XLOC_012311 (foxa2)


Basic Information

Item Value
gene id XLOC_012311
gene name foxa2
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007128.7
NCBI id CM002901.2
chromosome length 53461100
location 42565998 ~ 42568498 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00024220
ACAGAGCTATATCACAGCGTTAAGAGCCAGCAGCAGGCGTCATTTCAACTGCAGTCGtctcagatacacacacatacacaaacacacatgcgccAGTCCTTGACAGGAGGAGAGCACAACGACGACACGAGTGTATCCCGTGGTCCCCAACAACCACCTTTGGCTGCCAAAGGACACACAATACAGGCATTTCTCGTGTGGGGAAGCGTTTTAAAAAGTAGACGAAACTTTTTTCCAGGATGCTCGGTGCTGTCAAAATGGAGGGACACGAACACGCAGCAGACTGGAGCACTTACTACGGAGAGCCTGAGTGTTACACCTCGGTCAGCAACATGAACACTGGACTTGGAATGAATTCCATGAACACTTACATGACTATGTCCGGAATGAGTTCGACTGCAAACATGACAGCAGCTAACACCATGAACATGTCCTATGTCAACACGGGCATGAGCCCTTCAATGACAGGCATGTCCCCCGGTACGGGAGCGATGGCCGGCATGGGTGCGGGTATGACGGGCATGAGCGCAGCCCTGAGCCCTACCATGAGCCCAATAGCAGCGCAAGCGCCCTCCATGAACGCCCTAACCTCGTACAGCAACATGAACGCTATGAGCCCTATGTACGGCCAGTCGAACATAAACAGATCGAGAGATCCGAAGACCTACCGCAGGAGCTACACTCATGCCAAGCCCCCTTACTCGTACATTTCTCTAATAACCATGGCCATCCAGCAATCACCCAGTAAGATGCTGACCCTTAGTGAGATTTACCAGTGGATAATGGACCTTTTCCCTTTTTACCGACAGAACCAGCAACGCTGGCAAAACTCTATCCGCCACTCGCTGTCTTTTAACGACTGTTTCCTGAAAGTTCCGCGCTCTCCGGATAAGCCGGGTAAAGGCTCGTTTTGGACCCTTCATCCCGATTCCGGAAACATGTTCGAAAACGGCTGTTACCTGAGGAGGCAAAAGCGCTTCAAGTGCGATAAGAAACTAAGCAAGGATCCGAGTCGAAAAACATCAGAGGGCGGATCAAACAGCAGCTCCGAGAGCTGCAATGGGAACGAATCTCCTCATTCCAACTCTTCAAGTAACGAGCACAAAAGATCTCTGTCTGACATGAAGTCGGGTCAGGGTCTGAGTCCGGACCACGCAGCGTCCCCGACCTCCCAGGCGCAGCATCTGCTGGCTCAACATAACTCTGTTTTAGCGCACGAAGGACACCTGAAGCCAGAACATCACTACTCGTTCAATCACCCCTTCTCTATTAACAACCTAATGTCCTCGGAGCAGCAGCATCACAAAATGGACCTAAAGACATACGAGCAAGTGATGCATTATGGTTACGGTTCTCCGATGGCCGGCACGTTATCCATGGGCTCCATGGCAAGCAAAGCAGGCCTGGATTCACCGGACACATCCTATTACCAAGGTGTGTACTCCAGGCCCATCCTGAACTCTTCCTAAACTCTCTTGGACCTTGTGacaatttgtaaatttgtaaaatgtttgtgtatatgtattcATTTTTCGATGTTTCCTGTTAATTTAGATGATCATTAGTTATTAATTTGTAAAAGACATGTTAACAATGTGACGAACTCTTCAAGGCGGCTTTTGAAAATGGACCAAAATTACACCGAAGGACTGCGGACGGATTGGACTTCTTGAATCACATGTGTAAACTTATTTATGGCTTGTAAATGTGTATTCTTGTAGTTGATGACAAGAACAGAATCTATATTAAAGTGTTATTTGGACTTTTTTCGC

Function

symbol description
foxa2 Enables transcription cis-regulatory region binding activity. Acts upstream of or within axial mesoderm morphogenesis; endoderm development; and nervous system development. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; digestive system; endoderm; mesoderm; and swim bladder. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human FOXA2 (forkhead box A2).

