XLOC_034677 (mettl3)


Basic Information

Item Value
gene id XLOC_034677
gene name mettl3
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007118.7
NCBI id CM002891.2
chromosome length 74282399
location 21876548 ~ 21887104 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00067495
ACAGTTTAGCGGCACGGTGTGTATGGTGGTACAGTCACTCAGCGTTAGTTTGCTAGATGTAATCTAAACTTCATAAAACCCCTGTTTAATCAgtactgtttgtttatttgctgtttAGCTCGTTTAATTTAAGCCATGTCGGACACATGGAGTCACATCCAGGCGCACAAAAAGCAGCTGGATTCACTACGAGAGAGGCTGCAGAGGAGAAGAAAAGACCCAACTCAACTGGGCACTGAGGTTGGAAGTGTTGAGAGTGGATCTGCAAGAAGTGACAGCCCGGGACCAGCAATTCAGAGTCCTCCACAAGTAGAAGTTGAGCATCCTCCAGACCCAGAGCTAGAGAAGAGGCTGCTGGGATACCTCTCTGAACTGAGCCTTTCCCTGCCAACTGATTCCCTAACGATCACCAACCAGCTAAATACATCTGAGTCTCCAGTTTCCCATTCCTGCATTCAAAGTCTCCTTCTTAAATTTTCTGCTCAAGAGCTTATTGAAGTTCGGCAGCCATCCATCACCTCCTCTTCGTCCTCCACCCTCGTCACGTCAGTCGACCATACCAAACTATGGGCTATGATTGGCAGCGCAGGCCAGTCACAGAGAACTGCCGTTAAAAGGAAAGCAGACGACATCACTCATCAAAAAAGAGCCCTGGGCTCCTCCCCTTCGATTCAAGCACCGCCTTCTCCTCCAAGGAAATCCTCAGTCTCATTGGCTACTGCCTCAATCTCGCAACTCACTGCATCCTCTGGGGGAGGAGGGGGTGGAGCTGATAAAAAGGGGCGGAGCAATAAGGTGCAAGCATCTCACCTGGATATGGAGATTGAAAGTCTACTGAGCCAGCAATCCACTAAGGAACAGCAAAGCAAAAAGGTGAGCCAAGAGATCCTAGAGCTGCTGAATACCAGTTCAGCAAAAGAACAGTCGATTGTGGAGAAGTTTCGCTCACGAGGCAGAGCTCAAGTTCAGGAGTTCTGTGATTATGGAACCAAAGAAGAGTGTGTGCAGTCGGGGGACACTCCTCAGCCCTGCACCAAGCTGCACTTCAGGCGAATCATCAACAAACACACAGATGAGAGCCTTGGCGACTGCTCCTTTCTAAACACTTGCTTCCACATGGACACCTGTAAATATGTGCACTATGAGATTGACAGTCCTCCTGAAGCAGAGGGAGATGCACTGGGGCCACAGGCAGGGGCAGCTGAGCTTGGGCTGCACTCTACTGTGGGAGACAGCAATGTGGGCAAGCTGTTTCCTTCCCAGTGGATTTGCTGTGACATTCGTTATCTGGATGTGTCCATCCTGGGGAAGTTTGCAGTGGTGATGGCTGACCCGCCGTGGGATATTCACATGGAGCTTCCCTACGGAACACTCACAGATGACGAGATGAGGAAGCTCAACATTCCTATTCTGCAGGACGACGGTTTCCTCTTCCTCTGGGTGACAGGAAGGGCTATGGAGCTAGGCAGAGAGTGTTTAAGCTTATGGGGCTATGATCGTGTAGATGAAATTATCTGGGTGAAAACCAACCAGCTCCAGAGAATCATTCGTACTGGAAGGACTGGACATTGGCTGAATCATGGCAAAGAGCATTGCTTGGTTGGAGTGAAAGGAAACCCACAAGGATTTAATCGAGGCCTTGACTGTGATGTTATAGTGGCAGAGGTCCGTTCCACTAGCCATAAACCAGATGAGATCTATGGAATGATTGAGCGCCTGTCTCCAGGCACACGAAAGATTGAATTGTTTGGCAGGCCACACAATGTACAACCTAACTGGATAACTCTTGGTAATCAGCTGGACGGCATTCACCTTTTAGATCCGGAAGTTGTTGCTCGTTTTAAGAAACGCTACCCTGATGGAGTCATTTCTAAGCCTAAAAACATGTAAGAACTGGGCTAGTGGGAGAACACACTGTTGGTTAAACTCAAGACTTATTGATGCTTTCTAGTTACTTTTGTACTACATTTCTTTTGTAATAAAATCGATGAAACACA
>TCONS_00067496
tatttaattgtatttattttagtatattatttaatacaataatatttcctgaacacatttttataatcattttcattttattataaatgtttaactgATGATTTGTTGAATTGCATTACATCGTGACTTTTCTAGGCGAATCATCAACAAACACACAGATGAGAGCCTTGGCGACTGCTCCTTTCTAAACACTTGCTTCCACATGGACACCTGTAAATATGTGCACTATGAGATTGACAGTCCTCCTGAAGCAGAGGGAGATGCACTGGGGCCACAGGCAGGGGCAGCTGAGCTTGGGCTGCACTCTACTGTGGGAGACAGCAATGTGGGCAAGCTGTTTCCTTCCCAGTGGATTTGCTGTGACATTCGTTATCTGGATGTGTCCATCCTGGGGAAGTTTGCAGTGGTGATGGCTGACCCGCCGTGGGATATTCACATGGAGCTTCCCTACGGAACACTCACAGATGACGAGATGAGGAAGCTCAACATTCCTATTCTGCAGGACGACGGTTTCCTCTTCCTCTGGGTGACAGGAAGGGCTATGGAGCTAGGCAGAGAGTGTTTAAGCTTATGGGGCTATGATCGTGTAGATGAAATTATCTGGGTGAAAACCAACCAGCTCCAGAGAATCATTCGTACTGGAAGGACTGGACATTGGCTGAATCATGGCAAAGAGCATTGCTT

