XLOC_012098 (fas)


Basic Information

Item Value
gene id XLOC_012098
gene name fas
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007128.7
NCBI id CM002901.2
chromosome length 53461100
location 23619924 ~ 23631411 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00023850
tatgaCTTACTGTACAGTTCATCTGACGTTCGAGATTCGCTTCTAATTCGGGTGACCTCCTCGAGATGTTTGTTTGCAAATTCGGCGTTTTTATCGTCTTTGTGATGCCCACTTTGACTTATAGCTGGCGCTTGAGACGCGATGCCTCCTGTGAGTTTGGAACTTACCAGCATGAGAGGAACACATGTTGCCTCTGTCCTGCAGGATTCAAGGTTTCTACACActgcacaaacacagacaaaacaGAATGTAAGCAATGTGAGGATGGCtactatttaaacaacaacaataatgaaaaCCAATGTCGACCTTGTAAGATCTGTGACGCTAATGCAAAAATGAAGGAGATTGAGAAATGTTCCAAGAGTTCAAACACAGTCTGTGGGTGTGAGGAGGGTCGCTTTTGTGACAAGGACAAAGACTGCAACGTCTGTTACCCCTGTGATCCATGTCCAAATGGTGTGAAAGAACAATGCACAGAAACCCACAACACAGTGTGCCATGATGCCAAAGACTTAACTGgAACCATTGCTGCTGTTTTGGTGCCACTCATCCTAATAGCTGTTCTAGCTTTTATGATTTTTATatggaaaaaaaagaagttttgcTTTCAGGTCCGCCCGAGTACAGATAAAGTGCAGACTGAGgaaGCACTTCCTCTGATTGATTTAAGCCCTCACCTCCCAAAAATTGCTGATGTTCTATGCTGGAAAACAGTGAAAGAAGTTGCGCGCCGCAGTGGCATGACTGCAAAAGATATTGAGGAACAGGAGATGAACCACCCAAAAGACGTGAGAGAACAGACTTTTGGGCTTCTGGAGGCTTGGTCCCAGAGACAGGGATTAGATAAAGCCTACAGAGCTCTCATCACCACTCTGCAGGACATCGGGGAAAAAGCAACAGCAGATAAAATCCGGAACATTGTCGAGGCTTCATCTCAGCCATAAACTGCAGTCCAGAAGCACAGTGTTAAAAATGAAGCAC
>TCONS_00023851
attcattcacttatgaCTTACTGTACAGTTCATCTGACGTTCGAGATTCGCTTCTAATTCGGGTGACCTCCTCGAGATGTTTGTTTGCAAATTCGGCGTTTTTATCGTCTTTGTGGTGAATGCCCACTTTGACTTATAGCTGGCGCTTGAGACGCGATGCCTCCTGTGAGTTTGGAACTTACCAGCATGAGAGGAACACATGTTGCCTCTGTCCTGCAGGATTCAAGGTTTCTACACActgcacaaacacagacaaaacaGAATGTAAGCAATGTGAGGATGGCtactatttaaacaacaacaataatgaaaaCCAATGTCGACCTTGTAAGATCTGTGACGCTAATGGTAAGCCTTAATGTCTTTGCCTTTGCCTTGTTACTGTAGTCTGTTGAATATCGATTTGCTGCAAACTTTTTTGATCTCctgtcagaaaaaaaatgcaaagaaatgataAAGAAATCATCAAATGctgtttaataaatacacatGTTTAGCAGCTGGGCAGAAGCCAGTTAACTAATTAAGAAATGAATAATCAAAAGTTCACTACTGAATACCAGAGATGGGCTGGAATTATGTTTCTTGAAGTATGGGcatataatatagtttttttcaATGGTTTTGCCACAAATTTCCGAAACctgatgtcaattttcaaaactctagacacaaaactctaaaccaggcatgtccaaactcggtcctggagggccggtgtcctgcaaagtt

Function

symbol description
fas Predicted to enable tumor necrosis factor-activated receptor activity. Acts upstream of or within notochord development and positive regulation of apoptotic process. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of CD95 death-inducing signaling complex. Predicted to be active in external side of plasma membrane and membrane raft. Is expressed in several structures, including blastoderm; eye; gut; notochord; and ovary. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cystic fibrosis; hematologic cancer (multiple); pre-eclampsia (multiple); and urinary system cancer (multiple). Orthologous to human FAS (Fas cell surface death receptor).

