XLOC_004026 (chrna4b)


Basic Information

Item Value
gene id XLOC_004026
gene name chrna4b
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007122.7
NCBI id CM002895.2
chromosome length 45484837
location 12982260 ~ 12998400 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00007677
ACTTTTACAAGAGGTTTGGGCGCTGAAAGACTTTTTGTGGCCTTATTTAACACACTTTTGACTCAGTTTTTGGAGTGATGATCTACTGGTCTGTTCAGAGATTTTTTTATGATCAAAACTGGACGAAGATTTTTATTCTTTAGTTCCTATGCCGAAATTCTTCCAGAGTTGAATATCATCTGACATAAGAAAATGAGAGCAGCGTGGAGGGTCTTCTTTCTTCTGTGCGTCCATCTGCAACTGGCGTATGTGTTTTCCATGAGCCCAGCTCATGCCCATGCGGAAGAAAGACTCCTCCAGTCTTTGTTCATCAACTACAACAAGCTTTCACGTCCAGTAGCAAACATCTCTGATGTGGTTCTGGTCCATTTCGGCTTGTCCATTGCTCAGCTCATTGATGTGGATGAGAAGAATCAGATGATGACCACAAATGTCTGGGTGAAGCAGGAGTGGAACGACTACAAGCTGCGCTGGAACCCAGAGGAGTATGAGAATGTCACCTCCATCAGGATCCCCTCTGAGATCATCTGGAGACCGGATATTGTGCTCTATAACAACGCGGACGGAGACTTTGCGGTGACTCACTTGACAAAAGCTCAGGTGTTTTACAACGGGAGAATCAAATGGAAACCTCCCGCCATCTATAAAAGCTCCTGCAGCATCGATGTCACCTTCTTCCCCTTTGACCAACAAAACTGCAAGATGAAATTCGGCTCTTGGACGTACGACAGGGCCAAGATTGACCTGATCAGCATGGCCAGTGACGTAGACCAGATGGACTACTGGGAAAGTGGCGAATGGGTGATAATAAATGCAGTTGGCACCTACAACATCAAGAAATACGAGTGCTGCACTGAAATCTACCCAGATATCACCTACTCTTTCATCATCAGACGCCTTCCTTTGTTCTACACCATCAATCTCATCATCCCCTGCCTGCTAATCTCCTGCCTGACAGTCCTGGTCTTCTACCTCCCCTCagaatgtgctgagaaaatcacGCTGTGTATATCTGTCCTCCTATCCCTGACTGTCTTCCTCCTGCTAATCACCGAAATTATCCCTTCAACCTCATTGGTCATCCCACTGATTGGCGAGTACCTACTGTTCACCATGATCTTCGTCACTCTGTCCATCATCATCACGGTGTTTGTACTCAACGTGCACCACCGTTCGTCTCGTACGCACAGCATGCCACACTGGGTCCGTCAGCTATTTCTCCACCTGGTGCCTCGTTACCTGTTCATGAAACGTCCACCAGCCTCGGGCAAGAGAAACTGCGGGAAGCTGATTGAGATGATGCACAAACAGGCTAATTCGCAATCTATGTTTCTGCGGAACAACATCCTGGATATCTCTCCGCAAAGTCCGATCCCGCATTTGGGACCTACTTCAGCTGCCCAGCAGGATCAAGTTCAGCAGGACTCAACTTCCCCCAAACCCCTGTTTTTCTGCAGTTCCCCCAGCAGCCAGTATTCAATCCTTCAAGAGGAAAACTCACAAACCCCCCAAACACCAGTTCTCAGCTACACATGCGCATATACAAACAGCATCTTCGCCTCCAGCACAACTTCCTTTCCAGATACTCTCCTTGGCACCCTGCTGCACACCATACCGCAGGACGGAGCCAAGAGCACAGAATGCGATTTCCAAGGCCACAGTGCTGAGAGTGTCTTCATGGAAGCCAAGGAGAGTGTTCTGGGAGCAGGGAGTTGTCAACACTGCCTTACGTCTGAAGGGACGAGTCTGCAGAAGCTTGATCTCGATGAGGCAGGGAGGTGTACCAGACATAACATGCCCAGCGCTCAGATCTTCAGCCCCAGCAGTGACGGCTCCACTGATCTGAATGCAGCAGAGCCAGTCAGCAATCTGTCTCAGTCCCTGCTCAAAGCCTTGGAAGGAGTTCAGTACATCGCTGACCATCTCAGAGCCGAGGATTCAGACTTTTCAGTGAGGGAAGACTGGAAATATGTTGCCATGGTGATTGATAGAATATTCCTCTGGATGTTTGTGCTGGTGTGCATTTTGGGGACCGTCGGACTGTTCCTCCCTCCGTGGCTCGCTGGGATGATCTAGAACATCATGCGGAGTCTTTAACTGGCCTTGTCAATCACACTTGACTGCAGTGACCTCATTAAACATCCGCTGGCATGGAAATTAAGTGATGTTTAATGTCAGTGCTTTTTTTTATGTAACAGGAAGTTATTTATGGGATTCTGTTTTGGGTTAAATGTGAGTTGatgattaattaaatgaaaattgatG

