XLOC_033165 (gnas)


Basic Information

Item Value
gene id XLOC_033165
gene name gnas
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007117.7
NCBI id CM002890.2
chromosome length 60270059
location 49811831 ~ 49873020 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00064437
tttatttttttaatttgtagcCACCCTTTCTATCTCGTTCTGCCCGTCTCGTTGCATCGGCGAACGGATTCGACAGCAAGCCACCGAAAAGAATCGCGTTTTGTGGAGCTATTCATGATTTTAATAGGAGTCGGTCGTTATTTCGGGAAAGCGACCATGGATTCGCGACGGGAAATCTGCTAAATCGCCGTCGTGGGAAAGCCGAGATCATTCATGTAACGTCGAAGGCTTTTGCTGGATGCACATCCATACACAGAAATCTCTTATTTTATAGTAGCAAGCGCTCGACAGGACTTGGCCGTCTGTAGGCCGGCCTAGTGTTTtcaccaccatcaccaccaccacctaTTCTCGCCAGTACTAGTCACCCAGAGCTTTTTCCTATTTCCCCGTGCTCCCCTGCCCACATCGGCGAAATCCAGGGTAGTTGTGTGCATACACGTATAAATGTCCCGGTTTTCCATCACAGTGTTCTGATCGGAGGCCAATCGAGGGATTtggatcatttattcattcggtAGATTCACCTTCCCCTCACCCCACCCCAAAACTTTTCTTGGGTTTTTGGGAAAATGGGTTGTTTGGGCAACAGTAAGACTGAGGACCAGCGAAATGAGGAGAAGGCCCAGCGAGAAGCTAACAAAAAGATAGAGAAGCAGCTCCAGAAAGACAAACAGATCTACAGAGCAACTCATCGACTACTGCTGCTGGGGGCTGGAGAATCGGGGAAAAGCACCATAGTCAAACAGATGCGCATTTTACATGTCAATGGCTTCAATGCTGAagAGAAAAAACAGAAAATTCAAGACATCAAGAATAATATAAAAGAAGCTATAGAGACTATTGTGACGGCGATGTCCGTGTTGGTACCTCCAGTCCAGTTAGCCTGTCCAGCAAATAAGTTTCGAATTGACTACATCCTCAACTTAGCCAATCAAAAGGACTTTGAGTTCACAACGGAATTTTATGAACACACAAAAACCCTGTGGCAGGATGAAGGGGTGAAAGCTTGCTTCGAAAGATCCAACGAATATCAACTGATCGACTGCGCGCAGTATTTCCTGGACAGGATTGACACTGTGAAACAAAGTGACTATACTCCCACTGATCAGGACTTGCTCAGATGCAGAGTTCTGACTTCAGGGATCTTTGAGACAAGATTCCAAGTGGATAAAGTTAATTTTCATATGTTCGATGTTGGCGGACAGAGAGATGAACGCAGGAAATGGATCCAGTGTTTCAATGACGTGACAGCCATCATTTTCGTGGTAGCCAGCAGCAGTTATAACATGGTGCTCAGAGAGGACAATCAGACCAACAGACTCCAGGAGGCACTTAACCTGTTCAAGAACATCTGGAATAACAGGTGGCTTCGAACCATTTCTGTCATTCTGTTCCTAAATAAGCAGGATTTGCTGGCTGAGAAGGTTTTGGCGGGAAAATCAAAAATTGAGGATTATTTCCCAGAGTTTGCACGCTACACTACACCAGATGATgCAACACCAGAGCAAGGGGAAGATCCAAGAGTTACGAGAGCAAAATATTTCATCCGAGACGAGTTCTTGAGGATCAGTACAGCGAGTGGAGATGGCCGGCATTACTGCTACCCCCACTTCACCTGCGCCGTGGACACGGAAAACATCCGCCGAGTGTTTAACGACTGCAGAGACATCATCCAGCGCATGCACCTACGACAGTACGAACTCTTGTGATCGCAGCAGGGATGACAGGACGCAAACTCACCACCTGAACTTTCTTTAGGCCCCCCTGCCCTACATCACGCCCCAATTTCAAAACCACGAACCTTCAAACTGATGAGTCCCCACctcttacacacacatgcatattatatagatatatacatatgcgtatgtatatatattcacatatatatatatacatacagacactcacacacgcacacaaacacacacacatggcctTTCTCCATCCTGAGTGACTAGGGGCTGGGGCAAGGGGACGCACTGTGTTACTGATGAAAGCGTGGCTGTGATATCTGGCAAAAAGACTTGTTAACACAGCCAAGGACTACCGATGTTAataaagagagagaggaaaacaaAACATgtgagagggagagggaggggggggcgaaaagagggaagaaaaaaaaaaaaactgtccggGACTGCTCAGGACAAGGAAGCCATTTCGTACACATGCAGACACATAATGCGTCCAGCTAAACTCCTGACCCGCAGTCCTATGTATGTTACATGTCAAACTTGTCTTTT
>TCONS_00064438
GGAGCGAGCGAGAAGCGGACGAGGAGGGACTTGGAGCGGCGTCCAGAAATAGTAGAGCAAGAATAACAAACAGTGAAAAGTGCGCTATGTGTGTCAGGTCAAAGTTCACTCCTGTCAATACCAGAACCTGAGGGGGAAAAGCCGATGCGGCTAAACGACACCTTTGGAAAGCCTGAGCGGTAATGCTGTAAGGGATAGCGAGCCTTTCTCTCCACCTGACCTGGAtaaccaccatcatcatcatcaccatcttcatcatcatcatcatcatggtgTTCTTATCCTTCAAGACTTTCCTATACGGATGTTAAACAGCAAGCATTGGTCATGGGGATGTGCCACAGCTTCAGATCTCGGTTATCAGAATCGGCGATCACGTACACGGGCGGCCGTAGCGCAGCGGGCGCGGGGATCGATGCGGAGTCGGGCGGCCACTCGGACAGCTGTGACCCGCAGCTCAGAGAGCGGCGGCGGGCGGAGGAGCGGGCGCGGGTCAAGGCGGAGAACAAGCGGAGCAGAAACATTGACAAGAGCCTGAAGGCGGAGAAGAGAGAGTACAAGCAGACGCACAGGCTGCTCTTATTAGGGGCTGGAGAATCGGGGAAAAGCACCATAGTCAAACAGATGCGCATTTTACATGTCAATGGCTTCAATGCTGAagAGAAAAAA

