npc1 (npc1)


Basic Information

Item Value
gene id npc1
gene name npc1
gene type misc
species striped catfish (Pangasianodon hypophthalmus)
category of species economic fish

Chromosome Information

Item Value
chromosome id NC_047615.1
NCBI id CM018561.1
chromosome length 21248730
location 17589072 ~ 17666213 (+)
genome version GENO_Phyp_1.0_2019_striped_catfish_Genome

Sequence

>TU381461
acaaaaaaaaaagtttgtgtgaTTTATGGGAAATTTTTCCACTTTGGGATTCTGCTTTCGTCGATCCTTGCAACGGATGAACCAGGACCCATGACTAAATCTGTGTTCAAGCTATTTTTATAACACAGAATTACACATAcatgcaatattttatataacaagCAACTGAAACTGAAACGTGTGCCTGATCTCacggtttatttattttgtgtccACATTTATGATTTGTCAGTCTAATTTCATTAAGGGGATATGTATTATTCTGTCCGCTCTAACATGAATAGTCATTTGGCTATGAGAATTTTTTAATGAAGCCTCATTTTGATGCTTTAAATCACACtgcacgtaaaaaaaaaaaagtgaactaCAGCACCAGTGTTTAATTGGTTTAATTTATGGGATTcacacagaatttttttttccttccttaaCTACTGGTTATGGTTGCTCATCGCTGAAGATTCAGCATTTAAATACTACAAAATAAGAAGTTAGCATGCCCTGAAATGGGTCCGTGAACAGGATTTGACTCGTCAAGAACCTCACGTGGTATTTGCACTGAACGTAGAATGACCTCGGTTCAGGACTTGCCGGTTGCTATGAAGTGCTGTGTCTTTTCTAGAACAGCGTATTCTTATACCTCAGTGGTAGAATGTTTGAGAAGTAATTTCCAGGGGAATAGAAACTTAAATGTGATGTATTTGTGAGGTTGTATCATGTTCATGAGGCATGTAACACGCTAGTACAGGAGACTGAAATCTACATCATCATGCGTATTTTATGCAAACTGCAATCTACTGTGGTTGTGTGTACAtgcatacatttctttttccttttgaaGTTATGTGTAATTTAGTATTGTAGGTCTTGGTGTGCATGGTCACGCCCTAATGTAGCCGTGACACTGATGTGTCAGTCAAGACACGTGAGCTCTTTATGAAGAAATTATGAAAGAAATGTTACATAGCGAGAGTGGGAGTTTgcatttttaacctttttttttttttttttttttttttttttttttttaacgaatgTTGCAATTTGAAATATAATGAATTGTTCAAGACTGCATTCCACAAAGGA
>XM_026946215.2
TGTTGACCGGCGTTGGAatgttgcgcatgcgcagtgcagGTCGGACGAGCGCTTGCGTAGTGACAGATGATAACAAGAGCGAGCGGCGCACTGTTTCTCACAGCAGCCTGGTGTAGCGCAGGAGGGGAGAAAGAATGACTCTTTGCAAAACAAGCTACATTTTGGGGCTGTTAGGAATTATCATTTTACTCTCGGAGACGCGACAGGCCGAGGCGCAGCATTGTATCTGGTATGGAGAATGCGGCAACTCGACTCTCCTCCCAGATAAGAAGTACAACTGTAACTACACAGGACCTCCTAAACCCCTACCTAAAGACGGACAAGACCTCTTACTGGAACTTTGTCCAGGTTTGGTCTACGGTAACCAGAGCGTCTGCTGTGACACCCAGCAACTGCGTACACTGAAAGGCAACATCCAGATACCTTTACAATACCTGTCCAGGTGTCCAGCATGTTTCTTCAACTTCATGACCCTGTTCTGCGAGCTGACCTGCAGCCCCCGGCAGAGCGAGTTCCTCAACGCCACCCAGTTCTCAGTCAACCCCGTCGACAACAGCACCAACGTAGTCGAGCTCTCGTACTACATCAGCCAGGACTTCGCTAACGctatGTACAATGCGTGCAAGGACGTAGAAGCTCCGTCCAGCAATGTGAAGGCTCTTAGTTTGCTGTGTGGCCGAGACGCCAGTGCCTGCACCCCCACCAACTGGATCCAGTACATGTTTGACACCAACAACGGCCAGGTTCCCTTTGCCATCGATCCCGTGTTCTCAGGTAATCCGCCCTCTGGAATGACCTTCATGAATAACCACACGTTTGGCTGCACCGAGTCTCTGGACGACGGCTCAGCGCCGTGCTCGTGTCAGGACTGCAGTGCAGCTTGTGGGCCCTCGCCCGTCCCTCCACCCAGCCCTCTGCCATGGACCATTTTGGGCTACGATGCCATGTGCTTCATCATGTGGGTCTCGTACGCGGCCTTTCTTCTCGTCTTCTTCGGCATGCTGAGTTTAGCGTGGTGCTTCAGaAAAAGGGACATCACGTCGGAGTATGGCCCCATCCAAGACAGCAACGAGCCTCTTTCTCTGAACAAGGACCCTGCCAGATCATCCAgtGAAGTGACGTGTTGTGAGTCTCTAGGTGAGCGCTTTGAGAATTTCCTCCGTAATGTCTTCAGCTGCTGGGGTTCGTTCTGTGTGCGCTGTCCCCTGCTGGTGATCTTAGTGAGCATCGTGCTGGTGGTGATCTGCTGCATGGGTTTGAGGCACATGCGCATCACCACCGACCCGGTGGACCTGTGGTCGGCCCCTCACAGCCGCGCCAGGCAGGAGAAACAGTACTTCGACGAGCACTTCGGCCCGTTCTTCCGCACTGAGCAGCTCATCATCACCACACCATGGACCAACTGGTTCACGTTTGAGTCCACCACCGGGGGTGATATCCCCTTTGCGCCCATCCTGAACATATCTCTGCTCCATCAGATTCTAGATCTCCAGATTGCCATTGAGCAACTGGAGGCAGACTTTAATGGAGAGAAGGTTACCCTGAAGGATATCTGCATATCTCCTCTGGCTCCCTACAACAACAACTGCACCATTCTGAGCGTGCTCAATTACTTCCAGAACAGCCATGAAGTTTTGGATCACATCTGGCGTGATGAGTTTTATGTGTACTTTGATTATCACACGCACTTCATGTACTGTGTAAgTTCCCCGGTAGCCCTGGACGATACAGGGCATTTCCACGACCCCTGCATGGGCACTTTTGGTGGTCCTGTCTTCCCCTGGCTGGTCCTCGGAGGCTATGAAGGAACAGCGTACAACAATGCCACTGCTCTAGTGATCACCTTCCCTATCAATAACTCCCTCAACGTCACAGAAAAGCTGGGCAGAGCTCTCGCTTGGGAGAAAGAattcGTCAGCTTTTTGAAAAACTACAGCAACCCCGACCTCATCATCTCCTTCAACTCGGAGCGCAGCATCGAGGATGAGATCAATCGGGAAAgcaacagtgacatcaccaccGTACTGATCAGCTACGCCACCATGTTTGTCTACATCTCCCTGGCTCTGGGACACATCAGGAGCTTCCGTACCCTGCTGGTGGACTCGAAGATCTCTCTGGGTATAGCGGGCATCCTGATCGTCCTCAGCTCAGTCGCCTGCTCTCTGGGCATCTTCAGCTACGTCGGCATTCCCCTCACCCTCATCGTCATCGAGGTCATCCCCTTCCTTGTGCTGGCCGTGGGAGTGGACAACATCTTCATCATCGTGCAGACCTTCCAGAGAGATGAGCGGCTGGAGCATGAGGAGCTGCATCAACAGATAGGCCGTATCCTGGGAGACGTTGCCCCCAGCATGTTCCTGTCCTCCCTCTCAGAGACTGTCGCATTTTTCTTAGGAGCTCTGTCCCACATGCCGGCCGTGAGGACGTTCTCGCTCTTTGCTGGCTTGGCTGTCTTTATTGACTTCCTGTTGCAGATCAGCTGCTTTGTCTCCTTGCTTGGTCTGGATGTCAAGAGGCAAGAGaGAAATCGGCTGGACATCCTGTGCTGCATCAAGCTGCCTGACAGGCAGGAAGAGAATACCGAAGACGGTATCCTCTATCGCTTCTTTAAGAAAATCTACGCTCCCTTTATTCTGAAGGACTGCGTGCGCCCTCTGGTGGTTGCTGTGTTTGTGGGAATGCTCTCGTTCAGCATAGCAGTCATTGACAAAGTAGACATTGGACTCGACCAACAGCTGTCCATGCCTGATGACTCGTTTGTGTTGTACTACTTCGGGAACCTGACTAAATACCTGCATACGGGTCCTCCTGTCTACTTCGTGGTGAAGGACGGTCACGATTACCGCACCTCGGAGGGACAGAACCAAGTGTGTGGTGGCGTGGGCTGCAACAATAACTCGCTCATCCAGCAAATCTACACGGCATCACTCATGAGTGACTACTCTAAGATAAGCACGACCCCCTCCTCGTGGTTAGACGACTACTTTGACTGGGTGAAACCGCAGTCGTCCTGCTGCCGATACTACAACTCTACTGGAGAATTCTGCAACGCCTCAGtggtGGATCCCTCCTGTGTGCACTGCAGGCCTTCGACTCCCAGTGGCAAATTGAGACCTAATGGCACTGACTTCATGAGGTTCCTGCCAATGTTCCTGTCTGATAACCCCAACGTCAAGTGCGGGAAAGGAGGTCATGCTGCGTACAGCACTGCTGTAGTGCTGAAGGACAACAACACCAATGTGGGCGCCACCCATTTCATGAGCTACCACACCATCCTCAAGACGTCTGCGGATAACATCAACGCCATGAAGATGGCCCGAGAGCTGGCCAAAAACATCTCGCTCTCCATGGGGCTGGAGAACAAGACGCACGGTGTCTTTCCTTACAGTGTGTTCTACGTGTTCTACGAGCAGTACCTCACCATCGCCCACGACACGGCGTTGAACCTGGGCGTGTCCCTGGCAGCCATCTTTGTGGTCAGCGCCGTGCTGCTGGGCTTTGAGCTGTGCTCGGCCGTGCTCGTCTCGCTCACCATCGCCATGATCCTGGTCAACATGTTCGGTGTCATGTGGCTGTGGGGCATCAGCCTCAATGCGGTGTCACTCGTTAACTTAGTCATgAGCTGTGGTATTTCGGTGGAGTTCTGCAGCCATATCGTGAGGGCGTTCTCCATCAGTACTAAGGCTACACGGGTGGAGAGAGCTGAAGAGGCCCTGGCACACATGGGCAGCTCTGTGTTCAGTGGCATCACCTTAACGAAGTTTGGCGGGATCGTCGTCCTGGCTTTCTCCAAGTCCCAGATCTTCCAGGTCTTCTACTTCCGCATGTATTTAGCCATAGTGCTTCTGGGAGCGGCTCACGGTCTCATCTTCCTACCAGTGCTCCTGAGTTACGCAGGTCCGTCTGTTAATAAAGCTAAGGTCTTGGCAGCACGCAGCAGGTTCACCGGGACGGAGCGTGAATATCTACTCGCCAATTGACAGCACTGAGGAAGCTGAAACATCAATCCACAAGGGACTATGTGGGTACAGCAGCTtgtcacaaacacactaacacacgcacacatctcAACTAAGAGACCCTAACTCAGGATCCCTGCTAGGGAGAAcccaaaaaaaacctcacaaaaaaaaaaacagtttgtgtgaTTTATGGGAAATTTTTCCACTTTGGGATTCTGCTTTCGTCGATCCTTGCAACGGATGAACCAGGACCCATGACTAAATCTGTGTTCAAGCTATTTTTATAACACAGAATTACACATAcatgcaatattttatataacaagCAACTGAAACTGAAACGTGTGCCTGATCTCacggtttatttattttgtgtccACATTTATGATTTGTCAGTCTAATTTCATTAAGGGGATATGTATTATTCTGTCCGCTCTAACATGAATAGTCATTTGGCTATGAGAATTTTTTAATGAAGCCTCATTTTGATGCTTTAAATCACACtgcacgtaaaaaaaaaaaagtgaactaCAGCACCAGTGTTTAATTGGTTTAATTTATGGGATTcacacagaatttttttttccttccttaaCTACTGGTTATGGTTGCTCATCGCTGAAGATTCAGCATTTAAATACT

