XLOC_006297 (nkx6.2)


Basic Information

Item Value
gene id XLOC_006297
gene name nkx6.2
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007124.7
NCBI id CM002897.2
chromosome length 52186027
location 51579851 ~ 51584264 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00012293
ATGTTAGCGGTGGGACAGATGGATAGTAACCGGCAGAGTGCGTTCGTCCTGGGCAGCACTCCACTGGCTGCGCTGCACAACATGACCGAGATGAAGACCTCTTTATTCCCGTACGCTCTGCAGAGTCCCGCCGGCTTCAAGGCTCCTTCTCTCGGCAACCTGAACTCTCAGATCCCGCTGGGGACGCCTCATGGAATAAGCGATATTTTGGGCAGACCCATCACCACTGCAGGACAGCTGCTCTCGGGTTTCCCTAGGATCAACGGATTGGCCACTTCAGCCGGGATGTACTTCAACCCGGCGGCCGTTTCTAGATACCCCAAACCGCTGACGGAGCTGCCCGGGCGGGCGCCCATATTCTGGCCGGGAATGATGCAAGGCTCGCCGTGGAGAGACCCGCGGGTTCCCTGTGCGGccCAAGCAAACATGATGCTGGACAAAGATGGCAAGAAGAAACATTCCAGACCGACTTTTTCAGGACAGCAGATTTTCGCACTGGAGAAAACCTTCGAGCAGACCAAATATCTGGCCGGTCCGGAGAGAGCCAGACTCGCCTATTCTCTGGGAATGACCGAGAGCCAAGtcaagGTTTGGTTTCAGAACAGAAGAACTAAATGGCGAAAGAGGCACGCGGCAGAAATGGCCACGGCCAAGAAAAAGCACGACTCTGAGACGGAGAAGATGAAGGAGAGCTCGGATAACGACGAAGATGATGAATATAACAAACCCCTGGACCCGAACTCTGACGACGAGAAAATCACAAGACTTTTGAAGAAGCACAAGACGAGTAACCTGTCGCTCCTCAGCCCGTGCAGCAACAGCTCGGACACTTTGTGATCAATCTGAGCTCAAAGACTCTTCATGCACTGAAACCAAAACATGatgcattggatttactacatgtGTTTAAAGGTAACTGGCTGCAAGCAATTAATATGGGCTGAATGTTAGCAAGTTGAACATTACtgcatttaatttgtgtttaaattcagccgACACACTCTCTAtttcaacacaaatccattaagctaatcgttttttacaaatttgagtggattgaacataaaacaattaagttatcccaaaaCAAAAGTAAAGAATTGTGTTTcttcaactcattttaatttagtttaatcacaCAGAAGTCATCTTTTGAGtgcatataaattgtttgcagccaGTTACCTTAAATTCTTCAGTAAATTCAATAACTCATTCCCTTTTCAGTGCATCTTCAGCATCATCTTCATCAGTCTCAGATTCTCCTGCAGAACTGGGGCAGAATTAAGCAGGGTATAATAAACACACTGTTCACACTGCTTTGGCTTCGCTGCAGTTGTACAGTTAGAGTGGACGTgagatgtatatatattttttactgagtaaattatgttattaaagcATCACGAAGACGTGCCAATCTCCCCTCATCATCATCATAGGTCATTTAAGATCAGACGGTCGCACTTTACAACAAGGCTGTACTAGTTAAtatcagttaatgcatttattagcATGAACGAACAGGACATTCAtggcagtatttattcatgttaatacaGTGTTCACTGTTAGTtcgttaactcacggtgcatgaatttggatgttaataatgcatacaTGTTGAACTATCATTAAGAAATTATGTACATGTATTGTTGATTAATAATTCATGTAGTAAATACATTaccaatgcattaactaatgcaacctgATTGTAAAGCGTGACCAAAATCGATCGCAGAAGAATAACGACGCCTCTTTCGCCTAAAAAcatgtacttttttattattttgaaagcaGGTACACAAAGTGTATAAAGTGCCAGTGTTGTAAATGATGTGAATAGAGTTTGTTTTAATAACAATGTCCTTTTTTTGGCCGCTTATACTTTCAATGGAAGGAGTTTATGTTTTACCTCACAACACGAGAAATACTCAAAGATGGACTTAAATATCGATGAAGAGAATATTATTGCTTCCGTGATGAAGGAAGAAAAACTTTGTATtatcaataaattatttaacaagCCGATGTTTTAAATATGTCATGATCTTTCTGTCATTTAGTGCATATTTTTGACCAAACTGTTTGGTTTTTGGGGTTGTGATGTCTGTTTATTTGACCGCGAATGTTGTAAACACTTAATACacgcttttattattattattattttactttttaattgttattattattttattatttctttttaataataattattattactttaataattattattattatattattattatatccataCACTCTAAAATgctggatgtttatatttgttttaaattaacgTTAATGTTTTTCCCGAATTTtggggtttgtccatattttacaatTGCTTGcaaattaatatgaataattgtataatgacattgcataattttaaaaaagctaaCATATCACAAATATGAATTTACAGACGAGCgacaaaattataattaaacgacaacataaatatatactaacaaaaattaatacaattataatacTACACTCTAATGCTGGGTTCTTATAACTCAACGTTGGGTAAGttgtgtttaaattatttttaaataacaattaaacaacaacaagttgggtttatatatatttgacccaacagGGGTTAAAGCAACCTATAATTATTCAGTGCAATAATACgcctaataacaacaacaataatttgttcaaatcttttctttaaatgtttaatatacaCTCTAAAATGCAGGGTTGTTATAACTAAACGCTGGGTTAATTGgttttcaattaattttaaacaattaaaaaacccagcggttgggtttgtctatatttgacccaacatggGGTTACAACAACCTGtaattttacagtgcaataaca

