XLOC_008015 (itk)


Basic Information

Item Value
gene id XLOC_008015
gene name itk
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007125.7
NCBI id CM002898.2
chromosome length 52660232
location 34045284 ~ 34074510 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00015673
GTACATGATTGTGAGCTCCACAAGTGTATAATGATTTTTAAACCTCATTTGCCATGAGTCAACCAACTGTGTGGTGATTAAATATCCCAAATCCACTATGTACCCAAGGGTCATCCTAAAGGAGACGCTGTACAAGAAGTCACAGCAGAAGAGAAGAACATCACCGTGCAATTACAAAGAGAGGACATTCATATTAAACACACAGGACCTGGCTTACTTTGAACAGCGTCCCGGGAAAAAGCCAACTCAAAAAGGCTGCATCGAGCTTTCTCATATAAAGTGTGTGGAGATTGTGCGTAGTGATGTTCCCATTCCCTGTGATTACAAGTATCCTTTCCAGATCATCCATGACAGCTACTATCTGTATGTGTTTGCTCCAGACAACGACTGCAGGTTAAAATGGGTCAAAGCTTTAAAAGAAGCCATACAAAATAACAGCTTATTCCTGAAATACCATCCTGACTTCTGGGGAGAAGGAAAATGGAGATGTTGTCAGCAGACGGAGAAGCTGGCGACGGGATGCAGTGAATACTATCCCAATGGAGCCAAACCTCTTCCGCCAACGCCGGATCCATCGCGCCGATCCTCAGAGCCAGAGGAGAGGATTGTTGTGGCTTTGAGGAATTTCACCCCTAAAGAACACACAGATCTGCCCCTGCAAAAAGATGAAGAGTATTTTATTGTTGATTGTTCCGAACCCAACTGGTGGACCGTGAAAGACAAAGACGGAAATGTTGGTTCAGTGCCATGCATATACGTTACAGAAAAACTCTCAAACAACATTGAGAAATTTGAATGGTACAATAAGGACATAAATCGAACGGAGGCAGAGGACTTACTAATGCAAGAGAACAAGGACGGGGGTTTCATGGTCCGTAATTCTAAGCATGCAGGTGTTTACACCGTGTCCATATTCACCAGAGTTTCAGGGTCTAATGGCGAGAAATGTCCCCAAGTTAAGCACTACCAGATCAAAGTACAGAGTGAAGGTGAAAAAGTCTTGTATTACTTAGCTGAGAAATATTTGTTCCCAACCATTCCAGAGCTCATCCGCTACCACCAACACAATCCGGCAGGTTTGATCACCAGACTGAGGCACTGTGTGTCTAGAAATGTCCCAAACTCTGCAAGGATCAAGGAGTTATCATCAGATAAGTGGGAGATTCACCCTGATGAAGTGAAATTAAGTGTGGAACTGGGCAGTGGGCAGTTTGGCTTGGTGTGGAAGGGAAGTTGGCAAGACATGGAGGTGGCAGTTAAGACGGTTCGTGAGGGATTTATGTCAGAGGAGGAATTCAAAGAAGAAGCACAAGTTATGATGAAACTATCCCACAATAGGCTGGTGCAGTTGTATGGTGTGGTCACTCAGCGTTCACCCATATACCTGGTATTCGAATTCATGGAAAACGGTTGCCTTACGGAGTTCTTGCGGGCTAAAAAAGGCAAACTTTCCCAAAAGGCTCTGCTGGAGATGTGTTTGGACGTAAGTGAAGGAATGGCCTACCTTGAAAGCTCTAACTTCATCCACAGGGACTTGGCTGCGAGAAACTGTTTGGTTTCTGAAAATAGTGTGGTGAAGATAGCAGATTTTGGAATGACAAGGTTTGTCCTGGATGACCAGTATACAAGTTCTCATGGATCCAAATTTCCAGTCAGGTGGTCTTCTCCAGAGGTGATCAAATTTGGGAAGTACAGCAGCAAATCAGATGTGTGGTCCTTTGGTGTGTTCATGTGGGAGGTGTACAGTGAGGGACGCACACCCTATGACAACCGTAGCAATTCAGAAGTAGTGGAGACCCTAAATGCAGGGCATAGACTCCTGAAACCACGGCTCTGTCCTCAGAGTGTGTACGAGTTAATGCAGTGGAGCTGGAAAGAGAAACCTGAGGATCGACCCTCATTTGCGCTTCTCCTGCATGAACTGGCCTGCCTTGATCAAGAACCTTGAACCTGATCATCACACCTTTCTCTTTTTGCAaaattaaatggatagttcacttaaaaggAACAATTTTTAATTATCTTATATCATCGTGAACCTGTTAGCTATTTATGGTGGAACACAGATACGTTTTTGGGAAAATGTTTGAATCCctgtaatgaaatgtaaaaaattataataataataattgtaatgtgCCTCAAGCTACAGCTCAAATCAAATATACAGTAGCCTACTTAGAGATTTTGACCTGTTATTACAAAAATCATTTGTACAGTTTGTAATGACAAAGTAAATAATGACCGAATTTTGTTTtactgtgtgaactatccctttagagtTAAAATAGTGTATATTGTACAAATcacatattgtatttatttttgtactttatttatttcacagGTATTGTTTTATGCCACTgaatggtattttattttatgtacatgCATGTTTTCTGCAATCTCAAATCTGTCCCTTAGGAGGCACACATGAGccatgtttgtttaattttaatttcataccAGTGAAAGTGTATAATTacaatgttaattattttaattgcaaTGTTTTCAGTAAACTgtcacttttttatatatttgcaggCTACTGATTTATTTAGTAGTGCATTTGTCTGCGTGCATAGAGTTGTATGTACAATTTCCAAATGATGTGAATGTTAACAACACCCTATTCGAGCTGAATTGTTCATGAAATATGATTACATTAAATCTACTTTACTATCCAAA
>TCONS_00015674
GAGACAGAATGCTTCAGATATTGGAAAGCATGAAAAATCATTCACTCATATCGGAAAGAGGGGTCATCCTAAAGGAGACGCTGTACAAGAAGTCACAGCAGAAGAGAAGAACATCACCGTGCAATTACAAAGAGAGGACATTCATATTAAACACACAGGACCTGGCTTACTTTGAACAGCGTCCCGGG

