XLOC_004628 (pms2)


Basic Information

Item Value
gene id XLOC_004628
gene name pms2
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007123.7
NCBI id CM002896.2
chromosome length 49182954
location 17603528 ~ 17619524 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00009167
cagaacaacacagactaGAGAGGTGCAGTTATCTTTCTGCGTGTACCAATAACAAAAAGCAAAACGTGTTTCATCGTAGTTTTTCCGGGATATTGTACTTGTTGAACCAATGAAAACGCATACCGGAGTTACTTCTTGAATGCAACATGGAGCAACAGCTATCAAAGTAACGTTAGCCACAACAAAATAAGCCGCAATGCAGCGTTTGCAAGTTAGACGTCTGATCTAGTGATCTAACGTTATATCATATCTTTAGCTATTTTAAAGATGTCAGAATTGTGCATAGAATCTGCTGGAGCCATAAAGGCAATAGACAAACAGTCCGTCCATCAGATCTGCTCAGGACAGGTGGTGCTGAGTCTGGCCACAGCTGTGAAAGAGCTGGTGGAAAACAGCATTGATGCTGGAGCTACTAATGTTGATGTGAAGCTAAAAGACAATGGCATTGAGCTGGTGGAAGTGTCTGACAATGGAAAAGGTGTTGAGGAGCAAAACTACGAGGGACTAACTTTAAAACATCACACCTCAAAACTGAAAGAATTTTCTGACCTGATACACGTGGAGACGTTCGGGTTTCGTGGTGAAGCTCTCAGTTCACTTTGTGCTCTCAGTGATCTTAGTGTTGTGACCTGTCATGAGAGTGCTCAGATTGGAGCTCGGCTGGTTTATGACCACGATGGTCGTCTCACTCAGTGTGTACCACATCCACGCCAACACGGCACTACCGTCACTCTTCAGAAGCTTTTCTCTACATTACCTGTTCGGCACAAGGAGTTCCAGCGCAACATCAAAAAGGAATATTCCAAGATGATCTTCGTCTTGCAGTCCTACTGTATCATCTCCACCGGTGTGAGGATTACATGCAGCAATCAGATGGGACAAGGAAAGCGCAGCACAGTACTGTGCACCAGTGGCAGTAATAGCATGAGAGACAATATTGGAGCTGTGTTTGGACCTAAACAGCTTCAAAGTCTGATTCCTTTTCGTCAAATATCTCCCAATGATTCAGTTAAGGAAGACTATGGCCTAGGTGGGGTAGACGTTCCAAAAGACCTTTTTAACATTGATGGGTTTGTGTCACAAGGAGATCATGGCGTTGGCCGAAGTGCTACAGACAGACAATTCTTCTTCATCAATAAAAGACCCTGTGATCCAGTAAAGGTCTCCAAGCTTGTGAATGAGGTTTATCACATGTACAATCGGCATCAATACCCTTTTGTTGCTCTGAACATCGCTGTTGCTTCAGACTGTGTCGATGTGAATGTGACCCCAGACAAACGTCAGATTCTTCTACAAGAGGAAAAACTTTTGCTGGCAATTCTGAAAAGCTCACTCATTGCTATGTTTGAGACGGGTGTCAATAAAATCAGTCTCAATCACATTTCTCCTGCGTTTACCAGCATGAGTAGACCAACTGGGACAAGTGCTTGTTCGGACGATCAAGAAATGGGCTCTGTCTCTGAAACCCTTACTTATGATGGTCCTCCCAAAACTTCCATCAATCTAGCCGGACTGAAAGAAGCATTTTCAAACCACCAGGCTCCTGGAATTGGGTCAAAACAATCTAGTCACAAAGCTGCTTGTGCTGGTCCTTCTCAAAAGAAGATGCTTTCCTTTGTGAGCTGCTCTAAAAAAGTGACTGATTTTTTACCACCTTTAAAATCGCCTACAACTTTCACCGCTGTTTCATCTATAAAACTATCAACTGTTTGTTCAGTTAAATATAAAAGCACTTTTGATAGTGATGCTGATGGTTCTGGAGCTGCAAGCCTAAAATCAGCTGAAGATTATCCAGAGATTAAACAGGAAAACCATTCTGAGTCCTTTTTACACCATGGCATAAATAAAACCGATGTTAAAGCTGAGATTGTTGATAAGCCTATGGATGAGAATTTATGGAGTTATGAAACTTTGCCTGAGACAAAGTCAGAACAACACCAGAACAGAATTTTCAGTCCTGAAGCAAAAAGAGCGAGACGGGAAGATGAACCTCCAGCACAGAACTGTTTGGTGGACTTTAAAAGCAGGAATGCCTCTCTGAAATTTGATGCACCAGTCAACATAAAGAAGAAAACAGTGCTTTTACCGTTTTCTCAGCAGGAACTTTCTAAAAGAATGCAGAGGCTACAGGCTCAGAGGACAAAGAGCAATGAACAAGAGCCGAAATACAGAAGGTTCAGGGCGAAGATTAACCCTGGAGAAAACCAGACTGCTGAGGATGAGCTTAAAAAAGAAATAAGcaaagatATGTTCAAGGAAATGGAAATCATTGGTCAATTCAACCTAGGTTTTATTATCACCAAGATAAAGTCTGACCTTTTCATTATCGACCAGCATGCCACAGACGAAAAGTACAATTTTGAAATGCTACAGCAGAACACCGTCTTAAAGGGACAGCGGCTCATTGTTCCACAAAGTCTCCATCTCCCAGCAATCAGTGAAACGGTGCTCATGGAAAACCTTGAAATCTTCAGAAAGAATGGTTTTGACTTTCTCATTGATGAGGATGCTCAGGTTATGGACCGAGTAAAGCTGGTGTCTTTACCTACAAGTAAGAATTGGACCTTTGGCCCGAATGACATTGAAGAACTCATCTTCATGCTTAGCGACAGTCCTGGAATCATGTGTCGACCTTCTAGAGTAAGACAGATGTTTGCATCCAGGGCATGTCGCAAATCGGTTATGGTTGGCACTGCCCTTAACACCAGTGAAATGAAGAAACTTGTGCTTCACATGGGAGAAATCGAACAGCCTTGGAATTGTCCTCATGGAAGACCCACCATGAGGCACCTTGCTAATCTGGATATGATTTCGCAGGactgaaacctttttttttttttgatgtgtgtaaatatattgaAAGTCACAACAACgctattgtattatttaaagattttattctttttactttgttttataatAAAGTAACTTTTTCCCATA

