top2a (top2a)


Basic Information

Item Value
gene id top2a
gene name top2a
gene type coding
species mexican tetra (Astyanax mexicanus)
category of species ornamental fish

Chromosome Information

Item Value
chromosome id NC_035900.1
NCBI id CM008303.1
chromosome length 25652880
location 15116824 ~ 15133253 (+)
genome version Astyanax_mexicanus-2.0_2017_mexican_tetra_Genome

Sequence

>XM_007255156.3
AAATCGGTCCGTTAGCTCGCAGTAGGGCTGTTAGAGTCGGTCAGTGCATTAGCTAGTTTGGTAGGTGAAGTAAggtaaaatagttattttacagAGGCGACAGTCGGGCGTGTAGCTTTAGGTAAGCGCGGTTTTGCAGGTTAATAAAGTCTCAGGATAAATTTTCGGTTTTAACCAGTATTTTAATAGAGTTTGAGTTAACTGATAAAGAGGGAACATGGCTGAGACGGACGGAGTGCTGAAGTCATACTTTGAGAACAAGGCCCTGAGCAAGCCTAAGAAAGATGACAGGAGGATGTCCGTGGAGCGCATTTACCAAAAGAAGACCCAGCTGGAGCACATTTTGCTCCGGCCAGACACCTATATTGGTTCTGTGGAGCCGCTCTCACAGCAAATGTGGGTGTTTGACGAAGATGTTGGACTGAACTGTCGGGACATCACATTCGTGCCCGGCCTCTATAAAATCTTTGATGAAATTTTGGTCAATGCTGCGGATAACAAGCAGAGGGACAACAGCATGAACTGTATCAAGATTAACATCGACTCTGAGAACAACACCATCAGTGTTTGGAACAATGGAAAAGGAATTCCTGTGGTAGAGCACAAAGTGGAGAAAGTCTTTGTGCCTGCTCTCATTTTTGGTCAGCTGCTTACATCCAGCAACTATGATGATGACCAGAAGAAGGTCACAGGTGGTCGAAATGGCTATGGAGCAAAGCTGTGTAACATCTTCAGCACCAAGTTCACCGTAGAGACTGCCTGTGCAGAGTCAAAGTATTCCTTCAAGCAGACCTGGTTTGATAACATGAGCCGTGCTGGTGAGGCAAAAATCAAGCCGTTTAGTGGCGATGACTACACTTGCATCACCTTCCGGCCAGACTTGACCAAGTTCAAGATGCAGTCACTGGACCGAGACACTGTGGCCCTTATGACCAGACGAGCATATGACATTGCTGGGGCCTCCAAGGGTGTGCGTGTCCTCCTCAACGGCACCAAGCTGTCTGTGAATGGATTCCGTAGTTACGTGGACCTGTATTTGAAGGATAAAGTGGATGAGACCGGTACTCCTCTCACTGTAGTGCATGAAGTGGTGAACTCACGCTGGGAAGTGTGTCTCACCCTGAGTGAAAAGGGCTTCCAACAAGTCAGTTTTGTCAACAGCATCGCTACCACAAAGGGTGGTAGACACACGGACTATGTGGCAGATCAGATTGTGTCAAAGCTGATTGAAGTGGTGAAGAAAAGGAATAAAGGTGGTGTGGCTGTCAAACCATTCCAGGTGAAGAACCACATGTGGCTGTTCGTGAACTGCCTGATCGAGAATCCAAGCTTCGACTCTCAGACCAAAGAGAACATGACTCTACAGCAAAAAAGCTTCGGATCTACCTGCCTTCTCAGCGAGAAGTTCATTAAGCAGGCCAATACTTGTGGCATTGTGGACAGCATAATGAACTGGGTAAAGTTTAAGGCTCAAAATCAGCTCAACAAGAAATGCTCTGCCGTCAAACACACCAAGATCAAGGGAGTTCCTAAACTGGATGACGCCAATGATGCAGGTGGCAAACACTCTGCCGGTTGCACTCTGATCCTTACCGAGGGAGACTCGGCCAAAACCCTGGCCGTGTCTGGACTTGGTGTGGTGGGCCGCGATCGCTACGGGGTCTTTCCCCTGAGGGGTAAAATGCTGAACGTGCGAGAGGCCTCTCACAAACAGATCATGGAGAATGCTGAGATCAATAACATCATTAAGATCATGGGCCTGCAGTATCGGAAGAACTACAGCGACCCTGATTCACTTAAATCGCTCAGATACGGAAAACTGATGATCATGACAGATCAGGATCAGGATGGATCTCATATTAAAGGGCTCCTGATTAATTTCATTCACCACAACTGGCCCTCGCTGCTGCGGCACAACTTTCTGGAGGAGTTCATCACTCCCATCATTAAGGTGTCCTCTAAGAACCAGGAGTTTTCCTTCTACAGTATTCCAGAGTTCACAGAATGGAAAGAGAAGCAAAACAACATTAAATCATGGAAAATCAAATACTACAAAGGTTTGGGTACCAGCACATCCAAAGAGGCCAAAGAGTATTTCTCGGACATGGCGAGGCATCGCATTCCGTTTAGGTACTCTGGGCCTGCAGATGACGAGGCTATCACCCTGGCCTTTAGTAGGAAGAAAATTGAGGAAAGAAAGGATTGGCTCACCAGCTTCATGATAAACAGGCGCCAGCGTCGAGAGCACAACCtgccagagGAGTACCTCTATGGTAAGGAGACTTCATCCCTTACCTACCATGACTTCGTCAACAAGGAGCTGGTGCTGTTTTCCAACTCAGACAATGAGCGCTCCATCCCGTGCCTGGTTGATGGTCTGAAGCCAGGTCAGAGGAAGGTGTTGTTCTGCTGCTTCAAACGAAATGACAAGAGGGAGGTGAAAGTGGCTCAGCTTGCTGGTTCTGTTGCAGAGATGTCTGCTTACCACCATGGAGAGATTTCTCTGATGATGACCATCGTGGGTTTGGCGCAGAACTTTGTTGGTAGCAACAATCTGAACCTGCTACAGCCTTTGGGTCAGTTTGGCACACGCCTGCACGGAGGCAAAGACTCTGCCAGTCCCAGATACATCTTCACCATGCTCAGCTCTCTTTCCCGACTGCTGTTCCCTTCTGTGGATGACAACCTGCTCAAGTACAACTACGATGATAACGTAAAGGTGGAGCCTGAGTGGTACATCCCTATCATCCCCCTGGTGCTGGTCAacggtggtgatggcatcggcACAGGCTGGGCATGCAAACTTCCCAACTTTGATGTTCGTGAAATCATTAACAACATCCATCGAATGCTTAATGGTGATGAGCCGCTGCCAATGCTTCCCAGTTATAAGGGTTTCAAGGGAACCATTGAGGAGTTGACAAGCAACCACTACCTGATCAGCGGAGAGGTGTCAATCATAGACTCCACCACTATCGAGATCTCTGAGTTGCCTGTGAAAACCTGGACACAGTCGTACAAAGAGAATGTGCTGGAGGTGATGCTGAACGGCTCTGACAAAGTCCCCGCCCTGATCACTGACTACAGGGAGTACCACACTGACTCCACAGTGCGCTTTGTGGTGAAAATGACTGAGGAGAGACTCATAGAGGCCGAGGCTGCAGGTCTGCACAAAGTTTTCAAACTGCAGAGCCCCCTCACCTGCACTTCCATGGTGTTGTTTGACCATGTGGGCAGTCTAAAGAAGTACGAATTTGTCCAGGACATTCTAAAGGACTTCTTTGAGCTTCGTTTGAAATACTATGTCCTGAGGAAGGCCTGGCTCGTTGGCATGCTGGGAGCTGAAAGTGCTAAGCTGTCTAATCAGGCCCGTTTCATTCTGGAGAAAATTGAGGGCACTCTGGTAATCGAAAACAAACCTAAGAAGGAGTTGATCCGCATGCTGCAGGAGATGGGATACGACTCTGACCCTGTTAAAGTGTGGAAACAAGCCCAGGAAAAGGAGGTGGAGATAGATGCAGGGGAGGAAGATGAACAAAAGGAGGAACAAACATCAGGACCTGACTACAACTACCTGCTGAGCATGCCCATGTGGTACCTCACCAAAGAGAAGAAGGATGAGCTTTGCAAGCAAAGAGATGCTAAGCTCACAGAGTTGAACATGCTGGAAAAAAAGACCCCTTCAGATTTGTGGCAGGCGGATCTAGCTGCCTTCACAGAGGAGCTGGAGCGTGTAGAGCAGGCTGAAAAGGAGTCCCAGGCCAAAGTGACCCAGGTTAAGGGAAAAGGTGGCAGAACCAAGGTGGTAAAGATGAAGGACGAGACCCTGCCTACACCTCAGGGCCGCAGAGTCATCCCCCGCATCACCAGCACTATGAAAGACCAGGCAGTCAAGAAGGCTGACTACAAGAAGACAAAAGGCAAGAAAGGTTCAGTCAAGggTGAAAATGAGGAAAGTGTAGTGATGAAGATGGAATTTGAAGATGAGGAAGCAGAAGAGCCTCTTGAGGTTGGACTGGCTGCACGTCTTACCAAGAAAGTTAAAAAAGAGTCTACTAAGGAGAAAGGCTCTAAGTCAAGCAAGCAGACCACACTCCAATTTGAACCTGTGCAGGAGAAACCAAGAAACCCTTGGTCTgatgaggaagatgaagacCTTTCAGGCTCTGATAAGACCACTAGCCCAATGGACACGGCCCCTAGAGAAAAACATGGAAGAAAAGCTGCTGCTTCTGTTAAATATTCCCTGGACAGCAGCATGGATGAGGCAGAAAATTGGGAAAGCTTGGGCAAAAAGAAAACTTCAGCAGTTCTTGACAGTGATGATGACATGTTTGTTCCGGAGCCCAAAGCTGCTTCTGACAGTGAAGACTCTCCTGTCAAGCCTCCACCgaAAAAAGCAGCAGCCAAACCTAAACCAAAGGAGAAAGCGGTTGTCACCAGCACTGATACCTctgatAGTGCTCCTTTGAAACCCACAGCCAAGCCTAAAGAAAAAGCTGTCAAAAAGACAGCAGAAGAAGGTGCCAAGAAACCTGCAGTTAAGAAGACTGCTGCCCCCAAGAAGACCGCTGcccccaagaagaaaggaacagTTGCTGACGTGAAGCAGCCCTCTATCCTTGACGCCCTGTCCAAACCCCCTGCTAAAACAACCGCGGCCAAAAAGTCAAACTCCAGCGACTCTGAAGGCTCTGCTCCAGCCCCAGCAGCCAAAAAGGCATCCGTGCGCAAGAGGAAGGTTGTTTTGAGCAGTGATGAGTCGAGCAGCGATTCTGATGGAGGAAACCTTATGGCCCGCCTCATGGGTAAAGCCACCGCTGGAAAGAAATCTAAGTGGGAGGATGACGATAGCTTCTCACTGGATGTGATGTCATCTTCTGTGGCCCCCAGGTCAAAAACAGCACGGACCAAAAAACCAATCACCTATGCTTTGGATTCTGACTCTGATGAATGATATTTCCCTCCTTGCTAGTTATGATCTAGTGAccttttacagtaaaattccTTTTAGTACTTGAGTTAGTGGGAACCTGAAGCACTGTTACATCTAGTTGATCTGATGTAAAgctttgttttacagttttattaacaagtttaaaaattgtatttggTTTCATTAGAATTATTGAAGATTTCATATGTGTACTGTAATTGATTGATCCTTTATTCTGATTCTGAAGTTTTTTATggctttttttgtgttgtgatgTCTTGTAAATATTTTCTATGTTGTCTTTTTACACTTAAAGCTTTGCCAAAATAAACTTTATACCAGTTGTTGTATTTGACTCTGCATCTGGGCCTTTGTAACCCTA

