XLOC_009771 (flcn)


Basic Information

Item Value
gene id XLOC_009771
gene name flcn
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007127.7
NCBI id CM002900.2
chromosome length 55266484
location 13818500 ~ 13847335 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00019541
AAAGATCCGATTCACCCTGAAGAAGATTCACTAAAGGATCAAGGCTTGCTCGAAGGCATTCGGAGATTACGGAAGAGCTCACATCAATTACAAATATCAAAATATACCTCGTTCACCATGTAAAAAACACCAGAAGAACATTTTGGTGGATTATTTGGACTGTACCGATGGCTGTTCAGCGTGAGAGACAAGAGCAGCTATGAACGCTTTAGTTGCCCTGTGCCACTTTTGTGAGCTCCATGGCCCACGGACGCTGTTTTGTACCGAAGCCGTCCACCCTCCGTCCCCTTCACCTCCACAGCCGGGCTCAGCCATTCCCGGAGAGCGAGAGCGGGAGGCTGACCGAGAGGGTGAAGGGCTCACCATGAGGGCCAACAGCTCTGCCACACAGAGAGCGGACATGTGTGAGGGCTGTCGCTCTTTACCTGCGTCTCACCCAGGCTTTGTGAGTGTGGATGGTGAGACAGGAATCCGCTATCTGAGCCATCAACATCCCCGGCAGCCTCAGCTCTTCAGCGTGGTGCGACAGGCATGTGTGCGCAGTCTCAGCTGTGAGGTTTGTCCTGGTCGCGAGGGGCCAATCTTCTTCGGAGACGAACAGCATGGCTTCGTTTTCTCTCATACGTTTTTCATCAAAGACAACCTGGCACGGGGCTTTCAGCGCTGGTACAGCATCGTGGTGGTGGCCATGGACAGGATTTACCTTATCAACTCGTGGCCGTTTCTATTACGCCACCTGCGGCTCACCATTCAGAGTCTCCAGAACACAGCGCTCAAGGT
>TCONS_00019542
CTTTCCCATCACATGACACACAAGACTGAAAAGGACAACATAAACacaataaaactattaattaCGATCGCGTTTCAGGATAAATTTACTAAGCTCTGTATCGATGAGAATAGCGACCCATTTATGTTGAATAGTAGTTATACGTTAAATTGTAAGGAAGGCTGATGAACATGCAGAACCTGTAGATGGTTGCCATTGTCAAcgctttgtaatgtaatgttcaGTTGTTCATAATTTACTGTAAGTACCAGTCGGCGCTAAAGCTTCACGCAGCTAACCCAGATGAACGCTTTAGTTGCCCTGTGCCACTTTTGTGAGCTCCATGGCCCACGGACGCTGTTTTGTACCGAAGCCGTCCACCCTCCGTCCCCTTCACCTCCACAGCCGGGCTCAGCCATTCCCGGAGAGCGAGAGCGGGAGGCTGACCGAGAGGGTGAAGGGCTCACCATGAGGGCCAACAGCTCTGCCACACAGAGAGCGGACATGTGTGAGGGCTGTCGCTCTTTACCTGCGTCTCACCCAGGCTTTGTGAGTGTGGATGGTGAGACAGGAATCCGCTATCTGAGCCATCAACATCCCCGGCAGCCTCAGCTCTTCAGCGTGGTGCGACAGGCATGTGTGCGCAGTCTCAGCTGTGAGGTTTGTCCTGGTCGCGAGGGGCCAATCTTCTTCGGAGACGAACAGCATGGCTTCGTTTTCTCTCATACGTTTTTCATCAAAGACAACCTGGCACGGGGCTTTCAGCGCTGGTACAGCATCGTGGTGGTGGCCATGGACAGGATTTACCTTATCAACTCGTGGCCGTTTCTATTACGCCACCTGCGGCTCACCATTCAGAGTCTCCAGAACACAGCGCTCAAGGTGTTTGACAGCGAGCAGTGTGTGTGTCCTCAGAGGGCTCTGCGGATGAACAGTACCTTCTCTCCGGCAGTGTTTCCTCACCAGCGCAGTGGAAACGCAGCCCGTTCGCTCACCTCTCTGACACAGCATCCCAATCTGTGGGACAGTCTGCACTCCTCATTCAGCTGGTTGCTGAAAGCTTGTGGCAGTCGGTTAACAGAGAAACTTTTGGAAGGAGCACCCACAGAAGATACACTCGTTCTTATTGAAAGACAAACTGAGCAGGAGGAAGAGATGAGTGGCTGGGATGGTGCTGAAGGGGGCGGATCTAACCCACAGTCCAGCCAGTCAGAGAGTGTTCAGGCTAAAGACTTTCAGTTTGATGATAGAAGGCAAGAGGACCTCATTGGGCCGAAATTCAAATCACTAAGACATTTAAGACAGGTCTTGGGTACTGCAGATTTCCGGCAGTTGACATGGCATGTGCTCATGGGAAACCAAGTCATATGGAGAGGAGCAGACCCTGGTCTTATCCAGTCAGCTTTCAATGTGCTGAAGGCTTTGCTTCCAGTTGGCTGTGTGCGAGCAGTGCAGTACAGTCCTCACTATGAGGAAGCATATCGGTGCAACTTCCTTGGCCTTAGTCCAGACGTACCCATCCCAGCCCACGTCAGCTCCTCAGAGTTTTCTGTGCTGGTGGATGTACTGAGCGCAGAGCGAGGTTGTGTAAACCCCGTTTCAGACGATGACATTCTGTCACTTTACCAGTTCCACATTAGCAGTGCCAACACACAACCAACAGATAAAGGTCCAACTCTTCTGAATAAGCTCGAAGTGGCTCTTTCTAATGAGAATCTGTCCGTGGAGGTGGTCTCGCTCTGCCTTCTCTGTCTGAAAGAGGAGTGGATGAACAAAGTAAAAGTGCTGTTCAAGTTCTCTAAAGTGGACGGCAGAGGTAAAGAGGACACCCAAAAGGTTTTGGCCCTGCTGGGGGCCACGGGGCCAGGAGAAGAGGACAATGTGCGGCTTCTTAAGTTCTGGATGACAGGATTGAGCAAACTCTACAAGAGCCATCTGATGACAGCAGTCAGAGGTGGAGAGAGGACTTTGAGCCAGTGAGAGAGACTGAAAGCGGGGGACAATGGACTCATTGCTAGCATTAGATGAAAGgaatgcgtgtgtatgtgtgcggttgtgtctatgtgtgtgtgtgtcagttacTGGAAATGGGGGCCAGGCCTGAGAATGTGTTTTTCTTGCATGCTACGAAGAGAAAGTTAAAGCTATCAATGTGATTGAAGCCTCAAACGTTTTCACTTCGACATGTGCATTTTAATGGAATGTTGTTTTACCGTCATGACTAGACATGTCCTTTTTCTGTCTTCTTCACCGTGCGTCTAATAAACCGCACGGTCCATTGCGTTTATGGGAACCAGGCAGAGTATCAGTTGACATGATACTGTTTGGGGTTTTGTAATTCACATTATCTCATGTTTGAGTGCATCTGACACGTCcgagagagagaatgtgtatTTTAGGAGCgatgttatttatatttgttttaacttattttaaacaaatggCTTTTATTTTGGACTCACACGTGTTCAATAAAGACTGTGTGCTAA
>TCONS_00019543
gtattggaagtgaacttaggcagctgatgatgacgttgcatgagaacacgaggacgcaagaccgctgaagaactcatattgagaaacagccacagacTCTataagtttgatcaggtgtgtttaattagggctggaactaaactgcagagctgcggccctccaggaactggctttgacacctgtgctataaACCAAACTCATAATATCAAAATCTATATCTCTAAAATCTATAAAGCTGATAATTCATCATCTCATATAAGAATATGTTTGTTTCCTCCAGATGAACGCTTTAGTTGCCCTGTGCCACTTTTGTGAGCTCCATGGCCCACGGACGCTGTTTTGTACCGAAGCCGTCCACCCTCCGTCCCCTTCACCTCCACAGCCGGGCTCAGCCATTCCCGGAGAGCGAGAGCGGGAGGCTGACCGAGAGGGTGAAGGGCTCACCATGAGGGCCAACAGCTCTGCCACACAGAGAGCGGACATGTGTGAGGGCTGTCGCTCTTTACCTGCGTCTCACCCAGGCTTTGTGAGTGTGGATGGTGAGACAGGAATCCGCTATCTGAGCCATCAACATCCCCGGCAGCCTCAGCTCTTCAGCGTGGTGCGACAGGCATGTGTGCGCAGTCTCAGCTGTGAGGTTTGTCCTGGTCGCGAGGGGCCAATCTTCTTCGGAGACGAACAGCATGGCTTCGTTTTCTCTCATACGTTTTTCATCAAAGACAACCTGGCACGGGGCTTTCAGCGCTGGTACAGCATCGTGGTGGTGGCCATGGACAGGATTTACCTTATCAACTCGTGGCCGTTTCTATTACGCCACCTGCGGCTCACCATTCAGAGTCTCCAGAACACAGCGCTCAAGGTGTTTGACAGCGAGCAGTGTGTGTGTCCTCAGAGGGCTCTGCGGATGAACAGTACCTTCTCTCCGGCAGTGTTTCCTCACCAGCGCAGTGGAAACGCAGCCCGTTCGCTCACCTCTCTGACACAGCATCCCAATCTGTGGGACAGTCTGCACTCCTCATTCAGCTGGTTGCTGAAAGCTTGTGGCAGTCGGTTAACAGAGAAACTTTTGGAAGGAGCACCCACAGAAGATACACTCGTTCTTATTGAAAGACAAACTGAGCAGGAGGAAGAGATGAGTGGCTGGGATGGTGCTGAAGGGGGCGGATCTAACCCACAGTCCAGCCAGTCAGAGAGTGTTCAGGCTAAAGACTTTCAGTTTGATGATAGAAGGCAAGAGGACCTCATTGGGCCGAAATTCAAATCACTAAGACATTTAAGACAGGTCTTGGGTACTGCAGATTTCCGGCAGTTGACATGGCATGTGCTCATGGGAAACCAAGTCATATGGAGAGGAGCAGACCCTGGTCTTATCCAGTCAGCTTTCAATGTGCTGAAGGCTTTGCTTCCAGTTGGCTGTGTGCGAGCAGTGCAGTACAGTCCTCACTATGAGGAAGCATATCGGTGCAACTTCCTTGGCCTTAGTCCAGACGTACCCATCCCAGCCCACGTCAGCTCCTCAGAGTTTTCTGTGCTGGTGGATGTACTGAGCGCAGAGCGAGGTTGTGTAAACCCCGTTTCAGACGATGACATTCTGTCACTTTACCAGTTCCACATTAGCAGTGCCAACACACAACCAACAGATAAAGGTCCAACTCTTCTGAATAAGCTCGAAGTGGCTCTTTCTAATGAGAATCTGTCCGTGGAGGTGGTCTCGCTCTGCCTTCTCTGTCTGAAAGAGGAGTGGATGAACAAAGTAAAAGTGCTGTTCAAGTTCTCTAAAGTGGACGGCAGAGGTAAAGAGGACACCCAAAAGGTTTTGGCCCTGCTGGGGGCCACGGGGCCAGGAGAAGAGGACAATGTGCGGCTTCTTAAGTTCTGGATGACAGGATTGAGCAAACTCTACAAGAGCCATCTGATGACAGCAGTCAGAGGTGGAGAGAGGACTTTGAGCCAGTGAGAGAGACTGAAAGCGGGGGACAATGGACTCATTGCTAGCATTAGATGAAAGgaatgcgtgtgtatgtgtgcggttgtgtctatgtgtgtgtgtgtcagttacTGGAAATGGGGGCCAGGCCTGAGAATGTGTTTTTCTTGCATGCTACGAAGAGAAAGTTAAAGCTATCAATGTGATTGAAGCCTCAAACGTTTTCACTTCGACATGTGCATTTTAATGGAATGTTGTTTTACCGTCATGACTAGACATGTCCTTTTTCTGTCTTCTTCACCGTGCGTCTAATAAACCGCACGGTCCATTGCGTTTATGGGAACCAGGCAGAGTATCAGTTGACATGATACTGTTTGGGGTTTTGTAATTCACATTATCTCATGTTTGAGTGCATCTGACACGTCcgagagagagaatgtgtatTTTAGGAGCgatgttatttatatttgttttaacttattttaaacaaatggCTTTTATTTTGGACTCACACGTGTTCAATAAAGACTGTGTGCTAATTAAGTTGTGAGGACtcaaacttatttttatattaattatatgaagagttcaaatgcaaaaacctctaaataccATCTGAAATTTTTCAGAAGCTCCTGTCTGTATGTTCACTGTCTGTAAATCCACTATTATGGCAAAAATAGGTTCTTTGCATTGCCTTTACaatgaaataactaaacaaaaatattaaaggctgagaaaaatgctcattttagaagagaatttcagacagcacttttttgcatctgaactcaccATATGTTTTTTCGTAAGATAATTATACAGtcaacaaacaatgaacattacatttattgttgaagatagacagatgaatggatggatggatggacgggcggagatagatagatagatagatagatagatagatagatagatagatagatagatagatagatagatagatagatagatagatagatagatagatggatggatggatggatggatggatggatggatggatggatggatggatggatggatggatggatgatggatggatggatggatagatgatagatagatagatagatagatagatagatagatagatagatagatagatagatagatagatagagatggacggacggattgatggatggatggacggatagacagatacatgaatagatagatagatagatagatagatagatagatagatagatagatagatagatagatagatagatagatagatagatagatagatagagtaaaTTTTGTTTGTATTGTCTTTTCAATAATTAATATCATATTTCGTGTAAAAATGCATTCTTTCGTCTTTGTTTTCAGAAACTTGCAATTaagacagactgacagatagacagatagatagataaatagatagatagctagatagatagatagatagatagatagatagatagatagatagatagatagatagatagatagatagatagatagatagatagatagatagatggatggatggacgaacgggcggatggacagatagatggatagacagatagaaagacgGATAGACAAACTACTGGATAGATGGATAGTTAGacaaacagaaaaacagacagaaggatgaatggatggatggacggatagataggtAGACGGATAGACAAAaagatatatagacagatagaaagacgGATAGACACAAACAAATGGATAGATAGTTagtcagatagacagacagacagaaagactaATATAGATGGATCAAAGGATGGACAAACGAATGGATAAGTAGATAGAGATTTCTGAAATAAAGAGCTCATTTGTGAAAGATAACCatcatttttaccatttttagaAATGAAACGCTTCAA