Function

symbol description
itk Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in several processes, including NK T cell differentiation; antigen receptor-mediated signaling pathway; and peptidyl-tyrosine autophosphorylation. Predicted to act upstream of or within immune system process; intracellular signal transduction; and protein phosphorylation. Human ortholog(s) of this gene implicated in lymphoproliferative syndrome 1. Orthologous to human ITK (IL2 inducible T cell kinase).

GO:

id name namespace
GO:0002250 adaptive immune response biological_process
GO:0035556 intracellular signal transduction biological_process
GO:0038083 peptidyl-tyrosine autophosphorylation biological_process
GO:0006468 protein phosphorylation biological_process
GO:0001865 NK T cell differentiation biological_process
GO:0016310 phosphorylation biological_process
GO:0050852 T cell receptor signaling pathway biological_process
GO:0050853 B cell receptor signaling pathway biological_process
GO:0016740 transferase activity molecular_function
GO:0005524 ATP binding molecular_function
GO:0046872 metal ion binding molecular_function
GO:0000166 nucleotide binding molecular_function
GO:0004672 protein kinase activity molecular_function
GO:0016301 kinase activity molecular_function
GO:0004713 protein tyrosine kinase activity molecular_function
GO:0004715 non-membrane spanning protein tyrosine kinase activity molecular_function

KEGG:

id description
ko04660 T cell receptor signaling pathway
ko04670 Leukocyte transendothelial migration
ko04062 Chemokine signaling pathway
ko01001 Protein kinases

ZFIN:

id description
ZDB-GENE-990415-261 Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in several processes, including NK T cell differentiation; antigen receptor-mediated signaling pathway; and peptidyl-tyrosine autophosphorylation. Predicted to act upstream of or within immune system process; intracellular signal transduction; and protein phosphorylation. Human ortholog(s) of this gene implicated in lymphoproliferative syndrome 1. Orthologous to human ITK (IL2 inducible T cell kinase).

Ensembl:

ensembl_id ENSDARG00000017565

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00015673 False 2691 mRNA 0.41 17 34045284 34059681
TCONS_00015674 True 188 mRNA 0.44 2 34059447 34074510

Neighbor

gene id symbol gene type direction distance location
XLOC_008014 cyfip2 coding downstream 832 33982007 ~ 34044452 (-)
XLOC_008013 foxa coding downstream 63740 33973146 ~ 33981544 (-)
XLOC_008012 zdhhc24 coding downstream 99485 33939213 ~ 33945799 (-)
XLOC_008011 slc24a6a coding downstream 108760 33898976 ~ 33936524 (-)
XLOC_008009 FP016208.2 coding downstream 146695 33875058 ~ 33898589 (-)
XLOC_008016 gria1a coding upstream 51345 34125855 ~ 34276574 (-)
XLOC_008017 NA coding upstream 269572 34344082 ~ 34490887 (-)
XLOC_008018 si:ch211-232m8.3 coding upstream 436190 34510700 ~ 34513103 (-)
XLOC_008019 NA coding upstream 455374 34529884 ~ 34535102 (-)
XLOC_008020 NA coding upstream 478185 34552695 ~ 34556328 (-)
XLOC_007641 CU855896.1 misc downstream 31637444 2407736 ~ 2407840 (-)
XLOC_007640 CU855896.2 misc downstream 31637853 2407328 ~ 2407431 (-)
XLOC_007639 CU855896.3 misc downstream 31638212 2406945 ~ 2407072 (-)
XLOC_008004 NA non-coding downstream 267032 33666082 ~ 33778252 (-)
XLOC_008005 NA non-coding downstream 300531 33722042 ~ 33744753 (-)
XLOC_007999 NA non-coding downstream 577593 33464948 ~ 33467691 (-)
XLOC_007983 CR812836.1 non-coding downstream 995204 33048519 ~ 33050080 (-)
XLOC_008023 NA non-coding upstream 723118 34797628 ~ 34797996 (-)
XLOC_008025 NA non-coding upstream 1014149 35088659 ~ 35112362 (-)

Expression


Co-expression Network