XLOC_033007 (gabra5)


Basic Information

Item Value
gene id XLOC_033007
gene name gabra5
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007117.7
NCBI id CM002890.2
chromosome length 60270059
location 38366936 ~ 38426942 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00064132
GAGTGATGAAGAGGTCTTTGGGATGCGAGGCAAAGGAAGGGATGCTCTGCAGCGGCTGCTCAGTCACTGGATCGTGAAAGAGGACGGAACAATGAGCCTGTATGGTTAAGACTGGATATTTCTGAAGAAGAAGAACAACGCGTCGCACTACTGCTGTAAGCTGAACGTTGCGGGATTTTGCTCACTGCTTCAAAAGGAATTCGTTGCAGTTGTTCAACGTGGATCCACTGCACCATTCAGGTATTTAAGGTATGGGATATGGACCACACTGCAGCGGCAAAATGAGAAGTCTGTGGGTTGGTGTTTTGTTCATGACTTTGACCTGCCATCTGAGCCTCTCCCAGTCAACTACAGGGACCCCTAAAGAGTCAGAGCTCAATGATAACATCACAGTATTCACACGAATCCTTGACGGATTGCTGGATGGCTATGATAACAGACTTCGACCTGGGCTTGGAGAGAAAGTGACAGAAATCAAGACCAACATCTTTGTCACCAGCTTTGGACCAGTGTCAGATACTGAGATGGAATACACCATTGATGTGTTTTTCCGTCAAAGCTGGAAAGATGAGCGATTGTGCTTCAAGGGTCCAATGGAGATGCTACCTCTGAATAACCTGCTGGCCAGCAACATCTGGACACCCGACACCTTTTTCCTCAATGGCAAAAAATCCATTGCTCACAACATGACAACACCCAACAAGCTCCTGAGACTGAAGGATGATGGGACACTACTGTACACCATGAGATTGACCATATCAGCGGAGTGTCCAATGCAGTTGGAGGATTTCCCTATGGATGCCCATGCCTGCCCGCTCAAATTTGGCAGCTatgcCTATCCTATCTCGGAGGTGGTGTATAAATGGACAAAAGGCCCTGGCAAGTCTGTGGTAGTGGCAGAAGAAGGGTCACGTCTCAATCAATACCATCTAATTGGCCACACAGCTGGTACGGAAGACATCAGCACAAGTAGAGGTCAATACACTGTAATGATGGCCCACTTCTACCTGAAGAGGAAGATTGGTTACTTTGTGATTCAGACCTACATGCCGTGCTTCATGACTGTCATTCTGTCCCAAGTCTCATTCTGGCTCAACCGTGAATCCGTCCCAGCCAGGACTGTGTTTGGGGTGACCACAGTGTTGACCATGACCACCCTCAGCATCAGCGCCCGTAACTCTCTACCTAAAGTGGCGTATGCTACCGCCATGGACTGGTTCATAGCTGTCTGCTATGCCTTCGTGTTCTCTGCGCTTATTGAGTTCGCCACTGTCAACTACTTCACCAAACGCAGCTGGGCTTGGGATGGAAAGAAGGCGCTAGAAGCTCAGCAGCCTAAAAAAAAAGACCCATTGGCGCTCTCCAAAAAGCCAAACAACTTCACCGCCAACATCAACAAGGATGCGGCTATATCCACCATCTCCAACAGCACCACGGTCCAATTGAAGAGTGCCGAGGCCAAGCCTGCACCGGACCCCAAAAAGACCTACAATAGCGTCAGCAAAATTGACAAGATGTCCCGGATAGTGTTTCCGGTTCTCTTTGGAACTTTCAATTTGGTTTACTGGGCCACATACCTCAACAGGGAACCAGTGATTAAAGGAGCCGTTTAG
>TCONS_00064133
ATTTTCAAGCGTCCGCGCTTGTGCCGCACGCAGGCGCCAGTTTAATCGCGCTTTTCTCTGAATAAGCTCAAACAAGATAAGTTTGGAACCCAAGCGGCCGCTCAAATTTCCCTCGGGGGGTAATTATGCAGCGCGCGGAGGTGACGTCCTATTACTTTGGTCCCAAACACGAACAAATGCCACTGGAGTGACAGTCTGGCGATAGTCGGGAGAGCATCGGACGTCCAAACCGGCGACCCGGAGTGATGAAGAGGTCTTTGGGATGCGAGGCAAAGGAAGGGATGCTCTGCAGCGGCTGCTCAGTCACTGGATCGTGAAAGAGGACGGAACAATGAGCCTGTATGGTTAAGACTGGATATTTCTGAAGAAGAAGAACAACGCGTCGCACTACTGCTGTAAGCTGAACGTTGCGGGATTTTGCTCACTGCTTCAAAAGGAATTCGTTGCAGTTGTTCAACGTGGATCCACTGCACCATTCAGGTATTTAAGGTATGGGATATGGACCACACTGCAGCGGCAAAATGAGAAGTCTGTGGGTTGGTGTTTTGTTCATGACTTTGACCTGCCATCTGAGCCTCTCCCAGTCAACTACAGGGACCCCTAAAGAGTCAGAGCTCAATGATAACATCACAGTATTCACACGAATCCTTGACGGATTGCTGGATGGCTATGATAACAGACTTCGACCTGGGCTTGGAGAGAAAGTGACAGAAATCAAGACCAACATCTTTGTCACCAGCTTTGGACCAGTGTCAGATACTGAGATGGAATACACCATTGATGTGTTTTTCCGTCAAAGCTGGAAAGATGAGCGATTGTGCTTCAAGGGTCCAATGGAGATGCTACCTCTGAATAACCTGCTGGCCAGCAACATCTGGACACCCGACACCTTTTTCCTCAATGGCAAAAAATCCATTGCTCACAACATGACAACACCCAACAAGCTCCTGAGACTGAAGGATGATGGGACACTACTGTACACCATGAGATTGACCATATCAGCGGAGTGTCCAATGCAGTTGGAGGATTTCCCTATGGATGCCCATGCCTGCCCGCTCAAATTTGGCAGCTatgcCTATCCTATCTCGGAGGTGGTGTATAAATGGACAAAAGGCCCTGGCAAGTCTGTGGTAGTGGCAGAAGAAGGGTCACGTCTCAATCAATACCATCTAATTGGCCACACAGCTGGTACGGAAGACATCAGCACAAGTAGAGGTCAATACACTGTAATGATGGCCCACTTCTACCTGAAGAGGAAGATTGGTTACTTTGTGATTCAGACCTACATGCCGTGCTTCATGACTGTCATTCTGTCCCAAGTCTCATTCTGGCTCAACCGTGAATCCGTCCCAGCCAGGACTGTGTTTGGGGTGACCACAGTGTTGACCATGACCACCCTCAGCATCAGCGCCCGTAACTCTCTACCTAAAGTGGCGTATGCTACCGCCATGGACTGGTTCATAGCTGTCTGCTATGCCTTCGTGTTCTCTGCGCTTATTGAGTTCGCCACTGTCAACTACTTCACCAAACGCAGCTGGGCTTGGGATGGAAAGAAGGCGCTAGAAGCTCAGCAGCCTAAAAAAAAAGACCCATTGGCGCTCTCCAAAAAGCCAAACAACTTCACCGCCAACATCAACAAGGATGCGGCTATATCCACCATCTCCAACAGCACCACGGTCCAATTGAAGAGTGCCGAGGCCAAGCCTGCACCGGACCCCAAAAAGACCTACAATAGCGTCAGCAAAATTGACAAGATGTCCCGGATAGTGTTTCCGGTTCTCTTTGGAACTTTCAATTTGGTTTACTGGGCCACATACCTCAACAGGGAACCAGTGATTAAAGGAGCCGTTTAG
>TCONS_00064134
CTGTCGACAAAAACTCATCCTACATGTTAATTCAAACAAGAATTTAACACAAGCAGAGTTAGTTATATAGCAGAGAGAATGTACGCGAGAAAAAAGTTGAAGTGGACAACTGGAGGGGTTTCCAACTCTTTTTAACTCTTCCTTCGCGGGGAGCAATACAACGatgcCTATCCTATCTCGGAGGTGGTGTATAAATGGACAAAAGGCCCTGGCAAGTCTGTGGTAGTGGCAGAAGAAGGGTCACGTCTCAATCAATACCATCTAATTGGCCACACAGCTGGTACGGAAGACATCAGCACAAGTAGAGGTCAATACACTGTAATGATGGCCCACTTCTACCTGAAGAGGAAGATTGGTTACTTTGTGATTCAGACCTACATGCCGTGCTTCATGACTGTCATTCTGTCCCAAGTCTCATTCTGGCTCAACCGTGAATCCGTCCCAGCCAGGACTGTGTTTGGGGTGACCACAGTGTTGACCATGACCACCCTCAGCATCAGCGCCCGTAACTCTCTACCTAAAGTGGCGTATGCTACCGCCATGGACTGGTTCATAGCTGTCTGCTATGCCTTCGTGTTCTCTGCGCTTATTGAGTTCGCCACTGTCAACTACTTCACCAAACGCAGCTGGGCTTGGGATGGAAAGAAGGCGCTAGAAGCTCAGCAGCCTAAAAAAAAAGACCCATTGGCGCTCTCCAAAAAGCCAAACAACTTCACCGCCAACATCAACAAGGATGCGGCTATATCCACCATCTCCAACAGCACCACGGTCCAATTGAAGAGTGC

