XLOC_004780 (tbx21)


Basic Information

Item Value
gene id XLOC_004780
gene name tbx21
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007123.7
NCBI id CM002896.2
chromosome length 49182954
location 28749189 ~ 28770817 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00009447
TATGACACCTCTAGTGAGCTCGAACCGGTGCTGCAGATGGGCGGCATAGGCAGGAATTTCTATCTCAATATGTTGAATGGAACAGACGCGCAAAGTTTCGCCAAAGACGCAGAATTAAGCAGCCACCTGCACAGACACCGCGACTTATCGGACTTCAAAATGGGCATCCAAGACACGAGGTTTTACTACCAGGACTCGATTCCAAACGGCCAGGAAAGTCTGACGTTGCCGTTTCACGCTGAGCACCACCAAAGTGCCGGAGCACAGACGGGGAGGTTTTACGCACCGGCTCCGCTCGGCAGCTGTCACTTCACCAGCCGGAGCGGGACGGGACATACTTACGTTCCAGCCGGAGCCGATGCGTATTCTTCGGCCAACGGGAAAGACGTGTACCCGAGCAGCGCAGACGGCTACACGGCGTCTTTTCAGCACGGGTTCCCGCGAGCACCCATGTACTCTTTACCTGGTCTACAGGTGTCCGGGAAGACACAAGTGCTCCTCAACAACTACCCGCTGTGGGCAAAGTTTCACAAGTATCAAACAGAGATGATTATAACGAAACAAGGACGGAGGATGTTTCCTTTCCTCAGCTTTAACATCACCTCTCTGGATCCCTCGGCTCATTATAACATATACGTGGATGTGGTTCTGGCCGACCAGCATCACTGGAGGTACCAGGGAGGAAAATGGGTCCAATGCGGCAAAGCGGAAGGCAACATGCCAGgaaaCCGAATGTATATGCACCCAGACTCTCCCAACACTGGCACTCACTGGATGAGACAGGAAGTTTCCTTTGGCAAACTGAAGCTTACAAATAACAAAGGCAGCTCCAACAACGTAGCACAGATGATCGTGTTGCAGTCGCTCCATAAATACCAACCACGTCTTCACATCGTGGAGGTGAAGGAGGATGGAACAGAGGATCCTTTCCTGACCTCTAAAACGCAGACGTTTGTCTTCCCTGAGACTCAATTCATTGCCGTCACGGCCTACCAGAATGCAGACATCACTCAGCTGAAAATAGATCATAACCCTTTTGCTAAAGGTTTCCGGGACAATTATGACACGCTGTACGCACCTCCTGACCCGGACCGCCTCACACCTTCCCCAACCGAGAGCCAGCAGCTTCTTTCAGGCAGCTGTTACCCTCACCAACCATACCTCTCTGATCAATACATGAGCCCCCTTCCTCAAAGTCGCTTCTACAGCCGAGAGCCAGTCAGCATGACCCAACCTTGCCCCAAAGACCCCACTTCAAGTCCTCACAGCCGCTGGTACCTGTCCAGCCAACAAGCGGTGCCACCAAACCGCCTTGACTTCAGCGCTTACGAGACCGAATACACTTCCAACAGCCTCTACAAGCCCTTCCCACTTCAGTCATCCCCTCATCACCCTTTGAGCTACTACTCCGAGAATCCCTTCACCTCCGGGGCGGTTTCCAGTGCAAATCCAGGAGCATGGACAGCCTCAGGACGGCCCTCGCCCCAATACCTCAACCACCCACACCACAGCAAACCCACATCCAGTCTCAGCTGGTTCCGAGCAGTCCCATCCCCCGCTGCATCTTCCTCTCCCACAGCCACAAACTCACGCTTTCACGCCTCGCCGTCGCTCCTAGAGCCACAACGTCAGCCACTTCTCCAGGACAAGTCCAAAGAGTCCACGGAGGACACCTGGATTGAAGCGCCCTCGGTTAAATCGGTGGACTCTGCCGACTCTGGTTTGTTTGAGGGAGGTGAGAGCAAGAAGAGGCGTGTGTCACCTTACACGTCCAGCACAGAAAATTCCCCACCCAACCGCAGTGCTGAAACTTGCGAAAAGGACAATTGCAGTGACGCGGGCTACTATGGCTTCTACACCCACTGAGTCTGCGCTCCTGCTCGTCTTCCACCCACCGTCTGTCTACACGACCCGAGACCCAGGGATCAAGCTCTCTGTGATAGTAGCCACAGCGTCAGGCGGCCCCTCTCTGTGTTTTGTGTTCCCCGTGTTAGATGTTTGGGGGTCATGTGGAGGTGTTCTGAAGGTCACGGTCACACAAAAGATGAAGACGATGTGACTGCAATGAGACACTGGCCTGGAGACACGCAGACAGACAGACCTGTGTGACTTTAGCAGATGAAGACTTCACAGCACACCTGCTGACACTCCCCCAAAGGAACTGTCTCTGTCCTCCTCATCAGccacagacataaaaaaaaaacacccacccGCCACTAACATGCTCCAACAAACAATCACCTGTATTTGCCACATTCTTAGtgctccttaaaaaaaaaa