Function

symbol description
top2a Predicted to enable DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity. Acts upstream of or within animal organ regeneration and chromosome segregation. Predicted to be located in nucleoplasm. Predicted to be part of DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex. Predicted to be active in nucleus. Is expressed in digestive system; head; nervous system; neural tube; and pectoral fin. Orthologous to human TOP2A (DNA topoisomerase II alpha).

NR:

description
DNA topoisomerase 2-alpha

GO:

id name namespace
GO:0006312 mitotic recombination biological_process
GO:0000819 sister chromatid segregation biological_process
GO:0030261 chromosome condensation biological_process
GO:0031100 animal organ regeneration biological_process
GO:0006200 obsolete ATP catabolic process biological_process
GO:0000712 resolution of meiotic recombination intermediates biological_process
GO:0045944 positive regulation of transcription by RNA polymerase II biological_process
GO:0006261 DNA-dependent DNA replication biological_process
GO:0006265 DNA topological change biological_process
GO:0000795 synaptonemal complex cellular_component
GO:0009295 nucleoid cellular_component
GO:0009330 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex cellular_component
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity molecular_function
GO:0005524 ATP binding molecular_function
GO:0003677 DNA binding molecular_function

KEGG:

id description
K03164 TOP2; DNA topoisomerase II

RNA

RNA id representative length rna type GC content exon number start site end site
XM_007255156.3 True 5318 mRNA 0.47 37 15116824 15133253

Neighbor

gene id symbol gene type direction distance location
LOC103032173 NA coding upstream 80870 15032389 ~ 15035954 (+)
LOC103032486 lrrc3c,lrrc3ca,LOC107598050,LOC107716457,LOC107660473,LOC107678436 coding upstream 125525 14967880 ~ 14991299 (+)
get4 get4 coding upstream 282477 14823653 ~ 14834347 (+)
LOC103041718 LOC108435036 coding upstream 294661 14798910 ~ 14822163 (+)
LOC103041103 htra1,LOC107660481,LOC107745581 coding upstream 341627 14720879 ~ 14775197 (+)
gjd3 gjd3 coding downstream 1049 15134302 ~ 15135903 (+)
LOC103030376 raraa,rara,LOC108410801,LOC107678286,LOC107745620,LOC107716487 coding downstream 91199 15224452 ~ 15383888 (+)
LOC103029630 NA coding downstream 259762 15393015 ~ 15406356 (+)
LOC103029312 NA coding downstream 274232 15407485 ~ 15423095 (+)
LOC103028270 mpp2,LOC108410806,LOC108273574 coding downstream 308314 15441567 ~ 15520594 (+)
G36512 NA non-coding upstream 26448 15086356 ~ 15090376 (+)
G36511 med24,LOC107598039,LOC107660474 non-coding upstream 32884 15081564 ~ 15083940 (+)
G36510 med24,LOC107716488,LOC107660474 non-coding upstream 35479 15077784 ~ 15081345 (+)
G36503 med24,LOC107716488,LOC107598039,LOC107706820,LOC107678252,LOC107560528 non-coding upstream 52711 15053042 ~ 15064113 (+)
G36499 NA non-coding upstream 78847 15037778 ~ 15037977 (+)
LOC111192405 NA non-coding downstream 16918 15150171 ~ 15152128 (+)
G36524 NA non-coding downstream 43853 15177106 ~ 15181078 (+)
G36532 NA non-coding downstream 66569 15199822 ~ 15200073 (+)
G36560 NA non-coding downstream 243029 15376282 ~ 15379928 (+)
G36582 psmc5,LOC102777430,LOC107684752 non-coding downstream 407861 15541114 ~ 15547526 (+)
G36439 LOC103041415 other upstream 325991 14789380 ~ 14790833 (+)
LOC107197918 NA other upstream 548912 14564925 ~ 14567912 (+)
G36371 NA other upstream 653185 14463137 ~ 14463639 (+)
LOC103039668 LOC108435045 other upstream 1596122 13502246 ~ 13520702 (+)
G35995 NA other upstream 2413768 12702305 ~ 12703056 (+)
LOC103028998 pyyb,LOC103028998,LOC108410797,LOC107745683,LOC107569181,LOC107684781,LOC107695522,LOC107753323,LOC107560546 other downstream 299576 15432829 ~ 15440157 (+)
cabcoco1 NA other downstream 1080537 16213790 ~ 16233839 (+)
sun1 NA other downstream 1867129 17000382 ~ 17040957 (+)
phf5a phf5a,PHF5A,LOC107584099,LOC102780084,LOC106609350 other downstream 2068244 17201497 ~ 17205033 (+)
cby1 cby1 other downstream 2099567 17232820 ~ 17234559 (+)

Expression


Co-expression Network