XLOC_034976 (en2a)


Basic Information

Item Value
gene id XLOC_034976
gene name en2a
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007118.7
NCBI id CM002891.2
chromosome length 74282399
location 40988901 ~ 40993456 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00068024
CAGAGTAGCCACTGAAGCCTCGCTAGTTGCACTGCGCAGCAAACCAGTAGCACCAAACTGGCAAGTTACGGTTCATCAACCTTAAACTGCAAACATTCCGTGTTTGGAAGGCGTAACTATGTTTTTCCTTTGTGACCACGGTGCGCAAAGGCTTTTTACTGTCGCTAAAACTCACTGACAGTTTTTTGGccgttttgaattttttttttcctgaagtgAACAAAGTGGACGGAGTCGCCCGTGGAGTGGGGTGCGACTGCCAGAGTGCGGGAGAGCGATAAAGGGTTAAGGACGGAAGGTGGAAAGTGCGTCTCAGCATGGATGAGAATGAGCAGAGCGCAAGAGACGTGGAACAGCGAGGAGCGTCGGACGAGTCCAACAGTGCCATACGACCCCTTTTACAAGCTCCAGGAAACCTGCAGCTGCCACACCGAATCACAAACTTCTTCATCGACAACATCCTGCGACCAGATTTTGGCCGTAAAAAAGAAGCGAATATTACGCGCTATGAGGACAATCACGGCGCACGAGAGAATCACAACCCTACGGGTCCAAGCACGGGACAGGTGGGAAGTACTGTACCAGCGGAAGAAGCTTCCACAACGCATACGAGCAGCGGAGGAAAGGAGGCAGAGATAGAGAGCGAAGAACCCCTGAAGCCCCGCGGGGAGAATGTGGATCAGTGCTTGGGTTCAGAATCGGATAGTTCACAGAGCAATTCAAACGGACAGACTGGTCAGGGTATGCTGTGGCCCGCTTGGGTTTACTGCACACGCTACTCGGACAGGCCGTCGTCAGGTCCCAGGTCTCGTAAACCAAAGAAGAAAGCCGCAAGTAAAGAAGACAAACGACCACGCACGGCCTTCACGGCGGAGCAGCTTCAGAGACTCAAGGCCGAGTTCCAGACCAACCGCTACCTGACCGAGCAGCGGCGGCAAAGCCTGGCGCAGGAACTGGGCCTCAACGAATCTCAGATCAAAATCTGGTTCCAAAACAAGCGGGCCAAAATCAAAAAGGCCAGCGGCGTCAAGAACGGTCTGGCAATACACCTGATGGCACAGGGACTGTACAACCACAGCACCACGTCAAAGGAGGACAAATCAGACAGTGACTGAGGCAGAGAGAGCGGGGAGGGGGAAGAGATGGGTGGGGTGGACCGGGTGGGGGGCAAGGTTATATTTACAATGCAATAATTCAAAAGAATAAAGGGCCAGTTAATAAATATACCAGCATTACTGACGTTAAAATAGAGGCTATATCGAATTATGTCAAAGTACATTTATTGAACACAATTCTCTTATGAAATAATGGTCAAATTATTTCAAAAATAGGCTATACGTGCCGTTGTTTGCACTTGGATAGAGTGTCTATGTTAGAAACAAGTGTTTCTATCGCTCTTTGTCATGTCACCAGAACCAAGCGCTATTAGCGCAACGGGcgtttatatatacatttatgtcagtttatgtgagaaaaaaaacattgcgCGAAACCTTGCTTAAGTCCAAAGAGTCTTTTCTGCTGCATCCAGGCAACTGTGAGTACTATGAAATGCGTTAGACTTGTTTTTTCCACGTTTTTCGTATTATTTGGTTTGATGTTTGATACGAAATGGACGCAGCAATCGTTCGGATCTCAGCAGGattttttaacaaacagaaaaaaggaaACTGAGAAGAAACACTGtcctttttattgtaaataagttCACAGTCTTAGCCTGGCTAATTTAAAAGAGTGAAATGGAGGAGGAAGAAATCACAAAACTTGTTTAACAGTGCATTGTAGGTTATCTGGTTGAACTACATGTGAACTAGCCTAATATTTTCGAAATAACATTGAACTAACCTTCATAGCCTGgtcaaaacacaaaacacaaaatactGGGTGcgctaaataaacaaatgtaccGCAGCGTCTTAAATCGCATACATAGTTTTATAAAAGAGCAATATAATCATCTTTTGTAGCAAAGTATGTTTTAACCATTTAAATGCTGCCTATAATCGTGTAGCACTGACAATGATTTCGCTTATGCGCACTCTTGACTGAAGCCAGGGTAAGCGCCACAACACATCACacagaaatataaacaaatatataaatatacagctatatataaaacacaaacacacacaactatcgaataaaaaataagcaaaccAGCTGTTTACTGTATGACAGATGttaaaatactgttttaatgTTGACTTCATATTTGTTATGTATTTATATAGATTATattaaggaagaaaaaaaactttatccAATGACCGGTGTTGCTTTTTATGTGAGAGTAGATTTCTAAGGTGTTTAAATTGcttatttatattgcaataactTCTTTATGTGAATAAAGCGGTATTGGGGCCTTTGCATGAAAGCTGCAAATTGTCATATTAGGCATATTCACGCGTGTTTAGAAAAGTAAAAAAGGGTATGATCGAGATTTAAGTTGCAGACTGTATCCATATACCaaattgtggattttttttacttgtcgAATCTTTGTTTTACACCTGAAAAGAGTGTGTGACTATATAGCCACCAAACCTAACACACTTTGCCTTACAAGTTCAAGTGCGAACTTAATATCACAGAACTGTGCCGAATCAGAGAAACAGTATTAGTTCAATTGCATATGAGCATATCTATGAATATGGCCTTCTATCTGATATACGACCTAATGAATTTACTCATCAGCGAAGATCTATCTATAAAAGCTATGTTGAaagctgaaatgaaaaaaattgagATAATacaatgctatttttattttgtgtttacaggTACTGTTTGTTATATGTGTAAATAATTTGTATCACGTACCTACGTATTAATTGTGTAATTAACTGCCTCCTGAAATCTTGAtaagaattaaataaacaatatgaataataataataataa