Function

symbol description
gabra5 Predicted to enable GABA-gated chloride ion channel activity; inhibitory extracellular ligand-gated ion channel activity; and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to contribute to GABA-A receptor activity; benzodiazepine receptor activity; and chloride channel activity. Predicted to be involved in several processes, including GABAergic synaptic transmission; chloride transmembrane transport; and gamma-aminobutyric acid signaling pathway. Predicted to act upstream of or within chloride transport. Predicted to be located in postsynaptic membrane. Predicted to be integral component of membrane. Predicted to be part of GABA-A receptor complex. Predicted to be active in dendrite membrane and postsynapse. Predicted to be integral component of plasma membrane. Is expressed in central nervous system. Human ortholog(s) of this gene implicated in bipolar disorder; developmental and epileptic encephalopathy 79; and mental depression. Orthologous to human GABRA5 (gamma-aminobutyric acid type A receptor subunit alpha5).

GO:

id name namespace
GO:0060078 regulation of postsynaptic membrane potential biological_process
GO:0042391 regulation of membrane potential biological_process
GO:0050877 nervous system process biological_process
GO:0007214 gamma-aminobutyric acid signaling pathway biological_process
GO:0034220 ion transmembrane transport biological_process
GO:0007268 chemical synaptic transmission biological_process
GO:1902476 chloride transmembrane transport biological_process
GO:0006811 ion transport biological_process
GO:0051932 synaptic transmission, GABAergic biological_process
GO:0007165 signal transduction biological_process
GO:0032590 dendrite membrane cellular_component
GO:0043005 neuron projection cellular_component
GO:0045202 synapse cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005887 integral component of plasma membrane cellular_component
GO:1902711 GABA-A receptor complex cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0098794 postsynapse cellular_component
GO:0022851 GABA-gated chloride ion channel activity molecular_function
GO:0008503 benzodiazepine receptor activity molecular_function
GO:0004888 transmembrane signaling receptor activity molecular_function
GO:0004890 GABA-A receptor activity molecular_function
GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential molecular_function
GO:0005216 ion channel activity molecular_function
GO:0005230 extracellular ligand-gated ion channel activity molecular_function
GO:0005237 inhibitory extracellular ligand-gated ion channel activity molecular_function
GO:0005254 chloride channel activity molecular_function
GO:0030594 neurotransmitter receptor activity molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-081104-30 Predicted to enable GABA-gated chloride ion channel activity; inhibitory extracellular ligand-gated ion channel activity; and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to contribute to GABA-A receptor activity; benzodiazepine receptor activity; and chloride channel activity. Predicted to be involved in several processes, including GABAergic synaptic transmission; chloride transmembrane transport; and gamma-aminobutyric acid signaling pathway. Predicted to act upstream of or within chloride transport. Predicted to be located in postsynaptic membrane. Predicted to be integral component of membrane. Predicted to be part of GABA-A receptor complex. Predicted to be active in dendrite membrane and postsynapse. Predicted to be integral component of plasma membrane. Is expressed in central nervous system. Human ortholog(s) of this gene implicated in bipolar disorder; developmental and epileptic encephalopathy 79; and mental depression. Orthologous to human GABRA5 (gamma-aminobutyric acid type A receptor subunit alpha5).

Ensembl:

ensembl_id ENSDARG00000070730

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00064132 False 1613 mRNA 0.49 10 38366936 38418862
TCONS_00064133 False 1853 mRNA 0.49 11 38366936 38419318
TCONS_00064134 True 785 processed_transcript 0.48 5 38367096 38426942

Neighbor

gene id symbol gene type direction distance location
XLOC_033006 CR407584.1 coding downstream 8856 38132511 ~ 38358080 (-)
XLOC_033005 nipa1 coding downstream 617225 37745719 ~ 37749711 (-)
XLOC_033004 nipa2 coding downstream 621428 37733608 ~ 37745508 (-)
XLOC_033002 chst7 coding downstream 744360 37603968 ~ 37622576 (-)
XLOC_033003 BX322552.1 coding downstream 751453 37615366 ~ 37615483 (-)
XLOC_033008 CR628341.2 coding upstream 170727 38597669 ~ 38597784 (-)
XLOC_033009 NA coding upstream 332604 38759546 ~ 38764326 (-)
XLOC_033010 cnga3a coding upstream 364958 38791900 ~ 38818582 (-)
XLOC_033011 hdac7b coding upstream 478105 38905047 ~ 38930726 (-)
XLOC_033012 vdrb coding upstream 527791 38954733 ~ 39006449 (-)
XLOC_032997 BX324166.3 non-coding downstream 919793 37447028 ~ 37447143 (-)
XLOC_032996 BX324166.2 non-coding downstream 927566 37439255 ~ 37439370 (-)
XLOC_032992 NA non-coding downstream 1022342 37342328 ~ 37344594 (-)
XLOC_033024 NA non-coding upstream 1064904 39491846 ~ 39521832 (-)
XLOC_033025 CU467856.1 non-coding upstream 1097982 39524924 ~ 39525505 (-)
XLOC_033038 NA non-coding upstream 1611750 40038692 ~ 40044111 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000340_08502336_08507603 NA coding CI01000340 null 8502245 ~ 8509133 (-)