Function

symbol description
npc1 Predicted to enable lipid transporter activity. Acts upstream of or within several processes, including cholesterol homeostasis; epiboly involved in gastrulation with mouth forming second; and megakaryocyte development. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including heart; liver; nervous system; pleuroperitoneal region; and yolk syncytial layer. Used to study Niemann-Pick disease type C1. Human ortholog(s) of this gene implicated in Niemann-Pick disease type C1. Orthologous to human NPC1 (NPC intracellular cholesterol transporter 1).

NR:

description
Niemann-Pick C1 protein-like

GO:

id name namespace
GO:0035855 megakaryocyte development biological_process
GO:0055113 epiboly involved in gastrulation with mouth forming second biological_process
GO:0030301 cholesterol transport biological_process
GO:0001666 response to hypoxia biological_process
GO:0016021 integral component of membrane cellular_component
GO:0008158 hedgehog receptor activity molecular_function

KEGG:

id description
K12385 NPC1; Niemann-Pick C1 protein

RNA

RNA id representative length rna type GC content exon number start site end site
TU381461 False 1086 lncRNA 0.35 2 17589072 17666213
XM_026946215.2 True 4607 mRNA 0.51 26 17640627 17665605

Neighbor

gene id symbol gene type direction distance location
c1ql3b c1ql3b,LOC108280659,LOC107747511,LOC107566459,LOC107599856,LOC107691085,LOC107691073,LOC107681760,LOC107708591 coding upstream 71705 17514697 ~ 17517367 (+)
gpt2l LOC108280657,LOC108430180,LOC107599855,LOC107708598 coding upstream 81685 17487387 ~ 17507387 (+)
hecw1b hecw1b,LOC108280656,LOC108433086,LOC107600217,LOC107662981 coding upstream 111251 17433918 ~ 17477821 (+)
ccr12a LOC108280814 coding upstream 159347 17427910 ~ 17429725 (+)
si:ch211-106n13.3 LOC108280813,LOC108433067 coding upstream 161808 17400391 ~ 17427264 (+)
yme1l1b yme1l1,yme1l1b,LOC108430171,LOC107708459,LOC107566723,LOC107747521 coding downstream 176236 17842449 ~ 17853870 (+)
rab18b rab18,rab18b,LOC108430170,LOC107566717,LOC107708473,LOC107681801,LOC107691240,LOC107550439 coding downstream 194098 17860311 ~ 17872029 (+)
wacb LOC108280665 coding downstream 299680 17965893 ~ 17979122 (+)
bambib LOC108280666,LOC108430169 coding downstream 324512 17990725 ~ 17994678 (+)
gnb4a gnb4,LOC108280743,LOC108440866,LOC103030165,LOC107705311,LOC107653516,LOC107564248,LOC105899196,LOC107724752 coding downstream 769136 18435349 ~ 18449078 (+)
LOC117599934 NA non-coding upstream 51912 17525571 ~ 17537160 (+)
G321704 LOC108410862 non-coding upstream 628338 16958745 ~ 16960734 (+)
G321602 NA non-coding upstream 696048 16892813 ~ 16893024 (+)
G321591 NA non-coding upstream 729494 16792714 ~ 16859578 (+)
G321585 NA non-coding upstream 799465 16789186 ~ 16789607 (+)
G322146 NA non-coding downstream 55725 17721938 ~ 17786701 (+)
G322233 LOC108280496 non-coding downstream 188335 17854548 ~ 17855258 (+)
G322324 NA non-coding downstream 408116 18074329 ~ 18074748 (+)
G322365 NA non-coding downstream 532627 18198840 ~ 18199709 (+)
G322398 NA non-coding downstream 563182 18229395 ~ 18231463 (+)
fuz fuz other upstream 105395 17478834 ~ 17483677 (+)
LOC117599970 LOC108280611,LOC108261562,LOC108261692,LOC108261605 other upstream 729390 16838768 ~ 16859682 (+)
LOC117595733 LOC108280611,LOC108261562,LOC108280614,LOC108280616,LOC108261605,LOC108261692 other upstream 795374 16791402 ~ 16793698 (+)
LOC117599973 LOC108280611,LOC108261605,LOC108261562,LOC108261692,LOC108280616 other upstream 800104 16756631 ~ 16788968 (+)
LOC117599972 LOC108280611,LOC108280616,LOC108261562,LOC108261605,LOC108280614,LOC108280615,LOC108261692 other upstream 840732 16742805 ~ 16748340 (+)
si:ch211-162e15.3 LOC108280563 other downstream 559708 18225921 ~ 18227233 (+)
pex5lb pex5lb,LOC108280742,LOC108440867,LOC107653517,LOC107564246,LOC107660316 other downstream 727810 18394023 ~ 18430022 (+)
slc44a5a slc44a5,slc44a5a,LOC108280730 other downstream 1149796 18816009 ~ 18871360 (+)
ssbp3a ssbp3,ssbp3a other downstream 1278485 18944698 ~ 18985082 (+)
gng12a gbg12,gng12a,gng12,LOC107705318,LOC107700509,LOC105895117 other downstream 1538445 19204658 ~ 19220229 (+)

Expression


Co-expression Network