Function

symbol description
pms2 Predicted to enable ATP hydrolysis activity. Predicted to be involved in mismatch repair. Predicted to act upstream of or within cellular response to DNA damage stimulus. Predicted to be located in nucleus. Predicted to be part of MutLalpha complex. Human ortholog(s) of this gene implicated in Lynch syndrome; hereditary nonpolyposis colorectal cancer type 4; mismatch repair cancer syndrome; ovarian cancer; and urinary bladder cancer. Orthologous to human PMS2 (PMS1 homolog 2, mismatch repair system component).

GO:

id name namespace
GO:0006298 mismatch repair biological_process
GO:0032300 mismatch repair complex cellular_component
GO:0032389 MutLalpha complex cellular_component
GO:0030983 mismatched DNA binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0016887 ATPase activity molecular_function

KEGG:

id description
ko03430 Mismatch repair
ko03460 Fanconi anemia pathway
ko03400 DNA repair and recombination proteins

ZFIN:

id description
ZDB-GENE-030131-686 Predicted to enable ATP hydrolysis activity. Predicted to be involved in mismatch repair. Predicted to act upstream of or within cellular response to DNA damage stimulus. Predicted to be located in nucleus. Predicted to be part of MutLalpha complex. Human ortholog(s) of this gene implicated in Lynch syndrome; hereditary nonpolyposis colorectal cancer type 4; mismatch repair cancer syndrome; ovarian cancer; and urinary bladder cancer. Orthologous to human PMS2 (PMS1 homolog 2, mismatch repair system component).

Ensembl:

ensembl_id ENSDARG00000075672

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00009167 True 2940 mRNA 0.42 15 17603528 17619524

Neighbor

gene id symbol gene type direction distance location
XLOC_004627 cyth3a coding upstream 40825 17504559 ~ 17562703 (+)
XLOC_004626 atad1b coding upstream 147445 17436904 ~ 17456083 (+)
XLOC_004625 NA coding upstream 176148 17424431 ~ 17427380 (+)
XLOC_004624 AL731788.1 coding upstream 257861 17345550 ~ 17345667 (+)
XLOC_004623 rnls coding upstream 280187 17201522 ~ 17323341 (+)
XLOC_004629 rsph10b coding downstream 543 17620067 ~ 17633727 (+)
XLOC_004630 CR932017.1 coding downstream 82101 17701625 ~ 17739456 (+)
XLOC_004631 bhlha15 coding downstream 135335 17754859 ~ 17756905 (+)
XLOC_004632 tmem130 coding downstream 245850 17865374 ~ 17875270 (+)
XLOC_004633 trrap coding downstream 308347 17927871 ~ 18105116 (+)
XLOC_004618 dre-mir-107a non-coding upstream 642747 16960693 ~ 16960781 (+)
XLOC_004615 NA non-coding upstream 728825 16742395 ~ 16874703 (+)
XLOC_004614 NA non-coding upstream 1018474 16583373 ~ 16585054 (+)
XLOC_004634 BX005075.1 non-coding downstream 506134 18125658 ~ 18125774 (+)
XLOC_004635 NA non-coding downstream 590347 18209871 ~ 18228004 (+)
XLOC_004644 AL772266.2 non-coding downstream 979326 18598850 ~ 18598964 (+)
XLOC_004648 NA non-coding downstream 1241754 18861278 ~ 18867975 (+)
XLOC_004660 NA non-coding downstream 1648235 19267759 ~ 19271156 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000063_01089059_01094639 PMS2 coding CI01000063 null 1089059 ~ 1095022 (+)
bowfin (Amia calva) AMCG00018414 pms2 coding CM030135.1 CM030135.1 10150965 ~ 10159643 (+)