LOC110491484 (sost)


Basic Information

Item Value
gene id LOC110491484
gene name sost
gene type misc
species rainbow trout (Oncorhynchus mykiss)
category of species economic fish

Chromosome Information

Item Value
chromosome id NC_048580.1
NCBI id CM023234.2
chromosome length 78541548
location 17490773 ~ 17497981 (+)
genome version USDA_OmykA_1.1_2020_rainbow_trout_Genome

Sequence

>XM_021564968.2
CTGCGTTACAGGAACTCAAAGAGACCAGAGACGGAGGTGGATGCGCTATCTCCCTAAAACCAACGTACCCAAACCCGTGCGCACCTCTCCTTGCGAGCGCCCATGCACCTCCccaccattttttaaataaatgaatttGGCTGGGGCTGGACCCCTCCCACTTTGTGTATGCTCTTAATTGTCAGTTTTGACGAAAGCTTGGGTATTTAAATAGCGTCAACGTCTCTTGTATGGGTGGAATTGGTGAAGTTGTTACAGAGCGCATCTTACCCGACGTTTTTCACCTGCTCTACCGCGGATCGATAAGCATGCAGGTGTCTCTCGCGCTCCTCGTCTCCAGCACggggctgctgctgctacagggATGTTGTACGGTCGTGCAGGGATGGAGGGTACTAAAAAACGATGCTACAGAAATAATACCAGAATATACTGAGAACGCACAGCCTCCCGAGCAACCAATACTACAGGCTtctaataataacagtaatacaATGAATCGACCAAAACACGGGGGAAgaagatcatcagcaaacagagCCTCTTATAGTGCCTCGGAGCTGAGCTGCAGGGAGCTGCGCTCCACCCGTTACATCACTGACGGCTCCTGCCGCAGTGCCAAGCCCGTCAAGGAGCTGGTGTGCTCGGGTCAATGCATGCCCGCCCACCTCCTACCCAACTCCATCGTGCGCGGCAAATGGTGGCGGAGCAGCGCCTCTGACTACCGCTGCATCCCGGCCCACTCCCGAACACAGCGGGTGCAGCTGCAGTGCCCCAACGGCAACTACCGGGCTTACAAAATCCGCGTGGTCACCTCCTGCAAGTGCAAACGCTACAGCCGCCACCACAACCAGTCAGAGGCCAAGGAGAGCTCCTCAGAGGCCAAGCCCAGACGAGACAAGAAACGCACCCGGCTGCCTGGGAGTCGGAACAAAAGCAACACACCGACACTGGTCAGCAATTCATACTGAGGATGCTCTTCCTTCCTTCGTACACGGACAGAGACCAAAGCAGTACACACGCACATGTTACACACATCCAACACGGCTCCTTCACtggaagagggagaagaagagccTTTTCAACAAATAAAAGGATTTGTAAAGCTGTTTGTTGGACTGATTTGACACAAGTCTTTCTCACCAGAGAGGCACTATAGATTTTGCAGCCTATTTTACAAAATATTTCAGAACTTTTGATTTGCATGACCAAATGAGTCGACAAAATGCCAGGGAAGGCCATGTGACTGGTCAGGAAAGGTGGAACACTGCTAGGATGGgagtgtacagtattatacatgTTCCGGTTCGTAGCTAACAGCCTCTGACTCAGACACTAAGAGTATCTATCCACCTTCGCCACAGCAAGAGGTGAACCTAAACTCAAACCCCACCTGTCAAAACATCCACCGGGCAGGCTACATTGCCTGATAGGCCTATAGGGTTGAAAAGTGTGTCTGTGCTCTAACTGTGCTCTAGCGCCTCTATGGCTGGGTGTTCTGTACTGAGCAGCCTGTGGCAGCCCTTGGGCGTCCTGGCTATGAAGGTGGGCTGCTGACAGGCCCTGGCCTCGACCCCAGACCACGCAGCCTCCTGACAGCCCGGGGAGCACCGCACTCACCAGGAGCCCCCCCAGGGTCCTCCTCACTCCATAGCAGCAGTATAGGAGCTGTCAGTTAAGGCCCCTGGCCCAGTGGCCCTAGTGGCCCGTGATGGTgaaagagatagggggagagagaggggtggggaatgGTTGTGTCAGCACTCCAAGACCAGGGTGCCTGCGGTCAAACAGGTGACTGAGCATTCCAGTGACCCGTCTTAATGACTAAATGAGCCCATTCCTGTGTTTAAGATTTGAGTCATGAAAAGCCATTTCCTCTAGACATGGCTAGTTCCTGTTTGCtgaaaccacacagacacacaaaagaTCCTCATGTGTAGAGGAGGCTCCAGCAATTGTGCCTGTTGTTACCTTGAGGCACAGCATTCTATACTCATCTACACCCTGAATGGAGACTATTTGTTAGAAGCAAATAGCATTGGTAACCAACTAGCCGTATCCCTATTCTATTCATTGAGAACCTAGATGGTGAGGGAGAGAAAACAACTCCACTTCTCTGACTATCAGCCCTACACTGTAAATAGCAATTAGTTCTGCTAACAATTTTTTTGGAGGGTGGAAACCACTCAACTTAAACTATACAGTGTTCAATACTTAAAGTAATAAAGTGACATCATCACCCATATTGTTATATTTTTAAGTTGTAAATACTTAACTGTTTTGGGTTTTCTGAAATATTTGACACAAAATCATATTATGTATTCTGAACTATAAAAATGGAAGTTATTTTAGCATGAATATTTGTTGTAGGGAACCTAAACATTTCGGGTCCCTTCTACTTACATTTTCAAGTGCACGTAGTAAGTAGTTCTGATAAGTAATTTTCAGCGGTCGTGTCTAACATTGTTTTATGTATTTGACAATTTGTCATTTTAACCCACCTTAGCAGgcattgttgagcacagtgctcattcctctagcagtaactGGAGGTAGAGTTTTAAGCATGACAGGATTCTGCATTTGCCTCTGTCAATCGGAGTGACTGTTGATAGTGGCAATTTCTTGTCTCATTATTGAAAGTATATTTTCCCGATGGTTTTGATATCGTTTTCCATAATCTGTTACACTTCACAGCACAGAAAACTGCTTAATACCATTTTAGAAATGTACTTTTCTTTCTTCAAACATGCATACAACATTGTGTAAAAGTACTGTATCATAaagtactttttattttattaccaACAATCCTATACAAACAGAGCCATGTGGCATTATTAGGTATTCATAACTTGCAAAAATACGTAACAATTCTATATCAGCACAAACACAGATAAATCAAGTGTTTTTTGCTCTAATATCCATGTCTACTACTTTATTATTTTAAGTAAAttttcattttacctttatttaaccaggcaagtcggaaaattcttattttcaatgatggcctaggaacagtgggttaactgcctgttcaggagcagaacgacagatttgtaccttgtcagctcgagggttTGAACTTGCATCTACAAGTGGTTGCATCTACAAGTGGTTGCAtctactagtccaacactctaaccactgggctaccctaCCAAGTAACAACAATTTGAGTAATGTTTAATGTTAGATTGACTTTAAAATATTAAATAATCATTACTTGTAACGTCTCAATATCTTCAGATTAGCAGAACACAAATAAATGAAGTTATATTTACTCAATAACTTAATATTTGTTAACAGTTCTTAAAAATATTAAGTGGCATATGAGTTAGTACCACTTCTAAAATTGTTGTTCTACTTACCGTTGGAAATATTTGAATAGCCACTAATCAATTTATTTAATGAGTAAGACAGTTAATTTTTACAGTACAATCTCTGAATAGAACTGACAAGAAAGATAGGAATGAGGTAAAAGACTGAAACTAAATCTGAATTGTTTTATATTGGCTGCTGCTATCCCgcaggagggatggagacagacagacagacagacagacagacagacagacagacagacagacagacagacagacagagacagacagacaggaaaaggTTCTGGATCCCCAATTTGCCCATGCTGACAAACCCATTCCCCTTTCTCATCCCTACTACAGTCTGACCTGTATTTAATTAAGAGTACTATGAACCTTTCAGCTTATTGTCCACATTCCGTTGTGCCATTCTCTCATAATACTTCCTTGTTTTGGTGTTCTAAACTGTACTGACAATGTTTGCTTCTTGTTCAATTGTGTGTTTGAAATAGCAACTGGAAGGGATTTTGTCATGTAAGCAGAGTTGTCCGTGTATAGCCTGATTGTACTTTAGAGACTCAAAGAAGGACTGCTACAAAGAATAAACtgcatatttatattttatttctacaTTTAAATTATTTATGCAACTTGTAGTAAATGATGAAGCCATTATTGTCACATAAAATAATAGTGACTTTCAGATAATAATgaaatactgtacagtacaataATAAAGTAGAGGCAGGTTTATTTGAAA
>TU1540690
GGTAGAGTTTTAAGCATGACAGGATTCTGCATTTGCCTCTGTCAATCGGAGTGACTGTTGATAGTGGCAATTTCTTGTCTCATTATTGAAAGTATATTTTCCCGATGGTTTTGATATCGTTTTCCATAATCTGTTACACTTCACAGCACAGAAAACTGCTTAATACCATTTTAGAAATGTACTTTTCTTTCTTCAAACATGCATACAACATTGTGTAAAAGTACTGTATCATAaagtactttttattttattaccaACAATCCTATACAAACAGAGCCATGTGGCATTATTAGGTATTCATAACTTGCAAAAATACGTAACAATTCTATATCAGCACAAACACAGATAAATCAAGTGTTTTTTGCTCTAATATCCATGTCTACTACTTTATTATTTTAAGTAAAttttcattttacctttatttaaccaggcaagtcggaaaattcttattttcaatgatggcctaggaacagtgggttaactgcctgttcaggagcagaacgacagatttgtaccttgtcagctcgagggttTGAACTTGCATCTACAAGTGGTTGCATCTACAAGTGGTTGCAtctactagtccaacactctaaccactgggctaccctaCCAAGTAACAACAATTTGAGTAATGTTTAATGTTAGATTGACTTTAAAATATTAAATAATCATTACTTGTAACGTCTCAATATCTTCAGATTAGCAGAACACAAATAAATGAAGTTATATTTACTCAATAACTTAATATTTGTTAACAGTTCTTAAAAATATTAAGTGGCATATGAGTTAGTACCACTTCTAAAATTGTTGTTCTACTTACCGTTGGAAATATTTGAATAGCCACTAATCAATTTATTTAATGAGTAAGACAGTTAATTTTTACAGTACAATCTCTGAATAGAACTGACAAGAAAGATAGGAATGAGGTAAAAGACTGAAACTAAATCTGAATTGTTTTATATTGGCTGCTGCTATCCCgcaggagggatggagacagacagacagacagacagacagacagacagacagacagacagacagacaggaaaaggTTCTGGATCCCCAATTTGCCCATGCTGACAAACCCATTCCCCTTTCTCATCCCTACTACAGTCTGACCTGTATTTAATTAAGAGTACTATGAACCTTTCAGCTTATTGTCCACATTCCGTTGTGCCATTCTCTCATAATACTTCCTTGTTTTGGTGTTCTAAACTGTACTGACAATGTTTGCTTCTTGTTCAATTGTGTGTTTGAAATAGCAACTGGAAGGGATTTTGTCATGTAAGCAGAGTTGTCCGTGTATAGCCTGATTGTACTTTAGAGACTCAAAGAAGGACTGCTACAAAGAATAAACtgcatatttatattttatttctacaTTTAAATTATTTATGCAACTTGTAGTAAATGATGAAGCCATTATTGTCACATAAAATAATAGTGACTTTCAGATAATAATgaaatactgtacagtacaataATAAAGTAGAGGCAGGTTTATTTGAAAGAG

