CI01000006_12520122_12540383 (GRIN1, GRIN1A)


Basic Information

Item Value
gene id CI01000006_12520122_12540383
gene name GRIN1, GRIN1A
gene type coding
species grasscarp (Ctenopharyngodon idella)
category of species economic fish

Chromosome Information

Item Value
chromosome id CI01000006
NCBI id null
chromosome length 13024002
location 12519971 ~ 12540383 (-)
genome version v1_2015/06_NatureGenetics_grasscarp_Genome

Sequence

>CI01000006_12520122_12540383.mRNA
TGTGCGTGAATATCGCACCTGGGATTCTATAACTGCAACACTGGACATTGCTTTCATTCTCCTCAACCGAATAGCCCCCACACGAGGCTCCGGCAGCGATACTAGAGGAGGATACTGGGGCTCTCCGTGCGCTCTTCTGGCCATTTATACGATGCGTCTGCTTCTTCTAGCTGCGTTATTCTCCTGCTCCTGCGTGCGGGGCGGCTGCGAGCCCAAGATTGTGAACATTGGGGCCGTCCTGAGCCAGAAGAGATACGAGCAGGTGTTCAAGGATGCGGTTACCCAGGCGAACCAGGTGTACGGAAGGGAAAAATTCAAGTTGACCGCCATCTCCGTCACTCACAAAGCCAATGCGATTCAGATGGCTCTTTCTGTGTGCGAGGATCTTATTTCCAGTCAGGTATACGCCATCCTGGTGAGCCATCCACCACAGTCTAATGACCATCTGACGCCCACTCCGGTCTCCTACACCGCAGGGTTCTACCGCATACCTGTAGTAGGGCTCACTACCAGGATGTCCATTTACTCAGACAAGAGCATCCATCTCTCGTTCCTGCGTACAGTGCCACCATATTCCCACCAGGCACATGTGTGGTTTGACATGATGCGGGAATTCCGCTGGAATCACATCATCCTTATCGTCAGTGACGACCATGAAGGCAGAGCGGCGCAGAAAAGACTAGAAACTCTTCTGGAGGAGAGAGAGACCAAGGCCGAGAAAGTGCTTCAGTTCAACCAAGAGACTAACTTAACTGCTCTGCTCCTGGAGGCCAAAGAGCTGGAGGCTCGAGTGATCATTCTCTCTGCCAGTGAGGAAGATGCAGCCGCCGTGTACAAAACAGCGCGCTTCCTCAACATGACAGGCTCAGGCTATGTATGGCTGGTCGGGGAGCGTGAGATGTCCGGTAAAGCTTTGAGCGAAGCCCCTGATGGTACGTACGCCTACCTCTGTATAACTGAGGCAGAAGCAGAGGAAAAGAAGCCATTTGTCTCAGTTGTTCTGTTAACTTTGACTAGAGAGGTTTTATTGATGAAGCAAGTTGTGGATGTCAGTGTATGGCTGATTGGCCTCCAGCTCATCAACGGCAAGAATGAGTCGGCACACATCAGCGATGCCGTTGCAGTCGTAGCCCAGTCCATCCAAGAGCTCTTCGAGAAAGAGAACATCACAGAACCTCCAAGGGGCTGTGTGGGAAATACCAACATCTGGAAGACAGGGCCACTCTTTAAAAGGGTATTGATGTCTTCTAAGTACCCTGAGGGCCTAACTGGACGCGTTGAGTTCAATGACGACGGTGACAGAAAATACGCTCATTACAGCATTCTCAACTACCAGAAGAGCAGACTGATTCAAGTCGGCATTTACAATGGAACACAAGTGGTGATGAATAAACAGAGGAAGATCATTTGGCCTGGAGGTGAAACAGAGAGACCGAGAGGATTCCAGATGTCTACTCGATTAAAGATAGTGACCATTCATCAGGAACCCTTTGTATATGTGAAGCCAACTATGCTGGATGGAACCTGCAAGGAAGAGTACACGCCTAATGGAGTCTTAATTAAAAAGGTGATCTGCACTGGACCAAATGAGACCATCCCAGGACGCCCAATTGTTCCCCAGTGTTGCTACGGATTTTGTGTTGATCTTCTGATCAAACTGGCAATGACCATGAACTTCACCTATGAAGTACACTTGGTGGCAGATGGGAAATTTGGAACACAGGAAAGAGTAAATAACAGTAACAAGAAGGAGTGGAACGGCATGATGGGTGAGCTCCTGGGTGGCCTTGCTGATATGATCGTTGCTCCCTTGACGATCAACAATGAACGAGCCCAGTACATAGAATTCTCCAAGCCTTTTAAATACCAGGGACTGACTATCCTTGTGAAAAAGGAAATTCCTCGTAGTACACTGGACTCGTTCATGCAGCCATTTCAGAGTACACTGTGGCTACTGGTGGGTCTGTCGGTACATGTGGTGGCGGTGATGCTTTACCTACTAGACCGGTTCAGCCCATTTGGAAGGTTTAAAGTAAACAGCGAAGAAGAAGAAGAGGATGCCCTCACCTTATCTTCAGCTATGTGGTTTTCCTGGGGCGTTTTGTTGAACTCTGGAATCGGAGAAGGTGCCCCACGTAGTTTTTCAGCGAGAATCTTAGGAATGGTGTGGGCTGGCTTCGCTATGATTATAGTAGCATCTTATACTGCCAACCTGGCTGCCTTCCTGGTGTTGGACCGGCCTGAGGAGCGCATCACCGGCATCAATGACCCAAGGCTGAGGAACCCATCAGACAAGTTCATCTATGCCACAGTGAAGCAGAGTTCGGTGGATATTTACTTCCGGCGACAAGTTGAGCTGAGCACCATGTACCGCCACATGGAGAAGCACAACTACGAGAGCGCCGCTGAAGCCATCCAGGCTGTTCGGGACAACAAAAACGTCATTGAGGGAATCCAATGGGGGACAAAGCTCCACTCGTCCGGCATTGGATTTCATTTGCCTATGAGGTGGCAGTCTAGTTTCCTGGTAACACAAGTCGCACAAGAAGGCAAGCTGCATGCTTTCATCTGGGACTCTGCGGTGCTGGAGTTTGAAGCCTCGCAGAAGTGCGACCTGGTGACCACGGGAGAGCTGTTTTTCCGTTCGGGCTTTGGCATAGGCATGCGCAAGGACAGCCCCTGGAAACAGAATGTGTCCCTGGCTATTCTCAGTTCCCATGAGAATGGCTTCATGGAGGACCTAGATAAAACCTGGGTGAGATACCAGGAGTGTGACTCAAGGAGCAATGCCCCAGCCACACTCACCTTTGAGAATATGGCAGGTGTCTTCATGCTAGTTGCTGGAGGCATTGCAGCAGGCATCTTCCTCATCTTCATCGAAATTGCATATAAGCGCCATAAAGACGCCCGCAGGAAGCAGATGCAGCTAGCCTTTGCGGCCGTCAACGTTTGGAGGAAGAACCTACAGATCCATGGTTGCACTGTTTGGTGTGGTGACCAAAGGTGGACCAACTTACATTGCGTGCTTCTAAAAGGACCAACAAAGAAAAACAGCCTCTTTCCCAATTTCTGGGCTGGTCTAGGATTGCGTAGGCTGCTCTGGTTCAATCAGCCTCCTTCTTCTTATCTGTACCAACAGGACAATAAGGAGAGCTCAGGGAGTCAAGCTGTGGGTGCGGCTGGGACTCCATCTTTAGTATGTAAAACAAGCTGATCCATCTTGTTGCCACGTCATCCTTGCTATGCGAATTAGTATATTTAAAATTGCTGATATGCTCAGTTCATCAAAATATAAAGCTGCTTTCATGGCATGAACCACTTAAATGCTTCAAACCACTTAGCGTATTACAGTTAGTTGAAATAAA

