XLOC_034977 (insig1)


Basic Information

Item Value
gene id XLOC_034977
gene name insig1
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007118.7
NCBI id CM002891.2
chromosome length 74282399
location 41007773 ~ 41014773 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00068025
TGTTTTCTGCAGAGGAAGCGCGCGTGTGGCAGTGTTCAACTGAGGGATGAAAAGAGGCAGCAGTATTTCTCTTACAGATGATGTGATCAAACAACACATCTAAACTATTTGTAGGTAGCCTTTCGTTTTTGTAAAAGAGTTTTGAAAGCACAGACGTGTTCTGCTTTAGACGAAGACATCGCTAAAAGATCAAGTGCCAAATGCCAAGACTAGAGGAACATTGTTGGAGCTGCTCCTGTTCGACCAGTGTGAAGACGAAGGACCTGTCAAGCGCCGGCTGGATTGTCTGTAAAACGGGTGAAATGATGTCCATCATAACCTCAGTGCTGAGCCACGCGTACGGCTCTCTGCACAGCCTCCAGTCCGCCAATTTAATTCGACGGGGGCTTGTGTTGTTTATCGTGGGAGTTGTGCTCGCTTTGGTGTTAAACTTGCTACAGATCCAGAGAAACGTTACATTGTTTCCAGAGGAAGTGCTGGACACGCTATTTTCGTCCGCCTGGTGGATTCCCCTCTGCTGTGGCACCGCTGCTGCTGTGGTTGGTCTGTTGTACCCCTGCTTGGACCACCATCTTGGAGAACCACACAAGTTCAAGCGGGAGTGGGCAAGCGTGATGCGCTGCATTGCTGTCTTTGTGGGCATCAATCACGCCAGTGCTAAACTGGACTTTGCTAACAATGTGCAGCTATCGCTAACTCTGGCTGCCCTGTCTCTGGGTCTGTGGTGGACATTTGACCGCTCCAGGAGTGGCTTTGGTTTAGGGCTGACCACTGCCCTGCTGGCCACTCTCATTGCTCAGCTGCTGGTCTACAACGGCATCTACCAGTATACTTCTCCAGACTTCTTGTATGTCCGTTCATGGCTGCCTTGTATATTCTTCTCTGGCGGAGTGACTGTTGGAAATATTGGCAGACAACTAGCTATGGGCTCGACTGAGAAGATTCATAATGACTAAACAGGTGTCAGAGGGCATGAAGTGAGCTTCGAAGAGTGCCAAAAAAGGACATCTGATATTCTATACTGGGCGTCCCTGGTGTCTATCCAAGCGTATCTTCTGCTTTTAATTTTGCTCCTCTTTATAactataaaagaaaagaaagagcgGGTTGGTCTGAGCTGGCCCAATGTGCCATGAACAACACCTCTGAATAGCCAAAAGATTCCCCCTGGCATTCATTACTACCATCAGCGTCATTatcgtcgttgttgttgttgttgttacagcTCCTAGCAGTAGTGTTACGGTTGCTGAAGTGCCACTATAggactgtgaaaaaaaaatcatagctgGTTTCACTGACGATGAAACTACTTGTGAAACCACATCTACAATTGAGCGTGTGCTGGTCCTATGGATAAGACCAgggggaaaaaagacagtgtgaaaaTTCAcacttttttagttttactttgtGCTGGAGAACTGAAAGAAGAAATCAAAGGGAATAAATACAAGAATACCTAAAATATCCAAAGAGGTCTGTGTACTGTCTATATAGGATTAGTTGTAGTTTGATTTTTGAGCTACCCTTAAAGACTGACCACTTTGAGTATTACTATGAATACCAGAGAGCTTTGATTGCCAATCACATTTGTGCCGACTGGTTAGTGTAGTATACTGACTGAATTGATCGTGTTTTTACCATACTTTGTTGCTAATGTAAACCAAAAGTAAGACTAGAAACATTAGCTATCGAGACGTTAAGTGGCACCTTGAAGAAAGAgtcaaacagaagaaaaaaaacaaggatGCTCTTTGTATTAATGTAAATTCACAATGTAGAATCATATAAAATGGTGTAATGAAGTCCTTTTAAAGTTTCTAAACCAAAAGGTTGGAAACTTTTGATAACTAAACATCAGGAAGACATTTTACTGCGGCCTCGAAGGTTTGCAATCTGTGATTGCCTTTGTATTATAGAATTAAGTGCTTTTGTCACTTTCACCCGTAcagtcaatttttttattttatttttttgtattctattcaTTGTGTATTGCTTTTCACCTGTAGCAGCTTCTCTGTCTAAATAAAGAGGTATCACTGGGCTAGTGTGCAGGTTTGGGGGTCTTAGCAAATTAAGTGCAATCACTTTCTTTGAGCCTGGTATTCTTTCATATTTATTACCTTTTACAATGTTAAGGAACCCCAGATGACTCATATGCAGTATAGTGGCAAACCAGCAATAATCACTTTGTTTATACGTACATACATGAAGGTGTAGTAGGATGGCAAACTCGTTTTTAAAAGAAGTCACACATGAAAGATAATCTTGCAAATGATACCAATGACCATTTCCACTgttatggggaaaaaaaaacattgatgttCATTGTCTTTACTAGCAGTAGtgaattattttaagcaaaatactGTGCGCTGTATTTTGGGAATGTTTGATGAAGACCATGAGGGATATGTTTTAAAACCACGATAAAACGTTCCTCTCTGAACCACTCTGTTTCAGGGAAGGAGAGATGTTAAAGTGAATGAAAGCTTTATTTCGAAGGGAGTGAGAAATGTGTTTCTAGGagtgaatgtgcatgtgtgtttttaccACTTTGGTTCATTTATACTGTTTTAGTTCAATTATGGATGAAATTCAATAAAATTGTGTATTGTACATCAGGCTTTTGAGTTATTTGTTCAGTCTTCAGATATCAgggtaaatacaaaaaaaaaaaaaaaacattattacaagGACACTGTATAAAGTTACTTTATTGTTACTGTTAAGACCAATAGTTTGATTAAACAATAGATTACTTGCAGAAATAGTcagtaatattaaatgtaaacatttgagAACAAATTAGAAAACAACCTACAATTTTCAAGGCCACTCCTTAGTAGTTCTTGAATTGACTGTAACAGGAGTTATACTAGTTTAAACAATTCATGAGTTACATATTCTGCAGAACACTTTAATATCCTCACAGTCACTGGTTTATCTGGGACCTGGCGGTAGGTTCCTTAATTATCTGACAAACCATATTTAACTGTCAGCCAAACTTTCCGGATTTCACTGACTGCAAGAGTGACTGAAAAGCCTCTGTGGCTGAAAGCCTCCAATAACAGGTTATCCAAATTATAGCCAAAGGGATAacgataaataataaatatccaaaatcaaacatgtataaaaaatgtatatatgtgtgtgggtTATGTATTTGGACACTATAACCctgtttatatactttttttggtGGTTTCACTCTATACACAAGATGATATAGATGACTATATATAAGACTCatcttttttgtttgattttaattcTTTTCTGTCTCAATACTGAATAAATAATGATTGTTGAGTTG
>TCONS_00068026
TATACTAAAAGGCGTCAAACAATACCAAGCagatCTGTGGTTGGTCTGTTGTACCCCTGCTTGGACCACCATCTTGGAGAACCACACAAGTTCAAGCGGGAGTGGGCAAGCGTGATGCGCTGCATTGCTGTCTTTGTGGGCATCAATCACGCCAGTGCTAAACTGGACTTTGCTAACAATGTGCAGCTATCGCTAACTCTGGCTGCCCTGTCTCTGGGTCTGTGGTGGACATTTGACCGCTCCAGGAGTGGCTTTGGTTTAGGGCTGACCACTGCCCTGCTGGCCACTCTCATTGCTCAGCTGCTGGTCTACAACGGCATCTACCAGTATACTTCTCCAGACTTCTTGTATGTCCGTTCATGGCTGCCTTGTATATTCTTCTCTGGCGGAGTGACTGTTGGAAATATTGGCAGACAACTAGCTATGGGCTCGACTGAGAAGATTCATAATGACTAAACAGGTGTCAGAGGGCATGAAGTGAGCTTCGAAGAGTGCCAAAAAAGGACATCTGATATTCTATACTGGGCGTCCCTGGTGTCTATCCAAGCGTATCTTCTGCTTTTAATTTTGCTCCTCTTTATAactataaaagaaaagaaagagcgGGTTGGTCTGAGCTGGCCCAATGTGCCATGAACAACACCTCTGAATAGCCAAAAGATTCCCCCTGGCATTCATTACTACCATCAGCGTCATTatcgtcgttgttgttgttgttgttacagcTCCTAGCAGTAGTGTTACGGTTGCTGAAGTGCCACTATAggactgtgaaaaaaaaatcatagctgGTTTCACTGACGATGAAACTACTTGTGAAACCACAT
>TCONS_00068027
GAGTTTTGAAAGCACAGACGTGTTCTGCTTTAGACGAAGACATCGCTAAAAGATCAAGTGCCAAATGCCAAGACTAGAGGAACATTGTTGGAGCTGCTCCTGTTCGACCAGTGTGAAGACGAAGGACCTGTCAAGCGCCGGCTGGATTGTCTGTAAAACGGGTGAAATGATGTCCATCATAACCTCAGTGCTGAGCCACGCGTACGGCTCTCTGCACAGCCTCCAGTCCGCCAATTTAATTCGACGGGGGCTTGTGTTGTTTATCGTGGGAGTTGTGCTCGCTTTGGTGTTAAACTTGCTACAGATCCAGAGAAACGTTACATTGTTTCCAGAGGAAGTGCTGGACACGCTATTTTCGTCCGCCTGGTGGATTCCCCTCTGCTGTGGCACCGCTGCTGCTGTGGTTGGTCTGTTGTACCCCTGCTTGGACCACCATCTTGGAGAACCACACAAGTTCAAGCGGGAGTGGGCAAGCGTGATGCGCTGCATTGCTGTCTTTGTGGGCATCAATCACGCCAGTGCTGTATCCTTAACAGTGACACTTTTACAGTTGCAACCATTGTGGACAATGAAAACTTCCAAACCTTTTTGAGATTTTTGTTTTAAGTCTGTAATAAGCCATGTTACTATTCAATAGCATTAGACAAATCCTTTTTTTtcttaatctcttaactgtcacatatttatttgtttttgtctgaACCTGAATTTATCTTGACAAATTATACATCAAAGGCTAAACTAAAAAAGTGGGGTGACCCGTTAAAGTACTAAACATATTTACACAGCAATAATCTATGCAACGAGAATTATGCTtatctaatatttttaaaaagtcttatgtATTGAGGATAGTTGTAATAACGCTGAAAAATGACTAGAAATGCTCAGTACTCTGACCCGGCCAGAAGTTGAAAACTCTGCACACGATATCATTTAAccttttttaagttttgttttgacGACTCTGAGTCTGTGTTTTTGggtaaatgaacagcaaaaatgcataaaagtttttattttttgttgtcatgtAAATATACCTTAAAACTTTACATTAACTCTGAACTCAAACAGTAACATGCACTTCATTGCCAAGAAAC