Function

symbol description
tbx21 Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including heart looping; lymphocyte migration; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription, DNA-templated. Predicted to be located in nucleus. Is expressed in several structures, including digestive system; hematopoietic system; integument; kidney; and telencephalon. Human ortholog(s) of this gene implicated in asthma, nasal polyps, and aspirin intolerance. Orthologous to human TBX21 (T-box transcription factor 21).

GO:

id name namespace
GO:0001708 cell fate specification biological_process
GO:0072676 lymphocyte migration biological_process
GO:0006355 regulation of transcription, DNA-templated biological_process
GO:0000122 negative regulation of transcription by RNA polymerase II biological_process
GO:0045944 positive regulation of transcription by RNA polymerase II biological_process
GO:0001947 heart looping biological_process
GO:0005634 nucleus cellular_component
GO:0003677 DNA binding molecular_function
GO:0003700 DNA-binding transcription factor activity molecular_function
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding molecular_function
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific molecular_function

KEGG:

id description
ko04658 Th1 and Th2 cell differentiation
ko04659 Th17 cell differentiation
ko05321 Inflammatory bowel disease
ko03000 Transcription factors

ZFIN:

id description
ZDB-GENE-080104-3 Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including heart looping; lymphocyte migration; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription, DNA-templated. Predicted to be located in nucleus. Is expressed in several structures, including digestive system; hematopoietic system; integument; kidney; and telencephalon. Human ortholog(s) of this gene implicated in asthma, nasal polyps, and aspirin intolerance. Orthologous to human TBX21 (T-box transcription factor 21).

Ensembl:

ensembl_id ENSDARG00000004473

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00009447 True 2280 mRNA 0.53 6 28749189 28770817

Neighbor

gene id symbol gene type direction distance location
XLOC_004778 tbkbp1 coding upstream 70866 28574863 ~ 28678323 (+)
XLOC_004779 NA coding upstream 131224 28617701 ~ 28617965 (+)
XLOC_004777 NA coding upstream 367934 28377030 ~ 28381255 (+)
XLOC_004776 cdk5r1b coding upstream 378705 28367557 ~ 28370484 (+)
XLOC_004775 LO017791.1 coding upstream 449260 28298859 ~ 28299929 (+)
XLOC_004781 pnpo coding downstream 29171 28799988 ~ 28807184 (+)
XLOC_004782 cdk5rap3 coding downstream 54918 28825735 ~ 28837752 (+)
XLOC_004783 nfe2l1b coding downstream 83593 28854410 ~ 28866095 (+)
XLOC_004784 phkg2 coding downstream 118158 28888975 ~ 28901184 (+)
XLOC_004785 rnf40 coding downstream 139945 28910762 ~ 28933282 (+)
XLOC_004762 dre-mir-10a non-coding upstream 1614222 27134869 ~ 27134967 (+)
XLOC_004754 BX469896.1 non-coding upstream 1852573 26894321 ~ 26896616 (+)
XLOC_004752 NA non-coding upstream 1914997 26737431 ~ 26834192 (+)
XLOC_004786 NA non-coding downstream 162707 28933524 ~ 28946150 (+)
XLOC_004791 AL732488.1 non-coding downstream 242756 29013573 ~ 29013690 (+)
XLOC_004796 NA non-coding downstream 541748 29312565 ~ 29373414 (+)
XLOC_004797 BX072570.2 non-coding downstream 661258 29432075 ~ 29432191 (+)
XLOC_004799 BX004794.2 non-coding downstream 1041027 29811844 ~ 29811960 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000063_07335335_07350224 TBX21 coding CI01000063 null 7335335 ~ 7350224 (+)