CI01000024_03593801_03622283 (ALS2, ALS2B)


Basic Information

Item Value
gene id CI01000024_03593801_03622283
gene name ALS2, ALS2B
gene type coding
species grasscarp (Ctenopharyngodon idella)
category of species economic fish

Chromosome Information

Item Value
chromosome id CI01000024
NCBI id null
chromosome length 8644187
location 3593469 ~ 3622283 (-)
genome version v1_2015/06_NatureGenetics_grasscarp_Genome

Sequence

>CI01000024_03593801_03622283.mRNA
GACAATCATCCACGGTGACAAACGCAACAGCTGTGACATGGGGAACGTTTAGAGATGGAGAAACAGATAAGTGTATGCATCACTGTCTTTGTAGTTCTGGTGATGAGGACGGTTCTGGGGAGAGGGGTCTGCTCCACACGTGGAGGGGATATTCCTACAGCACCACACCAGAGCGGGTGCTGCTCTCCCGGCCTGTGCTCCAGGCTGCCCTGGGAGCTAGACATGGTGTGCTGCTAGTAGAGGGGGGACAAGTCTACAGTTTTGGTGAGTTGCCTTGGAAACAAAACCAAACATCATCAGTAGTGACTGAGCCTGTTTTGGAGGCAGTGCTTAGCGAACAACGTGTTGTTTTTGTGGCTGCTGGCTCCGCCCATAGTGGAGTAGTAACGGAGGATGGAGGTGTGCACATGTGGGGAGAAAACGCTCATGGCCAGTGTGGCCTGTCGGGACTCTCTGTTATCCCTAACCCCACACCTGTGGCCGTGCTTGACTCTGAGGCCACGCCCCCTCAGACGGTGAAGATCCTGGAGGTGGCGTGTGGGGATCAGCACACTTTGGCTCTTTCAGCCAAGCATGAAGTCTGGGCTTGGGGCAGCGGGTGCCAGCTGGGCCTGAACACATCAACGTTTCCTGTCTGGAAGCCCCAGAAGGTAGAGCCCCTGGCCGGAAGGCACGTGTTGCAGGTGGCCTGTGGAGCCGCTCACAGCCTGGCTCTGGTGCGATGTCTCCCCCCTCCGCAGGAGCCTCGGAAACCCCCTCAAGACAAGTGCGGTCAGTGCCATCAGCTGCTGTACACTATGACGGACAAAGAGGACCATGTCATCATCTCTGATGGCCATCACTGTCCACTAGGTGTTGAGCAGGACAGCAGCGAGACCAAGTCTGCATTAGAAGGCAGCCCAGAACAGGGTAAACAAGGCAAAAGCTCTCCTACAGAACCTGTTCCATCCATGTCCACCCAGATCCCAAGATCACCCACCTCAAGCACAATCCCTGACAGCACACCTGCCTCTGAATCCCAAAATCAGGTTCCTGCATCTAGCCAAGAACCTGTAGAACCAACCATAGAAGACTCGACTGAACCTGAAGCTCCGGTCACAAATGGAGAGGTTTGTGTCGAAGCCTCAGAGTCCTGCACCCCTGAGCCGGACAGCTGTCGAGCCATAGGGGGGAAGTGCTCCCCATTCCCCGATGAGCAGGCAGTGAAGGCCTATCTTAAGAGACTTTCTGATCATGCCCTGGCAGAGCACACCAACAAGACCCCCACGATTCATTCTGCTCAGAGCTCTCACGTCCAGCTCACATCTGTCCCATCACAGCTCTCCAGTGACCCCACTGATCCTTTCACCTCTGACCCCTTGATCCCGGTCGCCCAGTCTGTGACTCCAATGGGCTCTGCGTTGAACAACTTGGTGGTGTCCTGTGCCTCTGCAGTGGGGGAACGTGTAGTGTCTACATATGAAGCTCTCTCTCTGAGAAAAGTCATTGGTTACTGGGTTCCAGGAGAGGGCCGTGAGCGAGTGGAGGAGAGACTCCGTCTGGAGGAGCCCATGCAGGGGAAGAAAAGCTCCAGCCTGGGGGATATCCGAGAGGAGGAGGCGGAGCTCAGCCGTCGCCTGTCCCTGCCTGGCCTGCTCTCTCAGGGTACACACGCTCTCCTTCTCTTACACCCAGTGTACCGTCTCCACATTGCAGCATTTGAGGTGACGGTGTCGGTATCCCACACAACAACTGAAGGAGGCATACCTGAGGCCGATGCCCACCTGCCTTCTTTGCAGACAGAAGTGTGGAGCTGGGGCCGAGGCCAGGAAGGGCAGCTTGGACATGGTGACATCCTTCCCAGACTGCAGCCCGTCTGTGTAAAGAGTCTGAATGGTAAAGAGGTGTTGAGAGTGGCTGCAGGTGCTCATCACTCTCTCGCCCTGACCGCCCAATCACAGGTGTTTTCCTGGGGCTGCAACACTTCTGGGCAGCTTGGACACATGGAATCACCCACCACCTTCCCTCACTTAACCAAGCTGTCAGATGGGATTCGCGTGTGGGATATAGGGGCGGGTCAACAACACACTCTCTTATTGGCTGATGGAGACTGTATCCAGCCAATCCTGTACTACAGTGGGCAGCAGGTGAAAGAGGTGACGGAGATGACGGAGCAAACGGAGGAGGAGGAGCAGACCGGAGAATACACACAGCAACCGGTGCTGCTGCCCTTTTGTATGAATTTGGGCTATGTAAGCAGTGTGTGCTCAGGAGGACGGACTTGTGCGGCGCTGACTGATCGTAATGTAATGGGTTTTATTGCCAGTCTGCATGAGCTGGCGGCTGCAGAGAGGAAATATTACTGCAAACTCAGCAATATCAAGAGTCTTCTGCTCCAGCCATTGCTCAAACTGGAACCTCAGTTGTTCAAGATGACGTACTGTTCTGCAGTGGGTGATCTCTTAGTCATGGGAGGGTTTCAAGCCCTTGTCAAACCTTGCCATGATGTGTTTGGCAAGGGGGCAGAGGTTGTTCAGAGGTTGTCTGAATGTTCTGAAGAGGGTTTGCCCTTAGCGGACGTTCTGGCGCATCTCTTTTACCTGCCCATAAAGCACCTGCATGAATATGGGCGACTGCTGCTGAAACTGGCTACCTGCTATGAGGTGAGTTCTGTGGATTATCAGAAGCTGCAGGATGCCTGCTCAAAGTATGAATCCATGGCTCTTCATCTGAAGAAGAGGAGGAAGGAAGCTGAATACACGCTCCACTTCTGGAAGAGCTTTCCTGGAAAGATGACCGACTCTCTTCGTAAACCATCTCGTCGTCTGATCTGTGAGAGCAGTAATAAGGCTTTAACTCTTCAGAACGCAGGACGTTTTTCCGTCAACTGGTTCATGCTATTCAACGATGCACTTGTTCACGCACAGGGCATGGTCCCCTATAAGAGTCTTTTTTCCACTCATCACGTCTTTCCATTGGCTACTCTGTGGGTGGAGCCGATTTCTGAGGAGAACACGGGCCTATATGGTTTAAAAGTGACTTCACCTGAAGAGAGCTTCACTCTGCTGGCCTCGTCTCCAGCTGAAAAGGCAAAATGGCTTCGTTCTATAAACCAGGCAGTGGAGCAGGCGCTTAGCGGACTGGGGCATGATGGGATACCGTCTTCTACAGGGGTGACACAGAGAGCAGACCCGCCAATTTCACGGACGGCAGCGTACACGTTCTACAAAGACAGTCGGCTCAAGGAGGCCACGTACGAGGGCCGTTGGGTCTCAGGGAAACCCCATGGACGGGGCGTGGTTAAATGGGTCGATGGACGAATGTACACAGGGACATTCAAGAACGGCCTTGAAGATGGTTTTGGAGATTACATTGTGCCGAACAAAAACCTGAACAGCTGTGATCATTACCAAGGGCAATGGAAGGATGGCAAGATGCACGGCTTTGGAACATTCAGGTATGCATCTGGTGAAGTGTACGAGGGCTCATTTCAAGATAACATGCGTCACGGTCATGGGATGTTGCGTAGTGGGAAGCTGAATTCCACCTCCCCCAGTGTCTTCATCGGCCAGTGGCAGTATGACAAAAAATCTGGCTATGGAGTTTTTGATGACATCACCAGAGGGGAGAAGTACATGGGCATGTGGTTGGATGATCAGCGGCAGGGGAACGGAGTTGTTGTTACACAATTCGGCCTGTACTATGAAGGTGCTTTTAGCAACAACAAAATGATGGGGACTGGGGTGTTACTGTCTGAAGATGACACCACATTTGAAGGGGAATTTTCAGAAGATTGGACTCTAAATGGAAAGGGTGTGTTGACCATGCCAAATGGAGACTATATCGAAGGCTCTTTTAGTGGGGTTTGGGGAACCGGACTAAAGATGTCAGGTTCCTACTACAAACCCAGCCTCTACGACTCAGACAAGGAGAAGGCTCATGCACTTAAACTGGGCAGGTTAGCGGTTCACTCCGAAGATAAGTGGAAGGCCGTGTTCATGGAGTGCTGGAACAGGCTCGGCTGTGATTCTCCCGGACAGGGACAAACCACTACAGCGTGGGACAGCATCGCCGTAGCGCTCACTGCTAACCTGAGACAGCAGAGAGACAGTCCAGAGTTGCTGAGTCGCTCTCATCACAAAACGCTGGAGAGTCTGGAGTTCATCCCTCAGCATGTGGGTCCTGTGACTTTAGAGGTGTATCACACAATCCGTCGGTACCTTGTCAAGGCATGTGATACCCCACTGCATCCTCTGGGTCGGCTAGTGGAGACATTGGTTTCGGTGTACCGTATGACATACGTTGGTGTCGGGGCCAACCGCAGATTACTGCACCAGGCCGTCAATGAGATCAAGTCCTATCTCAGCCGCATCTTCCAGCTCGTCAGATTCCTCTTTCCTGATCTGCCAGAGGAAGGAGGTTCACTGGCTGACCCTCCAAAAGAGACAAGCGGCTCAGACCCTGCTGGGAAGCAGCTTGAGTCTCCTAAACCTGGGTGTGTGGTCAGCAGCTCTGCTCTCCTCCTGCCGGTGCTGTTGCCACGTCTCTATCCTCCTCTCTTCACTCTCTACGCTTTAGAGAAAGAGAAGGAGGATGATGTGTACTGGGAGTGTGTGCTCCGACTCAACAAACAACCAGACCTGGCGCTGCTCGCCTTCCTCGGGGTGCAACACACAACTTTCACCCCCTCAGACAAGCTTCAGGTCATCCAGCTGACCTTCGAGGAGATAACCCAGGAAGTACTTGCACTTCTGAAACAGGATTTCTTGTGGTCTATGGATGACCTGTTTCCTGTCTTCCTCTTTGTTGTTCTGCGTGCACGGATAAGGAATCTGGGGTCAGAGGTCAGTCTCATCGAGGACCTGATGGATCCATGTGTACAACATGGAGAGCATGGCATCATGTTCACCACACTCAAGGCATGCTACTATCAAATCCAGCATGAGAAGGTCACATAATGAACACGTAATGATCTCTCCAAACCCATCTGGTAAGGCAGTGCAATGACTGACAAACTGACCAGCCAAACATAGTGTTCGAGACACAGCGCTTGCCATGACTTGATGTGTGAGGAGCCAATCATGTTCTGAGCCTGGATCACATGGCCGGCGAAGGGTGATTCCATGAAATCTGAGCTCTCACATTCAAACAGTCCAGTTTATGTGCAAGTCAGTCTTTGGTTTGGTATTTATTAACATATATTCTTTATATTTTTGTGTCTTCCTCACTCAAAAAGCCTTTTAACTGCTGCCATTCCATCATACAACAGATATATTGTTCTTTTATTAAA

