XLOC_030168 (hmbsa)


Basic Information

Item Value
gene id XLOC_030168
gene name hmbsa
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007116.7
NCBI id CM002889.2
chromosome length 72500376
location 30518036 ~ 30534426 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00058983
TGGCCTTTGTAATTTGAAATTTAGAGGATACAGTATGTTCTCAGTtctcacattttaatattttatacaaaCACATTCTAAACCAAAAGATTCCAGTAAAGCCAGATAAACTgggaaactcattcattcattttcttttcgacgaatcaggggtcaccacagcacagcggaatgaactgccaacttctccagcatatgttttacacagcggatgcccttccagatgcaacccagtactgtgaaaaaaCTGAGAAATGTCAAATGATGTTTCAATCGACATTTTTCAGCATGAATTCAGTGATTTTACAGCATGTGCGGCGACATCAGTGTTGTTGTGTCGAAGTAAGCGCTGTGTGGCGCTGCATGACGAGCCTGAACTGAACACACCCCCAGCGCGGCGTGTTCACAGCAAACGGAAGTTTCGTTCCCGTCTAGGTCACGCCACAGAAATCGGGTCACGAGCAGAGTTTGCGGTTGCAGTTTGACATTACAGGAATCATTCAACCAAAACAACTGTTGCAAATGACCGAAAAACCGTGACGACACAGTTTGGGGAACATATCGTTCCACTTCCATGATGGAGATGTCTGGGAACGATACTATCTCTCAAGAGGGAAATGGCAAAGCCAGTCGGGTTATTCGCATGGGAACGAGGAAAAGCcagTTGGCTCGCATTCAAACTGACAGTGTGGCCGGCACACTAAAACAACTTTATCCAGACGTTCATCTAGAGATTGTTGCCATGTCCACAATTGGAGACAAGATCCTGGACACTGCATTATCAAAGATTGGCGAAAAGAGCCTCTTCACCAAAGAGCTGGAGAACGCGCTTGAGAGAAACGAAGTGGATATTGTGGTGCACTCTCTAAAGGATTTACCTACCTCATTGCCCCCTGGATTCACTATTGGAGCCATTCTTGAGCGTGAAAATCCTCATGATGCAGTGGTGCTTCATCCAAAAAATGCTGGACTGACCCTTGACAGCCTGCCAGAGAAGAGTGTGATTGGCACAAGTTCACTTCGCAGAGCAGCTCAGCTGAAGAAACGATTTCCTCAACTGGAGTTTGAAAATATTAGAGGGAACCTGAACACCCGTTTAAAGAAGCTGGATGAAAAGGACGACTATGCTGCTATCATTCTGGCTGCTGCAGGCCTCAAACGTATGGGCTGGGAAAGCAGAATCAGTCAGGTTCTGGGCCCTGAGGATTGCATGTATGCCGTGGGTCAGGGTGCTCTGGCAGTGGAAGTCCGAGCTCAAGATAAAGACATTCTGGAAATGGTGTCCGTCCTGCATCATCCCGACACAGTTCTACGCTGCATCTCCGAGAGAGCTTTCCTCAAACAGCTGGAAGGAGGCTGCAGTGTACCTGTGGCTGTTCATACTGAAGTCAAAGGGTCTATGCTGTATCTGACTGGAGCTGTGTATAGTTTGGATGGAGCTGATTGTTTAAAGGACACCATGCAGACGTGTGTGGAATTGGACAACAAAgtGAACGAGAGTACACAGCGCTCTGCAAATGTTGGAGTCACTGCGTGCAATATCTCATCATCAGCCCTCGAAGCTGCTGAGAAACTGGGGCTGGATCTGGCAAATGTTCTCCTTAATAAAGGGGCCAAAGACATTCTTACAACAGCCAGAAAACTAAATGATGCTCGATAA
>TCONS_00058984
ACAGCAAACGGAAGTTTCGTTCCCGTCTAGGTCACGCCACAGAAATCGGGTCACGAGCAGAGTTTGCGGTTGCAGTTTGACATTACAGGAATCATTCAACCAAAACAACTGTTGCAAATGACCGAAAAACCGTGACGACACAGTTTGGGGAACATATCGTTCCACTTCCATGATGGAGATGTCTGGGAACGATACTATCTCTCAAGAGGGAAATGGCAAAGCCAGTCGGGTTATTCGCATGGGAACGAGGAAAAGCcagTTGGCTCGCATTCAAACTGACAGTGTGGCCGGCACACTAAAACAACTTTATCCAGACGTTCATCTAGAGATTGTTGCCATGTCCACAATTGGAGACAAGATCCTGGACACTGCATTATCAAAGATTGGCGAAAAGAGCCTCTTCACCAAAGAGCTGGAGAACGCGCTTGAGAGAAACGAAGTGGATATTGTGGTGCACTCTCTAAAGGATTTACCTACCTCATTGCCCCCTGGATTCACTATTGGAGCCATTCTTGAGCGTGAAAATCCTCATGATGCAGTGGTGCTTCATCCAAAAAATGCTGGACTGACCCTTGACAGCCTGCCAGAGAAGAGTGTGATTGGCACAAGTTCACTTCGCAGAGCAGCTCAGCTGAAGAAACGATTTCCTCAACTGGAGTTTGAAAATATTAGAGGGAACCTGAACACCCGTTTAAAGAAGCTGGATGAAAAGGACGACTATGCTGCTATCATTCTGGCTGCTGCAGGCCTCAAACGTATGGGCTGGGAAAGCAGAATCAGTCAGGTTCTGGGCCCTGAGGATTGCATGTATGCCGTGGGTCAGGGTGCTCTGGCAGTGGAAGTCCGAGCTCAAGATAAAGACATTCTGGAAATGGTGTCCGTCCTGCATCATCCCGACACAGTTCTACGCTG
>TCONS_00058985
GACCCAGCACAGCATCCTGAACTGTTAAAGTGTCAGCAAAGATCATGGAAGGGCCATTCAAGTATATTAGAGAGGGAAATGGCAAAGCCAGTCGGGTTATTCGCATGGGAACGAGGAAAAGCcagTTGGCTCGCATTCAAACTGACAGTGTGGCCGGCACACTAAAACAACTTTATCCAGACGTTCATCTAGAGATTGTTGCCATGTCCACAATTGGAGACAAGATCCTGGACACTGCATTATCAAAGATTGGCGAAAAGAGCCTCTTCACCAAAGAGCTGGAGAACGCGCTTGAGAGAAACGAAGTGGATATTGTGGTGCACTCTCTAAAGGATTTACCTACCTCATTGCCCCCTGGATTCACTATTGGAGCCATTCTTGAGCGTGAAAATCCTCATGATGCAGTGGTGCTTCATCCAAAAAATGCTGGACTGACCCTTGACAGCCTGCCAGAGAAGAGTGTGATTGGCACAAGTTCACTTCGCAGAGCAGCTCAGCTGAAGAAACGATTTCCTCAACTGGAGTTTGAAAATATTAGAGGGAACCTGAACACCCGTTTAAAGAAGCTGGATGAAAAGGACGACTATGCTGCTATCATTCTGGCTGCTGCAGGCCTCAAACGTATGGGCTGGGAAAGCAGAATCAGTCAGGTTCTGGGCCCTGAGGATTGCATGTATGCCGTGGGTCAGGGTGCTCTGGCAGTGGAAGTCCGAGCTCAAGATAAAGACATTCTGGAAATGGTGTCCGTCCTGCATCATCCCGACACAGTTCTACGCTGCATCTCCGAGAGAGCTTTCCTCAAACAGCTGGAAGGAGGCTGCAGTGTACCTGTGGCTGTTCATACTGAAGTCAAAGGGTCTATGCTGTATCTGACTGGAGCTGTGTATAGTTTGGATGGAGCTGATTGTTTAAAGGACACCATGCAGACGTGTGTGGAATTGGACAACAAAgtGAACGAGAGTACACAGCGCTCTGCAAATGTTGGAGTCACTGCGTGCAATATCTCATCATCAGCCCTCGAAGCTGCTGAGAAACTGGGGCTGGATCTGGCAAATGTTCTCCTTAATAAAGGGGCCAAAGACATTCTTACAACAGCCAGAAAACTAAATGATGCTCGATAACCCTGATGTTTCTGTTCATTTCATGTTGTGCACTGGAATATCATTAGACCTAGATATTTTGGAAACTTTGACATGCTGTTAACTTGGATAAACAGTCAAATCAACGATAGCTGAATAACTACCATGATTAGAGGAACATGTTGTTTTATCTATACCTCAGTGCCTTGCTTTAACAGAGACACTACTTTTAGATGACTGCTATTCTCTGGTCTCAAGCACTgagttttgtaaaaaataaataaatttaaaaaaccgCCAATTCTGCCTTtacagcataggtctcaaactcaattcctggagggttgcagctctgcagtttttctccaaccctatcaaacacagctgacccaaataatcaaggtgttcgagAGTTATGAACATCTTCATAAGGTGCATTTGAtcagggttgaagcaaaactgcgAGCTGCAACCATCCAGGaattgagacctatgctttacaGTGTCTCTGAACCTCATTATTACAAGGAAGTGAACAGATGTCTACTTTTTACATCAGAGCTTTTTTTCATCTTTAGCTTTTACGTAAAcggagtaaaaaaaaatgtgtcaaagtaTCCCACATTTCCTTTTATCACTGGAAGAATATTCATGTAATAATCAAAGTACTGAGGTGCTAAGATTTTATGGGTGTTTTAGCACCATGTAAGATTTTTACTGGCAAAATTAGCTGTCTAAGTTCgtgttaatattttatatttatgtagcaAGTTGTAAAGTGCCTTCCAAATGTGAAATTGACCAGCTATACTATAGCAATTACTTGGCCAGCAACATTGTGTTGTCAAATCAACAtgagaatgaattaaaaaatgtgttataaataataaagtatatcAACAACCCCCTGA

