XLOC_004769 (sost)


Basic Information

Item Value
gene id XLOC_004769
gene name sost
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007123.7
NCBI id CM002896.2
chromosome length 49182954
location 27331324 ~ 27335652 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00009435
GTGGTAGTTTAAAAAGGCAAGCCTCTCCCGAAGAGAAGAAAACTGGTCGAAGTTTGCCCGCTGAACGGCTCGTTCTCGGTTGTATTATGCAGGTGTCTCTGGCGCTCGTGCACTGCGGCGCGcggctgttgctgctgctgctgcttcaggGATGTTTCACAGCTGCGCACGGATGGAGGCCTTTAAAAAACGATGCTACAGAAATTATACCAGAATACGCGGAGGACACGCACAAACCCGAGGAGCAGATACAACTGTCTGACAATAACACAATGAATCGGGCGAAGAACGGTGGAAGGCGGTCGTCAGCAAACACACGGACTTATGGAGCCTCAGAACTCAGCTGTCGGGAGTTGCGTTCGACCCGATATGTGACCGATGGATCTTGCCGCAGTGTCAAACCCGTGAAGGAACTTGTGTGTTCTGGTCAGTGCCTTCCAGCTCACCTGATGCCAAACTCAATTCTACGGGGGAAATGGTGGAGAAGCAGCTCCTCCGATTACCGTTGCATCCCTGCTCACTCCCGCACCCAGCGGATACAGCTCCAGTGTCCAAACGGACCAAACCGGACATACAAAATACGAGTTGTCACATCTTGCAAGTGCAAACACTACACTCGACAACACAACCAATCGGATGTCAAAGAGTCGTCCAAGAAACCACGGCGCAATAAGAAGCACCGCAGCAAAGTGCCGTCCATCAACAGCAATTCATACTGAGGGGAAAAGATGCAGAACTGATACAGAAAACACTCTCttgcacacatacaaaaaaaaagaaagtacaccaatacatatgcacacatattaCAGAAACTGCAATCCTCATCTACAAGGGAAGGAATAAACGCATTAGCATTTACCAAGCTTGTTGGCATGCTAACAAGTTTCCAATGTATTTCAGATGTCTCGCTGTTTGTATGTGCTCTTGAGCCTAAATCGTCCCAGTTTGATCACAATATGCCAGCGGACTGAGTGAAAAGACGTCCGCTGTTATGCGAGATTAGATCAGGCAATGTGATTTTTTTGAGGGAGGAGAAATATTCCTGCTCAAGCGGTTCATTTCAAGTTCACCGAAGTTCATTGAAAGGCTAACTTACGGGCAAGCATACTGAGTGCTCCACCAGTCCAGCAAGTGCTCATGTGAATGTTTGTGCACCAGATTTGTCCTCTTTTGGGATTCGGAGCAGTGTATGATTTGAGCGCTCAGCCGCGTCTGGCCCAAAAGACACGCTGCTGCTGACAGACCACTGAAGCCCAGAATTCTTAACCTTGGTCACTTTTACCAGGTCCTTTTTGACAGGCTGGGGAGTCCATGTGAGTGTCTGCAAATTCACATTTCCACAAGAAACTGATCGACACTGGCAGCTAGAGCCGCCTTACGGAGAGTTCGGAAAGTTGTGTCAGCCCTCCACGGTCCAAGTCCCTGGAGGTCGAGAACAGCAAACGGTATTCCTGTGACTTGTCCTAATTACCAAATAGTTCCATTCCTGTGTTTAGGATTTGAGTCATAAAAAGCCATTTCCTCTAGACATGGTCAGTTCCTGTTTGTTCGAACACCCGAAAAAGAGGCCCACATGTGTGCACGAATCTGCAGCAATTCCTCGCGGGCAAATAACCTTTACGCACCCTCCTTCAATGGAAACCATTTGGAGATATTCAGCTATCTGCAATCGCTAGCAGGTTACCTACATCCATTACTGAAGTCTTCAGCAGAGATGTCATCCTTCCTGTCTCCACACATGACCggaaaagaacaaacaaataagtGAACCAATCTCTGAAATCGTGGGCTGGATGTTGATTCTACACAGGATACAGAGATCAGAGAAGGCCAATTGTTCAACATTTTTTCTGCCCACCTCGATGATATTTGCTCATTTTTTCAATTGTGTGTTTGAAATAGCAACTGGAAGGGATTTCTTATAATGTAAGCAGACTTGTCGTGAATAGTAACTTGTACATAGTATACCTGTGTGGTATACCTGTGTAGTTTACCTGTGTGGTCTGTGTGGTGAGCGGTATCCTCCTTCAACCAATGGATCCTCTTTCAGACCAAAAGACTGTTACAAAGAATGAactgtgtatttatttttgtatttttatcatttaaattatttatgcaatctgttttttttttgtagaaaataaTAGCCATTATTGTACTATATGTAATTATAGTGAATTTCATACCGAAAAAAAAGAGTACATGAATAAAGTTAAGCAACCTATATATGTG