Function

symbol description
nkx6.2 Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within pancreatic A cell differentiation; spinal cord motor neuron differentiation; and type B pancreatic cell differentiation. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; endoderm; neural plate; neuroectoderm; and pancreatic system. Human ortholog(s) of this gene implicated in spastic ataxia 8. Orthologous to human NKX6-2 (NK6 homeobox 2).

GO:

id name namespace
GO:0021522 spinal cord motor neuron differentiation biological_process
GO:0006355 regulation of transcription, DNA-templated biological_process
GO:0006357 regulation of transcription by RNA polymerase II biological_process
GO:0030154 cell differentiation biological_process
GO:0031018 endocrine pancreas development biological_process
GO:0003309 type B pancreatic cell differentiation biological_process
GO:0003310 pancreatic A cell differentiation biological_process
GO:0005634 nucleus cellular_component
GO:0043565 sequence-specific DNA binding molecular_function
GO:0003677 DNA binding molecular_function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding molecular_function
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-070626-1 Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within pancreatic A cell differentiation; spinal cord motor neuron differentiation; and type B pancreatic cell differentiation. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; endoderm; neural plate; neuroectoderm; and pancreatic system. Human ortholog(s) of this gene implicated in spastic ataxia 8. Orthologous to human NKX6-2 (NK6 homeobox 2).

Ensembl:

ensembl_id ENSDARG00000104735

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00012293 True 2865 mRNA 0.37 3 51579851 51584264

Neighbor

gene id symbol gene type direction distance location
XLOC_006296 NA coding upstream 117184 51444994 ~ 51462667 (+)
XLOC_006295 NA coding upstream 139958 51433834 ~ 51439893 (+)
XLOC_006294 CABZ01094390.1 coding upstream 148534 51428398 ~ 51431317 (+)
XLOC_006291 CU929144.1 coding upstream 204143 51297553 ~ 51375708 (+)
XLOC_006298 NA coding downstream 33519 51617783 ~ 51625567 (+)
XLOC_006299 pwwp2b coding downstream 126461 51710725 ~ 51731298 (+)
XLOC_006300 NA coding downstream 157290 51741554 ~ 51795401 (+)
XLOC_006301 LT631684.1 coding downstream 269452 51853716 ~ 51881759 (+)
XLOC_006302 lclat1 coding downstream 372133 51956397 ~ 51963460 (+)
XLOC_006307 NA non-coding downstream 536573 52120837 ~ 52136375 (+)
XLOC_006308 NA non-coding downstream 585685 52169949 ~ 52174571 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
bowfin (Amia calva) AMCG00002841 nkx6.2,nkx6-2,LOC106576777,LOC106605004,LOC107745024 coding CM030139.1 CM030139.1 4219176 ~ 4221061 (-)