Function

symbol description
sost Predicted to enable BMP binding activity. Predicted to be involved in negative regulation of BMP signaling pathway; negative regulation of Wnt signaling pathway; and ossification. Predicted to act upstream of or within Wnt signaling pathway and negative regulation of ossification. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including Kupffer's vesicle; endochondral bone; nervous system; notochord outer sheath cell; and pharyngeal arch cartilage. Human ortholog(s) of this gene implicated in SOST-related sclerosing bone dysplasia; autosomal dominant craniodiaphyseal dysplasia; sclerosteosis; and sclerosteosis 1. Orthologous to human SOST (sclerostin).

GO:

id name namespace
GO:0005615 extracellular space cellular_component

KEGG: NA

RNA

RNA id representative length rna type GC content exon number start site end site
XM_021564968.2 False 4089 mRNA 0.43 2 17490773 17497978
TU1540690 True 1516 lncRNA 0.34 2 17496444 17497981

Neighbor

gene id symbol gene type direction distance location
dusp3a LOC106579333 coding upstream 24305 17442743 ~ 17466468 (+)
LOC110491479 LOC106579387 coding upstream 75388 17412299 ~ 17415385 (+)
LOC110491478 LOC106579335 coding upstream 80917 17405145 ~ 17409856 (+)
LOC110491476 LOC106579336 coding upstream 87607 17346027 ~ 17403166 (+)
aarsd1 aarsd1 coding upstream 114717 17363326 ~ 17376056 (+)
LOC110491483 LOC106579330 coding downstream 98182 17596160 ~ 17623382 (+)
LOC110491481 LOC106579328 coding downstream 141003 17638981 ~ 17668199 (+)
LOC110491490 LOC106579325 coding downstream 496377 17994355 ~ 18024642 (+)
cdk5r1b LOC106579323 coding downstream 590504 18088482 ~ 18095827 (+)
tbkbp1 tbkbp1 coding downstream 753852 18251830 ~ 18323632 (+)
G1347655 NA non-coding upstream 20645 17469904 ~ 17470128 (+)
G1347476 NA non-coding upstream 109582 17380429 ~ 17381191 (+)
G1347471 NA non-coding upstream 133008 17356405 ~ 17357765 (+)
G1347847 NA non-coding downstream 119993 17617971 ~ 17618254 (+)
G1347898 NA non-coding downstream 179889 17677867 ~ 17678075 (+)
G1347904 dhx8 non-coding downstream 186500 17684478 ~ 17691398 (+)
G1347913 NA non-coding downstream 202485 17700463 ~ 17700675 (+)
LOC110492842 LOC106579341 other upstream 216793 17235828 ~ 17305959 (+)
LOC110491464 LOC106579031 other upstream 334103 17152137 ~ 17156699 (+)
G1346758 NA other upstream 544529 16945928 ~ 16946244 (+)
G1345431 NA other upstream 1947236 15542391 ~ 15543537 (+)
G1345417 LOC106579048 other upstream 1966205 15524002 ~ 15524568 (+)
G1348897 LOC106579309 other downstream 1057199 18555177 ~ 18555452 (+)
LOC110491516 LOC106589273 other downstream 1254645 18682058 ~ 18760420 (+)
LOC110491534 LOC105006846 other downstream 1641049 19138817 ~ 19141680 (+)
G1350066 NA other downstream 2239184 19737162 ~ 19738034 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
zebrafish (Danio rerio) XLOC_004769 sost coding NC_007123.7 CM002896.2 27331324 ~ 27335652 (+)