCCTTCACCCTCACCTCTGCCCCGGAGGAAGACCACTTCAGCGTGCACATCCGAATCGTAGGGGACTGGACGCAGGCACTTTACTCTGCCTGTGGAGGGGATAAGACTGCGGTGCTGGATGCTTGGACACTACCAAAGATGGCAGTGGACGGGCCGTTTGGGACAGCCAGTGAAGATGTCTTTCGTTATGAAGCGGTGATGCTGGTTGGTGCTGGTATTGGTGTGACGCCCTTTGCTTCTGTTCTGAAGTCTGTCTGGTATAAACACGTCCAGGAGAACCAAAACGTCTTCACTAAAAAGATCTATTTCTATTGGCTGTGTCCGGAGACTCAGGCTTTTGAATGGTTCGCTGACCTGCTGCAGAGTTTGGAAAAGCAAATGTCTGACAAAAACATGAGTGATTTCCTCAGTTACAACATCTATCTAACACGCTGGAAAGATGCTGAGGCAGCTCATCTCAGAGTTCAATATGAAGCGGAGGACGATCCTATCACTGGGCTTAAGCAGAAAACTCGCTATGGAAAACCCAACTGGGACAATGAGTTCAGTCTCATTGCATCCCAACACCCTGGtaCAAAAGTAGGTGTATTTCTGTGTGGTCCTACTGCACTGGGAAAAGCTCTGAGCAAGCAGTGCCTTTCACACACTGAGGGCGGAACTGAGTTTATTTTCAACAAGGAAAACTTCTGATGTGCTGCAAGAAACATCCACTGTTTGGACAAATCATGTTTGTGATAAAATATGGGgaacattgttttattttgttggtttgttcTCTAACAACTATATCTATGCAGTGCTGGATATAAAACTGACGATATAAGAGAAATTTTATTGGCTGTAAACCTTGACACCGGTTTccgtcccatgcctagtctgGATTACGCAAACAGATTTCAAAGATGAAGTATTTATAATTTAAAGTTAGAAATCAGATTACAATCACTTTTTATGGATTACATGATTAAATAATataatcctaaaggtaatttcaataccatTTTAAGACTTtctaaagaccttctcagaatattttaagagctCATCTCCACTtgaagttctaatcagtatcaaacctttaacttaaacatttgttaataaacagttgtagttaaataaatcaatggagcacaaccatgcaacagaactcagataagctcagaagaaacaaagcttgaaggaataaattacgtggttgttttcagcattaggcttcagccactgtttaaacttgtCTTTCTTCAACCAGGCGtacacattttcccattttgccgtccGTTTCTCTACACTCGGAGTGCATCACATCACCTTCCCACGTTTGGGACCAGGGGCAGCCAAGCTGGAGCATATACTCTGGTCCGGTGGAGCTTGGCCAGACACGCCCAGCCCAAACCAATCGCATGGATCGAGGAAAAcgatatatttatgcttttttggagtcaaacactttggacaacgcttaaacaaaatttatatttatgaCGAATATAAAAATGCTCACATATATAGTACATGAATGTCACAGCCATATCAGCCCAAGACCGCTTACTCACCGAAGCTAAACAGGGCTGAACCTGGTcattacctggatgggagaccacatgggaaaactaggttgctgttggaagtggtgttagtgaggccagcagggggcgctcaacctgtgttatgtgtgagtcctaatgcctcagtatagtgaaggggacacaatAAACCTATTTAACACATTAAACCGAGGTCGTGATTCTCTGTGGTCATTgtaaatcccatggcacttctcacaTTATTTAgattaggggtgtaaccccaATGTCCTGGCCAAGTTCactccattggcccttacccatcattgcctcccaataaatatatttatgccgttttggagtcaaacactttggacaacgcttgaacaaaatttaaaacatcgtaaagacttttaaaatacatttaaggaCCTTGATTTTGTCATATTTGGTTTATcgacttttaaaacttttaagaaCCCACGGAAACCCACCCATTTCAAACCTAGAGGATCTTGGCTGTGTAATGTCAGTGCTGttttaacaaatattaatatttttgtattttagggATTTCCAAACTTCACTCAAAgtattttttgctgcttgtttaaactacttatgaATTTACACAAATCTTGCggtctttgttttatgttcaatccacttaaatttgtaaaaatgtatttaacttatcgatttgtgttgagacaatatAACGGAACTGTGTGGAAAtcaacattttttgtttgttttgagtaTGTCCAGTTTTTGTTGGATAATTTAATCCAATTATGTGAAGCCCTTCCCCCATCCACTGTTTTAACTAATATTTCAATAGTGTAATACACATTTTGCAAATAAACAATTACATCAGCCcta
>TCONS_00008029
GCAACTGTTTTCCTCCAGTCCGGCTCAGGGCTTTTGGGAGTGTTGCGGATCTCTCTGTATGCTCCGTGGGACTCTTTCGCAGCCTGGTTCCATGAGGAGCAAGCCACCGGGGAAGGAGACCGGAGATGATCCGGTCTGTGTTACCAAAGGAGACATGACACAGAGTCTGTGCGGTGCCGTGTGAGGAAAGCACAACTTAAAAGGAGAGTTCAGCACAAACATGGACATTGTCTTTCTTTTGTTCAACACCAAAAGATGTTATGAACAATGTTGGAAATTGGTTGCCGAAATTGcgaaaaacaattactatggaaatcaatgactgtttccaacttgcttcaaaatatcttcttttgtgattgaAACAAGTAGATGGTGAGAATATGATgacagttttcatttattttgggtgaattatcccttttaaAGTAAGGGACAGCTAAACTTGTAATATATTGTTAATGATCAAAATATAAGTTAAGATATTTTTGAGCAAACCTTGTAGGTTGCAGAcactctacactgaaaaaaatgaattagATTTAGTAATTCTTTAAGGttagtggttgtaaactatttatatgggctgaatttaagcaaagTAATTtactaatgttcaacttaatttgtttgcttaaattcagcccatataaattgtttgcaaccatttaccttaaaaaaaatgagtaaatccaatgaaacgtttttatttttcagtgatCAGAAATGAAGTAATGCTATTTTGGATCagcatgaagCTGGTATGGCTCGGGATCAATGTGTTTCTCTTTGTATATTTTTACATGGCCTTTTTGATTGACAAATACTACTATACTAGAGTCATTCTTGGGCATGCTCTCTCGTGGGCCAGAGCTCCAGCTGCATGTCTCAACTTTAACTGCATGTTGATCCTGCTGCCGGTCTGCAGAAATCTGCTCTCGTTTCTCCGAGGATCTATACAGTGCTGCAGCCGCACTGCAGCTCGACAGCTTGACAGAAACATCACTTTCCACAAATTGGTGGCCTACATGATTGCCTTCCACACAGCCGTCCACATCATAGCCCACCTGTTTAACTTTGAGAGATTCATGGACTCTCAGCTGATGATCAACAGCAGTCACCTGCCGTATGTGCTCTCTCAGATTGGCAACAATGACAACAGATCCTACCTGAACCCCATCAGGAGCAATGACACGAACCCGACCATAGTGATGTTTACGACAGTAGCAGGATTGACGGGTGTCGTGATCACCCTCGCCCTCATCCTCATCATCACCTCCTCCATGGAGGTCATCCGAAGGTCCTACTTTGAGGTCTTCTGGTTCACGCATCACCTGTTTATCGTCTTTTTCATTGGATTGGTGCTTCATGGAATCGGGCGTATTGTTCGAGGCCAGACTGATGCAGATCTACACGTTCATGACCCAACTATATGTCACAGCAAGTTTGAGAAGTGGGGCCAAAATGGCACCGACTGCCCAGTACCCATCTTTGCAGGAAACCCACCAAAGACATGGAAGTGGGTGGTTGGCCCCATGTTCCTGTATGTCTGTGAGAGACTGGTGCGCTTCTACCGCTCGCAGCAAAAAGTGGTCATTACTAAGGTTGTAACGCACCCTTCCAAAACCCTTGAGCTGCAGATGAAGAAGAAAGGCTTTAAGATGGAGGTGGGCCAATATATTTTCATGATGTGCCCGTCGATCTCTCAGTTAGAATGGCATCCCTTCACCCTCACCTCTGCCCCGGAGGAAGACCACTTCAGCGTGCACATCCGAATCGTAGGGGACTGGACGCAGGCACTTTACTCTGCCTGTGGAGGGGATAAGACTGCGGTGCTGGATGCTTGGACACTACCAAAGATGGCAGTGGACGGGCCGTTTGGGACAGCCAGTGAAGATGTCTTTCGTTATGAAGCGGTGATGCTGGTTGGTGCTGGTATTGGTGTGACGCCCTTTGCTTCTGTTCTGAAGTCTGTCTGGTATAAACACGTCCAGGAGAACCAAAACGTCTTCACTAAAAAGATCTATTTCTATTGGCTGTGTCCGGAGACTCAGGCTTTTGAATGGTTCGCTGACCTGCTGCAGAGTTTGGAAAAGCAAATGTCTGACAAAAACATGAGTGATTTCCTCAGTTACAACATCTATCTAACACGCTGGAAAGATGCTGAGGCAGCTCATCTCAGAGTTCAATATGAAGCGGAGGACGATCCTATCACTGGGCTTAAGCAGAAAACTCGCTATGGAAAACCCAACTGGGACAATGAGTTCAGTCTCATTGCATCCCAACACCCTGGtaCAAAAGTAGGTGTATTTCTGTGTGGTCCTACTGCACTGGGAAAAGCTCTGAGCAAGCAGTGCCTTTCACACACTGAGGGCGGAACTGAGTTTATTTTCAACAAGGAAAACTTCTGA
>TCONS_00008030
GTTTTACGCttcttttgtttgtgtatttCAGCTGGTATGGCTCGGGATCAATGTGTTTCTCTTTGTATATTTTTACATGGCCTTTTTGATTGACAAATACTACTATACTAGAGTCATTCTTGGGCATGCTCTCTCGTGGGCCAGAGCTCCAGCTGCATGTCTCAACTTTAACTGCATGTTGATCCTGCTGCCGGTCTGCAGAAATCTGCTCTCGTTTCTCCGAGGATCTATACAGTGCTGCAGCCGCACTGCAGCTCGACAGCTTGACAGAAACATCACTTTCCACAAATTGGTGGCCTACATGATTGCCTTCCACACAGCCGTCCACATCATAGCCCACCTGTTTAACTTTGAGAGATTCATGGACTCTCAGCTGATGATCAACAGCAGTCACCTGCCGTATGTGCTCTCTCAGATTGGCAACAATGACAACAGATCCTACCTGAACCCCATCAGGAGCAATGACACGAACCCGACCATAGTGATGTTTACGACAGTAGCAGGATTGACGGGTGTCGTGATCACCCTCGCCCTCATCCTCATCATCACCTCCTC
