XLOC_015514 (en2b)


Basic Information

Item Value
gene id XLOC_015514
gene name en2b
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007113.7
NCBI id CM002886.2
chromosome length 59640629
location 29976419 ~ 29979956 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00031022
ATTCTGGAGCCAGTTTGCGTTTCCTTATTTACTAGAGCAGGTCTACTGCTTTGATTCTGAATAGATTACATTTCCCTGTATGTTCCAAAGTAGATATAAAGACAATTACAAGAGGCACAATGTGgaattaatttataaaactatgtttttatttttacgcGCACAAGACGGTTTCGTCGCATTTACCcgacaaaaaaactgaaaaaaggaATTTGTTCTTTTTCCCGTTCGTTTCTTTTTGCAGAGAAACTCAGAAATAAGGAAAATATACTACTAAAACTGGAACACAAACATACTTGTGTGCAAGAGAGCGAAAGGGGTTAAAAAGAACATTTGGAGAGTTTCACTATGGAAGAAAATGATCATAGCAACAGAGATGTGGAGCGCCAGGATTCGGGCGACGAGTCCAATAGGGCTATTCTTCCCCTGTTGCAGGCTCCTGGAAACGTACTCCCTCACAGAATCACCAACTTTTACATCGACAATATTTTAAGACCAGACTTTGGTCGCAGGAAAGAAGGAAGCAGACGCGACGAAATTATCATAGTTGAAAGAGAGAACCGCTGTCCATCGGCTCCCGGATCAGGGCAGGTAGCTCCAGTATCGGGGGAAGGAACCTCGAGCCCTCGCGCTGTAAACGCATCTAAAAAAACTGATATTAGCACGGACGAATCTCTGAAATCCCGTGCAGAGACTGGAGATCAGTGTTTAAGTTCCGATTCGGACTGCTCACAAAGTAGCGCTGCGCAGGCGAAACAGCCAATGCTTTGGCCGGCTTGGGTATATTGCACAAGATATTCAGACAGACCTTCATCAGGACCAAGATCACGCAAACCAAAGAAGAAAACCCCAACCAAGGAAGACAAGCGTCCGAGAACAGCATTCACAGCGGAGCAACTACAGAGACTCAAGAATGAATTCCAGAATAATCGTTACCTGACGGAGCAAAGGAGACAAGCGTTGGCCCAGGAACTCGGCCTGAACGAGTCTCAAATCAAAATCTGGTTTCAAAACAAAAGGGCAAAGATCAAAAAAGCAACGGGGAACAAAAACACACTTGCCGTGCACCTGATGGCACAGGGACTTTACAATCACGCCACAGTAACAAAGGACGACAAATCAGACAGTGATTAACACGGAGGACAGGACATCTTAAATGCAATAATTCTAAACAAGGGCCAGTGTACAAAATACCAGCATTAAACGGATGAAAACTATGTATGAGATGTGATTTTgcaatattatatgtatatatactttGTGTAGGGTGgtgtacaacttttttttaattagcatcACTGCTGTGCACTGACTGAAACTTCAGATTTATTGCGCGAGGAAAAGGAcgcttctttatttaaaaaaaaaagaaaaaaaaggagcgATTTGATACACACTTGACGTTGAGCCACACGTGAACGTGTTTAATCCATGCTGAAGTCCAAAGATTTTTCCTGCTGCATTCAGGCGActgtgatttaaaataaatggtaaaaatgttttatctgatagatgtttgtttgtttgcataatTTTATTACTGGATGAATGTTTTACTTAATTGACTTGAGTTACAGAGACATGGTATTTAAAAAGACAACATTATCAACATATTCCACATTAAagaattcagtttattttatatttatggtCTATTGTCTGGCAAGGATGGTTTACCTCACATCTCACATTTTCAGGAAAAAGATCAACATCTGAATGCATACGAGTCAGTAAAACTCAAAACCACACTAATGCAAGTACTTGACTTTGTTGTCTGTTGAATTTAGCTGGGAGTGTACAATAAAAGTTATCAACTTTTTCAAAA

Function

symbol description
en2b Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cell fate specification; midbrain development; and midbrain-hindbrain boundary development. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; mandibular muscle; midbrain hindbrain boundary neural plate; midbrain hindbrain boundary neural rod; and neural keel. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EN2 (engrailed homeobox 2).

GO:

id name namespace
GO:0001708 cell fate specification biological_process
GO:0006355 regulation of transcription, DNA-templated biological_process
GO:0006357 regulation of transcription by RNA polymerase II biological_process
GO:0030182 neuron differentiation biological_process
GO:0007275 multicellular organism development biological_process
GO:0009952 anterior/posterior pattern specification biological_process
GO:0030901 midbrain development biological_process
GO:0030917 midbrain-hindbrain boundary development biological_process
GO:0005634 nucleus cellular_component
GO:0043565 sequence-specific DNA binding molecular_function
GO:0003677 DNA binding molecular_function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding molecular_function
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-980526-40 Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cell fate specification; midbrain development; and midbrain-hindbrain boundary development. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; mandibular muscle; midbrain hindbrain boundary neural plate; midbrain hindbrain boundary neural rod; and neural keel. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EN2 (engrailed homeobox 2).

Ensembl:

ensembl_id ENSDARG00000038868

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00031022 True 1825 mRNA 0.40 2 29976419 29979956

Neighbor

gene id symbol gene type direction distance location
XLOC_015513 htr5aa coding upstream 35900 29925561 ~ 29940519 (+)
XLOC_015512 si:ch211-207d6.2 coding upstream 79847 29795833 ~ 29896572 (+)
XLOC_015511 NA coding upstream 248962 29712210 ~ 29727457 (+)
XLOC_015510 ptf1a coding upstream 264658 29710857 ~ 29711761 (+)
XLOC_015509 dlgap1a coding upstream 283594 29491314 ~ 29692825 (+)
XLOC_015515 rbm33b coding downstream 15634 29995590 ~ 30047637 (+)
XLOC_015516 NA coding downstream 92723 30072679 ~ 30089989 (+)
XLOC_015517 dnajb6a coding downstream 123175 30103131 ~ 30116467 (+)
XLOC_015518 BX510360.1 coding downstream 146458 30126414 ~ 30126936 (+)
XLOC_015519 kcnb2 coding downstream 165023 30144979 ~ 30177469 (+)
XLOC_015503 NA non-coding upstream 1552932 28393943 ~ 28423487 (+)
XLOC_015502 NA non-coding upstream 1625972 28245460 ~ 28350447 (+)
XLOC_015501 NA non-coding upstream 1781811 28194138 ~ 28194608 (+)
XLOC_015500 CR925777.1 non-coding upstream 1937794 27975554 ~ 28038625 (+)
XLOC_015521 NA non-coding downstream 217414 30197370 ~ 30197741 (+)
XLOC_015523 CR788254.2 non-coding downstream 289350 30269306 ~ 30270163 (+)
XLOC_015524 CR788254.1 non-coding downstream 296261 30276217 ~ 30277062 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000004_10610634_10613290 ENG2B coding CI01000004 null 10609780 ~ 10613630 (+)