XLOC_003777 (cdk4)


Basic Information

Item Value
gene id XLOC_003777
gene name cdk4
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007122.7
NCBI id CM002895.2
chromosome length 45484837
location 135249 ~ 141592 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00007282
TTCTTGATGTGGTTGATGCGCACCAGCACACCCTGCCCACGGTCACGGAGGATCAGCAGCTTCTCCGCCAGTTTCAGCTGGTAGGCcatgatggCGCAGGAGGTGGGGCTGCAGTATGAGCCAGTAGCAGAGATCGGGGGCGGGGCTTACGGGACCGTCTATAAGGCTCGGGATCGGGACAGCGGGCAGTTTGTGGCGCTGAAGAGCGTTCGGGTGCAGACCAATCAGGACGGACTCCCACTGTCCACGGTTCGAGAGGTGGCTCTGCTGAAGCGCCTGGAGCAGTTCGACCATCCCAACATcgtcaggctgATGGACGTGTGCGCGACCCTCAGGACGGATCAGGAGACTAAAGTGACGCTGGTGTTTGAACATGTGGATCAGGATCTCAGGACATACCTGGAGAAAGTTCCAGCACCGGGACTGCCTGTGGACAAAATCAgagaccTGATGCAGCAGCTGCTGTGTGGTCTGGCGTTCCTGCACACTAATCGAGTTCTCCATCGGGATCTGAAGCCGGAGAACATCCTGGTGACCAGCAGAGGGCAGGTGAAGCTGGCGGACTTCGGGCTGGCGCGCATCTACAGCTGCCACATGGCACTGACCCCGGTGgtggtGACGCTGTGGTATCGCTCTCCTGAGGTGCTCCTGCAGAGCACATACGCCACACCAGTGGACATCTGGAGCACCGGCTGCATCTTTGCCGAGATGTTCAGACGCAAGCCTCTGTTCTGCGGAGATTCAGAGGCGGACCAGCTGGGGAAGATCTTTGCGGTGATCGGTCTGCCGGCGGAGGATCAGTGGCCCACAGACGTCACTCTTTCCCACCACAACTTCAGCCCTCAGAGCCCTCGGCCAATCACAGACTGCGTTCCGGACATCACAGagaaaggggcggagctattgctgAAAATGCTGACCTTCGACCCGCTGAAGAGGATCTCTGCGCTGAACGCTCTGGATCATCCCTTCTTCAGCGAGTGATGctgctctacacacacacacacacacacacacacacacacacacaagccagcAGACTGAAGATAAACAttccctgagtgtgtgtgtgtgtgtgt

Function

symbol description
cdk4 Predicted to enable RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation and regulation of cell cycle. Predicted to act upstream of or within phosphorylation. Predicted to be part of mediator complex. Predicted to be active in nucleus. Is expressed in oocyte stage I and ovary. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); familial melanoma; glioblastoma; obesity; and type 2 diabetes mellitus. Orthologous to human CDK4 (cyclin dependent kinase 4).

GO:

id name namespace
GO:0051726 regulation of cell cycle biological_process
GO:0006468 protein phosphorylation biological_process
GO:0016310 phosphorylation biological_process
GO:0005634 nucleus cellular_component
GO:0016592 mediator complex cellular_component
GO:0016740 transferase activity molecular_function
GO:0005524 ATP binding molecular_function
GO:0000166 nucleotide binding molecular_function
GO:0004672 protein kinase activity molecular_function
GO:0004674 protein serine/threonine kinase activity molecular_function
GO:0016301 kinase activity molecular_function
GO:0004693 cyclin-dependent protein serine/threonine kinase activity molecular_function
GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity molecular_function

KEGG:

id description
ko04151 PI3K-Akt signaling pathway
ko04110 Cell cycle
ko04115 p53 signaling pathway
ko04218 Cellular senescence
ko04530 Tight junction
ko04660 T cell receptor signaling pathway
ko05200 Pathways in cancer
ko05203 Viral carcinogenesis
ko05212 Pancreatic cancer
ko05225 Hepatocellular carcinoma
ko05214 Glioma
ko05220 Chronic myeloid leukemia
ko05218 Melanoma
ko05219 Bladder cancer
ko05224 Breast cancer
ko05222 Small cell lung cancer
ko05223 Non-small cell lung cancer
ko05166 Human T-cell leukemia virus 1 infection
ko05160 Hepatitis C
ko05164 Influenza A
ko05162 Measles
ko05163 Human cytomegalovirus infection
ko05167 Kaposi sarcoma-associated herpesvirus infection
ko05169 Epstein-Barr virus infection
ko05165 Human papillomavirus infection
ko04933 AGE-RAGE signaling pathway in diabetic complications
ko04934 Cushing syndrome
ko01522 Endocrine resistance
ko01001 Protein kinases

ZFIN:

id description
ZDB-GENE-060929-974 Predicted to enable RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation and regulation of cell cycle. Predicted to act upstream of or within phosphorylation. Predicted to be part of mediator complex. Predicted to be active in nucleus. Is expressed in oocyte stage I and ovary. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); familial melanoma; glioblastoma; obesity; and type 2 diabetes mellitus. Orthologous to human CDK4 (cyclin dependent kinase 4).

Ensembl:

ensembl_id ENSDARG00000087937

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00007282 True 1079 mRNA 0.58 8 135249 141592

Neighbor

gene id symbol gene type direction distance location
XLOC_003776 NA coding downstream 6083 128158 ~ 129166 (-)
XLOC_003775 arfgap1 coding downstream 7464 122634 ~ 127785 (-)
XLOC_003774 elmo2 coding downstream 32092 88247 ~ 103157 (-)
XLOC_003773 CABZ01072245.1 coding downstream 63709 61190 ~ 71540 (-)
XLOC_003772 col2a1b coding downstream 78486 32007 ~ 56763 (-)
XLOC_003778 tegt coding upstream 19604 161196 ~ 167451 (-)
XLOC_003779 avil coding upstream 27802 169394 ~ 183328 (-)
XLOC_003780 CU633745.1 coding upstream 41978 183570 ~ 190461 (-)
XLOC_003781 NA coding upstream 51868 193460 ~ 194715 (-)
XLOC_003782 dusp7 coding upstream 78952 220544 ~ 236766 (-)
XLOC_003938 BX324177.10 misc upstream 11197212 11338804 ~ 11339100 (-)
XLOC_003942 BX324177.17 misc upstream 11226002 11367594 ~ 11367890 (-)
XLOC_003943 BX324177.3 misc upstream 11228863 11370455 ~ 11370653 (-)
XLOC_003944 BX324177.4 misc upstream 11239312 11380904 ~ 11381204 (-)
XLOC_003945 BX324177.6 misc upstream 11242241 11383833 ~ 11384130 (-)
XLOC_003787 CR855375.2 non-coding upstream 207521 349113 ~ 351701 (-)
XLOC_003788 NA non-coding upstream 227535 369127 ~ 369686 (-)
XLOC_003793 CR855375.4 non-coding upstream 318223 459815 ~ 459930 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location