Function

symbol description
als2b Predicted to enable guanyl-nucleotide exchange factor activity. Is expressed in head; muscle; retinal inner nuclear layer; and retinal outer nuclear layer. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and amyotrophic lateral sclerosis type 2. Orthologous to human ALS2 (alsin Rho guanine nucleotide exchange factor ALS2).
als2 Enables enzyme activator activity; protein homodimerization activity; and small GTPase binding activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in several processes, including positive regulation of GTPase activity; positive regulation of protein kinase activity; and regulation of endosome size. Acts upstream of or within endosome organization; lysosomal transport; and protein homooligomerization. Located in several cellular components, including centrosome; dendrite; and early endosome. Part of protein-containing complex. Implicated in amyotrophic lateral sclerosis and amyotrophic lateral sclerosis type 2.

GO:      GO:0005089, GO:0035023

KEGG:

id description
K04575 ALS2; amyotrophic lateral sclerosis 2 protein

RNA

RNA id representative length rna type GC content exon number start site end site
CI01000024_03593801_03622283.mRNA True 5269 mRNA 0.52 34 3593469 3622283

Neighbor

gene id symbol gene type direction distance location
CI01000024_03583865_03588688 NA coding downstream 4684 3582159 ~ 3588785 (-)
CI01000024_03563702_03570505 TMEM237, TMEM237B coding downstream 22964 3563606 ~ 3570505 (-)
CI01000024_03550821_03556930 CYP20A1 coding downstream 36539 3550560 ~ 3556930 (-)
CI01000024_03526772_03550303 ABI2, ABI2B coding downstream 43166 3525204 ~ 3550303 (-)
CI01000024_03499415_03506746 SUCLA2, SUCLA2.S coding downstream 86723 3498507 ~ 3506746 (-)
CI01000024_03682769_03686417 SUMO1, SUMO1.L, SUMO-1 coding upstream 59565 3681848 ~ 3686417 (-)
CI01000024_03792493_03872952 KALRNB, KALRN coding upstream 170180 3792463 ~ 3872952 (-)
CI01000024_03919201_03934276 TBX19 coding upstream 296904 3919187 ~ 3934505 (-)
CI01000024_03938368_03941795 NA coding upstream 316032 3938315 ~ 3941924 (-)
CI01000024_03945597_03947286 NA coding upstream 323252 3945535 ~ 3947286 (-)
G123560 NA non-coding downstream 70892 3438967 ~ 3522577 (-)
G123593 NA non-coding downstream 156670 3436051 ~ 3436799 (-)
G123584 NA non-coding downstream 170454 3422686 ~ 3423015 (-)
G123583 NA non-coding downstream 186177 3406066 ~ 3407292 (-)
G123557 NA non-coding downstream 215165 3378011 ~ 3378304 (-)
G123639 NA non-coding upstream 50856 3673139 ~ 3673343 (-)
G123641 NA non-coding upstream 58412 3680695 ~ 3680962 (-)
G123648 NA non-coding upstream 106484 3728767 ~ 3729062 (-)
G123577 NA non-coding upstream 130736 3753019 ~ 3754215 (-)
G123668 NA non-coding upstream 141161 3763444 ~ 3764097 (-)
G123233 NA other downstream 1038433 2547460 ~ 2555036 (-)
CI01000024_00825386_00837898 NA other downstream 2766618 824968 ~ 838550 (-)
G125457 NA other upstream 3734954 7357237 ~ 7358104 (-)
G125798 NA other upstream 4353384 7975667 ~ 7976047 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
zebrafish (Danio rerio) XLOC_031861 als2b coding NC_007117.7 CM002890.2 9793495 ~ 9861191 (+)