Function

symbol description
mettl3 Enables mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity and mRNA (N6-adenosine)-methyltransferase activity. Involved in endothelial to hematopoietic transition and regulation of hematopoietic stem cell differentiation. Acts upstream of or within several processes, including Notch signaling pathway involved in arterial endothelial cell fate commitment; hematopoietic stem cell proliferation; and oocyte maturation. Predicted to be located in cytoplasm. Predicted to be part of RNA N6-methyladenosine methyltransferase complex. Predicted to be active in nuclear speck. Is expressed in several structures, including gill; heart; liver; nervous system; and pleuroperitoneal region. Used to study infertility. Orthologous to human METTL3 (methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit).

GO:

id name namespace
GO:0060853 Notch signaling pathway involved in arterial endothelial cell fate commitment biological_process
GO:0060339 negative regulation of type I interferon-mediated signaling pathway biological_process
GO:0042981 regulation of apoptotic process biological_process
GO:1902036 regulation of hematopoietic stem cell differentiation biological_process
GO:0045746 negative regulation of Notch signaling pathway biological_process
GO:0061157 mRNA destabilization biological_process
GO:1903679 positive regulation of cap-independent translational initiation biological_process
GO:0051445 regulation of meiotic cell cycle biological_process
GO:0030154 cell differentiation biological_process
GO:0007530 sex determination biological_process
GO:0006382 adenosine to inosine editing biological_process
GO:0019827 stem cell population maintenance biological_process
GO:0021861 forebrain radial glial cell differentiation biological_process
GO:0006974 cellular response to DNA damage stimulus biological_process
GO:0000398 mRNA splicing, via spliceosome biological_process
GO:0001510 RNA methylation biological_process
GO:0007283 spermatogenesis biological_process
GO:0045580 regulation of T cell differentiation biological_process
GO:0090365 regulation of mRNA modification biological_process
GO:0001556 oocyte maturation biological_process
GO:1990744 primary miRNA methylation biological_process
GO:0071425 hematopoietic stem cell proliferation biological_process
GO:0030317 flagellated sperm motility biological_process
GO:0080009 mRNA methylation biological_process
GO:0034644 cellular response to UV biological_process
GO:0032259 methylation biological_process
GO:0098508 endothelial to hematopoietic transition biological_process
GO:0036396 RNA N6-methyladenosine methyltransferase complex cellular_component
GO:0005634 nucleus cellular_component
GO:0016607 nuclear speck cellular_component
GO:0005737 cytoplasm cellular_component
GO:0001734 mRNA (N6-adenosine)-methyltransferase activity molecular_function
GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity molecular_function
GO:0016740 transferase activity molecular_function
GO:0008168 methyltransferase activity molecular_function
GO:1904047 S-adenosyl-L-methionine binding molecular_function
GO:0003723 RNA binding molecular_function
GO:0003729 mRNA binding molecular_function
GO:0046982 protein heterodimerization activity molecular_function

KEGG:

id description
ko03019 Messenger RNA biogenesis

ZFIN:

id description
ZDB-GENE-030131-9498 Enables mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity and mRNA (N6-adenosine)-methyltransferase activity. Involved in endothelial to hematopoietic transition and regulation of hematopoietic stem cell differentiation. Acts upstream of or within several processes, including Notch signaling pathway involved in arterial endothelial cell fate commitment; hematopoietic stem cell proliferation; and oocyte maturation. Predicted to be located in cytoplasm. Predicted to be part of RNA N6-methyladenosine methyltransferase complex. Predicted to be active in nuclear speck. Is expressed in several structures, including gill; heart; liver; nervous system; and pleuroperitoneal region. Used to study infertility. Orthologous to human METTL3 (methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit).

Ensembl:

ensembl_id ENSDARG00000012827

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00067495 False 1997 mRNA 0.48 11 21876548 21887104
TCONS_00067496 True 684 lncRNA 0.44 4 21878445 21882149

Neighbor

gene id symbol gene type direction distance location
XLOC_034676 NA coding downstream 6196 21843904 ~ 21870352 (-)
XLOC_034672 NA coding downstream 38108 21785595 ~ 21838440 (-)
XLOC_034675 BX005336.4 coding downstream 39682 21836676 ~ 21836866 (-)
XLOC_034674 BX005336.2 coding downstream 45698 21830686 ~ 21830850 (-)
XLOC_034673 BX005336.3 coding downstream 53021 21823363 ~ 21823527 (-)
XLOC_034678 epoa coding upstream 3369 21890473 ~ 21918432 (-)
XLOC_034679 si:dkey-85k7.10 coding upstream 33558 21920662 ~ 21925863 (-)
XLOC_034680 si:dkey-85k7.11 coding upstream 40482 21927586 ~ 21928826 (-)
XLOC_034681 nlgn2a coding upstream 53753 21940857 ~ 22132265 (-)
XLOC_034682 NA coding upstream 356148 22243252 ~ 22245553 (-)
XLOC_034685 BX470211.1 non-coding upstream 777832 22664936 ~ 22667597 (-)
XLOC_034690 CR381635.1 non-coding upstream 1050025 22937129 ~ 22937248 (-)
XLOC_034692 NA non-coding upstream 1606321 23493425 ~ 23494508 (-)
XLOC_034693 NA non-coding upstream 1658589 23545693 ~ 23546584 (-)

Expression


Co-expression Network