XLOC_033041 (sec61a1)


Basic Information

Item Value
gene id XLOC_033041
gene name sec61a1
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007117.7
NCBI id CM002890.2
chromosome length 60270059
location 40065201 ~ 40071899 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00064213
tctttctctctcacccGGGCGGCGGAGCGCACCGGTAGCGCTAATTATCCGTTTACAACTCACTGGGACTCCAGACAGAGACCGTGATTTCAGGGGACCGTCATCATGGCGATTAAGTTCTTGGAGGTAATAAAACCGTTTTGTGCGGTTTTGCCTGAAATCCAGAAACCAGAACGAAAGATCCAGTTCAGAGAAAAGGTGCTATGGACTGCCATCACATTGTTCATCTTTCTTGTTTGCTGTCAGATCCCACTGTTTGGGATCATGTCTTCAGATTCAGCAGATCCATTCTACTGGATGAGAGTCATTTTGGCTTCCAACAGAGGTACTTTGATGGAGTTGGGTATCTCTCCCATTGTGACCTCTGGTCTGATCATGCAGCTGCTGGCTGGAGCTAAAATCATTGAGGTCGGAGACACACCGAAAGACAGAGCGCTCTTTAATGGAGCCCAAAAATTGTTTGGTATGATCATCACCATTGGCCAGGCTATTGTGTACGTCATGACTGGAATGTATGGAGACCCTTCAGAGATGGGTGCTGGCATCTGTCTGCTGATCATCATTCAGttGTTTGTGGCTGGTCTGATCGTGTTGCTGCTGGATGAGTTGCTGCAGAAAGGTTATGGTTTGGGCTCTGGTATCTCTCTCTTCATTGCCACTAACATCTGTGAGACTATCGTATGGAAAGCATTCAGCCCAACCACAGTCAACACAGGCAGAGGTACTGAGTTTGAGGGAGCCATTATTGCTCTGTTCCACCTTTTGGCCACTCGCACTGATAAAGTCAGAGCTCTGAGAGAGGCTTTCTACAGACAGAACCTGCCTAACCTCATGAACCTCATCGCTACAGTCTTCGTCTTTGCTGTGGTCATATACTTCCAGgGCTTCAGAGTTGATCTGCCCATCAAGTCTGCACGTTACCGTGGCCAATACAACACATATCCCATCAAGCTGTTCTATACCTCCAACATTCCCATCATCCTGCAGTCTGCTCTGGTTTCCAATCTTTACGTCATCTCTCAGATGCTCTCCACTCGATTCAGCGGCAACTTCCTAGTCAACCTTCTGGGGACTTGGTCTGACACCTCATCTGGAGGTCCAGCGCGCGCCTATCCTGTGGGCGGTCTCTGTTACTATCTGTCTCCTCCGGAGTCGTTTGGTTCTGTGCTTGATGACCCAGTTCATGCAGTGATCTACATTGTGTTCATGCTGGGATCCTGTGCCTTCTTTTCAAAGACCTGGATTGAAGTTTCTGGATCTTCTGCCAAAGATgtagCTAAGCAGCTGAAAGAACAGCAGATGGTGATGAGGGGACACAGAGAGACCTCCATGGTTCATGAACTCAACAGATACATCCCCACAGCGGCTGCATTTGGTGGACTGTGTATCGGAGGCCTTTCAGTAATGGCGGACTTCCTGGGCGCCATCGGCTCCGGAACGGGAATCCTATTGGCTGTTACCATCATCTATCAGTACTTTGAGATATTTGTTAAGGAACAGAGTGAAGTCGGCAGCATGGGAGCGTTACTCTTCTAAACAAggacactcacaaacacacacatacttgctgacacctttttattatttttatgattgttgttgtcatttaattcttttatttCGGTGCAATTTGAGCATAATTAGTGGTCTGTCACGAGCGCTGTCTTGGGAGAACGTGCTCTTAGCCGCTAGCTCAGGCCGAGTAAGTTCTCCTGTATGTCAGAAGTGGCAAAACGTTTCTAAAATTCAGTGATGAAGCTGAACTTCAGTAATGGAACAGTAAAGATGGACTCTGTGAGCTCTGACTAGGAATATTTAGATGAATTAAATTTTCTCTTCACATCAGTCTGTCCTTCATCTGTCTCCAGCCATCACCGAATCCATTCATCCACTCTTTTCTTTAGTTCCTGCCTGGTCCTAGTTGATAAAGATTTTCCAGAGAGTATTGCTTATGTTGGGTGACTGATTTACTCGACACTGCCAATTTTGACAACTGCTTCGTGTTTGTCAGTCATATCGGTCTTGTATGTAAAGCTGGCAGGCAGTTTGCTTTTCTAACTCATTGAATCATGCTAAGTCATAAAAAGTGTGATTTAGTTATGGCTACAAATATAAGAGCTAAACCACAGGTTCTTGTTTTCCAGTCAGCAATTGTCAATTCTAAACAAGGCAGCATAGGAGTAAAGCAACGCACAGTTTGGCaccaatggtgtgtgtgtgtgtggtttttctGTGTTTGTTGGACATGTATTTCATAACGctgggatctttttttttttttttttttttttgtacacaaCACATCTTACACAATAGAGAGCAAGGATTTTCTGTATTTGAAAGTACCTGGTCTTTAGTGAGAGCTTCAGTGACAGATGGAAGTGGTCACTTTCCCAAATTAAGCCCTTTTTACTGTATCATTGGGTGTCTGTATATATGACATTTAATGCTGTGCGCGACCATGTAAAATAAGcccttctttttctttctttttattttggacTGTAAAAAGAAATGTTCCGAACAAATATATTCAGCAAAGACTGATCATTCTCaataaaaactcattttttgGGAGATGCTGAA