Function

symbol description
gnas Predicted to enable G-protein beta/gamma-subunit complex binding activity; GTPase activity; and signaling receptor binding activity. Predicted to be involved in adenylate cyclase-activating dopamine receptor signaling pathway and sensory perception of chemical stimulus. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be part of heterotrimeric G-protein complex. Is expressed in brain; gill; head; heart; and olfactory epithelium. Human ortholog(s) of this gene implicated in several diseases, including ACTH-independent macronodular adrenal hyperplasia 1; McCune Albright syndrome; pituitary adenoma 3; progressive osseous heteroplasia; and pseudohypoparathyroidism (multiple). Orthologous to human GNAS (GNAS complex locus).

GO:

id name namespace
GO:0007186 G protein-coupled receptor signaling pathway biological_process
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway biological_process
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway biological_process
GO:0007606 sensory perception of chemical stimulus biological_process
GO:0007165 signal transduction biological_process
GO:0005834 heterotrimeric G-protein complex cellular_component
GO:0035255 ionotropic glutamate receptor binding molecular_function
GO:0051430 corticotropin-releasing hormone receptor 1 binding molecular_function
GO:0003924 GTPase activity molecular_function
GO:0005525 GTP binding molecular_function
GO:0019001 guanyl nucleotide binding molecular_function
GO:0005159 insulin-like growth factor receptor binding molecular_function
GO:0031852 mu-type opioid receptor binding molecular_function
GO:0000166 nucleotide binding molecular_function
GO:0031683 G-protein beta/gamma-subunit complex binding molecular_function
GO:0031698 beta-2 adrenergic receptor binding molecular_function
GO:0001664 G protein-coupled receptor binding molecular_function
GO:0031748 D1 dopamine receptor binding molecular_function