Function

symbol description
hmbsa Predicted to enable hydroxymethylbilane synthase activity. Predicted to be involved in heme biosynthetic process. Predicted to act upstream of or within peptidyl-pyrromethane cofactor linkage and porphyrin-containing compound biosynthetic process. Predicted to be active in cytoplasm. Is expressed in intermediate mesoderm. Human ortholog(s) of this gene implicated in acute intermittent porphyria and sickle cell anemia. Orthologous to human HMBS (hydroxymethylbilane synthase).

GO:

id name namespace
GO:0018160 peptidyl-pyrromethane cofactor linkage biological_process
GO:0033014 tetrapyrrole biosynthetic process biological_process
GO:0006783 heme biosynthetic process biological_process
GO:0005737 cytoplasm cellular_component
GO:0004418 hydroxymethylbilane synthase activity molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-040426-1375 Predicted to enable hydroxymethylbilane synthase activity. Predicted to be involved in heme biosynthetic process. Predicted to act upstream of or within peptidyl-pyrromethane cofactor linkage and porphyrin-containing compound biosynthetic process. Predicted to be active in cytoplasm. Is expressed in intermediate mesoderm. Human ortholog(s) of this gene implicated in acute intermittent porphyria and sickle cell anemia. Orthologous to human HMBS (hydroxymethylbilane synthase).

Ensembl:

ensembl_id ENSDARG00000008840

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00058983 False 1660 mRNA 0.47 14 30518036 30533557
TCONS_00058984 False 912 mRNA 0.48 11 30518441 30529072
TCONS_00058985 True 1990 mRNA 0.42 14 30520249 30534426

Neighbor

gene id symbol gene type direction distance location
XLOC_030167 stk36 coding upstream 106871 30392148 ~ 30411165 (+)
XLOC_030166 zgc:158412 coding upstream 126216 30384554 ~ 30391820 (+)
XLOC_030165 adamts15a coding upstream 308968 30179010 ~ 30209068 (+)
XLOC_030164 BX897688.1 coding upstream 351464 30166456 ~ 30166572 (+)
XLOC_030163 timm8b coding upstream 427530 30089715 ~ 30090506 (+)
XLOC_030169 dpagt1 coding downstream 54430 30588856 ~ 30595372 (+)
XLOC_030170 hinfp coding downstream 62051 30596477 ~ 30612729 (+)
XLOC_030171 abcg4a coding downstream 89757 30624183 ~ 30672482 (+)
XLOC_030172 pdzd3b coding downstream 146378 30680804 ~ 30697908 (+)
XLOC_030173 atp5l coding downstream 164834 30699260 ~ 30701891 (+)
XLOC_030162 dre-mir-125b-2 non-coding upstream 519189 29998762 ~ 29998847 (+)
XLOC_030161 dre-let-7a-4 non-coding upstream 527492 29990452 ~ 29990544 (+)
XLOC_030160 mir100-2 non-coding upstream 527815 29990147 ~ 29990221 (+)
XLOC_030159 NA non-coding upstream 529605 29902153 ~ 29988431 (+)
XLOC_030174 BX276103.2 non-coding downstream 188703 30723129 ~ 30727648 (+)
XLOC_030177 NA non-coding downstream 246004 30780430 ~ 30974079 (+)
XLOC_030178 NA non-coding downstream 417797 30952223 ~ 30954521 (+)
XLOC_030185 CR759893.1 non-coding downstream 1013886 31548312 ~ 31548787 (+)
XLOC_030191 NA non-coding downstream 1370421 31904847 ~ 31912078 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000339_05924933_05931878 HMBS, HMBSA coding CI01000339 null 5924715 ~ 5932584 (+)