Function

symbol description
flcn Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; positive regulation of GTPase activity; and positive regulation of signal transduction. Predicted to be located in several cellular components, including cilium; lysosomal membrane; and microtubule cytoskeleton. Predicted to be active in cytosol. Is expressed in brain; hatching gland; pectoral fin bud; retina; and tail bud. Used to study Birt-Hogg-Dube syndrome. Human ortholog(s) of this gene implicated in Birt-Hogg-Dube syndrome; colorectal cancer; primary spontaneous pneumothorax; and renal cell carcinoma. Orthologous to human FLCN (folliculin).

GO:

id name namespace
GO:0043547 positive regulation of GTPase activity biological_process
GO:1904263 positive regulation of TORC1 signaling biological_process
GO:0000122 negative regulation of transcription by RNA polymerase II biological_process
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway biological_process
GO:0005829 cytosol cellular_component
GO:0005085 guanyl-nucleotide exchange factor activity molecular_function

KEGG:

id description
ko04150 mTOR signaling pathway
ko05211 Renal cell carcinoma

ZFIN:

id description
ZDB-GENE-060421-3470 Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; positive regulation of GTPase activity; and positive regulation of signal transduction. Predicted to be located in several cellular components, including cilium; lysosomal membrane; and microtubule cytoskeleton. Predicted to be active in cytosol. Is expressed in brain; hatching gland; pectoral fin bud; retina; and tail bud. Used to study Birt-Hogg-Dube syndrome. Human ortholog(s) of this gene implicated in Birt-Hogg-Dube syndrome; colorectal cancer; primary spontaneous pneumothorax; and renal cell carcinoma. Orthologous to human FLCN (folliculin).

Ensembl:

ensembl_id ENSDARG00000062385

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00019541 False 780 mRNA 0.53 4 13818500 13825976
TCONS_00019542 False 2468 mRNA 0.49 12 13818743 13845997
TCONS_00019543 True 3804 mRNA 0.43 11 13822137 13847335

Neighbor

gene id symbol gene type direction distance location
XLOC_009770 josd2 coding upstream 111730 13683807 ~ 13706770 (+)
XLOC_009769 NA coding upstream 204312 13612654 ~ 13614188 (+)
XLOC_009768 NA coding upstream 316535 13499361 ~ 13501965 (+)
XLOC_009767 pitpnc1b coding upstream 364682 13424534 ~ 13453818 (+)
XLOC_009766 NA coding upstream 645802 13168872 ~ 13172698 (+)
XLOC_009772 zgc:174888 coding downstream 7704 13855039 ~ 13859164 (+)
XLOC_009773 grwd1 coding downstream 12964 13860299 ~ 13870899 (+)
XLOC_009774 atg12 coding downstream 36537 13883872 ~ 13888705 (+)
XLOC_009775 si:ch211-149k23.9 coding downstream 51064 13898399 ~ 13905633 (+)
XLOC_009776 NA coding downstream 94738 13942073 ~ 13945576 (+)
XLOC_009765 NA non-coding upstream 702891 13112264 ~ 13115609 (+)
XLOC_009764 NA non-coding upstream 854623 12962960 ~ 12963877 (+)
XLOC_009777 NA non-coding downstream 102682 13950017 ~ 13954147 (+)
XLOC_009782 NA non-coding downstream 306655 14153990 ~ 14158725 (+)
XLOC_009786 NA non-coding downstream 613927 14461262 ~ 14493478 (+)
XLOC_009787 NA non-coding downstream 627521 14474856 ~ 14481801 (+)

Expression


Co-expression Network