Function

symbol description
grin1a Predicted to enable ligand-gated ion channel activity and signaling receptor activity. Predicted to contribute to NMDA glutamate receptor activity. Predicted to be involved in chemical synaptic transmission; ionotropic glutamate receptor signaling pathway; and regulation of membrane potential. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and ion transport. Predicted to be located in postsynaptic membrane. Predicted to be integral component of membrane. Predicted to be part of NMDA selective glutamate receptor complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in brain; head; neural tube; presumptive neural retina; and spinal cord. Human ortholog(s) of this gene implicated in alcohol use disorder; autosomal dominant non-syndromic intellectual disability 8; and cerebral infarction. Orthologous to human GRIN1 (glutamate ionotropic receptor NMDA type subunit 1).
grin1 Enables glutamate binding activity; glutamate-gated calcium ion channel activity; and glycine binding activity. Contributes to NMDA glutamate receptor activity and calcium channel activity. Involved in several processes, including calcium ion transmembrane import into cytosol; ionotropic glutamate receptor signaling pathway; and response to glycine. Located in dendrite and plasma membrane. Is integral component of plasma membrane. Part of NMDA selective glutamate receptor complex. Implicated in alcohol use disorder; autosomal dominant non-syndromic intellectual disability 8; and cerebral infarction. Biomarker of Alzheimer's disease and vascular dementia.

GO:

id name namespace
GO:0004930 G protein-coupled receptor activity molecular_function

KEGG:

id description
K05208 GRIN1; glutamate receptor ionotropic, NMDA 1

RNA

RNA id representative length rna type GC content exon number start site end site
CI01000006_12520122_12540383.mRNA True 3365 mRNA 0.49 20 12519971 12540383

Neighbor

gene id symbol gene type direction distance location
CI01000006_12497695_12504605 ENTPD2B coding downstream 15366 12497104 ~ 12504605 (-)
CI01000006_12490152_12496647 NA coding downstream 23324 12489499 ~ 12496647 (-)
CI01000006_12479463_12483283 NA coding downstream 36688 12478408 ~ 12483283 (-)
CI01000006_12468191_12470593 NA coding downstream 48412 12467645 ~ 12471559 (-)
CI01000006_12380830_12394437 PCSK1 coding downstream 125534 12380465 ~ 12394437 (-)
CI01000006_12550833_12565605 NA coding upstream 10270 12550653 ~ 12566385 (-)
CI01000006_12569291_12581457 CELL, CEL.2, CEL.1 coding upstream 28844 12569205 ~ 12582487 (-)
CI01000006_12583905_12591335 GTF3C5 coding upstream 43401 12583784 ~ 12591335 (-)
CI01000006_12647432_12651091 NA coding upstream 106620 12647003 ~ 12651091 (-)
CI01000006_12670692_12674459 NA coding upstream 130309 12670692 ~ 12674459 (-)
G48459 NA non-coding downstream 56460 12462404 ~ 12463511 (-)
G48422 NA non-coding downstream 341777 12171561 ~ 12178194 (-)
G48490 NA non-coding downstream 359888 12159558 ~ 12160083 (-)
G48413 NA non-coding downstream 437344 12082243 ~ 12082627 (-)
G48393 NA non-coding downstream 468287 12051341 ~ 12051684 (-)
G48571 NA non-coding upstream 113246 12653629 ~ 12653890 (-)
G48576 NA non-coding upstream 159089 12699472 ~ 12699782 (-)
G48577 NA non-coding upstream 159686 12700069 ~ 12700268 (-)
G48578 NA non-coding upstream 161207 12701590 ~ 12701857 (-)
G48579 NA non-coding upstream 168887 12709270 ~ 12709479 (-)
CI01000006_12348300_12348961 GLRX other downstream 170900 12347180 ~ 12349383 (-)
CI01000006_11651067_11653761 SMD3, SNRPD3, SNRPD3L, MGC52856 other downstream 865564 11650363 ~ 11654424 (-)
G47658 NA other downstream 1486844 11030911 ~ 11033127 (-)
CI01000006_10453630_10483241 NA other downstream 2031536 10453613 ~ 10484006 (-)
CI01000006_07500281_07507754 NA other downstream 5009015 7500246 ~ 7507976 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
zebrafish (Danio rerio) XLOC_018726 grin1a coding NC_007132.7 CM002905.2 11468642 ~ 11502971 (+)