Function

symbol description
insig1 Predicted to enable oxysterol binding activity. Predicted to be involved in several processes, including SREBP signaling pathway; SREBP-SCAP complex retention in endoplasmic reticulum; and cholesterol biosynthetic process. Predicted to act upstream of or within cholesterol metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be part of SREBP-SCAP-Insig complex. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including anterior axial hypoblast; immature eye; liver; notochord; and yolk syncytial layer. Orthologous to human INSIG1 (insulin induced gene 1).

GO:

id name namespace
GO:0032869 cellular response to insulin stimulus biological_process
GO:0036316 SREBP-SCAP complex retention in endoplasmic reticulum biological_process
GO:0006629 lipid metabolic process biological_process
GO:0016126 sterol biosynthetic process biological_process
GO:0008202 steroid metabolic process biological_process
GO:0032933 SREBP signaling pathway biological_process
GO:0008203 cholesterol metabolic process biological_process
GO:0006695 cholesterol biosynthetic process biological_process
GO:0005783 endoplasmic reticulum cellular_component
GO:0032937 SREBP-SCAP-Insig complex cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0008142 oxysterol binding molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-030131-6121 Predicted to enable oxysterol binding activity. Predicted to be involved in several processes, including SREBP signaling pathway; SREBP-SCAP complex retention in endoplasmic reticulum; and cholesterol biosynthetic process. Predicted to act upstream of or within cholesterol metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be part of SREBP-SCAP-Insig complex. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including anterior axial hypoblast; immature eye; liver; notochord; and yolk syncytial layer. Orthologous to human INSIG1 (insulin induced gene 1).

Ensembl:

ensembl_id ENSDARG00000010658

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00068025 False 3325 mRNA 0.39 6 41007773 41014773
TCONS_00068026 False 827 mRNA 0.47 5 41009771 41013575
TCONS_00068027 True 1103 lncRNA 0.41 3 41012757 41014637

Neighbor

gene id symbol gene type direction distance location
XLOC_034976 en2a coding downstream 14317 40988901 ~ 40993456 (-)
XLOC_034974 rbm33a coding downstream 47906 40900212 ~ 40959867 (-)
XLOC_034975 CU041319.2 coding downstream 58583 40948875 ~ 40949190 (-)
XLOC_034973 CU041319.3 coding downstream 123068 40866815 ~ 40884705 (-)
XLOC_034972 rnf32 coding downstream 268999 40715756 ~ 40738774 (-)
XLOC_034978 htr5ab coding upstream 65876 41080649 ~ 41102498 (-)
XLOC_034979 kif9 coding upstream 260428 41275201 ~ 41295511 (-)
XLOC_034980 ncf2 coding upstream 314975 41329748 ~ 41338923 (-)
XLOC_034981 prkdc coding upstream 333770 41348543 ~ 41396860 (-)
XLOC_034982 BX322787.1 coding upstream 386715 41401488 ~ 41420226 (-)
XLOC_034969 NA non-coding downstream 446072 40557036 ~ 40561701 (-)
XLOC_034962 BX908792.1 non-coding downstream 1291700 39715712 ~ 39716073 (-)
XLOC_034958 BX842701.1 non-coding downstream 1566723 39437384 ~ 39441050 (-)
XLOC_034985 BX005319.3 non-coding upstream 478244 41493017 ~ 41493131 (-)
XLOC_034988 NA non-coding upstream 692767 41707540 ~ 41709193 (-)
XLOC_034995 NA non-coding upstream 963615 41978388 ~ 41980012 (-)
XLOC_034997 CR759753.1 non-coding upstream 1138637 42153410 ~ 42153524 (-)
XLOC_034998 CR847539.1 non-coding upstream 1276205 42290978 ~ 42291094 (-)

Expression


Co-expression Network