KEGG:

id description
ko04015 Rap1 signaling pathway
ko04020 Calcium signaling pathway
ko04072 Phospholipase D signaling pathway
ko04024 cAMP signaling pathway
ko04540 Gap junction
ko04611 Platelet activation
ko04911 Insulin secretion
ko04922 Glucagon signaling pathway
ko04923 Regulation of lipolysis in adipocytes
ko04912 GnRH signaling pathway
ko04913 Ovarian steroidogenesis
ko04915 Estrogen signaling pathway
ko04921 Oxytocin signaling pathway
ko04926 Relaxin signaling pathway
ko04935 Growth hormone synthesis, secretion and action
ko04918 Thyroid hormone synthesis
ko04928 Parathyroid hormone synthesis, secretion and action
ko04916 Melanogenesis
ko04924 Renin secretion
ko04925 Aldosterone synthesis and secretion
ko04927 Cortisol synthesis and secretion
ko04261 Adrenergic signaling in cardiomyocytes
ko04270 Vascular smooth muscle contraction
ko04970 Salivary secretion
ko04971 Gastric acid secretion
ko04972 Pancreatic secretion
ko04976 Bile secretion
ko04962 Vasopressin-regulated water reabsorption
ko04961 Endocrine and other factor-regulated calcium reabsorption
ko04724 Glutamatergic synapse
ko04728 Dopaminergic synapse
ko04726 Serotonergic synapse
ko04730 Long-term depression
ko04750 Inflammatory mediator regulation of TRP channels
ko04361 Axon regeneration
ko04713 Circadian entrainment
ko04714 Thermogenesis
ko05200 Pathways in cancer
ko05207 Chemical carcinogenesis - receptor activation
ko05163 Human cytomegalovirus infection
ko05165 Human papillomavirus infection
ko05110 Vibrio cholerae infection
ko05146 Amoebiasis
ko05142 Chagas disease
ko05012 Parkinson disease
ko05030 Cocaine addiction
ko05031 Amphetamine addiction
ko05032 Morphine addiction
ko05034 Alcoholism
ko05414 Dilated cardiomyopathy
ko04934 Cushing syndrome
ko01522 Endocrine resistance
ko04147 Exosome
ko04031 GTP-binding proteins

ZFIN:

id description
ZDB-GENE-090417-2 Predicted to enable G-protein beta/gamma-subunit complex binding activity; GTPase activity; and signaling receptor binding activity. Predicted to be involved in adenylate cyclase-activating dopamine receptor signaling pathway and sensory perception of chemical stimulus. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be part of heterotrimeric G-protein complex. Is expressed in brain; gill; head; heart; and olfactory epithelium. Human ortholog(s) of this gene implicated in several diseases, including ACTH-independent macronodular adrenal hyperplasia 1; McCune Albright syndrome; pituitary adenoma 3; progressive osseous heteroplasia; and pseudohypoparathyroidism (multiple). Orthologous to human GNAS (GNAS complex locus).

Ensembl:

ensembl_id ENSDARG00000043094

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00064437 False 2255 mRNA 0.46 12 49811831 49861506
TCONS_00064438 True 669 mRNA 0.54 3 49854260 49873020

Neighbor

gene id symbol gene type direction distance location
XLOC_033164 nelfcd coding downstream 10658 49781884 ~ 49801173 (-)
XLOC_033163 NA coding downstream 40192 49760355 ~ 49771639 (-)
XLOC_033162 apcdd1l coding downstream 138355 49650170 ~ 49673476 (-)
XLOC_033160 BX323459.2 coding downstream 156596 49585461 ~ 49655235 (-)
XLOC_033161 BX323459.1 coding downstream 177044 49628431 ~ 49634787 (-)
XLOC_033166 atp5f1e coding upstream 20468 49893488 ~ 49902140 (-)
XLOC_033167 BX629346.2 coding upstream 45234 49918254 ~ 49926317 (-)
XLOC_033168 BX629346.1 coding upstream 46916 49919936 ~ 49921857 (-)
XLOC_033169 asip1 coding upstream 102890 49975910 ~ 49983329 (-)
XLOC_033170 raly coding upstream 148390 50021410 ~ 50204262 (-)
XLOC_033155 BX569793.1 non-coding downstream 489299 49310908 ~ 49322532 (-)
XLOC_033152 NA non-coding downstream 707639 49100879 ~ 49104192 (-)
XLOC_033149 NA non-coding downstream 862316 48914868 ~ 48949515 (-)
XLOC_033148 CU137649.1 non-coding downstream 1199681 48612034 ~ 48612150 (-)
XLOC_033171 CU928043.1 non-coding upstream 262299 50135319 ~ 50135437 (-)
XLOC_033172 NA non-coding upstream 486637 50359657 ~ 50380212 (-)
XLOC_033174 NA non-coding upstream 584948 50457968 ~ 50505438 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) G494483 NA non-coding CI01000340 null 14506648 ~ 14507192 (+)