GO:

id name namespace
GO:0097049 motor neuron apoptotic process biological_process
GO:0032872 regulation of stress-activated MAPK cascade biological_process
GO:0006915 apoptotic process biological_process
GO:0006924 activation-induced cell death of T cells biological_process
GO:0006955 immune response biological_process
GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway biological_process
GO:0043065 positive regulation of apoptotic process biological_process
GO:0043066 negative regulation of apoptotic process biological_process
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand biological_process
GO:0097527 necroptotic signaling pathway biological_process
GO:0030903 notochord development biological_process
GO:0007165 signal transduction biological_process
GO:0031265 CD95 death-inducing signaling complex cellular_component
GO:0045121 membrane raft cellular_component
GO:0009897 external side of plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0004888 transmembrane signaling receptor activity molecular_function
GO:0005031 tumor necrosis factor-activated receptor activity molecular_function

KEGG:

id description
ko00061 Fatty acid biosynthesis
ko04010 MAPK signaling pathway
ko04668 TNF signaling pathway
ko04060 Cytokine-cytokine receptor interaction
ko04210 Apoptosis
ko04217 Necroptosis
ko04115 p53 signaling pathway
ko04650 Natural killer cell mediated cytotoxicity
ko05200 Pathways in cancer
ko05205 Proteoglycans in cancer
ko05170 Human immunodeficiency virus 1 infection
ko05161 Hepatitis B
ko05160 Hepatitis C
ko05164 Influenza A
ko05162 Measles
ko05168 Herpes simplex virus 1 infection
ko05163 Human cytomegalovirus infection
ko05167 Kaposi sarcoma-associated herpesvirus infection
ko05169 Epstein-Barr virus infection
ko05165 Human papillomavirus infection
ko05130 Pathogenic Escherichia coli infection
ko05142 Chagas disease
ko05143 African trypanosomiasis
ko05320 Autoimmune thyroid disease
ko05330 Allograft rejection
ko05332 Graft-versus-host disease
ko05010 Alzheimer disease
ko05022 Pathways of neurodegeneration - multiple diseases
ko05417 Lipid and atherosclerosis
ko04940 Type I diabetes mellitus
ko04932 Non-alcoholic fatty liver disease
ko04931 Insulin resistance
ko01524 Platinum drug resistance
ko01004 Lipid biosynthesis proteins
ko04050 Cytokine receptors
ko04090 CD molecules

ZFIN:

id description
ZDB-GENE-061019-2 Predicted to enable tumor necrosis factor-activated receptor activity. Acts upstream of or within notochord development and positive regulation of apoptotic process. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of CD95 death-inducing signaling complex. Predicted to be active in external side of plasma membrane and membrane raft. Is expressed in several structures, including blastoderm; eye; gut; notochord; and ovary. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cystic fibrosis; hematologic cancer (multiple); pre-eclampsia (multiple); and urinary system cancer (multiple). Orthologous to human FAS (Fas cell surface death receptor).

Ensembl:

ensembl_id ENSDARG00000043586

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00023850 False 984 mRNA 0.44 8 23619924 23631400
TCONS_00023851 True 732 lncRNA 0.39 3 23627576 23631411

Neighbor

gene id symbol gene type direction distance location
XLOC_012097 ifit14 coding downstream 3298 23612616 ~ 23616626 (-)
XLOC_012096 ifit15 coding downstream 10714 23607195 ~ 23609210 (-)
XLOC_012095 ifit16 coding downstream 16661 23598205 ~ 23603263 (-)
XLOC_012094 htr7a coding downstream 74208 23542115 ~ 23545716 (-)
XLOC_012093 NA coding downstream 134588 23483059 ~ 23485336 (-)
XLOC_012099 NA coding upstream 19123 23650534 ~ 23674495 (-)
XLOC_012100 papss2a coding upstream 49675 23681086 ~ 23709347 (-)
XLOC_012101 minpp1a coding upstream 79248 23710659 ~ 23727978 (-)
XLOC_012102 pdzd8 coding upstream 189039 23820450 ~ 23895026 (-)
XLOC_012103 NA coding upstream 354462 23985873 ~ 23987510 (-)
XLOC_012088 BX511309.1 non-coding downstream 694587 22925209 ~ 22925337 (-)
XLOC_012087 BX548077.1 non-coding downstream 833633 22786174 ~ 22786291 (-)
XLOC_012086 NA non-coding downstream 930137 22687170 ~ 22689787 (-)
XLOC_012083 BX511218.1 non-coding downstream 1094179 22521636 ~ 22525745 (-)
XLOC_012104 NA non-coding upstream 391896 24023307 ~ 24026857 (-)
XLOC_012105 NA non-coding upstream 572288 24203699 ~ 24219682 (-)
XLOC_012106 NA non-coding upstream 664939 24296350 ~ 24301689 (-)

Expression


Co-expression Network