XLOC_035574 (foxe3)


Basic Information

Item Value
gene id XLOC_035574
gene name foxe3
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007119.7
NCBI id CM002892.2
chromosome length 54304671
location 19668654 ~ 19670305 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00069756
AGACAAACACCTCTCTAATCGACAGCTGAGGATATACGCGCATTTTATTACTACTGCCCGTTTAGTTTGGCAAATTTAGGTAAATAAAATTCTGAAAGTTCTAAAAGTTAAGCTTTATTAGACAACTTTTATGAATCTTGCAAACTTTTCATATTTCACGGGCATGTGCAACATGACGGCAGAGTCCCAGCACTCACCAGCCGAGGCGGCCAGTCCAGTGGTGGTGTCTCCAAACGTGAGTCTGGACTCCCCGGTTCCTCTTCCACCACTTGCGCTTAACCACCAAGCTCGAACTAAAGATGGCATTCTCATCAAAGCCGAGCCTCAAGGCAGCAGTCCAAACACAGACAGAGAGGAAGTTGTTTCATTGGGTCAAACCGAAGAACATCTGCCCGCCACTGGTAGCCGGCGGAGGAAAAGGCCAGTGCAGCGAGGTAAACCTCCATACAGTTACATCGCACTGATTGCAATGGCCATCGCCAATTCACCTGAGAGAAAACTCACACTCGGCGGCATCTATAAGTTCATTATGGAGCGCTTTCCATTTTACCGCGAGAACTCCAAGAAGTGGCAGAACTCCATACGGCATAACCTTACCCTCAATGACTGTTTTGTGAAAATCCCCCGGGAGCCCGGTAGGCCCGGAAAAGGAAACTATTGGACGCTTGACCCTGCCGCTGAGGACATGTTCGACAACGGGAGCTTCTTAAGGCGGAGGAAGCGCTTTAAGCGGACTGATGTCAGCACCTATCCAGGTTACATGCAAAGCTCCAGCGCTTTTACGCCCACACCTATGGGTAGACAAGCGTACCCCAACACCTTGTACCCGGGTGTGACATCTGGCTACGGGTCTCAGCTGGCTGGTTCCCCACACCCGGCGATGCTGCATCACTATCAAGCATCGGCCGGGGTCACGCAGGGCCAGGCTAGGATGTTCAGCATTGATAATATTATTAGTCAGCAGACAGTGATGCAAAGTGGAGGAGATCTCAACACGCAATCTCTCGGCCTGGGTGCGGGTGATTTGGGTACCATGACCTCCAGCTGCTCCGTATCCACCTCTGACCCAACCTGCTTTCAGACCCAAGCGATTAATCCCACGAGCAACATGCTGAGCAGGAACACTGGATCTCTTGCTTCAAATATGACATCCAGCTACACTTACCCGTCTCCGACTTCGCCCTCTCACCTGTCCGGTGTGACGCAGTCCGGCTTCTCCCCTGGAGGTTCACAGGTGTACTGCTCGGGGAACAGGATTTCGCTGCCGCCCGTGCGTTCTGGGTCCTGCGCAGATCACACAGAGCCTCTTTTAGGTCTCTCGGGGCCAACGATGAATTCCTACAATAATTCATATATGAGACAAGCCAATTTTGCATCCGGACTGGAGCGATACATGTGAAAACTCGCGTTCAGCTGCATTTTACTGGTCTCGACACTGAGTTCTTGTTTTTGCTCTGTAAAATAAGTTATGTAGCCTATCTTGGCGGAATTGTGTGAAAAAATACCTTATGTAAAATTAACAAGTACAGTTTTGTTATTGACATGTAGTTTGAAACATTGTTTGGCTATTTTATAGGGTATATATCAGAGGACAAATGCACCTCTAAACAATGTAAATATTTgaagcaaataaatattttttgtgtaatAAA

Function

symbol description
foxe3 Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within aorta development; lens morphogenesis in camera-type eye; and negative regulation of lens fiber cell differentiation. Predicted to be located in nucleus. Is expressed in several structures, including adenohypophyseal placode; hatching gland; lens; lens placode; and optic primordium. Human ortholog(s) of this gene implicated in anterior segment dysgenesis; anterior segment dysgenesis 2; cataract 34 multiple types; and thoracic aortic aneurysm. Orthologous to human FOXE3 (forkhead box E3).

GO:

id name namespace
GO:0006355 regulation of transcription, DNA-templated biological_process
GO:0006357 regulation of transcription by RNA polymerase II biological_process
GO:0030154 cell differentiation biological_process
GO:0002088 lens development in camera-type eye biological_process
GO:0002089 lens morphogenesis in camera-type eye biological_process
GO:0009653 anatomical structure morphogenesis biological_process
GO:0035904 aorta development biological_process
GO:1902747 negative regulation of lens fiber cell differentiation biological_process
GO:0001654 eye development biological_process
GO:0005634 nucleus cellular_component
GO:0043565 sequence-specific DNA binding molecular_function
GO:0003677 DNA binding molecular_function
GO:0003700 DNA-binding transcription factor activity molecular_function
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-061214-6 Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within aorta development; lens morphogenesis in camera-type eye; and negative regulation of lens fiber cell differentiation. Predicted to be located in nucleus. Is expressed in several structures, including adenohypophyseal placode; hatching gland; lens; lens placode; and optic primordium. Human ortholog(s) of this gene implicated in anterior segment dysgenesis; anterior segment dysgenesis 2; cataract 34 multiple types; and thoracic aortic aneurysm. Orthologous to human FOXE3 (forkhead box E3).

Ensembl:

ensembl_id ENSDARG00000062892

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00069756 True 1652 mRNA 0.48 1 19668654 19670305

Neighbor

gene id symbol gene type direction distance location
XLOC_035572 slc35a3a coding upstream 30292 19621511 ~ 19638362 (+)
XLOC_035571 notch2 coding upstream 48862 19548985 ~ 19619792 (+)
XLOC_035570 si:ch73-281k2.5 coding upstream 148313 19514294 ~ 19520341 (+)
XLOC_035569 sec22bb coding upstream 156384 19504011 ~ 19512270 (+)
XLOC_035568 npl coding upstream 168300 19489854 ~ 19500354 (+)
XLOC_035575 foxd2 coding downstream 4064 19674369 ~ 19676640 (+)
XLOC_035576 NA coding downstream 10125 19680430 ~ 19682651 (+)
XLOC_035577 NA coding downstream 68698 19739003 ~ 19950333 (+)
XLOC_035578 BX901930.1 coding downstream 281428 19951733 ~ 19952380 (+)
XLOC_035579 BX901930.3 coding downstream 288180 19958485 ~ 19959118 (+)
XLOC_035566 NA non-coding upstream 435979 19227835 ~ 19232675 (+)
XLOC_035565 CR376858.1 non-coding upstream 645277 19023261 ~ 19023377 (+)
XLOC_035563 NA non-coding upstream 935060 18709974 ~ 18733594 (+)
XLOC_035562 BX247907.1 non-coding upstream 998292 18670237 ~ 18670362 (+)
XLOC_035556 NA non-coding upstream 1256626 18410984 ~ 18412028 (+)
XLOC_035580 BX901930.2 non-coding downstream 294918 19965223 ~ 19965877 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000010_03004426_03005652 FOXE3 coding CI01000010 null 3004167 ~ 3005814 (-)