>TCONS_00008031
AATGCAGGCTCAGGAGACCAGAAAGCAGGAAACCAGCATGGTTGAGTGAGGATGAGACTTCCCAGCTCTGTCCTTGTGTCGGTCTCTTTGTTTACGGCCGAGACGACAGCGGCTCTGTATCTGAGCTCCACGTACCGCTCCGCAGGCGATCAGATTTGGCAGGGTTTCACGCTCCTCTTCACGCTGGTGCCATCAGTGCTGGTGCAGCTCACACTCATCTTTATTCACAGAGACCTGAGCAGAGACAGACCTCTAGTGCTGCTGCTTCATATCTTACAACTAGGTCCAATAATAAGGTGCCTGGATGCCTTCTGTATCTATGGCAGTGCAGGAAAGGTGGAGGAGCCGTATGTCACCATCACCCGTAAAAAGCAGATTCCTCGCGAAGGACAGACGGAGGAGGTGGAGCAAGAAGTGGGACAGGCAGAGGGGAAGTTAGTGACCCACAGAGCCGCTTTCGCCAGGACTTCTGTCATACAGGCCTTCCTGGGCTCTGCACCCCAACTCACACTACAGCTCTACATCTGTGTGCTCCAGAGAAAACTTTCTATCGGCCGAGGCACACTGATGGTCATCTCCCTTCTCTCTATTGTATACGGAGCCTTACGTTGCAATATTCTCGCCATAAAGATACGCTACGATGACTACGAAGTCTCCGTGCGTCCACTGGCATACATGTGCGTGTTCCTGTGGCGTGGGTTTGAGATTGCCACCCGTGTGGCCGTCCTGGTCCTCTTCAGCTCCGTGCTGAAGGTATGGGTGTTTCCGGTGGTGTTGGCCAACTTCATCCTCTTCTTTCTTCACCCGTGGGCCCTTTTCTGGAGCAGCCGATCTCCATTTCCAGAGAACATTGAAAAAACATTGACCCGAGTGGGAACCACCATCGTCCTCTGCATGCTGACCTTTCTATATGCTGGCATTAATGTGTTCTGCTGGTCCGCCGTGCAGCTCAAATTGGATGACCCGGATCTGATCGACAAGGGTCAAGCTTGGAGGAGGTTAGCTGTGTATTATTCACTTCGTTTTGTTGAAAACACAGGTCTGACTTTGATGTGGTACATCCACCAGACTGAGTTCTACAATTGGGTGGATGCGCCGGTGTTAGAAGTAATGTTGTTGTTGGGTTACGGCACAGCGGTGTTCTTTATGTTGCTTTTTTACCAGTTCTGCCACCCTTGTAGGCAACTGTTTTCCTCCAGTCCGGCTCAGGGCTTTTGGGAGTGTTGCGGATCTCTCTGTATGCTCCGTGGGACTCTTTCGCAGCCTGGTTCCATGAGGAGCAAGCCACCGGGGAAGGAGACCGGAGATGATCCGGTCTGTGTTACCAAAGGAGACATGACACAGAGTCTGTGCGGTGCCGTGTGAGGAAAGCACAACTTAAAAGGAGAGTTCAGCACAAACATGGACATTGTCTTTCTTTTGTTCAACACCAAAAGATGTTATGAACAATGTTGGAAATTGGTTGCCGAAATTGcgaaaaacaattactatggaaatcaatgactgtttccaacttgcttcaaaatatcttcttttgtgattgaAACAAGTAGATGGTGAGAATATGATgacagttttcatttattttgggtgaattatcccttttaaAGTAAGGGACAGCTAAACTTGTAATATATTGTTAATGATCAAAATATAAGT