Function

symbol description
sost Predicted to enable BMP binding activity. Predicted to be involved in negative regulation of BMP signaling pathway; negative regulation of Wnt signaling pathway; and ossification. Predicted to act upstream of or within Wnt signaling pathway and negative regulation of ossification. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including Kupffer's vesicle; endochondral bone; nervous system; notochord outer sheath cell; and pharyngeal arch cartilage. Human ortholog(s) of this gene implicated in SOST-related sclerosing bone dysplasia; autosomal dominant craniodiaphyseal dysplasia; sclerosteosis; and sclerosteosis 1. Orthologous to human SOST (sclerostin).

GO:

id name namespace
GO:0030178 negative regulation of Wnt signaling pathway biological_process
GO:0001503 ossification biological_process
GO:0030514 negative regulation of BMP signaling pathway biological_process
GO:0030279 negative regulation of ossification biological_process
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0036122 BMP binding molecular_function

KEGG:

id description
ko04310 Wnt signaling pathway
ko04928 Parathyroid hormone synthesis, secretion and action

ZFIN:

id description
ZDB-GENE-110411-139 Predicted to enable BMP binding activity. Predicted to be involved in negative regulation of BMP signaling pathway; negative regulation of Wnt signaling pathway; and ossification. Predicted to act upstream of or within Wnt signaling pathway and negative regulation of ossification. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including Kupffer's vesicle; endochondral bone; nervous system; notochord outer sheath cell; and pharyngeal arch cartilage. Human ortholog(s) of this gene implicated in SOST-related sclerosing bone dysplasia; autosomal dominant craniodiaphyseal dysplasia; sclerosteosis; and sclerosteosis 1. Orthologous to human SOST (sclerostin).

Ensembl:

ensembl_id ENSDARG00000061259

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00009435 True 2238 mRNA 0.45 2 27331324 27335652

Neighbor

gene id symbol gene type direction distance location
XLOC_004768 dusp3a coding upstream 25501 27285994 ~ 27305823 (+)
XLOC_004767 arl4d coding upstream 85567 27243059 ~ 27245757 (+)
XLOC_004766 tmem106a coding upstream 94292 27231212 ~ 27237032 (+)
XLOC_004765 nbr1a coding upstream 101466 27213733 ~ 27229858 (+)
XLOC_004764 skap1 coding upstream 124420 27156943 ~ 27206904 (+)
XLOC_004770 meox1 coding downstream 126573 27462225 ~ 27469267 (+)
XLOC_004771 etv4 coding downstream 200443 27536095 ~ 27568694 (+)
XLOC_004772 spata20 coding downstream 253955 27589607 ~ 27665591 (+)
XLOC_004773 cacna1g coding downstream 368363 27704015 ~ 28073562 (+)
XLOC_004774 CABZ01027646.1 coding downstream 781713 28117365 ~ 28181720 (+)
XLOC_004762 dre-mir-10a non-coding upstream 196357 27134869 ~ 27134967 (+)
XLOC_004754 BX469896.1 non-coding upstream 434708 26894321 ~ 26896616 (+)
XLOC_004752 NA non-coding upstream 497132 26737431 ~ 26834192 (+)
XLOC_004751 NA non-coding upstream 639273 26691819 ~ 26692051 (+)
XLOC_004748 NA non-coding upstream 738026 26589644 ~ 26593298 (+)
XLOC_004777 NA non-coding downstream 1041378 28377030 ~ 28381255 (+)
XLOC_004779 NA non-coding downstream 1282049 28617701 ~ 28617965 (+)
XLOC_004786 NA non-coding downstream 1597872 28933524 ~ 28946150 (+)
XLOC_004791 AL732488.1 non-coding downstream 1677921 29013573 ~ 29013690 (+)
XLOC_004796 NA non-coding downstream 1976913 29312565 ~ 29373414 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000063_06491111_06495718 NA coding CI01000063 null 6489730 ~ 6496295 (+)
rainbow trout (Oncorhynchus mykiss) LOC110491484 sost misc NC_048580.1 CM023234.2 17490773 ~ 17497981 (+)