Function

symbol description
sec61a1 Predicted to enable protein transmembrane transporter activity; ribosome binding activity; and signal sequence binding activity. Involved in pronephric nephron development. Acts upstream of or within habenula development. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of Sec61 translocon complex. Is expressed in several structures, including axis; digestive system; hatching gland; midbrain hindbrain boundary; and polster. Human ortholog(s) of this gene implicated in familial juvenile hyperuricemic nephropathy. Orthologous to human SEC61A1 (SEC61 translocon subunit alpha 1).

GO:

id name namespace
GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation biological_process
GO:0007275 multicellular organism development biological_process
GO:0015031 protein transport biological_process
GO:0039019 pronephric nephron development biological_process
GO:0021986 habenula development biological_process
GO:0031204 posttranslational protein targeting to membrane, translocation biological_process
GO:0005783 endoplasmic reticulum cellular_component
GO:0005784 Sec61 translocon complex cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0005048 signal sequence binding molecular_function
GO:0043022 ribosome binding molecular_function
GO:0008320 protein transmembrane transporter activity molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-020418-2 Predicted to enable protein transmembrane transporter activity; ribosome binding activity; and signal sequence binding activity. Involved in pronephric nephron development. Acts upstream of or within habenula development. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of Sec61 translocon complex. Is expressed in several structures, including axis; digestive system; hatching gland; midbrain hindbrain boundary; and polster. Human ortholog(s) of this gene implicated in familial juvenile hyperuricemic nephropathy. Orthologous to human SEC61A1 (SEC61 translocon subunit alpha 1).

Ensembl:

ensembl_id ENSDARG00000021669

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00064213 True 2586 mRNA 0.44 12 40065201 40071899

Neighbor

gene id symbol gene type direction distance location
XLOC_033040 chchd4b coding downstream 1737 40060409 ~ 40063464 (-)
XLOC_033039 uroc1 coding downstream 6515 40045035 ~ 40058686 (-)
XLOC_033038 NA coding downstream 21090 40038692 ~ 40044111 (-)
XLOC_033037 si:dkey-197j19.6 coding downstream 26658 40031007 ~ 40038543 (-)
XLOC_033036 pfkfb4b coding downstream 35778 39993605 ~ 40029423 (-)
XLOC_033042 ip6k2b coding upstream 17844 40089743 ~ 40162750 (-)
XLOC_033043 NA coding upstream 101329 40173228 ~ 40182520 (-)
XLOC_033044 col7a1 coding upstream 112336 40184235 ~ 40312091 (-)
XLOC_033045 ttll3 coding upstream 257409 40329308 ~ 40352215 (-)
XLOC_033046 NA coding upstream 311525 40383424 ~ 40409125 (-)
XLOC_033025 CU467856.1 non-coding downstream 539696 39524924 ~ 39525505 (-)
XLOC_033024 NA non-coding downstream 543369 39491846 ~ 39521832 (-)
XLOC_033009 NA non-coding downstream 1300875 38759546 ~ 38764326 (-)
XLOC_033008 CR628341.2 non-coding downstream 1467417 38597669 ~ 38597784 (-)
XLOC_033052 NA non-coding upstream 405531 40477430 ~ 40482198 (-)
XLOC_033055 CU855953.1 non-coding upstream 553405 40625304 ~ 40625420 (-)
XLOC_033056 NA non-coding upstream 553732 40625631 ~ 40629161 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) G490858 NA non-coding CI01000340 null 9427520 ~ 9432764 (+)