Function

symbol description
cybb Predicted to enable superoxide-generating NAD(P)H oxidase activity. Predicted to be involved in defense response and superoxide anion generation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of NADPH oxidase complex. Predicted to be active in plasma membrane. Is expressed in blood; nervous system; and neutrophil. Human ortholog(s) of this gene implicated in X-linked chronic granulomatous disease; chronic granulomatous disease; and immunodeficiency 34. Orthologous to human CYBB (cytochrome b-245 beta chain).

GO:

id name namespace
GO:0006952 defense response biological_process
GO:0042554 superoxide anion generation biological_process
GO:0055114 oxidation-reduction process biological_process
GO:0043020 NADPH oxidase complex cellular_component
GO:0005886 plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0016491 oxidoreductase activity molecular_function
GO:0016175 superoxide-generating NAD(P)H oxidase activity molecular_function

KEGG:

id description
ko04066 HIF-1 signaling pathway
ko04145 Phagosome
ko04216 Ferroptosis
ko04217 Necroptosis
ko04613 Neutrophil extracellular trap formation
ko04621 NOD-like receptor signaling pathway
ko04670 Leukocyte transendothelial migration
ko05171 Coronavirus disease - COVID-19
ko05140 Leishmaniasis
ko05010 Alzheimer disease
ko05020 Prion disease
ko05022 Pathways of neurodegeneration - multiple diseases
ko05417 Lipid and atherosclerosis
ko05415 Diabetic cardiomyopathy
ko04933 AGE-RAGE signaling pathway in diabetic complications
ko04131 Membrane trafficking

ZFIN:

id description
ZDB-GENE-080908-1 Predicted to be located in membrane. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in McLeod syndrome and hematopoietic system disease. Orthologous to human XK (X-linked Kx blood group).
ZDB-GENE-040426-1380 Predicted to enable superoxide-generating NAD(P)H oxidase activity. Predicted to be involved in defense response and superoxide anion generation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of NADPH oxidase complex. Predicted to be active in plasma membrane. Is expressed in blood; nervous system; and neutrophil. Human ortholog(s) of this gene implicated in X-linked chronic granulomatous disease; chronic granulomatous disease; and immunodeficiency 34. Orthologous to human CYBB (cytochrome b-245 beta chain).

Ensembl:

ensembl_id ENSDARG00000056615 ENSDARG00000056618

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00008028 False 3495 mRNA 0.43 13 29795155 29816429
TCONS_00008029 False 2411 mRNA 0.45 13 29796870 29818866
TCONS_00008030 False 555 processed_transcript 0.48 5 29809697 29816202
TCONS_00008031 True 1659 mRNA 0.49 3 29818389 29833698

Neighbor

gene id symbol gene type direction distance location
XLOC_004194 plekha3 coding downstream 27101 29756860 ~ 29768054 (-)
XLOC_004193 NA coding downstream 57908 29734578 ~ 29737247 (-)
XLOC_004192 nr0b1 coding downstream 109302 29682909 ~ 29685853 (-)
XLOC_004191 chd5 coding downstream 136759 29574743 ~ 29658396 (-)
XLOC_004189 arhgef10la coding downstream 231718 29331142 ~ 29563437 (-)
XLOC_004196 vegfd coding upstream 56130 29889828 ~ 29916607 (-)
XLOC_004197 pir coding upstream 83915 29917613 ~ 29946927 (-)
XLOC_004198 CU652893.1 coding upstream 127416 29961114 ~ 29961901 (-)
XLOC_004199 ace2 coding upstream 147980 29981678 ~ 29996357 (-)
XLOC_004200 CR318645.1 coding upstream 267444 30101142 ~ 30101257 (-)
XLOC_004063 CR854846.1 misc downstream 13667477 16127382 ~ 16127678 (-)
XLOC_004019 CR450764.8 misc downstream 17103464 12691395 ~ 12691691 (-)
XLOC_004015 CR450764.4 misc downstream 17173388 12621518 ~ 12621767 (-)
XLOC_004013 CABZ01022569.1 misc downstream 17203859 12590999 ~ 12591296 (-)
XLOC_004008 BX000700.19 misc downstream 17281893 12512966 ~ 12513262 (-)
XLOC_004190 NA non-coding downstream 250166 29537982 ~ 29544989 (-)
XLOC_004188 NA non-coding downstream 475236 29099927 ~ 29319919 (-)
XLOC_004187 NA non-coding downstream 706529 29085366 ~ 29088626 (-)
XLOC_004183 BX649345.1 non-coding downstream 1269659 28522364 ~ 28525496 (-)
XLOC_004211 NA non-coding upstream 1366521 31200219 ~ 31202839 (-)
XLOC_004212 NA non-coding upstream 1371227 31204925 ~ 31211308 (-)
XLOC_004216 NA non-coding upstream 2316520 32150218 ~ 32157526 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000306_05555926_05562924 XK coding CI01000306 null 5555926 ~ 5562949 (-)