Function

symbol description
chrna4b Contributes to acetylcholine receptor activity. Acts upstream of or within response to nicotine. Part of acetylcholine-gated channel complex. Is expressed in central nervous system; cranial neural crest cell; and pharyngeal arch. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 1 and nicotine dependence. Orthologous to human CHRNA4 (cholinergic receptor nicotinic alpha 4 subunit).

GO:

id name namespace
GO:0042391 regulation of membrane potential biological_process
GO:0050877 nervous system process biological_process
GO:0034220 ion transmembrane transport biological_process
GO:0007268 chemical synaptic transmission biological_process
GO:0007271 synaptic transmission, cholinergic biological_process
GO:0035094 response to nicotine biological_process
GO:0006811 ion transport biological_process
GO:0007165 signal transduction biological_process
GO:0043005 neuron projection cellular_component
GO:0045202 synapse cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005887 integral component of plasma membrane cellular_component
GO:0045211 postsynaptic membrane cellular_component
GO:0005892 acetylcholine-gated channel complex cellular_component
GO:0030054 cell junction cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0022848 acetylcholine-gated cation-selective channel activity molecular_function
GO:0004888 transmembrane signaling receptor activity molecular_function
GO:0005216 ion channel activity molecular_function
GO:0005230 extracellular ligand-gated ion channel activity molecular_function
GO:0030594 neurotransmitter receptor activity molecular_function
GO:0015464 acetylcholine receptor activity molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-090505-3 Contributes to acetylcholine receptor activity. Acts upstream of or within response to nicotine. Part of acetylcholine-gated channel complex. Is expressed in central nervous system; cranial neural crest cell; and pharyngeal arch. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 1 and nicotine dependence. Orthologous to human CHRNA4 (cholinergic receptor nicotinic alpha 4 subunit).

Ensembl:

ensembl_id ENSDARG00000070724

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00007677 True 2265 mRNA 0.48 6 12982260 12998400

Neighbor

gene id symbol gene type direction distance location
XLOC_004025 txlng coding downstream 180137 12782296 ~ 12802123 (-)
XLOC_004024 CR450764.5 coding downstream 225985 12756143 ~ 12756275 (-)
XLOC_004023 zrsr2 coding downstream 238178 12732247 ~ 12744082 (-)
XLOC_004020 CR450764.10 coding downstream 242728 12703523 ~ 12739532 (-)
XLOC_004027 elovl1b coding upstream 95779 13094179 ~ 13152524 (-)
XLOC_004028 mast3b coding upstream 281848 13280248 ~ 13341483 (-)
XLOC_004029 BX530062.1 coding upstream 484271 13482671 ~ 13482787 (-)
XLOC_004030 si:ch211-1a19.2 coding upstream 607223 13605623 ~ 13611132 (-)
XLOC_004031 sid1 coding upstream 617615 13616015 ~ 13618412 (-)
XLOC_004019 CR450764.8 misc downstream 290569 12691395 ~ 12691691 (-)
XLOC_004015 CR450764.4 misc downstream 360493 12621518 ~ 12621767 (-)
XLOC_004013 CABZ01022569.1 misc downstream 390964 12590999 ~ 12591296 (-)
XLOC_004008 BX000700.19 misc downstream 468998 12512966 ~ 12513262 (-)
XLOC_004006 BX000700.27 misc downstream 481998 12499966 ~ 12500262 (-)
XLOC_004063 CR854846.1 misc upstream 3128982 16127382 ~ 16127678 (-)
XLOC_003997 NA non-coding downstream 490981 12429383 ~ 12491279 (-)
XLOC_003998 NA non-coding downstream 516851 12430155 ~ 12465409 (-)
XLOC_004002 NA non-coding downstream 517774 12463700 ~ 12464486 (-)
XLOC_003977 NA non-coding downstream 768829 12213149 ~ 12213431 (-)
XLOC_004032 CR555295.1 non-coding upstream 800053 13798453 ~ 13800802 (-)
XLOC_004034 NA non-coding upstream 1149263 14147663 ~ 14148426 (-)
XLOC_004035 NA non-coding upstream 1310497 14308897 ~ 14311237 (-)
XLOC_004036 NA non-coding upstream 1432522 14430922 ~ 14432200 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000051_07218226_07226180 CHRNA4B coding CI01000051 null 7218142 ~ 7226726 (-)