GO:

id name namespace
GO:0032289 central nervous system myelin formation biological_process
GO:0007492 endoderm development biological_process
GO:0006355 regulation of transcription, DNA-templated biological_process
GO:0006357 regulation of transcription by RNA polymerase II biological_process
GO:0030154 cell differentiation biological_process
GO:0007275 multicellular organism development biological_process
GO:0009653 anatomical structure morphogenesis biological_process
GO:0033504 floor plate development biological_process
GO:0048319 axial mesoderm morphogenesis biological_process
GO:0007418 ventral midline development biological_process
GO:0021779 oligodendrocyte cell fate commitment biological_process
GO:0005634 nucleus cellular_component
GO:0043565 sequence-specific DNA binding molecular_function
GO:0008134 transcription factor binding molecular_function
GO:0003677 DNA binding molecular_function
GO:0003700 DNA-binding transcription factor activity molecular_function
GO:0000976 transcription regulatory region sequence-specific DNA binding molecular_function
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific molecular_function
GO:0019904 protein domain specific binding molecular_function

KEGG:

id description
ko04212 Longevity regulating pathway - worm
ko04213 Longevity regulating pathway - multiple species
ko04950 Maturity onset diabetes of the young
ko03000 Transcription factors

ZFIN:

id description
ZDB-GENE-980526-404 Enables transcription cis-regulatory region binding activity. Acts upstream of or within axial mesoderm morphogenesis; endoderm development; and nervous system development. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; digestive system; endoderm; mesoderm; and swim bladder. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human FOXA2 (forkhead box A2).

Ensembl:

ensembl_id ENSDARG00000003411

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00024220 True 1772 mRNA 0.48 2 42565998 42568498

Neighbor

gene id symbol gene type direction distance location
XLOC_012310 NA coding downstream 1846 42540854 ~ 42564152 (-)
XLOC_012309 CR925755.2 coding downstream 73330 42486740 ~ 42492668 (-)
XLOC_012308 NA coding downstream 293400 42261845 ~ 42272598 (-)
XLOC_012307 nkx2.2a coding downstream 347346 42208623 ~ 42218652 (-)
XLOC_012306 NA coding downstream 389010 42167187 ~ 42176988 (-)
XLOC_012312 prkd3 coding upstream 41596 42610094 ~ 42799104 (-)
XLOC_012313 mocs3 coding upstream 243767 42812265 ~ 42842863 (-)
XLOC_012314 zgc:92137 coding upstream 415485 42983983 ~ 42988356 (-)
XLOC_012315 atg2b coding upstream 436930 43005428 ~ 43012390 (-)
XLOC_012316 NPC2 coding upstream 453164 43021662 ~ 43022468 (-)
XLOC_012304 NA non-coding downstream 473162 42092334 ~ 42092836 (-)
XLOC_012302 NA non-coding downstream 1137072 41382228 ~ 41428926 (-)
XLOC_012319 NA non-coding upstream 681760 43250258 ~ 43251920 (-)
XLOC_012328 NA non-coding upstream 1073319 43641817 ~ 43649494 (-)
XLOC_012330 FO704797.1 non-coding upstream 1139901 43708399 ~ 43718395 (-)
XLOC_012332 NA non-coding upstream 1435941 44004439 ~ 44010882 (-)
XLOC_012333 BX511267.1 non-coding upstream 1490313 44058811 ~ 44058927 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000314_00931320_00933166 FOXA2 coding CI01000314 null 930773 ~ 934321 (-)