XLOC_000119 (pmm2)


Basic Information

Item Value
gene id XLOC_000119
gene name pmm2
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007112.7
NCBI id CM002885.2
chromosome length 59578282
location 9860381 ~ 9866856 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00000218
ACTTACATATAAATTTGAATTGGTCGCATTGTCATTCACTACAATAACAACGTGGCCCATACATAGGGAAAACAGGTTATCCTTCTTATTTATGAAGTTGTTTGTCTGCTGTTGGCAGATGTTGTACACGTGGAGGTCGCTCACTCTGACGTACAGCTCTGGCGCTTCAATACACTTCCGACAACACGGAAGATGTGACGTTGCACtgctgaatgaatgaactgactGCCACTGAGTCTTCATAAAACTTCATACAGAGGAGATATTGATTTCTAAAGTTTCCAAATATCACAATGTCTGGTTCTACCGTGGATTCGACAAcgctgtgtctgtttgacgtggaCGGGACTTTAACAGCAGCTCGTCAAAAAGCCACCGCAGACATGCATGAGTTTCTGTCTAAACTGAAACAGCGTGTGAAAGTCGGAGTGGTTGGAGGATCAGATCTGGACAAAATCAAAGAGCAGCTTGGAGATGATGTGATTGACAGAGTGGATTACGTGTTTGCTGAGAACGGTTTGGTTGCGTACAGGTTTGGAAAGCTTCACTCTGTGCAGAATATTCAGGCCTACCTGGGAGAAGACATTTTGCAGGAATTCATCAATTTCTGCCTCAATTACCTTTCAAAGATTAAACTGCCTAAAAAAAGAGGCACATTTATTGAATTTCGGAATGGAATGCTGAATGTCTCTCCGATCGGTCGAAGCTGCAGCCAACAGGAAAGAATCGAATTCTTTGAACTTGATAAGaAGGAGAAGATTAGAGAAACATTTGTCTCCGTTTTAAAAGAAGAGTTTGCTGGGAAGGGACTAGCTTTCTCCATTGGTGGACAGATCAGTTTTGATGTGTTTCCAGAAGGCTGGGATAAGCGCTACTGTTTGGGAATTGTGGAGAAAGACTCCTATCAGCACATCCATTTCTTTGGAGACAAAACAATGCCTGGAGGAAATGACTACGAAATCTTTGTAGACCCCAGAACAATCGGCCATGAGGTCAAATCTCCTGAAGACACACAGAGGATCTGCAGGGAGCTCTTTTTCAGCTGAGAAAAGACCCTGAACACAACCTCTGCTATCTAGAATGAAGTATACAGAAGACTACACTGTCTATGAATCGTGAAACTATGAATGAAAGTCTCACTATTGACTTTATTGTCTTGTATATGCACATGCTTGTACCTCATGACAGGTGCTTATGATAAATCTGGGTTACTGTGTAcagtatgcatttatttttataggtAATGTTATGCATTACATACAGCTTTAAGGATCATTGTGGGTGCTAGGGTCATTATGTCTGAACTCCTGTGCCTTAAATCACATCAGTACTGGACATTCTAAAATCTTCTATtgatattaaacacattataatcCAAATAAAAGGGAAGATCT

Function

symbol description
pmm2 Predicted to enable phosphomannomutase activity. Acts upstream of or within neurogenesis; protein N-linked glycosylation; and skeletal system development. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including axis; digestive system; hatching gland; periderm; and polster. Used to study congenital disorder of glycosylation type I. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation and congenital disorder of glycosylation Ia. Orthologous to human PMM2 (phosphomannomutase 2).

GO:

id name namespace
GO:0009298 GDP-mannose biosynthetic process biological_process
GO:0006487 protein N-linked glycosylation biological_process
GO:0090171 chondrocyte morphogenesis biological_process
GO:0022008 neurogenesis biological_process
GO:0048701 embryonic cranial skeleton morphogenesis biological_process
GO:0006013 mannose metabolic process biological_process
GO:0045047 protein targeting to ER biological_process
GO:0005829 cytosol cellular_component
GO:0005737 cytoplasm cellular_component
GO:0004615 phosphomannomutase activity molecular_function
GO:0016853 isomerase activity molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-030722-6 Predicted to enable phosphomannomutase activity. Acts upstream of or within neurogenesis; protein N-linked glycosylation; and skeletal system development. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including axis; digestive system; hatching gland; periderm; and polster. Used to study congenital disorder of glycosylation type I. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation and congenital disorder of glycosylation Ia. Orthologous to human PMM2 (phosphomannomutase 2).

Ensembl:

ensembl_id ENSDARG00000037654

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00000218 True 1394 mRNA 0.41 8 9860381 9866856

Neighbor

gene id symbol gene type direction distance location
XLOC_000118 elfn1b coding upstream 148079 9557212 ~ 9712302 (+)
XLOC_000117 uncx4.1 coding upstream 566266 9290103 ~ 9294115 (+)
XLOC_000116 BX323038.1 coding upstream 575030 9277846 ~ 9285351 (+)
XLOC_000114 chtf18 coding upstream 633177 9199031 ~ 9227204 (+)
XLOC_000115 chtf18 coding upstream 638765 9218648 ~ 9221616 (+)
XLOC_000120 NA coding downstream 20099 9886955 ~ 9914630 (+)
XLOC_000121 NA coding downstream 79808 9946664 ~ 9951873 (+)
XLOC_000122 pdia2 coding downstream 87633 9954489 ~ 9966195 (+)
XLOC_000123 si:dkeyp-75b4.8 coding downstream 99528 9966384 ~ 9982114 (+)
XLOC_000124 si:dkeyp-75b4.10 coding downstream 127955 9994811 ~ 10000376 (+)
XLOC_000111 NA non-coding upstream 727891 9129386 ~ 9132490 (+)
XLOC_000106 NA non-coding upstream 883959 8967479 ~ 8976422 (+)
XLOC_000105 NA non-coding upstream 894442 8950874 ~ 8965939 (+)
XLOC_000100 NA non-coding upstream 1269745 8587230 ~ 8590636 (+)
XLOC_000133 AL935188.1 non-coding downstream 496864 10363720 ~ 10363851 (+)
XLOC_000135 NA non-coding downstream 595188 10462044 ~ 10462882 (+)
XLOC_000136 NA non-coding downstream 750668 10617524 ~ 10617930 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000300_01225430_01228695 PMM2 coding CI01000300 null 1225430 ~ 1228987 (+)