Function

symbol description
en2a Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within apoptotic process involved in morphogenesis; cell fate specification; and nervous system development. Predicted to be active in nucleus. Is expressed in several structures, including adaxial cell; central nervous system; muscle; neural plate; and pharyngeal arch. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EN2 (engrailed homeobox 2).

GO:

id name namespace
GO:0001708 cell fate specification biological_process
GO:0021555 midbrain-hindbrain boundary morphogenesis biological_process
GO:0006355 regulation of transcription, DNA-templated biological_process
GO:0006357 regulation of transcription by RNA polymerase II biological_process
GO:0060385 axonogenesis involved in innervation biological_process
GO:0030182 neuron differentiation biological_process
GO:0007275 multicellular organism development biological_process
GO:0009952 anterior/posterior pattern specification biological_process
GO:0030901 midbrain development biological_process
GO:0060561 apoptotic process involved in morphogenesis biological_process
GO:0030917 midbrain-hindbrain boundary development biological_process
GO:0005634 nucleus cellular_component
GO:0043565 sequence-specific DNA binding molecular_function
GO:0003677 DNA binding molecular_function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding molecular_function
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-980526-167 Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within apoptotic process involved in morphogenesis; cell fate specification; and nervous system development. Predicted to be active in nucleus. Is expressed in several structures, including adaxial cell; central nervous system; muscle; neural plate; and pharyngeal arch. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EN2 (engrailed homeobox 2).

Ensembl:

ensembl_id ENSDARG00000026599

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00068024 True 2910 mRNA 0.41 2 40988901 40993456

Neighbor

gene id symbol gene type direction distance location
XLOC_034974 rbm33a coding downstream 29034 40900212 ~ 40959867 (-)
XLOC_034975 CU041319.2 coding downstream 39711 40948875 ~ 40949190 (-)
XLOC_034973 CU041319.3 coding downstream 104196 40866815 ~ 40884705 (-)
XLOC_034972 rnf32 coding downstream 250127 40715756 ~ 40738774 (-)
XLOC_034971 nom1 coding downstream 331070 40644769 ~ 40657831 (-)
XLOC_034977 insig1 coding upstream 14317 41007773 ~ 41014773 (-)
XLOC_034978 htr5ab coding upstream 87193 41080649 ~ 41102498 (-)
XLOC_034979 kif9 coding upstream 281745 41275201 ~ 41295511 (-)
XLOC_034980 ncf2 coding upstream 336292 41329748 ~ 41338923 (-)
XLOC_034981 prkdc coding upstream 355087 41348543 ~ 41396860 (-)
XLOC_034969 NA non-coding downstream 427200 40557036 ~ 40561701 (-)
XLOC_034962 BX908792.1 non-coding downstream 1272828 39715712 ~ 39716073 (-)
XLOC_034958 BX842701.1 non-coding downstream 1547851 39437384 ~ 39441050 (-)
XLOC_034985 BX005319.3 non-coding upstream 499561 41493017 ~ 41493131 (-)
XLOC_034988 NA non-coding upstream 714084 41707540 ~ 41709193 (-)
XLOC_034995 NA non-coding upstream 984932 41978388 ~ 41980012 (-)
XLOC_034997 CR759753.1 non-coding upstream 1159954 42153410 ~ 42153524 (-)
XLOC_034998 CR847539.1 non-coding upstream 1297522 42290978 ~ 42291094 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000026_12289057_12291515 EN2, ENG2A coding CI01000026 null 12288936 ~ 12293418 (-)